A Protective Role of Protease-Activated Receptor 1 in Rat Gastric Mucosa

Gastroenterology

Volumn 126, Issue 1 SUPPL. 1, 2004, Pages 208-219

  Kawabata, Atsufumi ^a   Nishikawa, Hiroyuki ^b   Saitoh, Hitomi ^a   Nakaya, Yumiko ^a   Hiramatsu, Kaori ^a   Kubo, Satoko ^a   Nishida, Minoru ^b   Kawao, Naoyuki ^a   Kuroda, Ryotaro ^a   Sekiguchi, Fumiko ^a   Kinoshita, Mitsuhiro ^a   Kakehi, Kazuaki ^a   Arizono, Naoki ^c   Yamagishi, Hisakazu ^c   Kawai, Kenzo ^b  

^a KINKI UNIVERSITY   (Japan)

^b Fuso Pharmaceutical Industries Ltd   (Japan)

^c KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; AMASTATIN; CAPSAICIN; CARBACHOL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; HYDROCHLORIC ACID; INDOMETACIN; NITRIC OXIDE; PROTEINASE ACTIVATED RECEPTOR 1;

ACID SECRETION; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; CONTROLLED STUDY; EXPERIMENTAL RAT; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SENSORY NERVE CELL; SMOOTH MUSCLE; STOMACH MUCOSA BLOOD FLOW; STOMACH MUCOSA INJURY; STOMACH MUSCLE;

EID: 9144246209     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2003.10.071     Document Type: Article

References (39)

1. Vu TK, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991;64:1057-1068.
2. Nystedt S, Emilsson K, Wahlestedt C, Sundelin J. Molecular cloning of a potential proteinase activated receptor. Proc Natl Acad Sci U S A 1994;91:9208-9212.
3. Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV Jr, Tam C, Coughlin SR. A dual thrombin receptor system for platelet activation. Nature 1998;394:690-694.
4. Xu WF, Andersen H, Whitmore TE, Presnell SR, Yee DP, Ching A, Gilbert T, Davie EW, Foster DC. Cloning and characterization of human protease-activated receptor 4. Proc Natl Acad Sci U S A 1998;95:6642-6646.
5. Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T, Coughlin SR. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature 1997;386:502-506.
6. Macfarlane SR, Seatter MJ, Kanke T, Hunter GD, Plevin R. Proteinase-activated receptors. Pharmacol Rev 2001;53:245-282.
7. Kawabata A. PAR-2: structure, function and relevance to human diseases of the gastric mucosa. Available at: http://www. expertreviews.org/02004799h.htm. Accessed July 7, 2002.
8. Nishikawa H, Kawabata A. Modulation of gastric functions by PARs. Drug Dev Res 2003;60:9-13.
9. Kawabata A, Nishikawa H, Kuroda R, Kawai K, Hollenberg MD. Proteinase-activated receptor-2 (PAR-2): regulation of salivary and pancreatic exocrine secretion in vivo in rats and mice. Br J Pharmacol 2000;129:1808-1814.
10. Kawabata A, Morimoto N, Nishikawa H, Kuroda R, Oda Y, Kakehi K. Activation of protease-activated receptor-2 (PAR-2) triggers mucin secretion in the rat sublingual gland. Biochem Biophys Res Commun 2000;270:298-302.
11. Kawabata A, Kuroda R, Morimoto N, Kawao N, Masuko T, Kakehi K, Kataoka K, Taneda M, Nishikawa H, Araki H. Lipopolysaccharide-induced subsensitivity of protease-activated receptor-2 in the mouse salivary glands in vivo. Naunyn Schmiedebergs Arch Pharmacol 2001;364:281-284.
12. Bohm SK, Kong W, Bromme D, Smeekens SP, Anderson DC, Connolly A, Kahn M, Neiken NA, Coughlin SR, Payan DG, Bunnett NW. Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem J 1996;314: 1009-1016.
13. Nguyen TD, Moody MW, Steinhoff M, Okolo C, Koh DS, Bunnett NW. Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2. J Clin Invest 1999;103: 261-269.
14. Saifeddine M, Al-Ani B, Cheng CH, Wang L, Hollenberg MD. Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue. Br J Pharmacol 1996;118:521-530.
15. Corvera CU, Dery O, McConalogue K, Bohm SK, Khitin LM, Caughey GH, Payan DG, Bunnett NW. Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2. J Clin Invest 1997;100:1383-1393.
16. Cocks TM, Sozzi V, Moffatt JD, Selemidis S. Protease-activated receptors mediate apamin-sensitive relaxation of mouse and guinea pig gastrointestinal smooth muscle. Gastroenterology 1999;116:586-592.
17. Kawabata A, Kuroda R, Nagata N, Kawao N, Masuko T, Nishikawa H, Kawai K. In vivo evidence that protease-activated receptors 1 and 2 modulate gastrointestinal transit in the mouse. Br J Pharmacol 2001;133:1213-1218.
18. Vergnolle N, Macnaughton WK, Al-Ani B, Saifeddine M, Wallace JL, Hollenberg MD. Proteinase-activated receptor 2 (PAR2)-activating peptides: identification of a receptor distinct from PAR2 that regulates intestinal transport. Proc Natl Acad Sci U S A 1998;95:7766-7771.
19. Kawabata A, Kinoshita M, Nishikawa H, Kuroda R, Nishida M, Araki H, Arizono N, Oda Y, Kakehi K. The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection. J Clin Invest 2001;107:1443-1450.
20. Hollenberg MD, Saifeddine M, Al-Ani B, Kawabata A. Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides. Can J Physiol Pharmacol 1997;75:832-841.
21. Kawabata A, Kuroda R, Nishikawa H, Kawai K. Modulation by protease-activated receptors of the rat duodenal motility in vitro: possible mechanisms underlying the evoked contraction and relaxation. Br J Pharmacol 1999;128:865-872.
22. (-) secretion in human intestinal epithelial cells. Am J Physiol 2001;281:G323-G332.
23. Steinhoff M, Vergnolle N, Young SH, Tognetto M, Amadesi S, Ennes HS, Trevisani M, Hollenberg MD, Wallace JL, Caughey GH, Mitchell SE, Williams LM, Geppetti P, Mayer EA, Bunnett NW. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med 2000;6:151-158.
24. Kawabata A, Kawao N, Kuroda R, Tanaka A, Itoh H, Nishikawa H. Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats. Neuroreport 2001;12:715-719.
25. Vergnolle N, Bunnett NW, Sharkey KA, Brussee V, Compton SJ, Grady EF, Cirino G, Gerard N, Basbaum AI, Andrade-Gordon P, Hollenberg MD, Wallace JL. Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway. Nat Med 2001;7:821-826.
26. Coelho AM, Vergnolle N, Guiard B, Fioramonti J, Bueno L. Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats. Gastroenterology 2002; 122:1035-1047.
27. Hoogerwerf WA, Zou L, Shenoy M, Sun D, Micci MA, Lee-Hellmich H, Xiao SY, Winston JH, Pasricha PJ. The proteinase-activated receptor 2 is involved in nociception. J Neurosci 2001;21:9036-9042.
28. Nishikawa H, Kawai K, Nishimura S, Tanaka S, Araki H, Al-Ani B, Hollenberg MD, Kuroda R, Kawabata A. Suppression by protease-activated receptor-2 activation of gastric acid secretion in rats. Eur J Pharmacol 2002;447:87-90.
29. Kawao N, Sakaguchi Y, Tagome A, Kuroda R, Nishida S, Irimajiri K, Nishikawa H, Kawai K, Hollenberg MD, Kawabata A. Protease-activated receptor-2 (PAR-2) in the rat gastric mucosa: immunolocalization and facilitation of pepsin/pepsinogen secretion. Br J Pharmacol 2002;135:1292-1296.
30. Takeuchi K, Tanaka H, Furukawa O, Okabe S. Gastroduodenal HC03-secretion in anesthetized rats: effects of 16,16-dimethyl PGE2, topical acid and acetazolamide. Jpn J Pharmacol 1986; 41:87-99.
31. Naidu PS, Kulkarni SK. Possible involvement of prostaglandins in haloperidol-induced orofacial dyskinesia in rats. Eur J Pharmacol 2001;430:295-298.
32. Tanaka Y, Hayakawa S, Imai T, Akutsu A, Hirano H, Tanaka H, Nakahara T, Ishii K, Shigenobu K. Possible involvement of endothelium-derived hyperpolarizing factor (EDHF) in the depressor responses to platelet activating factor (PAF) in rats. Br J Pharmacol 2000;131:1113-1120.
33. McGuire JJ, Hollenberg MD, Andrade-Gordon P, Triggle CR. Multiple mechanisms of vascular smooth muscle relaxation by the activation of proteinase-activated receptor 2 in mouse mesenteric arterioles. Br J Pharmacol 2002;135:155-169.
34. Kawabata A, Kuroda R, Nishida M, Nagata N, Sakaguchi Y, Kawao N, Nishikawa H, Arizono N, Kawai K. Protease-activated receptor-2 (PAR-2) in the pancreas and parotid gland: Immunolocalization and involvement of nitric oxide in the evoked amylase secretion. Life Sci 2002;71:2435-2446.
35. Asfaha S, Brussee V, Chapman K, Zochodne DW, Vergnolle N. Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli. Br J Pharmacol 2002;135:1101-1106.
36. Kawabata A, Kawao N, Kuroda R, Tanaka A, Shimada C. The PAR-1-activating peptide attenuates carrageenan-induced hyperalgesia in rats. Peptides 2002;23:1181-1183.
37. Hollenberg MD, Laniyonu AA, Saifeddine M, Moore GJ. Role of the amino- and carboxyl-terminal domains of thrombin receptor-derived polypeptides in biological activity in vascular endothelium and gastric smooth muscle: evidence for receptor subtypes. Mol Pharmacol 1993;43:921-930.
38. Edwards G, Weston AH. EDHF-are there gaps in the pathway? J Physiol 2001;531:299.
39. Hollenberg MD, Yang SG, Laniyonu AA, Moore GJ, Saifeddine M. Action of thrombin receptor polypeptide in gastric smooth muscle: identification of a core pentapeptide retaining full thrombin-mimetic intrinsic activity. Mol Pharmacol 1992;42:186-191.