Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease

Neurobiology of Disease

Volumn 14, Issue 3, 2003, Pages 391-403

  Zhao, Ming ^a   Su, Joseph ^a   Head, Elizabeth ^a   Cotman, Carl W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease (AD); Amyloid precursor protein (APP); Caspase 3; Cleavage of APP (cAPP); Tau protein

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CASPASE 3;

AGING; ALZHEIMER DISEASE; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVATION; FRONTAL CORTEX; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; NEUROFIBRILLARY TANGLE; PHASE TRANSITION; PRECURSOR; PRIORITY JOURNAL; PROTEIN DEGRADATION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; WESTERN BLOTTING;

EID: 0347479366     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2003.07.006     Document Type: Article

References (49)

1. Barnes N.Y., Li L., Yoshikawa K., Schwartz L.M., Oppenheim R.W., Milligan C.E. Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons. J. Neurosci. 18:1998;5869-5880.
2. Braak H., Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 82:1991;239-259.
3. Busciglio J., Gabuzda D.H., Matsudaira P., Yankner B.A. Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells. Proc. Natl. Acad. Sci. USA. 90:1993;2092-2096.
4. Canu N., Dus L., Barbato C., Ciotti M.T., Brancolini C., Rinaldi A.M., Novak M., Cattaneo A., Bradbury A., Calissano P. Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis. J. Neurosci. 18:1998;7061-7074.
5. Cotman C.W. Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease. Neurobiol. Aging. 19:(1 Suppl):1998;S29-S32.
6. Cotman C.W., Su J.H. Mechanisms of neuronal death in Alzheimer's disease. Brain Pathol. 6:1996;493-506.
7. Fasulo L., Ugolini G., Visintin M., Bradbury A., Brancolini C., Verzillo V., Novak M., Cattaneo A. The neuronal microtubule-associated protein tau is a substrate for caspase-3 and an effector of apoptosis. J. Neurochem. 75:2000;624-633.
8. Gervais F.G., Xu D., Robertson G.S., Vaillancourt J.P., Zhu Y., Huang J., LeBlanc A., Smith D., Rigby M., Shearman M.S., Clarke E.E., Zheng H., Van Der Ploeg L.H., Ruffolo S.C., Thornberry N.A., Xanthoudakis S., Zamboni R.J., Roy S., Nicholson D.W. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. Cell. 97:1999;395-406.
9. Glabe C. Does Alzheimer disease tilt the scales of amyloid degradation versus accumulation? Nat. Med. 6:2000;133-134.
10. Goldman W.P., Price J.L., Storandt M., Grant E.A., McKeel D.W. Jr., Rubin E.H., Morris J.C. Absence of cognitive impairment or decline in preclinical Alzheimer's disease. Neurology. 56:2001;361-367.
11. Hartmann A., Hunot S., Michel P.P., Muriel M.P., Vyas S., Faucheux B.A., Mouatt-Prigent A., Turmel H., Srinivasan A., Ruberg M., Evan G.I., Agid Y., Hirsch E.C. Caspase-3 A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease . Proc. Natl. Acad. Sci. USA. 97:2000;2875-2880.
12. Keane R.W., Srinivasan A., Foster L.M., Testa M.P., Ord T., Nonner D., Wang H.G., Reed J.C., Bredesen D.E., Kayalar C. Activation of CPP32 during apoptosis of neurons and astrocytes. J. Neurosci. Res. 48:1997;168-180.
13. Kermer P., Klocker N., Labes M., Thomsen S., Srinivasan A., Bahr M. Activation of caspase-3 in axotomized rat retinal ganglion cells in vivo. FEBS Lett. 453:1999;361-364.
14. Khachaturian Z.S. Diagnosis of Alzheimer's disease. Arch. Neurol. 42:1985;1097-1106.
15. Koo E.H., Sisodia S.S., Cork L.C., Unterbeck A., Bayney R.M., Price D.L. Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates. Neuron. 4:1990;97-104.
16. LaFerla F.M., Tinkle B.T., Bieberich C.J., Haudenschild C.C., Jay G. The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat. Genet. 9:1995;21-30.
17. LeBlanc A., Liu H., Goodyer C., Bergeron C., Hammond J. Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease. J. Biol. Chem. 274:1999;23426-23436.
18. Lu D.C., Rabizadeh S., Chandra S., Shayya R.F., Ellerby L.M., Ye X., Salvesen G.S., Koo E.H., Bredesen D.E. A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor [see comments]. Nat. Med. 6:2000;397-404.
19. Masliah E. Mechanisms of synaptic pathology in Alzheimer's disease. J. Neural Transm. Suppl. 53:1998;147-158.
20. Mattson M.P., Partin J., Begley J.G. Amyloid beta-peptide induces apoptosis-related events in synapses and dendrites. Brain Res. 807:(1-2):1998;167-176.
21. Mirra S.S., Heyman A., McKeel D., Sumi S.M., Crain B.J., Brownlee L.M., Vogel F.S., Hughes J.P., van Belle G., Berg L. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology. 41:1991;479-486.
22. Namura S., Zhu J., Fink K., Endres M., Srinivasan A., Tomaselli K.J., Yuan J., Moskowitz M.A. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. J. Neurosci. 18:1998;3659-3668.
23. Patel T., Gores G.J., Kaufmann S.H. The role of proteases during apoptosis. FASEB J. 10:1996;587-597.
24. Pellegrini L., Passer B.J., Tabaton M., Ganjei J.K., D'Adamio L. Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8. J. Biol. Chem. 274:1999;21011-21016.
25. Rohn T.T., Head E., Su J.H., Anderson A.J., Bahr B.A., Cotman C.W., Cribbs D.H. Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease. Am. J. Pathol. 158:2001;189-198.
26. Rohn T.T., Ivins K.J., Bahr B.A., Cotman C.W., Cribbs D.H. A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis. J. Neurochem. 74:2000;2331-2342.
27. Selkoe D.J. Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease. Trends Neurosci. 16:1993;403-409.
28. Selkoe D.J. Amyloid beta-protein precursor new clues to the genesis of Alzheimer's disease . Curr. Opin. Neurobiol. 4:1994;708-716.
29. Selkoe D.J. The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell. Biol. 8:1998;447-453.
30. Shoji M., Golde T.E., Ghiso J., Cheung T.T., Estus S., Shaffer L.M., Cai X.D., McKay D.M., Tintner R., Frangione B., et al. Production of the Alzheimer amyloid beta protein by normal proteolytic processing. Science. 258:1992;126-129.
31. Sisodia S.S., Koo E.H., Hoffman P.N., Perry G., Price D.L. Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system. J. Neurosci. 13:1993;3136-3142.
32. Smale G., Nichols N.R., Brady D.R., Finch C.E., Horton W.E. Jr. Evidence for apoptotic cell death in Alzheimer's disease. Exp. Neurol. 133:1995;225-230.
33. Srinivasan A., Roth K.A., Sayers R.O., Shindler K.S., Wong A.M., Fritz L.C., Tomaselli K.J. In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system. Cell Death Differ. 5:1998;1004-1016.
34. Su J.H., Anderson A.J., Cummings B.J., Cotman C.W. Immunohistochemical evidence for apoptosis in Alzheimer's disease. Neuroreport. 5:1994;2529-2533.
35. Su J.H., Deng G., Cotman C.W. Bax protein expression is increased in Alzheimer's brain correlations with DNA damage, Bcl-2 expression, and brain pathology . J. Neuropathol. Exp. Neurol. 56:1997;86-93.
36. Su J.H., Deng G., Cotman C.W. Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain. Brain Res. 774:(1-2):1997;193-199.
37. Su J.H., Zhao M., Anderson A.J., Srinivasan A., Cotman C.W. Activated caspase-3 expression in Alzheimer's and aged control brain correlation with Alzheimer pathology . Brain Res. 898:2001;350-357.
38. Terry R.D., Masliah E., Salmon D.P., Butters N., DeTeresa R., Hill R., Hansen L.A., Katzman R. Physical basis of cognitive alterations in Alzheimer's disease synapse loss is the major correlate of cognitive impairment . Ann. Neurol. 30:1991;572-580.
39. Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Neurobiol. Aging. 18:(4 Suppl):1997;S1-S2.
40. Thornberry N.A., Rano T.A., Peterson E.P., Rasper D.M., Timkey T., Garcia-Calvo M., Houtzager V.M., Nordstrom P.A., Roy S., Vaillancourt J.P., Chapman K.T., Nicholson D.W. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J. Biol. Chem. 272:1997;17907-17911.
41. Uetsuki T., Takemoto K., Nishimura I., Okamoto M., Niinobe M., Momoi T., Miura M., Yoshikawa K. Activation of neuronal caspase-3 by intracellular accumulation of wild-type Alzheimer amyloid precursor protein. J. Neurosci. 19:1999;6955-6964.
42. Wang B.L., Larsson L.I. Simultaneous demonstration of multiple antigens by indirect immunofluorescence or immunogold staining. Novel light and electron microscopical double and triple staining method employing primary antibodies from the same species. Histochemistry. 83:1985;47-56.
43. Weidemann A., Konig G., Bunke D., Fischer P., Salbaum J.M., Masters C.L., Beyreuther K. Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell. 57:1989;115-126.
44. Weidemann, A., Paliga, K., U, D. r., Reinhard, F.B., Schuckert, O., Evin, G., Masters, C.L., 1999. Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases. J. Biol. Chem. 274, 5823-5829.
45. Weldon D.T., Rogers S.D., Ghilardi J.R., Finke M.P., Cleary J.P., O'Hare E., Esler W.P., Maggio J.E., Mantyh P.W. Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo. J. Neurosci. 18:1998;2161-2173.
46. West M.J., Coleman P.D., Flood D.G., Troncoso J.C. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet. 344:1994;769-772.
47. Yamazaki T., Selkoe D.J., Koo E.H. Trafficking of cell surface beta-amyloid precursor protein retrograde and transcytotic transport in cultured neurons . J. Cell Biol. 129:1995;431-442.
48. Yankner B.A. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron. 16:1996;921-932.
49. Zhao M., Cribbs D.H., Anderson A.J., Cummings B.J., Su J.H., Wasserman A.J., Cotman C.W. The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain. Neurochem. Res. 28:2003;307-318.