The RUB/Nedd8 conjugation pathway is required for early development in Arabidopsis

EMBO Journal

Volumn 22, Issue 8, 2003, Pages 1762-1770

  Dharmasiri, Sunethra ^a   Dharmasiri, Nihal ^a   Hellmann, Hanjo ^b   Estelle, Mark ^a  

^a INDIANA UNIVERSITY   (United States)

^b LEIBNIZ INSTITUT FÜR KATALYSE E V AN DER UNIVERSITÄT ROSTOCK   (Germany)

Author keywords

Auxin; Conjugation; CUL1; RCE1; RUB; RUB modification

Indexed keywords

MUTANT PROTEIN; PROTEIN AXR1; PROTEIN RBX1; RELATED TO UBIQUITIN PROTEIN; RELATED TO UBIQUITIN PROTEIN CONJUGATING ENZYME 1; SKP1 CULLIN F BOX PROTEIN; UNCLASSIFIED DRUG; VEGETABLE PROTEIN;

ARABIDOPSIS; ARTICLE; CONJUGATION; EMBRYO DEVELOPMENT; GENE DISRUPTION; GENE MUTATION; NONHUMAN; PHENOTYPE; PLANT DEVELOPMENT; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

ANIMALS; ARABIDOPSIS; ARABIDOPSIS PROTEINS; CELL CYCLE PROTEINS; CULLIN PROTEINS; CYCLOPENTANES; GENES, REPORTER; GROWTH SUBSTANCES; LIGASES; MUTATION; PHENOTYPE; PLANT GROWTH REGULATORS; RECOMBINANT FUSION PROTEINS; SEEDLING; UBIQUITINS;

ARABIDOPSIS;

EID: 0037447311     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg190     Document Type: Article

References (49)

1. Berleth, T. and Jurgens, G. (1993) The role of the monopteros gene in organising the basal body region of the Arabidopsis embryo. Development, 118, 575-587.
2. Berleth, T., Mattsson, J. and Hardtke, C.S. (2000) Vascular continuity and auxin signals. Trends Plant Sci., 5, 387-393.
3. del Pozo, J.C. and Estelle, M. (1999) The Arabidopsis cullin AtCUL1 is modified by the ubiquitin-related protein RUB1. Proc. Natl Acad. Sci. USA, 96, 15342-15347.
4. del Pozo, J.C., Timpte, C., Tan, S., Callis, J. and Estelle, M. (1998) The ubiquitin-related protein RUB1 and auxin response in Arabidopsis. Science, 280, 1760-1763.
5. del Pozo, J.C., Dharmasiri, S., Hellmann, H., Walker, L., Gray, W.M. and Estelle, M. (2002) AXR1-ECR1-dependent conjugation of RUB1 to the Arabidopsis cullin AtCUL1 is required for auxin response. Plant Cell, 14, 421-433.
6. Deshaies, R.J. (1999) SCF and Cullin/Ring H2-based ubiquitin ligases. Annu. Rev. Cell. Dev. Biol., 15, 435-467.
7. Dharmasiri, S. and Estelle, M. (2002) The role of regulated protein degradation in auxin response. Plant Mol. Biol., 49, 401-409.
8. Dieterle, M., Zhou, Y.C., Schafer, E., Funk, M. and Kretsch, T. (2001) EID1, an F-box protein involved in phytochrome A-specific light signaling. Genes Dev., 15, 939-944.
9. Furukawa, M., Zhang, Y., McCarville, J., Ohta, T. and Xiong, Y. (2000) The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification and ubiquitin ligase activity of CUL1. Mol. Cell. Biol., 20, 8185-8197.
10. Gagne, J.M., Downes, B.P., Shiu, S.H., Durski, A.M. and Vierstra, R.D. (2002) The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis. Proc. Natl Acad. Sci. USA, 99, 11519-11524.
11. Gray, W.M. et al. (1999) Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana. Genes Dev., 13, 1678-1691.
12. Gray, W.M., Kepinski, S., Rouse, D., Leyser, O. and Estelle, M. (2001) Auxin regulates SCFTIR1-dependent degradation of AUX/IAA proteins. Nature, 414, 271-276.
13. Gray, W.M., Hellmann, H., Dharmasiri, S. and Estelle, M. (2002) Role of the Arabidopsis RING-H2 protein RBX1 in RUB modification and SCF function. Plant Cell, 14, 2137-2144.
14. Hamann,T., Mayer, U. and Jurgens, G. (1999a) The auxin-insensitive bodenlos mutation affects primary root formation and apical-basal patterning in the Arabidopsis embryo. Development, 126, 1387-1395.
15. Hamann, T., Mayer, U. and Jurgens, G. (1999b) The auxin-insensitive bodenlos mutation affects primary root formation and apical-basal patterning in the Arabidopsis embryo. Development, 126, 1387-1395.
16. Hamann, T., Benkova, E., Baurle, I., Kientz, M. and Jurgens, G. (2002) The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning. Genes Dev., 16, 1610-1615.
17. Hardtke, C.S. and Berleth, T. (1998) The Arabidopsis gene MONOPTEROS encodes a transcription factor mediating embryo axis formation and vascular development. EMBO J., 17, 1405-1411.
18. Hellmann, H. and Estelle, M. (2002) Plant development: regulation by protein degradation. Science, 297, 793-797.
19. Himanen, K., Boucheron, E., Vanneste, S., De Almeida Engler, J., Inze, D. and Beeckman, T. (2002) Auxin-mediated cell cycle activation during early lateral root initiation. Plant Cell, 14, 2339-2351.
20. Hobbie, L., McGovern, M., Hurwitz, L.R., Pierro, A., Liu, N.Y., Bandyopadhyay, A. and Estelle, M. (2000) The axr6 mutants of Arabidopsis thaliana define a gene involved in auxin response and early development. Development, 127, 23-32.
21. Ingram, G.C., Doyle, S., Carpenter, R., Schultz, E.A., Simon, R. and Coen, E.S. (1997) Dual role for fimbriata in regulating floral homeotic genes and cell division in Antirrhinum. EMBO J., 16, 6521-6534.
22. Jefferson, R.A., Kavanagh, T.A. and Bevan, M.W. (1987) GUS fusions: β-glucuronidase as a sensitive and versatile gene fusion marker in higher plants. EMBO J., 6, 3901-3907.
23. Kamura, T., Conrad, M.N., Yan, Q., Conaway, R.C. and Conaway, J.W. (1999) The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2. Genes Dev., 13, 2928-2933.
24. Kurz, T., Pintard, L., Willis, J.H., Hamill, D.R., Gonczy, P., Peter, M. and Bowerman, B. (2002) Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway. Science, 295, 1294-1298.
25. Liakopoulos, D., Busgen, T., Brychzy, A., Jentsch, S. and Pause, A. (1999) Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function. Proc. Natl Acad. Sci. USA, 96, 5510-5515.
26. Liu, C.M. and Meinke, D.W. (1998) The titan mutants of Arabidopsis are disrupted in mitosis and cell cycle control during seed development. Plant J., 16, 21-31.
27. Lyapina, S., Cope, G., Shevchenko, A., Serino, G., Tsuge, T., Zhou, C., Wolf, D.A., Wei, N. and Deshaies, R.J. (2001) Promotion of NEDD8-CUL1 conjugate cleavage by COP9 signalosome. Science, 292, 1382-1385.
28. kip1. Biochem. Biophys. Res. Commun., 270, 1093-1096.
29. Nelson, D.C., Lasswell, J., Rogg, L.E., Cohen, M.A. and Bartel, B. (2000) FKF1, a clock-controlled gene that regulates the transition to flowering in Arabidopsis. Cell, 101, 331-340.
30. Osaka, F. et al. (2000) Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast. EMBO J., 19, 3475-3484.
31. Ou, C.Y., Lin, Y.F., Chen, Y.J. and Chien, C.T. (2002) Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development. Genes Dev., 16, 2403-2414.
32. Pickart, C.M. (2001) Mechanisms underlying ubiquitination. Annu. Rev. Biochem., 70, 503-533.
33. Podust, V.N., Brownell, J.E., Gladysheva, T.B., Luo, R.S., Wang, C., Coggins, M.B., Pierce, J.W., Lightcap, E.S. and Chau, V. (2000) A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination. Proc. Natl Acad. Sci. USA, 97, 4579-4584.
34. βTrCP-dependent ubiquitination of IκBα. Mol. Cell. Biol., 20, 2326-2333.
35. Samach, A., Klenz, J.E., Kohalmi, S.E., Risseeuw, E., Haughn, G.W. and Crosby, W.L. (1999) The UNUSUAL FLORAL ORGANS gene of Arabidopsis thaliana is an F-box protein required for normal patterning and growth in the floral meristem. Plant J., 20, 433-445.
36. Schwechheimer, C. and Deng, X.W. (2001) COP9 signalosome revisited: a novel mediator of protein degradation. Trends Cell Biol., 11, 420-426.
37. Schwechheimer, C., Serino, G., Callis, J., Crosby, W.L., Lyapina, S., Deshaies, R.J., Gray, W.M., Estelle, M. and Deng, X.W. (2001) Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIR1 in mediating auxin response. Science, 292, 1379-1382.
38. Schwechheimer, C., Serino, G. and Deng, X.W. (2002) Multiple ubiquitin ligase-mediated processes require COP9 signalosome and AXR1 function. Plant Cell, 14, 2553-2563.
39. Somers, D.E., Schultz, T.F., Milnamow, M. and Kay, S.A. (2000) ZEITLUPE encodes a novel clock-associated PAS protein from Arabidopsis. Cell, 101, 319-329.
40. Stirnberg, P., van De Sande, K. and Leyser, H.M. (2002) MAX1 and MAX2 control shoot lateral branching in Arabidopsis. Development, 129, 1131-1141.
41. Tateishi, K., Omata,M., Tanaka, K. and Chiba, T. (2001) The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice. J. Cell Biol., 155, 571-579.
42. Tiryaki, I. and Staswick, P.E. (2002) An Arabidopsis mutant defective in jasmonate response is allelic to the auxin-signaling mutant axr1. Plant Physiol., 130, 887-894.
43. Woo, H.R., Chung, K.M., Park, J.H., Oh, S.A., Ahn, T., Hong, S.H., Jang, S.K. and Nam, H.G. (2001) ORE9, an F-box protein that regulates leaf senescence in Arabidopsis. Plant Cell, 13, 1779-1790.
44. Wu, K., Chen, A. and Pan, Z.Q. (2000) Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization. J. Biol. Chem., 275, 32317-32324.
45. Wu, K., Chen, A., Tan, P. and Pan, Z.Q. (2002) The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34. J. Biol. Chem., 277, 516-527.
46. Xie, D.X., Feys, B.F., James, S., Nieto-Rostro, M. and Turner, J.G. (1998) COI1: an Arabidopsis gene required for jasmonate-regulated defense and fertility. Science, 280, 1091-1094.
47. COL1 ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis. Plant Cell, 14, 1919-1935.
48. Yeh, E.T., Gong, L. and Kamitani, T. (2000) Ubiquitin-like proteins: new wines in new bottles. Gene, 248, 1-14.
49. Zheng, N. et al. (2002) Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature, 416, 703-709.