Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells

Journal of Applied Physiology

Volumn 91, Issue 3, 2001, Pages 1372-1379

  Berger, Patrick ^a,b   Perng, Diahn Warng ^a   Thabrew, Hiran ^a   Compton, Steven J ^a   Cairns, Jennifer A ^a   McEuen, Alan R ^a   Marthan, Roger ^b   Tunon De Lara, José Manuel ^b   Walls, Andrew F ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^b INSERM   (France)

Author keywords

Mast cell; Proteinase activated receptor 2

Indexed keywords

BENZAMIDINE; CALPHOSTIN C; GENISTEIN; LEUPEPTIN; LUNG ENZYME; PEPTIDE DERIVATIVE; PERTUSSIS TOXIN; PROTEIN G; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; PROTEINASE ACTIVATED RECEPTOR 2; SERYLLEUCYLISOLEUCYLGLYCYLLYSYLVALINE; TRYPTASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; ENZYME INACTIVATION; HEATING; HUMAN; HUMAN TISSUE; MAST CELL DEGRANULATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

EID: 0034867321     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2001.91.3.1372     Document Type: Article

References (46)

1. Mast cell numbers are increased in the smooth muscle of human sensitized isolated bronchi
2. Mast cell tryptase as a mediator of hyperresponsiveness in human isolated bronchi
3. Human mast cells stimulate vascular tube formation. Tryptase is a novel, potent angiogenic factor
4. Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2
5. Induction of vascular smooth muscle cell growth by selective activation of the proteinase activated receptor-2 (PAR-2)
6. Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway
7. Tryptase, the dominant secretory granular protein in human mast cells, is a potent mitogen for cultured dog tracheal smooth muscle cells
8. Mast cell tryptase is a mitogen for epithelial cells. Stimulation of IL-8 production and intercellular adhesion molecule-1 expression
9. Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts
10. Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep
11. A protective role for protease-activated receptors in the airways
12. The role of mast cell tryptase in regulating endothelial cell proliferation, cytokine release, and adhesion molecule expression: Tryptase induces expression of mRNA for IL-1β and IL-8 and stimulates the selective release of IL-8 from human umbilical vein endothelial cells
13. Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2
14. Characterization of protease-activated receptor-2 immunoreactivity in normal human tissues
15. Proteinase-activated receptors: Novel mechanisms of signaling by serine proteases
16. Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study
17. Ragweed antigen E and anti-IgE in human central versus peripheral isolated bronchi
18. Synovial procollagenase activation by human mast cell tryptase dependence upon matrix metalloproteinase 3 activation
19. Human tryptase as a potent, cell-specific mitogen: Role of signaling pathways in synergistic responses
20. The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase
21. Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with increased airway obstruction
22. Mast cell tryptase potentiates histamine-induced contraction in human sensitized bronchus
23. Heparin and PGE2 inhibit DNA synthesis in human airway smooth muscle cells in culture
24. Mitogenic responses mediated through the proteinase-activated receptor-2 are induced by expressed forms of mast cell α- or β-tryptases
25. Inhaled tryptase causes bronchoconstriction in sheep via histamine release
26. Interactions of mast cell tryptase with thrombin receptors and PAR-2
27. Recombinant human mast cell tryptase beta: Stable expression in Pichia pastoris and purification of fully active enzyme
28. Molecular cloning of a potential proteinase activated receptor
29. α-thrombin increases cytosolic calcium and induces human airway smooth muscle cell proliferation
30. Histamine stimulates proliferation of airway smooth muscle and induces c-fos expression
31. Histochemical characteristics and degranulation of mast cells in epithelium and lamina propria of bronchial biopsies from asthmatic and normal subjects
32. Estimation of the volume of epithelial lining fluid recovered by lavage using urea as a marker of dilution
33. Mast cell tryptase is a mitogen for cultured fibroblasts
34. Regulation of tryptase from human lung mast cells by heparin. Stabilization of the active tetramer
35. Quantitation of histamine, tryptase and chymase in dispersed human T and TC mast cells
36. Mast cell tryptase causes airway smooth muscle hyperresponsiveness in dogs
37. Human lung tryptase. Purification and characterization
38. Human mast cell tryptase activates single-chain urinary-type plasminogen activator (pro-urokinase)
39. Degradation of airway neuropeptides by human lung tryptase
40. Mast cells in bronchoalveolar lumen of patients with bronchial asthma
41. The effect of indomethacin on immunologic release of histamine and sulfidopeptide leukotrienes from human bronchus and lung parenchyma
42. Structural consequences of airway inflammation in asthma
43. The structure and function of human mast cell tryptase
44. Production and characterization of monoclonal antibodies specific for human mast cell tryptase
45. Human mast cell tryptase attenuates the vasodilator activity of calcitonin gene-related peptide
46. Activation of pulmonary mast cells by bronchoalveolar allergen challenge. In vivo release of histamine and tryptase in atopic subjects with and without asthma