Heterogeneous mechanisms of endothelium-dependent relaxation for thrombin and peptide activators of protease-activated receptor-1 in porcine isolated coronary artery

British Journal of Pharmacology

Volumn 130, Issue 1, 2000, Pages 181-188

  Hamilton, Justin R ^a   Cocks, Thomas M ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Endothelium; Endothelium derived hyperpolarizing factor; Nifedipine; Nitric oxide; Porcine coronary artery; Protease activated receptors; Thrombin; Trypsin; Voltage operated calcium channels

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; ENZYME ACTIVATOR; N(G) NITROARGININE; NIFEDIPINE; NITRIC OXIDE SYNTHASE INHIBITOR; OXYHEMOGLOBIN; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; THROMBIN; TRYPSIN; VERAPAMIL;

ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; DRUG MECHANISM; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE RELAXATION; SWINE; VASODILATATION;

ANIMALS; BIOLOGICAL FACTORS; CALCIUM CHANNEL BLOCKERS; CORONARY VESSELS; ENDOTHELIUM, VASCULAR; FEMALE; HEMOSTATICS; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RECEPTOR, PAR-1; RECEPTOR, PAR-2; RECEPTORS, THROMBIN; SWINE; THROMBIN; VASODILATION;

EID: 0034019115     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703146     Document Type: Article

References (39)

1. BLACKHART, B.D., EMILSSON, K., NGUYEN, D., TENG, W., MARTELLI, A.J., NYSTEDT, S., SUNDELIN, J. & SCARBOROUGH, R.M. (1996). Ligand cross-reactivity within the protease-activated receptor family. J. Biol. Chem., 271, 16466-16471.
2. CHEN, G. & SUZUKI, H. (1989). Some electrical properties of the endothelium-dependent hyperpolarization recorded from rat arterial smooth muscle cells. J. Physiol., 410, 91-106.
3. CICALA, C., PINTO, A., BUCCI, M., SORRENTINO, R., WALKER, B., HARRIOT, P., CRUCHLEY, A., KAPAS, S., HOWELLS, G.L. & CIRINO, G. (1999). Protease-activated receptor-2 involvement in hypotension in normal and endotoxemic rats in vivo. Circulation, 99, 2590-2597.
4. CORRIU, C., FÉLÉTOU, M., CANET, E. & VANHOUTTE, P.M. (1996). Endothelium-derived factors and hyperpolarization of the carotid artery of the guinea-pig. Br. J. Pharmacol., 119, 959-964.
5. COUGHLIN, S.R. (1994). Protease-activated receptors start a family. Proc. Natl. Acad. Sci. U.S.A., 91, 9200-9202.
6. CUPIT, L.D., SCHMIDT, V.A. & BAHOU, W.F. (1999). Proteolytically activated receptor-3: a member of an emerging gene family of protease-activated receptors expressed on vascular endothelial cells and platelets. Trends Cardiovasc. Med., 9, 42-48.
7. DIAMANO, B. P., CHEUNG, W.-M., SANTULLI, R.J., FUNG-LEUNG, W.-P., NGO, K., YE, R.D., DARROW, A.L., DERIAN, C.K., DE GARAVILLA, L. & ANDREA-GORDON, P. (1999). Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1. J. Pharmacol. Exp. Ther., 288, 671-678.
8. DÉRY, O., CORVERA, C.U., STEINHOFF, M. & BUNNET, N.W. (1998). Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am. J. Physiol., 274, C1429-C1452.
9. 2+ channels. Br. J. Pharmacol., 117, 1035-1040.
10. FÉLÉTOU, M. & VANHOUTTE, P.M. (1999). Endothelial dysfunction: a novel therapeutic target. The alternative: EDHF. J. Mol. Cell Cardiol., 31, 15-22.
11. FENTON, J.W., II (1993). Understanding thrombin and hemostasis. Hematol. Oncol. Clin. North. Am., 7, 1107-1119.
12. FLEMING, I. & BUSSE, R. (1999). Endothelial dysfunction: a novel therapeutic target. NO: the primary EDRF. J. Mol. Cell Cardiol., 31, 5-14.
13. FOX, M.T., HARRIOTT, P., WALKER, B. & STONE, S.R. (1997). Identification of potential activators of proteinase-activated receptor-2. FEBS Lett., 417, 267-269.
14. GARLAND, C.J., PLANE, F., KEMP, B.K. & COCKS, T.M. (1995). Endothelium-dependent hyperpolarization: a role in control of vascular tone. Trends Pharmacol. Sci., 16, 23-30.
15. GLUSA, E. & MARKWARDT, F. (1988). Studies on thrombin-induced endothelium-dependent vascular effects. Biomed. Biochem. Acta. 47, 623-630.
16. HAMILTON, J.R., CHOW, J.M. & COCKS, T.M. (1999). Protease-activated receptor-2 turnover stimulated independently of receptor activation in porcine coronary endothelial cells. Br. J. Pharmacol., 127, 617-622.
17. HAMILTON, J.R., NGUYEN, P.B. & COCKS, T.M. (1998). Atypical protease-activated receptor mediates endothelium-dependent relaxation of human coronary arteries. Circ. Res., 82, 1306-1312.
18. HAMMES, S.R. & COUGHLIN, S.R. (1999). Protease-activated receptor-1 can mediate responses to SFLLRN in thrombindesensitized cells: evidence for a novel mechanism for preventing or terminating signaling by PARTs tethered ligand. Biochemistry. 38, 2486-2493.
19. 2+ channels. Mol. Pharmacol., 50, 1284-1294.
20. HATTON, M.W.C., MOAR, S.L. & RICHARDSON, M. (1989). Deendothelialization in vivo initiates a thrombogenic reaction at the rabbit aorta surface: correlation of uptake of fibrinogen and antithrombin III with thrombin generation by the exposed endothelium. Am. J. Path., 135, 499-508.
21. HWA, J.J., GHIBAUDI, L., WILLIAMS, P. CHINTALA, M., ZHANG, R., CHATTERJEE, M. & SYBERTZ, E. (1996). Evidence for the presence of a proteinase-activated receptor district from the thrombin receptor in vascular endothelial cells. Circ. Res., 78, 581-588.
22. ISHIHARA, H., CONNOLLY, A.J., ZENG, D., KAHN, M.L., ZENG, Y.W., TIMMONS, C., TRAM, T. & COUGHLIN, S.R. (1997). Protease-activated receptor 3 is a second thrombin receptor in humans. Nature. 386, 502-506.
23. ISHII, K., HEIN, L., KOBILKA, B. & COUGHLIN, S.R. (1993). Kinetics of thrombin receptor cleavage on intact cells: relation to signaling. J. Biol Chem., 268, 9780-9786.
24. KAWABATA, A., SAIFEDDINE, M., AL-ANI, B., LEBLOND, L. & HOLLENBERG, M.D. (1999). Evaluation of proteinase-activated receptor-1 (PAR1) agonists and antagonists using a cultured cell receptor desensitization assay: activation of PAR2 by PAR1-targeted ligands. J. Phrmacol. Exp. Ther., 288, 358-370.
25. KEMPS, B.K. & COCKS, T.M. (1997). Evidence that mechanisms dependent and independent of nitric oxide mediate endothelium-dependent relaxation to bradykinin in human small resistance-like coronary arteries. Br. J. Pharmacol., 120, 757-762.
26. KILPATRICK, E.V. & COCKS, T.M. (1994). Evidence for differential roles of nitric oxide (NO) and hyperpolarization in endothelium-dependent relaxation of pig isolated coronary artery. Br. J. Pharmacol., 112, 557-565.
27. KOVANEN, P.T., KAARTINEN, M. & PAAVONEN, T. (1995). Infiltrates of activated must cells at the site of coronary atheromatous erosion of rupture in myocardial infarction. Circulation, 92, 1084-1088.
28. KU, D.D. (1986). Mechanism of thrombin-induced endothelium-dependent coronary vasodilation in dogs: role of its proteolytic activity. J. Cardiovasc. Res., 8, 29-36.
29. KU, D.D., WINN, M.J., GRTGSBY, T. & CAUFIELD, J.B. (1992). Human coronary vascular smooth muscle and endothelium-dependent responses after storage at - 75°C. Cryobiology, 29, 199-209.
30. LÜSCHER, T.F., DIEDERICH, D., SIEBENMANN, R., LEHMANN, K., STULZ, P., VON SEGESSER, L., YANG, Z., TURINA, M., GRÄDEL, E., WEBER, E. & BÜHLER, F.R. (1988). Difference between endothelium-dependent relaxation in arterial and in venous coronary bypass grafts. N. Engl. J. Med., 319, 462-467.
31. MOLINO, M., BARNATHAN, E.S., NUMEROF, R., CLARK, J., DREYER, M., CUMASHI, A., HOXIE, J.A., SCHECHTER, N., WOOLKALIS, M. & BRASS, L.F. (1997). Interactions of mast cell tryptase with thrombin receptors and PAR-2. J. Biol. Chem., 272, 4043-4049.
32. MURAMATSU, I., LANIYONU, A., MOORE, G.J. & HOLLENBERG, M.D. (1992). Vascular actions of thrombin receptor peptide. Can. J. Physiol. Pharmacol., 70, 996-1003.
33. NAGAO, T. & VANHOUTTE, P.M. (1992). Hyperpolarization as a mechanism for endothelium-dependent relaxations in the porcine coronary artery. J. Physiol., 445, 355-367.
34. NYSTEDT, S., EMILSSON, K., WAHLESTEDT, C. & SUNDELIN, J. (1994). Molecular cloning of a potential proteinase activated receptor. Prof. Natl. Acad. Sci. U.S.A., 91, 9208-9212.
35. SAIFEDDINE, M., AL-ANI, B., CHENG, C.-H., WANG, L. & HOLLENBERG, M.D. (1996). Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue. Br. J. Pharmacol., 118, 521-530.
36. TESFAMARIAM, B., ALLEN, G.T., NORMANDIN, D. & ANTONACCIO, M.J. (1993). Involvement of the 'tethered ligand' receptor in thrombin-induced endothelium-mediated relaxations. Am. J. Physiol., 265, H1744-H1749.
37. VU, T.-K.H., HUNG, D.T., WHEATON, V.I. & COUGHLIN, S.R. (1991). Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell, 64, 1057-1068.
38. WHITE, R.P., SHIMAZAKI, Y. & ROBERTSON, J.T. (1984). Comparison of responses elicited by alpha-thrombin in isolated canine basilar, coronary, mesenteric and renal arteries. Blood Vessels, 21, 12-22.
39. XU, W., ANDERSEN, H., WHITMORE, T.E., PRESNELL, S.R., YEE, D.P., CHING, A., GILBERT, T., DAVIE, E.W. & FOSTER, D.C. (1998). Cloning and characterization of human protease-activated receptor 4. Proc. Natl. Acad. Sci. U.S.A., 95, 6642-6646.