Caspase-3-mediated cleavage of amyloid precursor protein and formation of amyloid α peptide in traumatic axonal injury

Journal of Neurotrauma

Volumn 19, Issue 5, 2002, Pages 601-614

  Stone, James R ^a,b   Okonkwo, David O ^a,b   Singleton, Richard H ^b   Mutlu, Leman K ^a   Helm, Gregory A ^a   Povlishock, John T ^b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Apoptosis; APP; A peptide; Caspase; Traumatic axonal injury; Traumatic brain injury

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CASPASE 3;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AXONAL INJURY; BRAIN INJURY; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; GENE TARGETING; IMMUNOHISTOCHEMISTRY; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN DOMAIN; RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIBODY SPECIFICITY; APOPTOSIS; AXONS; BRAIN INJURIES; CASPASE 3; CASPASES; FLUORESCENT ANTIBODY TECHNIQUE; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0036264173     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/089771502753754073     Document Type: Article

References (73)

1. Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis
2. Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons
3. Temporal profile and cell subtype distribution of activated caspase-3 following experimental traumatic brain injury
4. Staining of amyloid precursor protein to study axonal damage in mild head injury
5. Topography of axonal injury as defined by amyloid precursor protein and the sector scoring method in mild and severe closed head injury
6. The X11alpha protein slows cellular amyloid precursor protein processing and reduces Aβ40 and Aβ42 secretion
7. Temporal and regional patterns of axonal damage following traumatic brain injury: A beta-amyloid precursor protein immunocytochemical study in rats
8. Postinjury cyclosporin A administration limits axonal damage and disconnection in traumatic brain injury
9. The role of calpain-mediated spectrin proteolysis in traumatically induced axonal injury
10. Cytochrome c release and caspase activation in traumatic axonal injury
11. Post-traumatic diffuse axonal brain injury. Analysis of 78 patients studied with computed tomography
12. beta42 in mammalian cells
13. Axonal damage in severe traumatic brain injury: An experimental study in cat
14. Severe head injury hastens age of onset of Alzheimer's disease
15. betaAPP) as a marker for axonal injury after head injury
16. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation
17. The use of antibodies targeted against the neurofilament subunits for the detection of diffuse axonal injury in humans
18. Distribution of beta-amyloid protein in the brain following severe head injury
19. Head injury and the risk of AD in the MIRAGE study
20. Amyloid beta-peptide is produced by cultured cells during normal metabolism
21. Neurotransmitter-mediated mechanisms of traumatic brain injury: Acetylcholine and excitatory amino acids
22. beta40 and apoE immunostaining of plaques in fatal head injury
23. Aggregation state and neurotoxic properties of Alzheimer beta-amyloid peptide
24. Identification of a novel aspartic protease (Asp 2) as beta-secretase
25. Role of calpain- and interleukin-1 beta converting enzyme-like proteases in the beta-amyloid-induced death of rat hippocampal neurons in culture
26. Apoptotic and antiapoptotic mechanisms after traumatic brain injury
27. Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: Possible involvement of apoptosis
28. Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease
29. A new model of diffuse brain injury in rats. Part I: Pathophysiology and biomechanics
30. Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites
31. Is beta-APP a marker of axonal damage in short-surviving head injury?
32. Gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length
33. Traumatic brain injury and time to onset of Alzheimer's disease: A population-based study
34. Neuropathological changes in the white matter following head injury
35. An intrathecal bolus of cyclosporin A before injury preserves mitochondrial integrity and attenuates axonal disruption in traumatic brain injury
36. Head injury and risk of Alzheimer's disease by apolipoprotein E genotype
37. Characterization of a distinct set of intra-axonal ultrastructural changes associated with traumatically induced alteration in axolemmal permeability
38. Neurodegeneration induced by beta-amyloid peptides in vitro: The role of peptide assembly state
39. Regional calpain and caspase-3 proteolysis of alpha-spectrin after traumatic brain injury
40. Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias
41. Traumatically induced axonal injury: Pathogenesis and pathobiological implications
42. Pathobiology of traumatically induced axonal injury in animals and man
43. Are the pathobiological changes evoked by traumatic brain injury immediate and irreversible?
44. Impact acceleration injury in the rat: Evidence for focal axolemmal change and related neurofilament sidearm alteration
45. Beta A4 amyloid protein deposition in brain after head trauma
46. Beta amyloid protein deposition in the brain after severe head injury: Implications for the pathogenesis of Alzheimer's disease
47. Susceptibility of transgenic mice expressing human apolipoprotein E to closed head injury: The allele E3 is neuroprotective whereas E4 increases fatalities
48. Acute subdural hematoma and diffuse axonal injury after severe head trauma
49. Diffuse axonal injury after severe head trauma. A clinicopathological study
50. X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion
51. Alzheimer's disease after remote head injury: An incidence study
52. Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids
53. Early detection of axonal injury after human head trauma using immunocytochemistry for beta-amyloid precursor protein
54. Microwave antigen retrieval of beta-amyloid precursor protein immunoreactivity
55. Purification and cloning of amyloid precursor protein beta-secretase from human brain
56. Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig
57. The amyloidogenic pathway of amyloid precursor protein (APP) is independent of its cleavage by caspases
58. The visualization of a new class of traumatically injured axons through the use of a modified method of microwave antigen retrieval
59. Antibodies to the C-terminus of the β-amyloid precursor protein (APP): A site specific marker for the detection of traumatic axonal injury
60. Diffuse degeneration of the cerebral white matter in severe dementia
61. Shearing of nerve fibers as a cause of brain damage due to head injury
62. Simultaneous detection of two independent antigens by double staining with two mouse monoclonal antibodies
63. Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein
64. Caspase-2 mediates neuronal cell death induced by beta-amyloid
65. Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity
66. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
67. Is the supply of axoplasmic proteins a burden for the cell body? Morphometry of sensory neurons and amino acid incorporation into their cell bodies
68. Tyramide signal amplification method in multiple-label immunofluorescence confocal microscopy
69. Monitoring the impact of traumatic brain injury: A review and update
70. Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases
71. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury
72. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
73. 2-induced apoptosis in human neuronal cells