Caspase Activation Increases β-Amyloid Generation Independently of Caspase Cleavage of the β-Amyloid Precursor Protein (APP)

Journal of Biological Chemistry

Volumn 278, Issue 46, 2003, Pages 46074-46080

  Tesco, Giuseppina ^a   Koh, Young Ho ^a   Tanzi, Rudolph E ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELLS; CHEMICAL ACTIVATION; MUTAGENESIS;

APOPTOSIS; RECOGNITION SITES;

PROTEINS;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC ACID; CASPASE; ETOPOSIDE; MUTANT PROTEIN; STAUROSPORINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHO CELL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME DEGRADATION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; SITE DIRECTED MUTAGENESIS;

AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; ASPARTIC ACID; BINDING SITES; BLOTTING, WESTERN; CASPASE 3; CASPASES; CHO CELLS; CRICETINAE; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; ETOPOSIDE; IN SITU NICK-END LABELING; MUTAGENESIS, SITE-DIRECTED; NUCLEIC ACID SYNTHESIS INHIBITORS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STAUROSPORINE; TIME FACTORS; TRANSFECTION;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0242412504     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M307809200     Document Type: Article

References (28)

1. De Strooper, B., and Annaert, W. (2000) J. Cell Sci. 113, 1857-1870
2. Kerr, J. F., Wyllie, A. H., and Currie, A. R. (1972) Br. J. Cancer 26, 239-257
3. Thornberry, N. A. (1997) Br. Med. Bull. 53, 478-490
4. Fischer, U., Janicke, R. U., and Schulze-Osthoff, K. (2003) Cell Death Differ. 10, 76-100
5. Gervais, F. G., Xu, D., Robertson, G. S., Vaillancourt, J. P., Zhu, Y., Huang, J., LeBlanc, A., Smith, D., Rigby, M., Shearman, M. S., Clarke, E. E., Zheng, H., Van Der Ploeg, L. H., Ruffolo, S. C., Thornberry, N. A., Xanthoudakis, S., Zamboni, R. J., Roy, S., and Nicholson, D. W. (1999) Cell 97, 395-406
6. Pellegrini, L., Passer, B. J., Tabaton, M., Ganjei, J. K., and D'Adamio, L. (1999) J. Biol. Chem. 274, 21011-21016
7. Weidemann, A., Paliga, K., Durrwang, U., Reinhard, F. B., Schuckert, O., Evin, G., and Masters, C. L. (1999) J. Biol. Chem. 274, 5823-5829
8. LeBlanc, A., Liu, H., Goodyer, C., Bergeron, C., and Hammond, J. (1999) J. Biol. Chem. 274, 23426-23436
9. LeBlanc, A. (1995) J. Neurosci. 15, 7837-7846
10. Galli, C., Piccini, A., Ciotti, M. T., Castellani, L., Calissano, P., Zaccheo, D., and Tabaton, M. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 1247-1252
11. Barnes, N. Y., Li, L., Yoshikawa, K., Schwartz, L. M., Oppenheim, R. W., and Milligan, C. E. (1998) J. Neurosci. 18, 5869-5880
12. Selkoe, D. J., Podlisny, M. B., Joachim, C. L., Vickers, E. A., Lee, G., Fritz, L. C., and Oltersdorf, T. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 7341-7345
13. Hilbich, C., Monning, U., Grund, C., Masters, C. L., and Beyreuther, K. (1993) J. Biol. Chem. 268, 26571-26577
14. Wolfe, M. S., Xia, W., Ostaszewski, B. L., Diehl, T. S., Kimberly, W. T., and Selkoe, D. J. (1999) Nature 398, 513-517
15. Tesco, G., Kim, T. W., Diehlmann, A., Beyreuther, K., and Tanzi, R. E. (1998) J. Biol. Chem. 273, 33909-33914
16. Wild-Bode, C., Yamazaki, T., Capell, A., Leimer, U., Steiner, H., Ihara, Y., and Haass, C. (1997) J. Biol. Chem. 272, 16085-16088
17. Hartmann, T., Bieger, S. C., Bruhl, B., Tienari, P. J., Ida, N., Allsop, D., Roberts, G. W., Masters, C. L., Dotti, C. G., Unsicker, K., and Beyreuther, K. (1997) Nat. Med. 3, 1016-1020
18. Skovronsky, D. M., Pijak, D. S., Doms, R. W., and Lee, V. M. (2000) Biochemistry 39, 810-817
19. Citron, M., Diehl, T. S., Gordon, G., Biere, A. L., Seubert, P., and Selkoe, D. J. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 13170-13175
20. Klafki, H., Abramowski, D., Swoboda, R., Paganetti, P. A., and Staufenbiel, M. (1996) J. Biol. Chem. 271, 28655-28659
21. Murphy, M. P., Uljon, S. N., Fraser, P. E., Fauq, A., Lookingbill, H. A., Findlay, K. A., Smith, T. E., Lewis, P. A., McLendon, D. C., Wang, R., and Golde, T. E. (2000) J. Biol. Chem. 275, 26277-26284
22. Wilson, C. A., Doms, R. W., Zheng, H., and Lee, V. M. (2002) Nat. Neurosci. 5, 849-855
23. Lansbury, P. T., Jr. (1997) Neuron 19, 1151-1154
24. Kalaria, R. N. (2000) Neurobiol. Aging 21, 321-330
25. Namura, S., Zhu, J., Fink, K., Endres, M., Srinivasan, A., Tomaselli, K. J., Yuan, J., and Moskowitz, M. A. (1998) J. Neurosci. 18, 3659-3668
26. Yakovlev, A. G., Knoblach, S. M., Fan, L., Fox, G. B., Goodnight, R., and Faden, A. I. (1997) J. Neurosci. 17, 7415-7424
27. Perez, R. G., Soriano, S., Hayes, J. D., Ostaszewski, B., Xia, W., Selkoe, D. J., Chen, X., Stokin, G. B., and Koo, E. H. (1999) J. Biol. Chem. 274, 18851-18856
28. Soriano, S., Lu, D. C., Chandra, S., Pietrzik, C. U., and Koo, E. H. (2001) J. Biol. Chem. 276, 29045-29050