Inhibition of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60

Journal of Immunology

Volumn 169, Issue 6, 2002, Pages 3422-3428

  Quintana, Francisco J ^a   Carmi, Pnina ^a   Mor, Felix ^a   Cohen, Irun R ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; GAMMA INTERFERON; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 65; INTERLEUKIN 10; TRANSFORMING GROWTH FACTOR BETA1;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IMMUNOMODULATION; INTERFERON PRODUCTION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; T LYMPHOCYTE ACTIVATION; VACCINATION;

EID: 0037105543     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.6.3422     Document Type: Article

References (43)

1. Adjuvant arthritis
2. Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II
3. Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans
4. Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis
5. Suppression of adjuvant arthritis in rats by induction of oral tolerance to mycobacterial 65-kDa heat shock protein
6. Modulation of experimental autoimmunity: Treatment of adjuvant arthritis by immunization with a recombinant vaccinia virus
7. Protection of rats from adjuvant arthritis by immunization with naked DNA encoding for mycobacterial heat shock protein 65
8. Do heat shock proteins control the balance of T-cell regulation in inflammatory diseases?
9. T cell responses to conserved bacterial heat-shock-protein epitopes induce resistance in experimental autoimmunity
10. T-cell reactivity to human HSP60 in oligo-articular juvenile chronic arthritis is associated with a favorable prognosis and the generation of regulatory cytokines in the inflamed joint
11. Stimulation of suppressive T cell responses by human but not bacterial 60-kD heat-shock protein in synovial fluid of patients with rheumatoid arthritis
12. Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein
13. Differential mycobacterial 65-kDa heat shock protein T cell epitope recognition after adjuvant arthritis-inducing or protective immunization protocols
14. Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in nonobese diabetic mice: Modulation of spontaneous 60-kDa heat shock protein autoimmunity
15. Autoantibody patterns in diabetes-prone NOD mice and in standard C57BL/6 mice
16. Serum heat shock protein and anti-heat shock protein antibody levels in aging
17. Two monoclonal antibodies generated against human hsp60 show reactivity with synovial membranes of patients with juvenile chronic arthritis
18. Immunostimulatory DNA sequences influence the course of adjuvant arthritis
19. Immunohistochemical study of lymphoid tissues in adjuvant arthritis (AA) by image analysis: Relationship with synovial lesions
20. Antigen levels and antibody titers after DNA vaccination
21. Long-term expression of erythropoietin in the systemic circulation of mice after intramuscular injection of a plasmid DNA vector
22. Regulatory T cells and inflammatory bowel disease
23. An overview of regulatory T cells
24. + T-cell subsets in autoimmunity
25. Highly autoproliferative T cells specific for 60-kDa heat shock protein produce IL-4/IL-10 and IFN-γ and are protective in adjuvant arthritis
26. Myelin reactive T cells after T cell vaccination in multiple sclerosis: Cytokine profile and depletion by additional immunizations
27. Cellular and humoral immune responses against autoreactive T cells in multiple sclerosis patients after T cell vaccination
28. Regulation of NOD mouse autoimmune diabetes by T cells that recognize a TCR CDR3 peptide
29. Induction of a type 1 regulatory CD4 T cell response following Vβ8.2 DNA vaccination results in immune deviation and protection from experimental autoimmune encephalomyelitis
30. Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity
31. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
32. T regulatory cells 1 inhibit a Th2-specific response in vivo
33. Murine IL-10 gene transfer inhibits established collagen-induced arthritis and reduces adenovirus-mediated inflammatory responses in mouse liver
34. Antigen-specific T cells transduced with IL-10 ameliorate experimentally induced arthritis without impairing the systemic immune response to the antigen
35. Regulation of TGF-β response during T cell activation is modulated by IL-10
36. The inhibitory effects of transforming growth factor-β-1 (TGF-β1) in autoimmune diseases
37. Testicular-associated immune deviation and prevention of adjuvant-induced arthritis by three tolerization methods
38. Pathogenic lymphoid cells engineered to express TGFβ1 ameliorate disease in a collagen-induced arthritis model
39. Activation of T cells recognizing self 60-kD heat shock protein can protect against experimental arthritis
40. Discrimination and dialogue in the immune system
41. Autoimmunity can benefit self-maintenance
42. β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomized, double-blind, phase II trial