The COP9 Signalosome

Annual Review of Cell and Developmental Biology

Volumn 19, Issue , 2003, Pages 261-286

  Wei, Ning ^a   Deng, Xing Wang ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

CSN; Jab1; Nedd8 Rub1; Protein degradation; SCF; Ubiquitin proteasome pathway

Indexed keywords

CELL NUCLEUS RECEPTOR; COP9 SIGNALOSOME; GENE PRODUCT; HEPATOPOIETIN; I KAPPA B KINASE; INITIATION FACTOR 3; INOSITOL 1,3,4 TRISPHOSPHATE; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; LIGASE; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MACROPHAGE MIGRATION INHIBITION FACTOR; MEMBRANE PROTEIN; METALLOPROTEINASE; PROGESTERONE RECEPTOR; PROTEASOME; PROTEIN; PROTEIN BCL 3; PROTEIN KINASE; PROTEIN P27; PROTEIN P53; RNA HELICASE; SMAD4 PROTEIN; STEROID RECEPTOR COACTIVATOR 1; STRESS ACTIVATED PROTEIN KINASE; THYROID HORMONE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRUS PROTEIN;

ARABIDOPSIS; CAENORHABDITIS ELEGANS; CELL ACTIVITY; CELL CYCLE; CELL FUNCTION; CELLULAR DISTRIBUTION; CONFERENCE PAPER; DEVELOPMENT; DROSOPHILA; ENZYME ACTIVITY; EUKARYOTE; HUMAN; NONHUMAN; PHOTOMORPHOGENESIS; PLANT DEVELOPMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; REGULATORY MECHANISM; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; YEAST;

ANIMALS; ARABIDOPSIS PROTEINS; HUMANS; METALLOENDOPEPTIDASES; MULTIPROTEIN COMPLEXES; PEPTIDE HYDROLASES; PHOSPHORYLATION; PROTEIN SUBUNITS; PROTEIN TRANSPORT; PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASE COMPLEXES; UBIQUITINS;

ARABIDOPSIS; CAENORHABDITIS; CAENORHABDITIS ELEGANS; EUKARYOTA;

EID: 0344824691     PISSN: 10810706     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.cellbio.19.111301.112449     Document Type: Conference Paper

References (129)

1. Altincicek B, Tenbaum SP, Dressel U, Thormeyer D, Renkawitz R, Baniahmad A. 2000. Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita. J. Biol. Chem. 275:7662-67
2. Aravind L, Ponting CP. 1998. Homologues of 26S proteasome subunits are regulators of transcription and translation. Protein Sci. 7:1250-54
3. Bae MK, Ahn MY, Jeong JW, Bae MH, Lee YM, et al. 2002. Jab1 interacts directly with HIF-1alpha and regulates its stability. J. Biol. Chem. 277:9-12
4. Bech-Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, et al. 2001. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. EMBO J. 20:1630-39
5. Bech-Otschir D, Seeger M, Dubiel W. 2002. The COP9 signalosome: at the interface between signal transduction and ubiquitin-dependent proteolysis. J. Cell Sci. 115:467-73
6. Benvenuto G, Formiggini F, Laflamme P, Malakhov M, Bowler C. 2002. The photomorphogenesis regulator DET1 binds the amino-terminal tail of histone H2B in a nucleosome context. Curr. Biol 12:1529
7. Bianchi E, Denti S, Granata A, Bossi G, Geginat J, et al. 2000. Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. Nature 404:617-21
8. Bounpheng MA, Melnikova IN, Dodds SG, Chen H, Copeland NG, et al. 2000. Characterization of the mouse JAB1 cDNA and protein. Gene 242:41-50
9. Boussiotis VA, Freeman GJ, Taylor PA, Berezovskaya A, Grass I, et al. 2000. p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes. Nat. Med. 6:290-97
10. Caballero OL, Resto V, Patturajan M, Meerzaman D, Guo MZ, et al. 2002. Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1). Oncogene 21:3003-10
11. Chamovitz DA, Segal D. 2001. JAB1/CSN5 and the COP9 signalosome. A complex situation. EMBO Rep. 2:96-101
12. Chamovitz DA, Wei N, Osterlund MT, von Arnim AG, Staub JM, et al. 1996. The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch. Cell 86:115-21
13. Chauchereau A, Georgiakaki M, Perrin-Wolff M, Milgrom E, Loosfelt H. 2000. JAB1 interacts with both the progesterone receptor and SRC-1. J. Biol. Chem. 275:8540-48
14. Chopra S, Fernandez De Mattos S, Lam EW, Mann DJ. 2002. Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1. J. Biol. Chem. 277:32413-16
15. Claret FX, Hibi M, Dhut S, Toda T, Karin M. 1996. A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. Nature 383:453-57
16. Cohen H, Azriel A, Cohen T, Meraro D, Hashmueli S, et al. 2000. Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome. J. Biol. Chem. 275:39081-89
17. Cope GA, Suh GS, Aravind L, Schwarz SE, Zipursky SL, et al. 2002. Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science 298:608-11
18. Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, et al. 1999. The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Re1 and nuclear co-regulators. Oncogene 18:3316-23
19. del Pozo JC, Dharmasiri S, Hellmann H, Walker L, Gray WM, Estelle M. 2002. AXR1-ECR1-dependent conjugation of RUB1 to the Arabidopsis Cullin AtCUL1 is required for auxin response. Plant Cell 14:421-33
20. Deng XW, Dubiel W, Wei N, Hofmann K, Mundt K, et al. 2000. Unified nomenclature for the COP9 signalosome and its subunits: an essential regulator of development. Trends Genet. 16:202-3
21. Deng XW, Matsui M, Wei N, Wagner D, Chu AM, et al. 1992. COP1, an Arabidopsis regulatory gene, encodes a protein with both a zinc-binding motif and a G beta homologous domain. Cell 71:791-801
22. Deshaies RJ. 1999. SCF and cullin/ring H2-based ubiquitin ligases. Annu. Rev. Cell Dev. Biol. 15:435-67
23. Doronkin S, Djagaeva I, Beckendorf SK. 2002. CSN5/Jab1 mutations affect axis formation in the Drosophila oocyte by activating a meiotic checkpoint. Development 129:5053-64
24. Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, et al. 1999. Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily. Mol. Cell. Biol. 19:3383-94
25. Dunand-Sauthier I, Walker C, Wilkinson C, Gordon C, Crane R, et al. 2002. Sum1, a component of the fission yeast eIF3 translation initiation complex, is rapidly relocalized during environmental stress and interacts with components of the 26S proteasome. Mol. Biol. Cell 13:1626-40
26. Feng S, Ma L, Wang X, Xie D, Dinesh-Kumar SP, et al. 2003. The COP9 signalosome physically interacts with SCFCOI1 and modulates jasmonate responses. Plant Cell 15:1083-94
27. Freilich S, Oron E, Kapp Y, Nevo-Caspi Y, Orgad S, et al. 1999. The COP9 signalosome is essential for development of Drosophila melanogaster. Curr. Biol. 9:1187-90
28. Fu H, Reis N, Lee Y, Glickman MH, Vierstra RD. 2001. Subunit interaction maps for the regulatory particle of the 26S proteasome and the COP9 signalosome. EMBO J. 20:7096-107
29. Furukawa M, Zhang Y, McCarville J, Ohta T, Xiong Y. 2000. The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1. Mol. Cell. Biol. 20:8185-97
30. Gavin AC, Bosche M, Krause R, Grandi P, Marzioch M, et al. 2002. Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature 415:141-47
31. Gemmill RM, Bemis LT, Lee JP, Sozen MA, Baron A, et al. 2002. The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. Oncogene 21:3507-16
32. Glickman MH, Rubin DM, Coux O, Wefes I, Pfeifer G, et al. 1998. A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3. Cell 94:615-23
33. Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, et al. 2003. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. Cell 113:357-67
34. Henke W, Ferrell K, Bech-Otschir D, Seeger M, Schade R, et al. 1999. Comparison of human COP9 signalsome and 26S proteasome lid. Mol. Biol. Rep. 26:29-34
35. Hershko A, Ciechanover A. 1998. The ubiquitin system. Annu. Rev. Biochem. 67:425-79
36. Hoareau Alves K, Bochard V, Rety S, Jalinot P. 2002. Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome. FEBS Lett. 527:15
37. Hochstrasser M. 2000. Evolution and function of ubiquitin-like protein-conjugating systems. Nat. Cell Biol. 2:E153-57
38. Hofmann K, Bucher P. 1998. The PCI domain: a common theme in three multiprotein complexes. Trends Biochem. Sci. 23:204-5
39. Holm M, Hardtke CS, Gaudet R, Deng XW. 2001. Identification of a structural motif that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1. EMBO J. 20:118-27
40. Holm M, Ma LG, Qu LJ, Deng XW. 2002. Two interacting bZIP proteins are direct targets of COP1-mediated control of light-dependent gene expression in Arabidopsis. Genes Dev. 16:1247-59
41. Hong X, Xu L, Li X, Zhai Z, Shu H. 2001. CSN3 interacts with IKKgamma and inhibits TNF-but not IL-1-induced NF-kappaB activation. FEBS Lett. 499:133-36
42. Kamura T, Brower CS, Conaway RC, Conaway JW. 2002. A molecular basis for stabilization of the von Hippel-Lindau (VHL) tumor suppressor protein by components of the VHL ubiquitin ligase. J. Biol. Chem. 277:30388-93
43. Kang D, Wang X, Cao K, Sun C, Deng XW, Wei N. 2000. A gain-of-function phenotype conferred by over-expression of functional subunits of the COP9 signalosome in Arabidopsis. Plant J. 23:597-608
44. Kapelari B, Bech-Otschir D, Hegerl R, Schade R, Dumdey R, Dubiel W. 2000. Electron microscopy and subunit-subunit interaction studies reveal a first architecture of COP9 signalosome. J. Mol. Biol. 300:1169-78
45. Karniol B, Malec P, Chamovitz DA. 1999. Arabidopsis FUSCA5 encodes a novel phospho-protein that is a component of the COP9 complex. Plant Cell 11:839-48
46. Karniol B, Yahalom A, Kwok S, Tsuge T, Matsui M, et al. 1998. The Arabidopsis homologue of an eIF3 complex subunit associates with the COP9 complex. FEBS Lett. 439:173-79
47. Kawakami T, Chiba T, Suzuki T, Iwai K, Yamanaka K, et al. 2001. NEDD8 recruits E2-ubiquitin to SCF E3 ligase. EMBO J. 20: 4003-12
48. Kim T, Hofmann K, von Arnim AG, Chamovitz DA. 2001. PCI complexes: pretty complex interactions in diverse signaling pathways. Trends Plant Sci. 6:379-86
49. Kleemann R, Hausser A, Geiger G, Mischke R, Burger-Kentischer A, et al. 2000. Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1. Nature 408:211-16
50. Kwok SF, Solano R, Tsuge T, Chamovitz DA, Ecker JR, et al. 1998. Arabidopsis homologs of a c-Jun coactivator are present both in monomeric form and in the COP9 complex, and their abundance is differentially affected by the pleiotropic cop/det/fus mutations. Plant Cell 10:1779-90
51. Kwok SF, Staub JM, Deng XW. 1999. Characterization of two subunits of Arabidopsis 19S proteasome regulatory complex and its possible interaction with the COP9 complex. J. Mol. Biol. 285:85-95
52. Lee JW, Choi H-S, Gyuris S, Brent R, Moore DD. 1995. Two classes of protein dependent on either the presence or the absence of thyroid hormone interaction with thyroid hormone receptor. Mol. Endocrinol. 9:243-53
53. Li S, Liu X, Ascoli M. 2000. p38JAB1 binds to the intracellular precursor of the lutropin/choriogonadotropin receptor and promotes its degradation. J. Biol. Chem. 275: 13386-93
54. Liu C, Powell KA, Mundt K, Wu L, Carr AM, Caspari T. 2003. Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductases by checkpoint-dependent and -independent mechanisms. Genes Dev. 17(9):1130-40
55. Liu J, Furukawa M, Matsumoto T, Xiong Y. 2002. NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases. Mol. Cell 10:1511-18
56. Liu Y, Schiff M, Serino G, Deng XW, Dinesh-Kumar SP. 2002. Role of SCF ubiquitin-ligase and the COP9 signalosome in the N gene-mediated resistance response to tobacco mosaic virus. Plant Cell 14:1483-96
57. Lu C, Li Y Zhao Y, Xing G, Tang F, et al. 2002. Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway. FASEB J. 16:90-92
58. Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, et al. 2001. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science 292:1382-85
59. Ma L, Zhao H, Deng X. 2003. Analysis of the mutational effects of the COP/DET/FUS loci on genome expression profiles reveals their overlapping yet not identical roles in regulating Arabidopsis seedling development. Development 130:969-81
60. Mahalingam S, Ayyavoo V, Patel M, Kieber-Emmons T, Kao GD, et al. 1998. HTV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle. Proc. Natl. Acad. Sci. USA 95:3419-24
61. Maytal-Kivity V, Piran R, Pick E, Hofmann K, Glickman MH. 2002a. COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae. EMBO Rep. 3:1215-21
62. Maytal-Kivity V, Reis N, Hofmann K, Glickman MH. 2002b. MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function. BMC Biochem. 3:28
63. Misera S, Muller AJ, Weiland-Heidecker U, Jurgens G. 1994. The FUSCA genes of Arabidopsis: negative regulators of light responses. Mol. Gen. Genet. 244:242-52
64. Morimoto M, Nishida T, Honda R, Yasuda H. 2000. Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1). Biochem. Biophys. Res. Commun. 270:1093-96
65. Mundt KE, Liu C, Carr AM. 2002. Deletion mutants in COP9/signalosome subunits in fission yeast Schizosaccharomyces pombe display distinct phenotypes. Mol. Biol. Cell 13:493-502
66. Mundt KE, Porte J, Murray JM, Brikos C, Christensen PU, et al. 1999. The COP9/signalosome complex is conserved in fission yeast and has a role in S phase. Curr. Biol. 9:1427-30
67. Mustilli AC, Fenzi F, Ciliento R, Alfano F, Bowler C. 1999. Phenotype of the tomato high pigment-2 mutant is caused by a mutation in the tomato homolog of DEETIOLATED1. Plant Cell 11:145-57
68. Naumann M, Bech-Otschir D, Huang X, Ferrell K, Dubiel W. 1999. COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK. J. Biol. Chem. 274: 35297-300
69. Ohh M, Kim WY, Moslehi JJ, Chen Y, Chau V, et al. 2002. An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells. EMBO Rep. 3:177-82
70. Oron E, Mannervik M, Rencus S, Harari-Steinberg O, Neuman-Silberberg S, et al. 2002. COP9 signalosome subunits 4 and 5 regulate multiple pleiotropic pathways in Drosophila melanogaster. Development 129:4399-409
71. Osaka F, Saeki M, Katayama S, Aida N, Toh EA, et al. 2000. Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast. EMBO J. 19:3475-84
72. Osterlund MT, Ang LH, Deng XW. 1999. The role of COP1 in repression of Arabidopsis photomorphogenic development. Trends Cell Biol. 9:113-18
73. Osterlund MT, Hardtke CS, Wei N, Deng XW. 2000. Targeted destabilization of HY5 during light-regulated development of Arabidopsis. Nature 405:462-66
74. Peng Z, Serino G, Deng XW. 2001a. Molecular characterization of subunit 6 of the COP9 signalosome and its role in multifaceted developmental processes in Arabidopsis. Plant Cell 13:2393-407
75. Peng Z, Serino G, Deng XW. 2001b. A role of Arabidopsis COP9 signalosome in multifaceted developmental processes revealed by the characterization of its subunit 3. Development 128:4277-88
76. Peng Z, Staub JM, Serino G, Kwok SF, Kurepa J, et al. 2001c. The cellular level of PR500, a protein complex related to the 19S regulatory particle of the proteasome, is regulated in response to stresses in plants. Mol. Biol. Cell 12:383-92
77. Pepper A, Delaney T, Washburn T, Poole D, Chory J. 1994. DET1, a negative regulator of light-mediated development and gene expression in arabidopsis, encodes a novel nuclear-localized protein. Cell 78:109-16
78. Pickart CM. 2001. Mechanisms underlying ubiquitination. Annu. Rev. Biochem. 70:503-33
79. Podust VN, Brownell JE, Gladysheva TB, Luo RS, Wang C, et al. 2000. A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination. Proc. Natl. Acad. Sci. USA 97:4579-84
80. Ponting CP, Aravind L, Schultz J, Bork P, Koonin EV. 1999. Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer. J. Mol. Biol. 289:729-45
81. Read MA, Brownell JE, Gladysheva TB, Hottelet M, Parent LA, et al. 2000. Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha. Mol. Cell. Biol. 20:2326-33
82. Reinke V, Smith HE, Nance J, Wang J, Van Doren C, et al. 2000. A global profile of germline gene expression in C. elegans. Mol. Cell 6:605-16
83. Schaefer L, Beermann ML, Miller JB. 1999. Coding sequence, genomic organization, chromosomal localization, and expression pattern of the signalosome component Cops2: the mouse homologue of Drosophila alien. Genomics 56:310-16
84. Schoenfeld AR, Davidowitz EJ, Burk RD. 2000. Elongin BC complex prevents degradation of von Hippe1-Lindau tumor suppressor gene products. Proc. Natl. Acad. Sci. USA 97:8507-12
85. Schroeder D, Gahrtz M, Maxwell B, Cook R, Kan J, et al. 2002. De-etiolated 1 and damaged DNA binding protein 1 interact to regulate Arabidopsis photomorphogenesis. Curr. Biol. 12:1462
86. Schwechheimer C, Deng XW. 2001. COP9 signalosome revisited: a novel mediator of protein degradation. Trends Cell Biol. 11:420-26
87. Schwechheimer C, Serino G, Callis J, Crosby WL, Lyapina S, et al. 2001. Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response. Science 292:1379-82
88. Schwechheimer C, Serino G, Deng XW 2002. Multiple ubiquitin ligase-mediated processes require COP9 signalosome and AXR1 function. Plant Cell 14:2553-63
89. Seeger M, Gordon C, Dubiel W. 2001. Protein stability: the COP9 signalosome gets in on the act. Curr. Biol. 11:R643-46
90. Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, et al. 1998. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. FASEB J. 12:469-78
91. Serino G, Deng XW. 2003. The COP9 signalosome: regulating plant development through the control of proteolysis. Annu. Rev. Plant Biol. 54:165-82
92. Serino G, Su H, Peng Z, Tsuge T, Wei N, et al. 2003. Characterization of the last subunit of Arabidopsis COP9 signalosome: implications for the overall structure and origin of the complex. Plant Cell 15:719-31
93. Serino G, Tsuge T, Kwok S, Matsui M, Wei N, Deng XW 1999. Arabidopsis cop8 and fus4 mutations define the same gene that encodes subunit 4 of the COP9 signalosome. Plant Cell 11:1967-80
94. Shalev A, Valasek L, Pise-Masison CA, Radonovich M, Phan L, et al. 2001. Saccharomyces cerevisiae protein Pci8p and human protein eIF3e/Int-6 interact with the eIF3 core complex by binding to cognate eIF3b subunits. J. Biol. Chem. 276:34948-57
95. Smith P, Leung-Chiu WM, Montgomery R, Orsborn A, Kuznicki K, et al. 2002. The GLH proteins, Caenorhabditis elegans P granule components, associate with CSN-5 and KGB-1, proteins necessary for fertility, and with ZYX-1, a predicted cytoskeletal protein. Dev. Biol. 251:333-47
96. Spain BH, Bowdish KS, Pacal AR, Staub SF, Koo D, et al. 1996. Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein-and mitogen-activated protein kinase-mediated signal transduction in yeast and mammals. Mol. Cell. Biol. 16:6698-706
97. Staub JM, Wei N, Deng XW 1996. Evidence for FUS6 as a component of the nuclear-localized COP9 complex in Arabidopsis. Plant Cell 8:2047-56
98. Suh GS, Poeck B, Chouard T, Oron E, Segal D, et al. 2002. Drosophila JAB1/CSN5 acts in photoreceptor cells to induce glial cells. Neuron 33:35-46
99. Sun Y, Wilson MP, Majerus PW. 2002. Inositol 1,3,4-trisphosphate associates with the COP9 signalosome by binding to CSN1. J. Biol. Chem. 24:24
100. Suzuki G, Yanagawa Y, Kwok SF, Matsui M, Deng XW. 2002. Arabidopsis COP10 is a ubiquitin-conjugating enzyme variant that acts together with COP1 and the COP9 signalosome in repressing photomorphogenesis. Genes Dev 16:554-59
101. Tateishi K, Omata M, Tanaka K, Chiba T. 2001. The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice. J. Cell Biol. 155:571-79
102. Tomoda K, Kubota Y, Arata Y, Mori S, Maeda M, et al. 2002. The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex. J. Biol. Chem. 277:2302-10
103. Tomoda K, Kubota Y, Kato J. 1999. Degradation of the cyclin-dependent- kinase inhibitor p27Kip1 is instigated by Jab1. Nature 398:160-65
104. Tsuge T, Matsui M, Wei N. 2001. The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain. J. Mol. Biol. 305:1-9
105. Verma R, Aravind L, Oania R, McDonald WH, Yates JR 3rd, et al. 2002. Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. Science 298:611-15
106. von Arnim AG, Deng XW. 1994. Light inactivation of Arabidopsis photomorphogenic represser COP1 involves a cell-specific regulation of its nucleocytoplasmic partitioning. Cell 79:1035-45
107. Wada H, Yeh ET, Kamitani T. 1999. The von Hippel-Lindau tumor suppressor gene product promotes, but is not essential for, NEDD8 conjugation to cullin-2. J. Biol. Chem. 274:36025-29
108. Wan M, Cao X, Wu Y, Bai S, Wu L, et al. 2002. Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation. EMBO Rep. 3:171-76
109. Wang H, Kang D, Deng XW, Wei N. 1999. Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1. Curr. Biol. 9:711-14
110. UFO by the COP9 signalosome during Arabidopsis flower development. Plant Cell 15:1071-82
111. Wang X, Kang D, Feng S, Serino G, Schwechheimer C, Wei N. 2002. CSN1 N-terminal-dependent activity is required for Arabidopsis development but not for Rub1/Nedd8 deconjugation of cullins: a structure-function study of CSN1 subunit of COP9 signalosome. Mol. Biol. Cell 13:646-55
112. Wang Y, Devereux W, Stewart TM, Casero RA, Jr. 2002. Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression. Biochem J. 366:79-86
113. Wee S, Hetfeld B, Dubiel W, Wolf DA. 2002. Conservation of the COP9/signalosome in budding yeast. BMC Genet. 3:15
114. Wei N, Chamovitz DA, Deng XW 1994. Arabidopsis COP9 is a component of a novel signaling complex mediating light control of development. Cell 78:117-24
115. Wei N, Deng XW. 1992. COP9: a new genetic locus involved in light-regulated development and gene expression in Arabidopsis. Plant Cell 4:1507-18
116. Wei N, Deng XW 1998. Characterization and purification of the mammalian COP9 complex, a conserved nuclear regulator initially identified as a represser of photomorphogenesis in higher plants. Photochem. Photobiol. 68:237-41
117. Wei N, Deng XW 1999. Making sense of the COP9 signalosome. A regulatory protein complex conserved from Arabidopsis to human. Trends Genet. 15:98-103
118. Wei N, Tsuge T, Serino G, Dohmae N, Takio K, et al. 1998. The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr. Biol. 8:919-22
119. Wilson MP, Sun Y, Cao L, Majerus PW. 2001. Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2. J. Biol. Chem. 276:40998-1004
120. Wirbelauer C, Sutterluty H, Blondel M, Gstaiger M, Peter M, et al. 2000. The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts. EMBO J. 19:5362-75
121. Wu K, Chen A, Pan ZQ. 2000. Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization. J. Biol. Chem. 275:32317-24
122. Yahalom A, Kim TH, Winter E, Karniol B, von Amim AG, Chamovitz DA. 2001. Arabidopsis eIF3e (INT-6) associates with both eIF3c and the COP9 signalosome subunit CSN7. J. Biol. Chem. 276:334-40
123. Yang HY, Zhou BP, Hung MC, Lee MH. 2000. Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27. J. Biol. Chem. 275: 24735-39
124. Yang X, Menon S, Lykke-Andersen K, Tsuge T, Di X, et al. 2002. The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylationof SCFCu11. Curr. Biol. 12:667-72
125. Yogosawa S, Makino Y, Yoshida T, Kishimoto T, Muramatsu M, Tamura T. 1996. Molecular cloning of a novel 120-kDa TBP-interacting protein. Biochem. Biophys. Res. Commun. 229:612-17
126. Zheng J, Yang X, Harrell JM, Ryzhikov S, Shim EH, et al. 2002. CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex. Mol. Cell 10:1519-26
127. Zhou C, Seibert V, Geyer R, Rhee E, Lyapina S, et al. 2001. The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p. BMC Biochem. 2:7
128. Zhou C, Wee S, Rhee E, Naumann M, Dubiel W, Wolf DA. 2003. Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitination enzyme Ubp12p. Mol. Cell 11:927-38
129. Zhou P, Howley PM. 1998. Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases. Mol. Cell 2:571-80