Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein

Plant Cell

Volumn 16, Issue 7, 2004, Pages 1870-1882

  Feng, Suhua ^a   Shen, Yunping ^a,b   Sullivan, James A ^a   Rubio, Vicente ^a   Xiong, Yue ^c   Sun, Tai Ping ^d   Deng, Xing Wang ^a,b  

^a YALE UNIVERSITY   (United States)

^b PEKING UNIVERSITY   (China)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; HORMONES; PLANTS (BOTANY); PROTEINS;

FERTILITY; FLOWERING;

PLANT CELL CULTURE;

ARABIDOPSIS; ARABIDOPSIS THALIANA; BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 3142732890     PISSN: 10404651     EISSN: None     Source Type: Journal    
DOI: 10.1105/tpc.021949     Document Type: Article

References (80)

1. Alonso, J.M., et al. (2003). Genome-wide insertional mutagenesis of Arabidopsis thaliana. Science 301, 653-657.
2. TIR1 ubiquitin ligase. Plant Cell 16, 1883-1897.
3. Cope, G.A., and Deshaies, R.J. (2003). COP9 signalosome: A multifunctional regulator of SCF and other cullin-based ubiquitin ligases. Cell 114, 663-671.
4. Cope, G.A., Suh, G.S., Aravind, L., Schwarz, S.E., Zipursky, S.L., Koonin, E.V., and Deshaies, R.J. (2002). Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science 298, 608-611.
5. Deshaies, R.J. (1999). SCF and Cullin/Ring H2-based ubiquitin ligases. Annu. Rev. Cell Dev. Biol. 15, 435-467.
6. Dharmasiri, S., Dharmasiri, N., Hellmann, H., and Estelle, M. (2003). The RUB/Nedd8 conjugation pathway is required for early development in Arabidopsis. EMBO J. 22, 1762-1770.
7. Estelle, M. (1992). The plant hormone auxin: Insight in sight. Bioessays 14, 439-444.
8. COI1 and modulates jasmonate responses. Plant Cell 15, 1083-1094.
9. Furukawa, M., He, Y.J., Horchers, C., and Xiong, Y. (2003). Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. Nat. Cell Biol. 5, 1001-1007.
10. Furukawa, M., Zhang, Y., McCarville, J., Ohta, T., and Xiong, Y. (2000). The CUL1 C-terminal sequence and ROC1 are required for nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1. Mol. Cell. Biol. 20, 8185-8197.
11. Gagne, J.M., Downes, B.P., Shiu, S.H., Durski, A.M., and Vierstra, R.D. (2002). The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis. Proc. Natl. Acad. Sci. USA 99, 11519-11524.
12. Geyer, R., Wee, S., Anderson, S., Yates, J., and Wolf, D.A. (2003). BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases. Mol. Cell 12, 783-790.
13. Gray, W.M., del Pozo, J.C., Walker, L., Hobbie, L., Risseeuw, E., Banks, T., Crosby, W.L., Yang, M., Ma, H., and Estelle, M. (1999). Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana. Genes Dev. 13, 1678-1691.
14. Groisman, R., Polanowska, J., Kuraoka, I., Sawada, J., Saijo, M., Drapkin, R., Kisselev, A.F., Tanaka, K., and Nakatani, Y. (2003). The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. Cell 113, 357-367.
15. Harberd, N.P., King, K.E., Carol, P., Cowling, R.J., Peng, J., and Richards, D.E. (1998). Gibberellin: Inhibitor of an inhibitor of...? Bioessays 20, 1001-1008.
16. Hershko, A., and Ciechanover, A. (1998). The ubiquitin system. Annu. Rev. Biochem. 67, 425-479.
17. Hochstrasser, M. (2000), Evolution and function of ubiquitin-like protein-conjugation systems. Nat. Cell Biol, 2, E153-E157.
18. Hwang, J.W., Min, K.W., Tamura, T.A., and Yoon, J.B. (2003). TIP120A associates with unneddylated cullin 1 and regulates its neddylation. FEBS Lett. 541, 102-108.
19. Kaelin, W.G., Jr. (2002). Molecular basis of the VHL hereditary cancer syndrome. Nat. Rev. Cancer 2, 673-682.
20. Kamura, T., Burian, D., Van, Q., Schmidt, S.L., Lane, W.S., Querido, E., Branton, P.E., Shilatifard, A., Conaway, R.C., and Conaway, J.W. (2001). Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. J. Biol. Chem. 276, 29748-29753.
21. Kamura, T., Sato, S., Haque, D., Liu, L., Kaelin, W.G., Jr., Conaway, R.C., and Conaway, J.W. (1998). The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev. 12, 3872-3881.
22. Kawakami, T., Chiba, T., Suzuki, T., Iwai, K., Yamanaka, K., Minato, N., Suzuki, H., Shimbara, N., Hidaka, Y., Osaka, F., Omata, M., and Tanaka, K. (2001). NEDD8 recruits E2-ubiquitin to SCF E3 ligase. EMBO J. 20, 4003-4012.
23. Kurz, T., Pintard, L., Willis, J.H., Hamill, D.R., Gonczy, P., Peter, M., and Bowerman, B. (2002). Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway. Science 295, 1294-1298.
24. Kwok, S.F., Staub, J.M., and Deng, X.W. (1999). Characterization of two subunits of Arabidopsis 19S proteasome regulatory complex and its possible interaction with the COP9 complex. J. Mol. Biol. 285, 85-95.
25. Cdc4 complex. Genes Dev. 12, 914-926.
26. Li, Y., Gazdoiu, S., Pan, Z.Q., and Fuchs, S.Y. (2004). Stability of homologue of Slimb F-box protein is regulated by availability of its substrate. J. Biol. Chem. 279, 11074-11080.
27. Liakopoulos, D., Doenges, G., Matuschewski, K., and Jentsch, S. (1998). A novel protein modification pathway related to the ubiquitin system. EMBO J. 17, 2208-2214.
28. Lincoln, C., Britton, J.H., and Estelle, M. (1990). Growth and development of the axr1 mutants of Arabidopsis. Plant Cell 2, 1071-1080.
29. Liu, C., Powell, K.A., Mundt, K., Wu, L., Carr, A.M., and Caspari, T. (2003). Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanisms. Genes Dev. 17, 1130-1140.
30. CAND1, an inhibitor of CUL1-SKP1 binding and SCF ligases. Mol. Cell 10, 1511-1518.
31. Lyapina, S., Cope, G., Shevchenko, A., Serino, G., Tsuge, T., Zhou, C., Wolf, D.A., Wei, N., Shevchenko, A., and Deshaies, R.J. (2001). Promotion of NEDD8-CUL1 conjugate cleavage by COP9 signalosome. Science 292, 1382-1385.
32. McGinnis, K.M., Thomas, S.G., Soule, J.D., Strader, L.C., Zale, J.M., Sun, T.P., and Steber, C.M. (2003). The Arabidopsis SLEEPY1 gene encodes a putative F-box subunit of an SCF E3 ubiquitin ligase. Plant Cell 15, 1120-1130.
33. McNellis, T.W., von Arnim, A.G., Araki, T., Komeda, Y., Misera, S., and Deng, X.W. (1994). Genetic and molecular analysis of an allelic series of cop1 mutants suggests functional roles for the multiple protein domains. Plant Cell 6, 487-500.
34. Min, K.W., Hwang, J.W., Lee, J.S., Park, Y., Tamura, T.A., and Yoon, J.B. (2003). TIP120A associates with cullins and modulates ubiquitin ligase activity. J. Biol. Chem, 278, 15905-15910.
35. Nelson, D.C., Lasswell, J., Rogg, L.E., Cohen, M.A., and Bartel, B. (2000). FKF1, a clock-controlled gene that regulates the transition to flowering in Arabidopsis. Cell 101, 331-340.
36. Ohh, M., Kim, W.Y., Moslehi, J.J., Chen, Y., Chau, V., Read, M.A., and Kaelin, W.G., Jr. (2002). An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells. EMBO Rep. 3, 177-182.
37. Osaka, F., Saeki, M., Katayama, S., Aida, N., Toh-E, A., Kominami, K., Toda, T., Suzuki, T., Chiba, T., Tanaka, K., and Kato, S. (2000). Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast. EMBO J. 19, 3475-3484.
38. Oshikawa, K., Matsumoto, M., Yada, M., Kamura, T., Hatakeyama, S., and Nakayama, K.I. (2003). Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1. Biochem. Biophys. Res. Commun. 303, 1209-1216.
39. Osterlund, M.T., Hardtke, C.S., Wei, N., and Deng, X.W. (2000). Targeted destabilization of HY5 during light-regulated development of Arabidopsis. Nature 405, 462-466.
40. Ou, C.Y., Lin, Y.F., Chen, Y.J., and Chien, C.T. (2002). Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development. Genes Dev. 16, 2403-2414.
41. Pintard, L., Kurz, T., Glaser, S., Willis, J.H., Peter, M., and Bowerman, B. (2003a). Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosisto-mitosis transition in C. elegans. Curr. Biol. 13, 911-921.
42. Pintard, L., Willis, J.H., Willems, A., Johnson, J.L., Srayko, M., Kurz, T., Glaser, S., Mains, P.E., Tyers, M., Bowerman, B., and Peter, M. (2003b). The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase. Nature 425, 311-316.
43. Poduska, B., Humphrey, T., Redweik, A., and Grbic, V. (2003). The synergistic activation of FLOWERING LOCUS C by FRIGIDA and a new flowering gene AERIAL ROSETTE 1 underlies a novel morphology in Arabidopsis. Genetics 163, 1457-1465.
44. KIP1 by ubiquitination. Proc. Natl. Acad. Sci. USA 97, 4579-4584.
45. del Pozo, J.C., Dharmasiri, S., Hellmann, H., Walker, L., Gray, W.M., and Estelle, M. (2002). AXR1-ECR1-dependent conjugation of RUB1 to the Arabidopsis cullin AtCUL1 is required for auxin response. Plant Cell 14, 421-433.
46. del Pozo, J.C., and Estelle, M. (1999). The Arabidopsis cullin AtCUL1 is modified by the ubiquitin-related protein RUB1. Proc. Natl. Acad. Sci. USA 96, 15342-15347.
47. TrCP- dependent ubiquitination of IκBα. Mol. Cell. Biol. 20, 2326-2333.
48. Risseeuw, E.P., Daskalchuk, T.E., Banks, T.W., Liu, E., Cotelesage, J., Hellmann, H., Estelle, M., Somers, D.E., and Crosby, W.L. (2003). Protein interaction analysis of SCF ubiquitin E3 ligase subunits from Arabidopsis. Plant J. 346, 753-767.
49. Rosso, M.G., Li, Y., Strizhov, N., Reiss, B., Dekker, K., and Weisshaar, B. (2003). An Arabidopsis thaliana T-DNA mutagenized population (GABI-Kat) for flanking sequence tag-based reverse genetics. Plant Mol. Biol. 53, 247-259.
50. Saijo, Y., Sullivan, J.A., Wang, H., Yang, J., Shen, Y., Rubio, V., Ma, L., Hoecker, U., and Deng, X.W. (2003). The COP1-SPA1 interaction defines a critical step in phytochrome A-mediated regulation of HY5 activity. Genes Dev. 17, 2642-2647.
51. Samach, A., Klenz, J.E., Kohalmi, S.E., Rissesuw, E., Haughn, G.W., and Crosby, W.L. (1999). The UNUSUAL FLORAL ORGANS gene of Arabidopsis thaliana is an F-box protein required for normal patterning and growth in the floral meristem. Plant J. 20, 433-445.
52. TIR1 in mediating auxin response. Science 292, 1379-1382.
53. Seo, H.S., Yang, J.Y., Ishikawa, M., Bolle, C., Ballesteros, M.L., and Chua, N.H. (2003). LAF1 ubiquitination by COP1 controls photomorphogenesis and is stimulated by SPA1. Nature 424, 995-999.
54. Serino, G., and Deng, X.W. (2003). The COP9 signalosome: Regulating plant development through the control of proteolysis. Annu. Rev. Plant Biol. 54, 165-182.
55. Shen, W.H., Parmentier, Y., Hellmann, H., Lechner, E., Dong, A., Masson, J., Granier, F., Lepinisc, L., Estelle, M., and Genschik, P. (2002). Null mutation of AtCUL1 causes arrest in early embryogenesis in Arabidopsis. Mol. Biol. Cell 13, 1916-1928.
56. Silverstone, A.L., Ciampaglio, C.N., and Sun, T. (1998). The Arabidopsis RGA gene encodes a transcriptional regulator repressing the gibberellin signal transduction pathway. Plant Cell 10, 155-169.
57. Silverstone, A.L., Jung, H.S., Dill, A., Kawaide, H., Kamiya, Y., and Sun, T.P. (2001). Repressing a repressor: Gibberellin-induced rapid reduction of the RGA protein in Arabidopsis. Plant Cell 13, 1555-1566.
58. Simpson, G.G., and Dean, C. (2002). Arabidopsis, the Rosetta stone of flowering time? Science 296, 285-289.
59. Somers, D.E., Schultz, T.F., Milnamow, M., and Kay, S.A. (2000). ZEITLUPE encodes a novel clock-associated PAS protein from Arabidopsis. Cell 101, 319-329.
60. Suzuki, G., Yanagawa, Y., Kwok, S.F., Matsui, M., and Deng, X.W. (2002). Arabidopsis COP10 is a ubiquitin-conjugating enzyme variant that acts together with COP1 and the COP9 signalosome in repressing photomorphogenesis. Genes Dev. 16, 554-559.
61. Tateishi, K., Omata, M., Tanaka, K., and Chiba, T. (2001). The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice. J. Cell Biol. 155, 571-579.
62. Vierstra, R.D. (2003). The ubiquitin/26S proteasome pathway, the complex last chapter in the life of many plant proteins. Trends Plant Sci. 8, 135-142.
63. von Arnim, A.G., and Deng, X.W. (1993). Ring finger motif of Arabidopsis thaliana COP1 defines a new class of zinc-binding domain. J. Biol. Chem. 268, 19626-19631.
64. UFO and participates in Arabidopsis flower development. Plant Cell 15, 1071-1082.
65. Wang, X., Kang, D., Feng, S., Serino, G., Schwechheimer, C., and Wei, N. (2002). CSN1 N-terminal-dependent activity is required for Arabidopsis development but not for Rub1/Nedd8 deconjugation of cullins: A structure-function study of CSN1 subunit of COP9 signalosome. Mol. Biol. Cell 13, 646-655.
66. Wei, N., and Deng, X.W. (2003). The COP9 signalosome. Annu. Rev. Cell Dev. Biol. 19, 261-286.
67. Wei, N., Tsuge, T., Serino, G., Dohmae, N., Takio, K., Matsui, M., and Deng, X.W. (1998). The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr. Biol. 8, 919-922.
68. Wertz, I.E., O'Rourke, K.M., Zhang, Z., Dornan, D., Arnott, D., Deshaies, R.J., and Dixit, V.M. (2004). Human De-Etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science 303, 1371-1374.
69. Wirbelauer, C., Sutterluty, H., Blondel, M., Gstaiger, M., Peter, M., Reymond, F., and Krek, W. (2000). The F-box protein Skp2 is a ubiquitylation target of a Cull-based core ubiquitin ligase complex: Evidence for a role of Cull in the suppression of Skp2 expression in quiescent fibroblasts. EMBO J. 19, 5362-5375.
70. Wolf, D.A., Zhou, C., and Wee, S. (2003). The COP9 signalosome: An assembly and maintenance platform for cullin ubiquitin ligases? Nat. Cell Biol. 5, 1029-1033.
71. Wu, K., Chen, A., and Pan, Z.Q. (2000). Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization. J. Biol. Chem. 275, 32317-32324.
72. Xie, D.X., Feys, B.F., James, S., Nieto-Rostro, M., and Turner, J.G. (1998). COI1: An Arabidopsis gene required for jasmonate-regulated defense and fertility. Science 280, 1091-1094.
73. COI1 ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis. Plant Cell 14, 1919-1935.
74. Xu, L., Wei, Y., Reboul, J., Vaglio, P., Shin, T.H., Vidal, M., Elledge, S.J., and Harper, J.W. (2003). BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature 425, 316-321.
75. KIP1 degradation and impedes G1-S phase progression via deneddylation of SCF Cull. Curr. Biol. 12, 667-672.
76. Yogosawa, S., Makino, Y., Yoshida, T., Kishimoto, T., Muramatsu, M., and Tamura, T. (1996). Molecular cloning of a novel 120-kDa TBP-interacting protein. Biochem. Biophys. Res. Commun. 229, 612-617.
77. Skp2 SCF ubiquitin ligase complex. Nature 416, 703-709.
78. Zheng, J., Yang, X., Harrell, J.M., Ryzhikov, S., Shim, E.H., Lykke-Andersen, K., Wei, N., Sun, H., Kobayashi, R., and Zhang, H. (2002). CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex. Mol. Cell 10, 1519-1526.
79. Zhou, C., Seibert, V., Geyer, R., Rhee, E., Lyapina, S., Cope, G., Deshaies, R., and Wolf, D.A. (2001). The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p. BMC Biochem. 2, 7-17.
80. Zhou, P., and Howley, P.M. (1998). Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases. Mol. Cell 2, 571-580.