Protease-activated receptors (PARs) are partly pro-inflammatory and partly anti-inflammatory: Will PAR agonist or antagonists participate in future drug therapies?

Current Drug Targets

Volumn 7, Issue 5, 2006, Pages 629-637

  De Campo, B A ^a   Henry, P J ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Airway; Asthma; Cardiovascular system; Coagulation; Gastrointestinal tract; Protease; Protease activated receptor; Respiratory system; Thrombin; Trypsin

Indexed keywords

2 FUROYLLEUCYLISOLEUCYLGLYCYLARGINYLLEUCYLAMIDE; AMASTATIN; ANTICOAGULANT AGENT; ANTIINFLAMMATORY AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; FR 171113; GLYCYLTYROSYLPROLYLGLYCYLGLUTAMYLVALYLAMIDE; LEUKOTRIENE RECEPTOR STIMULATING AGENT; PHOSPHODIESTERASE INHIBITOR; PROTEINASE; PROTEINASE ACTIVATED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 3; PROTEINASE ACTIVATED RECEPTOR 4; PROTEINASE ACTIVATED RECEPTOR AGONIST; PROTEINASE ACTIVATED RECEPTOR ANTAGONIST; RWJ 58259; SERYLLEUCYLISOLEUCYLGLYCYLARGINYLLEUCYLAMIDE; SERYLPHENYLALANYLPHENYLALANYLLEUCYLARGINYLASPARAGINYLAMIDE; THREONYLPHENYLALANYLLEUCYLLEUCYLARGINYLAMIDE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ASTHMA; BLOOD PRESSURE REGULATION; BRONCHOSPASM; CARDIOVASCULAR SYSTEM; DISEASE MODEL; DRUG TARGETING; ENZYME ACTIVITY; GASTROINTESTINAL TRACT; GENE EXPRESSION REGULATION; HEART MUSCLE POTENTIAL; HUMAN; INFLAMMATION; INTESTINE MOTILITY; MOLECULAR BIOLOGY; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; RESPIRATORY SYSTEM; REVIEW; SMOOTH MUSCLE TONE; STOMACH INJURY; SYSTEMATIC REVIEW; VASCULAR SMOOTH MUSCLE;

ANIMALS; ASTHMA; BLOOD COAGULATION; BLOOD PLATELETS; BLOOD PRESSURE; BRONCHI; HUMANS; INFLAMMATION; MUSCLE, SMOOTH, VASCULAR; RECEPTORS, PROTEINASE-ACTIVATED; TRACHEA;

EID: 33646719441     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945006776818656     Document Type: Review

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