Thrombin activates the sarcolemmal Na+-H+ exchanger: Evidence for a receptor-mediated mechanism involving protein kinase C

Circulation Research

Volumn 79, Issue 4, 1996, Pages 705-715

  Yasutake, Masahiro ^a   Haworth, Robert S ^a   King, Anna ^a   Avkiran, Metin ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

heart; myocyte; Na+ H+ exchanger; protein kinase C; thrombin receptor

Indexed keywords

CHELERYTHRINE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CELL STIMULATION; ENZYME INHIBITION; ENZYME MECHANISM; NONHUMAN; PEPTIDE SYNTHESIS; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SARCOLEMMA; SMOOTH MUSCLE FIBER; THROMBOCYTE ACTIVATION; VASCULAR SMOOTH MUSCLE;

EID: 0029797233     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.79.4.705     Document Type: Article

References (53)

1. + exchange in cardiac physiology and pathophysiology: mediation of myocardial reperfusion injury by the pH paradox. Cardiovasc Res. 1993;27:915-924.
2. Avkiran M. Sodium-hydrogen exchange in myocardial ischemia and reperfusion: a critical determinant of injury? In: Karmazyn M, ed. Myocardial Ischemia: Mechanisms, Reperfusion, Protection. Basel, Switzerland: Birkhauser Verlag; 1996:299-311.
3. Pucéat M, Vassort G. Neurohumoral modulation of intracellular pH in the heart. Cardiovasc Res. 1995;29:178-183.
4. Coughlin SR. Thrombin receptor function and cardiovascular disease. Trends Cardiovasc Med. 1994;4;77-83.
5. Vu TH, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 1991;64:1057-1068.
6. Zhong C, Hayzer DJ, Corson MA, Runge MS. Molecular cloning of the rat vascular smooth muscle thrombin receptor. J Biol Chem. 1992;267:16975-16979.
7. + exchange via activation of the thrombin receptor Biochem J. 1994;297:47-52.
8. + exchange in thrombin-induced platelet-activating factor production by human endothelial cells. J Biol Chem. 1988;263:19437-19446.
9. Berk BC, Taubman MB, Cragoe EJ Jr, Fenton JW II, Griendling KK. Thrombin signal transduction mechanisms in rat vascular smooth muscle cells: calcium and protein kinase C-dependent and -independent pathways. J Biol Chem. 1990;265:17334-17340.
10. Steinberg SF, Robinson RB, Lieberman HB, Stern DM, Rosen MR. Thrombin modulates phosphoinositide metabolism, cytosolic calcium, and impulse initiation in the heart. Circ Res. 1991;68:1216-1229.
11. Glembotski CC, Irons CE, Krown KA, Murray SF, Sprenkle AB, Sei CA. Myocardial α-thrombin receptor activation induces hypertrophy and increases atrial natriuretic factor gene expression. J Biol Chem. 1993;268:20646-20652.
12. Mitra R, Morad M. A uniform enzymatic method for dissociation of myocytes from hearts and stomachs of vertebrates. Am J Physiol. 1985;249:H1056-H1060.
13. Blank PS, Silverman HS, Chung Y, Hogue RA, Stern MD, Hansford RG, Lakatta EG, Capogrossi MC. Cytosolic pH measurement in single cardiac myocytes using carboxy-seminaphthorhodafluor-1. Am J Physiol. 1992;263:H276-H284.
14. Buckler KJ, Vaughan-Jones RD. Application of a new pH-sensitive fluoroprobe (carboxy-SNARF-1) for intracellular pH measurement in small, isolated cells. Pflugers Arch. 1990;417:234-239.
15. Thomas JA. Buchsbaum RN, Zimniak A, Racker E. Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ. Biochemistry. 1979;81:2210-2218.
16. Gupta A, Schwiening CJ, Boron WF. Effects of CGRP, forskolin, PMA, and ionomycin on pH, dependence of Na-H exchange in UMR-106 cells. Am J Physiol. 1994;266:C1088-C1092.
17. + buffering power in the sheep cardiac Purkinje fibre. J Physiol (Lond). 1990;425:429-448.
18. Lagadic-Gossmann D, Buckler KJ, Vaughan-Jones RD. Role of bicarbonate in pH recovery from intracellular acidosis in the guineapig ventricular myocyte. J Physiol (Lond). 1992;458:361-384.
19. - Am J Physiol. 1988;255:C844-C856.
20. 2+ exchange and consequences for relaxation in guinea pig cardiac myocytes. Am J Physiol. 1994;267:H477-H487.
21. 3-free conditions. Circ Res. 1994;75:123-132.
22. 1-Adenergic stimulation of Na-H exchange in cardiac myocytes. Am J Physiol. 1992;263:C1096-C1102.
23. + exchanger. Circ Res. 1990;68:269-279.
24. Toullec D, Pianetti P, Coste H, Belevergue P, Grand-Perret T, Ajakane M, Baudet V, Boissin P, Boursier E, Loriolle F, Duhamel L, Charon D, Kirilovsky J. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem. 1991;266:15771-15781.
25. Herbert JM, Augereau JM, Maffrand JP. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990;172:993-999.
26. + exchange. J Mol Cell Cardiol. 1995;27:A188. Abstract.
27. + exchange inhibitor, and its effects in cardiac ischaemia. Br J Pharmacol. 1993; 109:562-568.
28. 1 and β-adrenoceptors. J Physiol (Lond). 1993;464:49-73.
29. 3 exchange in NIH-3T3 fibroblasts. J Biol Chem. 1994;269:4116-4124.
30. Steinberg SF, Alter A. Enhanced receptor-dependent inositol phosphate accumulation in hypoxic myocytes. Am J Physiol. 1993; 265:H691-H699.
31. Albitz R, Droogmans G, Nilius B, Casteels R. Thrombin stimulates L-type calcium channels of the guinea pig cardiomyocytes in cell-attached patches but not after intracellular dialysis. Cell Calcium. 1992;13:203-210.
32. Park TH, McHowat J, Wolf RA, Corr PB. Increased lysophosphatidylcholine content induced by thrombin receptor stimulation in adult rabbit cardiac ventricular myocytes. Cardiovasc Res. 1994;28:1263-1268.
33. Van Obberghen Schilling E, Pouysségur J. Signaling pathways of the thrombin receptor. Thromb Haemost. 1993;70:163-167.
34. Sugden PH, Bogoyevitch MA. intracellular signalling through protein kinases in the heart. Cardiovasc Res. 1995;30:478-492.
35. Bogoyevitch MA, Parker PJ, Sugden PH. Characterization of protein kinase C isotype expression in adult rat heart: protein kinase C-ε is a major isotype present, and it is activated by phorbol esters, epinephrine, and endothelin. Circ Res. 1993;72:757-767.
36. Pucéat M, Hilal-Dandan R, Strulovici B, Brunton LL, Brown JH. Differential regulation of protein kinase C isoforms in isolated neonatal and adult cardiac myocytes. J Biol Chem. 1994;269:16938-16944.
37. 2+/calmodulin-dependent protein kinase II. Biochem J. 1992;282: 139-145.
38. 3. Am J Physiol. 1990; 258-.H610-H615.
39. Callewaert G. Excitation-contraction coupling in mammalian cardiac cells. Cardiovasc Res. 1992;26:923-932.
40. Berridge MJ. Inositol trisphosphate and calcium signalling. Nature. 1993;361:315-325.
41. Barry WH, Bridge JHB. Intracellular calcium homeostasis in cardiac myocytes. Circulation. 1993;87:1806-1815.
42. Jiang T, Kuznetsov V, Pak E, Zhang H, Robinson RB, Steinberg SF. Thrombin receptor actions in neonatal rat ventricular myocytes. Circ Res. 1996;78:553-563.
43. 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy. J Biol Chem. 1993;268: 15374-15380.
44. Shubeita HE, McDonough PM, Harris AN, Knowlton KU, Glembotski CC, Brown JH, Chien KR. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes: a paracrine mechanism for myocardial cell hypertrophy. J Biol Chem. 1990;265:20555-20562.
45. Avkiran M, Ibuki C. Reperfusion-induced arrhythmias: a role for washout of extracellular protons? Circ Res. 1992;71:1429-1440.
46. + exchange and reperfusion arrhythmias: protection by intracoronary infusion of a novel inhibitor. Am J Physiol 1994;267:H2430-H2440.
47. 1 adrenergic stimulation: a potential role for receptor mediated activation of sarcolemmal sodium-hydrogen exchange. Cardiovasc Res. 1995;29:222-230.
48. Goldstein JA, Butterfield MC, Ohnishi Y, Shelton TJ, Corr PB. Arrhythmogenic influence of intracoronary thrombosis during acute myocardial ischemia. Circulation. 1994;90:139-147.
49. + during myocardial ischemia. Am J Physiol. 1995;268:H1740-H1748.
50. Davies MJ, Thomas A. Thrombosis and acute coronary artery lesions in sudden cardiac ischémic death. N Engl J Med. 1984;310:1137-1140.
51. Kuznetsov V, Pak E, Jiang T, Zhang H, Steinberg SF. Thrombin receptor agonist peptide actions in cardiac myocytes. Circulation. 1995;92(suppl I):114. Abstract.
52. Ishii K, Hein L, Kobilka B, Coughlin SR. Kinetics of thrombin receptor cleavage on intact cells. J Biol Chem. 1993;268:9780-9786.
53. Antonaccio MJ, Normandin D, Serafino R, Moreland S. Effects of thrombin and thrombin receptor activating peptides on rat aortic vascular smooth muscle. J Pharmacol Exp Ther. 1993;266: 125-132.