The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1

Molecular and Cellular Biology

Volumn 20, Issue 21, 2000, Pages 8185-8197

  Furukawa, M ^a   Zhang, Y ^a   McCarville, J ^a   Ohta, T ^a   Xiong, Y ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGASE; UBIQUITIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN LOCALIZATION;

AMINO ACID SEQUENCE; ANIMAL; BLOTTING, WESTERN; CELL CYCLE PROTEINS; CELL LINE; CELL NUCLEUS; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HELA CELLS; HUMAN; IMMUNOHISTOCHEMISTRY; LIGASES; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PLASMIDS; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSFECTION; UBIQUITINS;

EID: 0033781272     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.21.8185-8197.2000     Document Type: Article

References (54)

1. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
2. SCF and cullin/RING H2-based ubiquitin ligases
3. SUMO-1 modification of IκBα inhibits NF-κB activation
4. A complex of Cdc4p, Skp1p, and Cdc53p/Cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p
5. Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1
6. Role of ubiquitin-mediated proteolysis in cell cycle control
7. Ubiquitin-dependent protein degradation
8. There's the rub: A novel ubiquitin-like modification linked to cell cycle regulation
9. Covalent modification of all members of human cullin family proteins by NEDD8
10. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase
11. Immunoprecipitation and immunoblotting in cell cycle studies
12. The ubiquitin-conjugating system
13. Ubiquitous deja vu
14. The tyrosine kinase negative regulator c-Cbl as a RING-type E2-dependent ubiquitin-protein ligase
15. Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein
16. The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2
17. Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
18. How proteolysis drives the cell cycle
19. cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family
20. How the cyclin became a cyclin: Regulated proteolysis in the cell cycle
21. Cloning of a cDNA which encodes a novel ubiquitin-like protein
22. Modification of yeast Cdc53p by the ubiquitin-related protein Rub1p affects function of the SCF(Cdc4) complex
23. Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to van Hippel-Lindau tumor suppressor function
24. A novel protein modification pathway related to the ubiquitin system
25. Conjugates of ubiquitin cross-reactive protein distribute in a cytoskeletal pattern
26. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
27. A small ubiquitin-related polypeptide involved in targeting RanGAP1 to the nuclear pore complex protein RanBP2
28. A ubiquitin ligase complex essential for the NF-κB, Wnt/Wingless, and hedgehog signaling pathways
29. 1-to-S phase transition and identifies a conserved family of proteins
30. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex
31. Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A
32. Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(SKP2) toward p27(Kip1)
33. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity
34. A new NEDD-ligating system for cullin 4A
35. Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast
36. Combinatorial control in ubiquitin-dependent proteolysis: Don't skp the F-box hypothesis
37. A Nedd8 conjugation pathway is essential for proteolytic targeting of p27(Kip1) by ubiquitination
38. The ubiquitin-related protein RUB1 and auxin response in Arabidopsis
39. Nedd8 modification of cul-1 activates SCF(β-TrCP)-dependent ubiquitination of IκBα
40. SUMO-1 modification activates the transcriptional response of p53
41. Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34
42. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex
43. Reconstitution of G1 cyclin ubiquitination with complexes containing SCF(Grr1) and Rbx1
44. Signal-induced ubiquitination of IκBα by the F-box protein Slimb/β-TrCP
45. Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of IκBα
46. Identification of NEDD8-conjugation site in human cullin-2
47. Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway
48. The SCF(β-TrCP)-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro
49. Identification of the receptor component of the IκBα-ubiquitin ligase
50. Identification of a cullin homology region in a subunit of the anaphase-promoting complex
51. Whose end is destruction: Cell division and the anaphase-promoting complex
52. Mass spectrometric analysis of the anaphase-promoting complex from yeast: Identification of a subunit related to cullins
53. Bridging the gap: Composition, regulation, and physiological function of the IκBα kinase complex
54. Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53