Caspase inhibition therapy abolishes brain trauma-induced increases in Aβ peptide: Implications for clinical outcome

Experimental Neurology

Volumn 197, Issue 2, 2006, Pages 437-450

  Abrahamson, Eric E ^a   Ikonomovic, Milos D ^a   Ciallella, John R ^a   Hope, Caroline E ^a   Paljug, William R ^a   Isanski, Barbara A ^a   Flood, Dorothy G ^b   Clark, Robert S B ^a   DeKosky, Steven T ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b CEPHALON INC   (United States)

Author keywords

Alzheimer; Apoptosis; BOC fmk; Hippocampus; Knockin; Neurodegeneration

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BAF; CASPASE 3; CASPASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CELL LOSS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; HIPPOCAMPUS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; TISSUE INJURY; TRAUMATIC BRAIN INJURY;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ASPARTIC ACID; BLOTTING, WESTERN; BRAIN INJURIES; CASPASE 3; CASPASES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FUNCTIONAL LATERALITY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MICE; MICE, TRANSGENIC; NEURAL INHIBITION; PEPTIDE FRAGMENTS; STILBAMIDINES; TIME FACTORS;

EID: 30444437033     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2005.10.011     Document Type: Article

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