-
1
-
-
0036205587
-
Mechanisms of caspase activation and inhibition during apoptosis
-
SHI Y: Mechanisms of caspase activation and inhibition during apoptosis. Mol. Cell (2002) 9:459-470.
-
(2002)
Mol. Cell
, vol.9
, pp. 459-470
-
-
Shi, Y.1
-
2
-
-
0036716281
-
The Bcl-2 family: Regulators of the cellular life-or-death switch
-
CORY S, ADAMS JM: The Bcl-2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer (2002) 2:647-656.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 647-656
-
-
Cory, S.1
Adams, J.M.2
-
3
-
-
0036728834
-
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
-
LETAI A, BASSIK M, WALENSKY L, SORCINELLI M, WEILER S, KORSMEYER S: Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell (2002) 2:183-192.
-
(2002)
Cancer Cell
, vol.2
, pp. 183-192
-
-
Letai, A.1
Bassik, M.2
Walensky, L.3
Sorcinelli, M.4
Weiler, S.5
Korsmeyer, S.6
-
4
-
-
0029033866
-
Regulation of Bcl-2 expression by oncogenic Ras protein in hematopoietic cells
-
KINOSHITA T, YOKOTA T, ARAI K, MIYAJIMA A: Regulation of Bcl-2 expression by oncogenic Ras protein in hematopoietic cells. Oncogene (1995) 10:2207-2212.
-
(1995)
Oncogene
, vol.10
, pp. 2207-2212
-
-
Kinoshita, T.1
Yokota, T.2
Arai, K.3
Miyajima, A.4
-
5
-
-
0035898449
-
Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-κB, Bad, or caspase activation
-
LIU H, PERLMAN H, PAGLIARI LJ, POPE RM: Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-κB, Bad, or caspase activation. J. Exp. Med. (2001) 194:113-126.
-
(2001)
J. Exp. Med.
, vol.194
, pp. 113-126
-
-
Liu, H.1
Perlman, H.2
Pagliari, L.J.3
Pope, R.M.4
-
6
-
-
0033877297
-
Met/HGF receptor modulates bcl-w expression and inhibits apoptosis in human colorectal cancers
-
KITAMURA S, KONDO S, SHINOMURA Yet al.: Met/HGF receptor modulates bcl-w expression and inhibits apoptosis in human colorectal cancers. Br. J. Cancer (2000) 83:668-673.
-
(2000)
Br. J. Cancer
, vol.83
, pp. 668-673
-
-
Kitamura, S.1
Kondo, S.2
Shinomura, Y.3
-
7
-
-
0023877768
-
Expression in non Hodgkin's lymphoma of the bcl-2 protein associated with the t(14;18) chromosomal translocation
-
NGAN BY, CHEN-LEVY Z, WEISS LM, WARNKE RA, CLEARY ML: Expression in non Hodgkin's lymphoma of the bcl-2 protein associated with the t(14;18) chromosomal translocation. N. Engl. J. Med. (1988) 318:1638-1644.
-
(1988)
N. Engl. J. Med.
, vol.318
, pp. 1638-1644
-
-
Ngan, B.Y.1
Chen-Levy, Z.2
Weiss, L.M.3
Warnke, R.A.4
Cleary, M.L.5
-
8
-
-
1642618055
-
Molecular and pharmacokinetic properties associated with the therapeutics of Bcl-2 antisense oligonucleotide G3139 combined with free and liposomal doxorubicin
-
LOPES DE, MENEZES DE, HUDON N, MCINTOSH N, MAYER LD: Molecular and pharmacokinetic properties associated with the therapeutics of Bcl-2 antisense oligonucleotide G3139 combined with free and liposomal doxorubicin. Clin. Cancer Res. (2000) 6:2891-2902.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 2891-2902
-
-
Lopes, D.E.1
Menezes, D.E.2
Hudon, N.3
Mcintosh, N.4
Mayer, L.D.5
-
9
-
-
0032741282
-
Progression to androgen independence is delayed by adjuvant treatment with antisense Bcl-2 oligodeoxynucleotides after castration in the LNCaP prostate tumor model
-
GLEAVE M, TOLCHER A, MIYAKE H et al.: Progression to androgen independence is delayed by adjuvant treatment with antisense Bcl-2 oligodeoxynucleotides after castration in the LNCaP prostate tumor model. Clin. Cancer Res. (1999) 5:2891-2898.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 2891-2898
-
-
Gleave, M.1
Tolcher, A.2
Miyake, H.3
-
10
-
-
0034083410
-
Eradication of human non-Hodgkin's lymphoma in SCID mice by BCL-2 antisense oligonucleotides combined with low-dose cyclophosphamide
-
KLASA RJ, BALLY MB, NG R, GOLDIE JH, GASCOYNE RD, WONG FM: Eradication of human non-Hodgkin's lymphoma in SCID mice by BCL-2 antisense oligonucleotides combined with low-dose cyclophosphamide. Clin. Cancer Res. (2000) 6:2492-2500.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 2492-2500
-
-
Klasa, R.J.1
Bally, M.B.2
Ng, R.3
Goldie, J.H.4
Gascoyne, R.D.5
Wong, F.M.6
-
11
-
-
0031907428
-
Bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice
-
JANSEN B, SCHLAGBAUER-WADL H, BROWN BD et al.: Bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice. Nat. Med. (1998) 4:232-234.
-
(1998)
Nat. Med.
, vol.4
, pp. 232-234
-
-
Jansen, B.1
Schlagbauer-Wadl, H.2
Brown, B.D.3
-
12
-
-
0033993970
-
Bcl-2 antisense oligonucleotides (G3139) inhibit Merkel cell carcinoma growth in SCID mice
-
SCHLAGBAUER-WADL H, KLOSNER G, HEERE-RESS E et al.: Bcl-2 antisense oligonucleotides (G3139) inhibit Merkel cell carcinoma growth in SCID mice. J. Invest. Dermatol. (2000) 114:725-730.
-
(2000)
J. Invest. Dermatol.
, vol.114
, pp. 725-730
-
-
Schlagbauer-wadl, H.1
Klosner, G.2
Heere-ress, E.3
-
13
-
-
0033902003
-
Bcl-xl antisense treatment induces apoptosis in breast carcinoma cells
-
SIMOES-WUSTA AP, OLIE RA, GAUTSCHI O et al.: Bcl-xl antisense treatment induces apoptosis in breast carcinoma cells. Int. J. Cancer (2000) 87:582-590.
-
(2000)
Int. J. Cancer
, vol.87
, pp. 582-590
-
-
Simoes-Wusta, A.P.1
Olie, R.A.2
Gautschi, O.3
-
14
-
-
0033748335
-
Effects of Bcl-2 modulation with G3139 antisense oligonucleotide on human breast cancer cells are independent of inherent Bcl-2 protein expression
-
CHI KN, WALLIS AE, LEE CH et al.: Effects of Bcl-2 modulation with G3139 antisense oligonucleotide on human breast cancer cells are independent of inherent Bcl-2 protein expression. Breast Cancer Res. Treat. (2000) 63:199-212.
-
(2000)
Breast Cancer Res. Treat.
, vol.63
, pp. 199-212
-
-
Chi, K.N.1
Wallis, A.E.2
Lee, C.H.3
-
15
-
-
0028066802
-
Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model
-
COTTER FE, JOHNSON P, HALL P et al.: Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model. Oncogene (1994) 9:3049-3055.
-
(1994)
Oncogene
, vol.9
, pp. 3049-3055
-
-
Cotter, F.E.1
Johnson, P.2
Hall, P.3
-
16
-
-
0036400326
-
Effect of BCL-2 down-regulation on cellular life span
-
KUMAZAKI T, SASAKI M, NISHIYAMA M, TERANISHI Y, SUMIDA H, MITSUI Y: Effect of BCL-2 down-regulation on cellular life span. Biogerontology (2002) 3:291-300.
-
(2002)
Biogerontology
, vol.3
, pp. 291-300
-
-
Kumazaki, T.1
Sasaki, M.2
Nishiyama, M.3
Teranishi, Y.4
Sumida, H.5
Mitsui, Y.6
-
17
-
-
0033574578
-
The role of antiapoptotic Bcl-2 family members in endothelial apoptosis elucidated with antisense oligonucleotides
-
ACKERMANN EJ, TAYLOR JK, NARAYANA R, BENNETT CF.: The role of antiapoptotic Bcl-2 family members in endothelial apoptosis elucidated with antisense oligonucleotides. J. Biol. Chem. (1999) 274:11245-11252.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 11245-11252
-
-
Ackermann, E.J.1
Taylor, J.K.2
Narayana, R.3
Bennett, C.F.4
-
19
-
-
0036121142
-
L antisense oligonucleotides induce apoptosis in melanoma cells of different clinical stages
-
L antisense oligonucleotides induce apoptosis in melanoma cells of different clinical stages. J. Invest. Dermatol. (2002) 118:505-512.
-
(2002)
J. Invest. Dermatol.
, vol.118
, pp. 505-512
-
-
Olie, R.A.1
Hafner, C.2
Kuttel, R.3
-
20
-
-
0032422475
-
L might be the crucial member of the Bcl-2 gene family in colorectal cancer
-
L might be the crucial member of the Bcl-2 gene family in colorectal cancer. Dig. Dis. Sci. (1998) 43:2641-2648.
-
(1998)
Dig. Dis. Sci.
, vol.43
, pp. 2641-2648
-
-
Maurer, C.A.1
Friess, H.2
Buhler, S.S.3
-
21
-
-
0033989678
-
Bcl-w expression in colorectal adenocarcinoma
-
WILSON JW, NOSTRO MC, BALZI M et al.: Bcl-w expression in colorectal adenocarcinoma. Br. J. Cancer (2000) 82:178-185.
-
(2000)
Br. J. Cancer
, vol.82
, pp. 178-185
-
-
Wilson, J.W.1
Nostro, M.C.2
Balzi, M.3
-
25
-
-
0029795396
-
Elevated levels of apoptosis regulator proteins p53 and Bcl-2 are independent prognostic biomarkers in surgically treated clinically localized prostate cancer
-
BAUER JJ, SESTERHENN IA, MOSTOFI FK, MCLEOD DG, SRIVASTAVA S, MOUL JW: Elevated levels of apoptosis regulator proteins p53 and Bcl-2 are independent prognostic biomarkers in surgically treated clinically localized prostate cancer. J. Urol. (1996) 156:1511-1516.
-
(1996)
J. Urol.
, vol.156
, pp. 1511-1516
-
-
Bauer, J.J.1
Sesterhenn, I.A.2
Mostofi, F.K.3
Mcleod, D.G.4
Srivastava, S.5
Moul, J.W.6
-
26
-
-
0028894034
-
Bcl-2 protein expression in cutaneous malignant melanoma and benign melanocytic nevi
-
CERRONI L, SOYER HP, KERL H: Bcl-2 protein expression in cutaneous malignant melanoma and benign melanocytic nevi. Am. J. Dematopathol. (1995) 17:7-11.
-
(1995)
Am. J. Dematopathol.
, vol.17
, pp. 7-11
-
-
Cerroni, L.1
Soyer, H.P.2
Kerl, H.3
-
27
-
-
0033970414
-
Simultaneous detection of BCL-2 protein, trisomy 12, retinoblastoma and P53 monoallelic gene deletions in B-cell chronic lymphocytic leukemia by fluorescence in situ hybridization (FISH): Relation to disease status
-
LAZARIDOU A, MIRAXTSI C, KORANTZIS J, ELEFTHERIADIS N, CHRISTAKIS JI: Simultaneous detection of BCL-2 protein, trisomy 12, retinoblastoma and P53 monoallelic gene deletions in B-cell chronic lymphocytic leukemia by fluorescence in situ hybridization (FISH): relation to disease status. Leuk. Lymphoma (2000) 36:503-512.
-
(2000)
Leuk. Lymphoma
, vol.36
, pp. 503-512
-
-
Lazaridou, A.1
Miraxtsi, C.2
Korantzis, J.3
Eleftheriadis, N.4
Christakis, J.I.5
-
28
-
-
0031889769
-
High expression of bcl-2 mRNA as a determinant of poor prognosis in acute myeloid leukemia
-
KARAKAS T, MAURER U, WEIDMANN E, MIETHING CC, HOELZER D, BERGMANN L: High expression of bcl-2 mRNA as a determinant of poor prognosis in acute myeloid leukemia. Ann. Oncol. (1998) 9:129-130.
-
(1998)
Ann. Oncol.
, vol.9
, pp. 129-130
-
-
Karakas, T.1
Maurer, U.2
Weidmann, E.3
Miething, C.C.4
Hoelzer, D.5
Bergmann, L.6
-
29
-
-
0032890640
-
Association of Bcl-2 protein expression with gallbladder carcinoma differentiation and progression and its relation to apoptosis
-
MIKAMI T, YANAGISAWA N, BABA H, KOIKE M, OKAYASU I: Association of Bcl-2 protein expression with gallbladder carcinoma differentiation and progression and its relation to apoptosis. Cancer (1999) 85:318-325.
-
(1999)
Cancer
, vol.85
, pp. 318-325
-
-
Mikami, T.1
Yanagisawa, N.2
Baba, H.3
Koike, M.4
Okayasu, I.5
-
30
-
-
0032527649
-
Expression of Bcl-2 in testicular carcinoma: Correlation with tumor progression and MDR1/Pgp
-
EID H, GULYAS M, GECZI L, BODROGI I, INSTITORIS E, BAK M: Expression of Bcl-2 in testicular carcinoma: correlation with tumor progression and MDR1/Pgp. Cancer (1998) 83:331-336.
-
(1998)
Cancer
, vol.83
, pp. 331-336
-
-
Eid, H.1
Gulyas, M.2
Geczi, L.3
Bodrogi, I.4
Institoris, E.5
Bak, M.6
-
31
-
-
0035117143
-
Analysis of 2 antiapoptotic factors in gliomas: bcl-2 over-expression and p53 mutations
-
RODRIGUEZ-PEREIRA C, SUAREZ-PENARANDA JM, BARROS F, SOBRIDO MJ, VAZQUEZ-SALVADO M, FORTEZA J: Analysis of 2 antiapoptotic factors in gliomas: bcl-2 over-expression and p53 mutations. Arch. Pathol. Lab. Med. (2001) 125:218-223.
-
(2001)
Arch. Pathol. Lab. Med.
, vol.125
, pp. 218-223
-
-
Rodriguez-Pereira, C.1
Suarez-Penaranda, J.M.2
Barros, F.3
Sobrido, M.J.4
Vazquez-Salvado, M.5
Forteza, J.6
-
32
-
-
0033965759
-
BCL-2 family protein expression and platinum drug resistance in ovarian carcinoma
-
BEALE PJ, ROGERS P, BOXALL F, SHARP SY, KELLAND LR: BCL-2 family protein expression and platinum drug resistance in ovarian carcinoma. Br. J. Cancer (2000) 82:436-440.
-
(2000)
Br. J. Cancer
, vol.82
, pp. 436-440
-
-
Beale, P.J.1
Rogers, P.2
Boxall, F.3
Sharp, S.Y.4
Kelland, L.R.5
-
33
-
-
0036568524
-
Bcl-X(L) is a chemoresistance factor in human melanoma cells that can be inhibited by antisense therapy
-
HEERE-RESS E, THALLINGER C, LUCAS T et al: Bcl-X(L) is a chemoresistance factor in human melanoma cells that can be inhibited by antisense therapy. Int. J. Cancer (2002) 99:29-34.
-
(2002)
Int. J. Cancer
, vol.99
, pp. 29-34
-
-
Heere-Ress, E.1
Thallinger, C.2
Lucas, T.3
-
34
-
-
0037138267
-
L in a human ovarian carcinoma cell line: Paradoxic effects on chemosensitivity in vitro versus in vivo
-
L in a human ovarian carcinoma cell line: paradoxic effects on chemosensitivity in vitro versus in vivo. Int. J. Cancer (2002) 97:858-863.
-
(2002)
Int. J. Cancer
, vol.97
, pp. 858-863
-
-
Rogers, P.M.1
Beale, P.J.2
Al-Moundhri, M.3
-
35
-
-
0028060247
-
Reversal of chemoresistance of lymphoma cells by antisense-mediated reduction of bcl-2 gene expression
-
KITADA S, TAKAYAMA S, DE RIEL K, TANAKA S, REED JC: Reversal of chemoresistance of lymphoma cells by antisense-mediated reduction of bcl-2 gene expression. Antisense Res. Dev. (1994) 4:71-79.
-
(1994)
Antisense Res. Dev.
, vol.4
, pp. 71-79
-
-
Kitada, S.1
Takayama, S.2
De Riel, K.3
Tanaka, S.4
Reed, J.C.5
-
36
-
-
0034606686
-
Chemosensitization and delayed androgen-independent recurrence of prostate cancer with the use of antisense Bcl-2 of oligodeoxynucleotides
-
MIAYAKE H, TOLCHER A, GLEAVE ME. Chemosensitization and delayed androgen-independent recurrence of prostate cancer with the use of antisense Bcl-2 of oligodeoxynucleotides. J. Natl. Cancer Inst. (2000) 92:34-41.
-
(2000)
J. Natl. Cancer Inst.
, vol.92
, pp. 34-41
-
-
Miayake, H.1
Tolcher, A.2
Gleave, M.E.3
-
37
-
-
0033855710
-
L antisense sensitizes human colon cancer cell line to 5-fluorouracil
-
L antisense sensitizes human colon cancer cell line to 5-fluorouracil. Jpn. J. Cancer Res. (2000) 91(8):825-32.
-
(2000)
Jpn. J. Cancer Res.
, vol.91
, Issue.8
, pp. 825-832
-
-
Nita, M.E.1
Ono-Nita, S.K.2
Tsuno, N.3
-
38
-
-
0038154168
-
L down-regulation switches the response to topoisomerase I inhibition from senescence to apoptosis in colorectal cancer cells, enhancing global cytotoxicity
-
L down-regulation switches the response to topoisomerase I inhibition from senescence to apoptosis in colorectal cancer cells, enhancing global cytotoxicity. Clin. Cancer Res. (2003) 9:2856-2865.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 2856-2865
-
-
Hayward, R.I.1
Macpherson, J.S.2
Cummings, J.3
-
39
-
-
0036730430
-
L antisense oligonucleotides chemosensitize human glioblastoma cells
-
L antisense oligonucleotides chemosensitize human glioblastoma cells. Chemotherapy (2002) 48:189-195.
-
(2002)
Chemotherapy
, vol.48
, pp. 189-195
-
-
Guensberg, P.1
Wacheck, V.2
Lucas, T.3
-
40
-
-
0034326272
-
L in prostate cancer cells: Effects of over-expression and down-regulation on chemosensitivity
-
L in prostate cancer cells: effects of over-expression and down-regulation on chemosensitivity. Cancer Res. (2000) 60:6052-6060.
-
(2000)
Cancer Res.
, vol.60
, pp. 6052-6060
-
-
Lebedeva, I.1
Rando, R.2
Ojwang, J.3
Cossum, P.4
Stein, C.A.5
-
41
-
-
0035866339
-
L underlies the molecular basis for resistance to staurosporine-induced apoptosis in PC-3 cells
-
L underlies the molecular basis for resistance to staurosporine-induced apoptosis in PC-3 cells. Cancer Res. (2001) 61:1699-1706.
-
(2001)
Cancer Res.
, vol.61
, pp. 1699-1706
-
-
Li, X.1
Marani, M.2
Mannucci, R.3
-
43
-
-
0031018994
-
Relationship of p53, Bcl-2, and tumor proliferation to clinical drug resistance in non-Hodgkin's lymphomas
-
WILSON WH, TERUYA-FELDSTEIN J, FEST T et al.: Relationship of p53, Bcl-2, and tumor proliferation to clinical drug resistance in non-Hodgkin's lymphomas. Blood (1997) 89:601-609.
-
(1997)
Blood
, vol.89
, pp. 601-609
-
-
Wilson, W.H.1
Teruya-Feldstein, J.2
Fest, T.3
-
44
-
-
0030029443
-
Prognostic significance of Bcl-2 protein expression in aggessive non-Hodgkin's lymphoma
-
Groupe d'Etude des Lymphomes de l'Adulte (GELA)
-
HERMINE O, HAIOUN C, LEPAGE E et al.: Prognostic significance of Bcl-2 protein expression in aggessive non-Hodgkin's lymphoma. Groupe d'Etude des Lymphomes de l'Adulte (GELA). Blood (1996) 87:265-272.
-
(1996)
Blood
, vol.87
, pp. 265-272
-
-
Hermine, O.1
Haioun, C.2
Lepage, E.3
-
45
-
-
0030951877
-
Bcl-2, p53, and response to tamoxifen in estrogen receptor-positive metastatic breast cancer a Southwest Oncology Group study
-
ELLEDGE RM, GREEN S, HOWES L et al.: Bcl-2, p53, and response to tamoxifen in estrogen receptor-positive metastatic breast cancer a Southwest Oncology Group study. J. Clin. Oncol (1997) 15:1916-1922.
-
(1997)
J. Clin. Oncol
, vol.15
, pp. 1916-1922
-
-
Elledge, R.M.1
Green, S.2
Howes, L.3
-
47
-
-
1542269161
-
Progress in antisense technology
-
CROOKE ST: Progress in antisense technology. Ann. Rev. Med (2004) 55:61-95.
-
(2004)
Ann. Rev. Med.
, vol.55
, pp. 61-95
-
-
Crooke, S.T.1
-
48
-
-
0036846993
-
Antisense therapy for cancer - The time of truth
-
JANSEN B, ZANGEMEISTER-WITTKE U: Antisense therapy for cancer - the time of truth. Lancet Oncol. (2002) 3:672-683.
-
(2002)
Lancet Oncol.
, vol.3
, pp. 672-683
-
-
Jansen, B.1
Zangemeister-Wittke, U.2
-
49
-
-
0141790036
-
BCL-2 antisense oligonucleotide genasense is active against imatinib-resistant BCR-ABL-positive cells
-
TAUCHI T, SUMI M, NAKAJIMA A et al.: BCL-2 antisense oligonucleotide genasense is active against imatinib-resistant BCR-ABL-positive cells. Clin. Cancer Res. (2003) 9:4267-4273.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 4267-4273
-
-
Tauchi, T.1
Sumi, M.2
Nakajima, A.3
-
50
-
-
0030888664
-
Bcl-2 antisense therapy in patients with non-Hodgkin lymphoma
-
WEBB A, CUNNINGHAM D, COTTER F et al.: Bcl-2 antisense therapy in patients with non-Hodgkin lymphoma. Lancet (1997) 349:1137-1141.
-
(1997)
Lancet
, vol.349
, pp. 1137-1141
-
-
Webb, A.1
Cunningham, D.2
Cotter, F.3
-
51
-
-
0034015672
-
Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma
-
WATERS JS, WEBB A, CUNNINGHAM D et al.: Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma. J. Clin. Oncol. (2000) 18:1812-1823.
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 1812-1823
-
-
Waters, J.S.1
Webb, A.2
Cunningham, D.3
-
52
-
-
0034684471
-
Chemosensitisation of malignant melanoma by Bcl-2 antisense therapy
-
JANSEN B, WACHECK V, HEERE-RESS E et al.: Chemosensitisation of malignant melanoma by Bcl-2 antisense therapy. Lancet (2000) 356:1728-1733.
-
(2000)
Lancet
, vol.356
, pp. 1728-1733
-
-
Jansen, B.1
Wacheck, V.2
Heere-Ress, E.3
-
53
-
-
0030900680
-
Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma
-
WOOLDRIDGE JE, BALLAS Z, KRIEG AM, WEINER GJ: Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma. Blood (1997) 89:2994-2998.
-
(1997)
Blood
, vol.89
, pp. 2994-2998
-
-
Wooldridge, J.E.1
Ballas, Z.2
Krieg, A.M.3
Weiner, G.J.4
-
54
-
-
0036975955
-
Antitumor effect of G3139 Bcl-2 antisense oligonucleotide is independent of its immune stimulation by CpG motifs in SCID mice
-
WACHECK V, KREPLER C, STROMMER S et al.: Antitumor effect of G3139 Bcl-2 antisense oligonucleotide is independent of its immune stimulation by CpG motifs in SCID mice. Antisense Nucleic Acid Drug Dev. (2002) 12:359-367.
-
(2002)
Antisense Nucleic Acid Drug Dev.
, vol.12
, pp. 359-367
-
-
Wacheck, V.1
Krepler, C.2
Strommer, S.3
-
55
-
-
0242719919
-
Cellular pharmacology of P-ethoxy antisense oligonucleotides targeted to Bcl-2 in a follicular lymphoma cell line
-
GUTIERREZ-PUENTE Y, TARI AM, FORD RJ et al.: Cellular pharmacology of P-ethoxy antisense oligonucleotides targeted to Bcl-2 in a follicular lymphoma cell line. Leuk. Lymphoma (2003) 44:1979-1985.
-
(2003)
Leuk. Lymphoma
, vol.44
, pp. 1979-1985
-
-
Gutierrez-Puente, Y.1
Tari, A.M.2
Ford, R.J.3
-
56
-
-
0031664988
-
Synergistic cytotoxicity of the Bcl-2 antisense oligodeoxynucleotides and etoposide, doxorubicin and cisplatin on small-cell lung cancer cell lines
-
ZANGEMEISTER-WITTK U, SCHENKER T, LUEDKE GH, STAHEL RA. Synergistic cytotoxicity of the Bcl-2 antisense oligodeoxynucleotides and etoposide, doxorubicin and cisplatin on small-cell lung cancer cell lines. Br. J. Cancer (1998) 78:1035-1042
-
(1998)
Br. J. Cancer
, vol.78
, pp. 1035-1042
-
-
Zangemeister-Wittk, U.1
Schenker, T.2
Luedke, G.H.3
Stahel, R.A.4
-
57
-
-
0030759409
-
The antisense Bcl-2-IgH transcript is an optimal target for synthetic oligonucleotides
-
MORELLI S, DELIA D, CAPACCIOLI A et al.: The antisense Bcl-2-IgH transcript is an optimal target for synthetic oligonucleotides. Proc. Natl. Acad. Sci. USA (1997) 94:8150-8155.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 8150-8155
-
-
Morelli, S.1
Delia, D.2
Capaccioli, A.3
-
59
-
-
0035925537
-
L-bispecific antisense oligonucleotide against tumors of diverse histologic origins
-
L-bispecific antisense oligonucleotide against tumors of diverse histologic origins. J. Natl. Cancer Inst. (2001) 93:463-471.
-
(2001)
J. Natl. Cancer Inst.
, vol.93
, pp. 463-471
-
-
Gautschi, O.1
Tschopp, S.2
Olie, R.A.3
-
61
-
-
0037312522
-
L, epidermal growth factor receptor, and protein kinase A Type I causes potent antitumor, apoptotic, and antiangiogenic activity
-
L, epidermal growth factor receptor, and protein kinase A Type I causes potent antitumor, apoptotic, and antiangiogenic activity. Clin. Cancer Res. (2003) 9:866-871.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 866-871
-
-
Tortora, G.1
Caputo, R.2
Damiano, V.3
-
62
-
-
0038806293
-
Mcl-1 antisense therapy chemosensitizes human melanoma in a SCID mouse xenotransplantation model
-
THALLINGER C, WOLSCHEK MF, WACHECK V et al.: Mcl-1 antisense therapy chemosensitizes human melanoma in a SCID mouse xenotransplantation model. J. Invest. Dermatol. (2003) 120:1081-1086.
-
(2003)
J. Invest. Dermatol.
, vol.120
, pp. 1081-1086
-
-
Thallinger, C.1
Wolschek, M.F.2
Wacheck, V.3
-
63
-
-
0035816232
-
Induction of apoptosis in prostate carcinoma cells by BH3 peptides which inhibit Bak/Bcl-2 interactions
-
FINNEGAN NM, CURTIN JF, PREVOST G, MORGAN B, COTTER TG: Induction of apoptosis in prostate carcinoma cells by BH3 peptides which inhibit Bak/Bcl-2 interactions. Br. J. Cancer (2001) 85:115-121.
-
(2001)
Br. J. Cancer
, vol.85
, pp. 115-121
-
-
Finnegan, N.M.1
Curtin, J.F.2
Prevost, G.3
Morgan, B.4
Cotter, T.G.5
-
64
-
-
0034654522
-
Cell permeable Bcl-2 binding peptides: A chemical approach to apoptosis induction in tumor cells
-
WANG JL, ZHANG ZJ, CHOKSI S et al.: Cell permeable Bcl-2 binding peptides: a chemical approach to apoptosis induction in tumor cells. Cancer Res. (2000) 60:1498-1502.
-
(2000)
Cancer Res.
, vol.60
, pp. 1498-1502
-
-
Wang, J.L.1
Zhang, Z.J.2
Choksi, S.3
-
65
-
-
0037050253
-
The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1-overexpressing breast cancer cell lines
-
RADETZKI S, KOHNE CH, VON HAEFEN C et al.: The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1-overexpressing breast cancer cell lines. Oncogene (2002) 21:227-238.
-
(2002)
Oncogene
, vol.21
, pp. 227-238
-
-
Radetzki, S.1
Kohne, C.H.2
Von Haefen, C.3
-
66
-
-
0019205610
-
Tetrocarcins, novel antitumor antibiotics. I. Producing organism, fermentation and antimicrobial activity
-
TOMITA F, TAMAOKI T: Tetrocarcins, novel antitumor antibiotics. I. Producing organism, fermentation and antimicrobial activity. J. Antibiot. (1980) 33:946-950.
-
(1980)
J. Antibiot.
, vol.33
, pp. 946-950
-
-
Tomita, F.1
Tamaoki, T.2
-
67
-
-
0019137520
-
Tetrocarcins, novel antitumor antibiotics. II. Isolation, characterization and antitumor activity
-
TAMAOKI T, KASAI M, SHIRAHATA K et al.: Tetrocarcins, novel antitumor antibiotics. II. Isolation, characterization and antitumor activity. J. Antibiot. (1980) 33:940-945.
-
(1980)
J. Antibiot.
, vol.33
, pp. 940-945
-
-
Tamaoki, T.1
Kasai, M.2
Shirahata, K.3
-
68
-
-
0020415474
-
Tetrocarcins, new antitumor antibiotics. III. Antitumor activity of tetrocarcin A
-
MORIMOTO M, FUKUI M, OHKUBO S, TAMAOKI T. TOMITA F: Tetrocarcins, new antitumor antibiotics. III. Antitumor activity of tetrocarcin A. J. Antibiot. (1982) 35:1033-1037.
-
(1982)
J. Antibiot.
, vol.35
, pp. 1033-1037
-
-
Morimoto, M.1
Fukui, M.2
Ohkubo, S.3
Tamaoki, T.4
Tomita, F.5
-
69
-
-
0034162983
-
Tetrocarcin A inhibits mitochondrial functions of Bcl-2 and suppresses its antiapoptotic activity
-
NAKASHIMA T, MIURA M, HARA M: Tetrocarcin A inhibits mitochondrial functions of Bcl-2 and suppresses its antiapoptotic activity. Cancer Res. (2000) 60:1229-1235.
-
(2000)
Cancer Res.
, vol.60
, pp. 1229-1235
-
-
Nakashima, T.1
Miura, M.2
Hara, M.3
-
70
-
-
0035832097
-
Synthesis of tetrocarcin derivatives with specific inhibitory activity towards Bcl-2 functions
-
KANEKO M, NAKASHIMA T, UOSAKI Y, HARA M, IKEDA S, KANDA Y: Synthesis of tetrocarcin derivatives with specific inhibitory activity towards Bcl-2 functions. Bioorg. Med. Chem. Lett. (2001) 11:887-890.
-
(2001)
Bioorg. Med. Chem. Lett.
, vol.11
, pp. 887-890
-
-
Kaneko, M.1
Nakashima, T.2
Uosaki, Y.3
Hara, M.4
Ikeda, S.5
Kanda, Y.6
-
72
-
-
0030867866
-
Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria
-
XIA D, YU CA, KIM H et al.: Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria. Science (1997) 277:60-66.
-
(1997)
Science
, vol.277
, pp. 60-66
-
-
Xia, D.1
Yu, C.A.2
Kim, H.3
-
73
-
-
0035147650
-
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3
-
TZUNG SP, KIM KM, BASANEZ G et al.: Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3. Nat. Cell. Biol. (2001) 3:183-191.
-
(2001)
Nat. Cell. Biol.
, vol.3
, pp. 183-191
-
-
Tzung, S.P.1
Kim, K.M.2
Basanez, G.3
-
74
-
-
0035942324
-
Biophysical characterization of recombinant human Bcl-2 and its interaction with an inhibitory ligand, antimycin A
-
KIM KM, GIEDT CD, BASANEZ Get al.: Biophysical characterization of recombinant human Bcl-2 and its interaction with an inhibitory ligand, antimycin A. Biochemistry (2001) 40:4911-4922.
-
(2001)
Biochemistry
, vol.40
, pp. 4911-4922
-
-
Kim, K.M.1
Giedt, C.D.2
Basanez, G.3
-
75
-
-
0034691130
-
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
-
WANG J-L, LIU D, ZHANG Z-J et al.: Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc. Natl. Acad. Sci. USA (2000) 97:7124-7129.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 7124-7129
-
-
Wang, J.-L.1
Liu, D.2
Zhang, Z.-J.3
-
76
-
-
0036566242
-
Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia
-
MILELLA M, ESTROV Z, KORNBLAU SM et al.: Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia. Blood (2002) 99:3461-3464.
-
(2002)
Blood
, vol.99
, pp. 3461-3464
-
-
Milella, M.1
Estrov, Z.2
Kornblau, S.M.3
-
77
-
-
3042766027
-
The apoptotic effect of HA14-1, a Bcl-2-interacting small molecule compound, requires Bax translocation and is enhanced by PK11195
-
CHEN J, FREEMAN A, LIU J, DAI Q, LEE R: The apoptotic effect of HA14-1, a Bcl-2-interacting small molecule compound, requires Bax translocation and is enhanced by PK11195. Mol. Cancer Ther. (2002) 1:981-987.
-
(2002)
Mol. Cancer Ther.
, vol.1
, pp. 981-987
-
-
Chen, J.1
Freeman, A.2
Liu, J.3
Dai, Q.4
Lee, R.5
-
78
-
-
0142244338
-
The proteosome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA 14-1 in multiple myeloma cells
-
PEI X-Y, DAI Y, GRANT S: The proteosome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA 14-1 in multiple myeloma cells. Leukemia (2003) 17:2036-2045.
-
(2003)
Leukemia
, vol.17
, pp. 2036-2045
-
-
Pei, X.-Y.1
Dai, Y.2
Grant, S.3
-
80
-
-
0037138678
-
A novel approach for characterizing protein ligand complexes: Molecular basis for specificity of small-molecule Bcl-2 inhibitors
-
LUGOVSKOY AA. DEGTEREV AI, Fahmy AF et al.: A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors. J. Am. Chem. Soc. (2002) 124:1234-1240.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 1234-1240
-
-
Lugovskoy, A.A.1
Degterev, A.I.2
Fahmy, A.F.3
-
81
-
-
0035818885
-
Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening
-
ENYEDY IJ, LING YL, NACRO K et al.: Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening. J. Med. Chem. (2001) 44:4313-4324.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 4313-4324
-
-
Enyedy, I.J.1
Ling, Y.L.2
Nacro, K.3
-
82
-
-
0034801374
-
Toward proteomics: Terphenyl derivatives as structural and functional mimics of extended regions of an α-helix
-
ORNER BP, ERNST JT, HAMILTON AD: Toward proteomics: Terphenyl derivatives as structural and functional mimics of extended regions of an α-helix. J. Am. Chem. Soc. (2001) 123:5382-5383.
-
(2001)
J. Am. Chem. Soc.
, vol.123
, pp. 5382-5383
-
-
Orner, B.P.1
Ernst, J.T.2
Hamilton, A.D.3
-
83
-
-
0037126834
-
Design of a protein surface antagonist based on a-helix mimicry: Inhibition of gp41 assembly and viral fusion
-
ERNST JT, KUTZKI O, DEBNATH AK, JIANG S, LU H, HAMITLON AD: Design of a protein surface antagonist based on a-helix mimicry: inhibition of gp41 assembly and viral fusion.Angew. Chem. Int. Ed. (2002) 41:278-281.
-
(2002)
Angew. Chem. Int. Ed.
, vol.41
, pp. 278-281
-
-
Ernst, J.T.1
Kutzki, O.2
Debnath, A.K.3
Jiang, S.4
Lu, H.5
Hamitlon, A.D.6
-
84
-
-
0030614915
-
L-Bak peptide complex: Recognition between regulators of apoptosis
-
L-Bak peptide complex: recognition between regulators of apoptosis. Science (1997) 275:983-986.
-
(1997)
Science
, vol.275
, pp. 983-986
-
-
Sattler, M.1
Liang, H.2
Nettesheim, D.3
-
86
-
-
0024394011
-
An overview of the clinical pharmacology and therapeutic potential of gossypol as a male contraceptive agents and gynaecological disease
-
WU D: An overview of the clinical pharmacology and therapeutic potential of gossypol as a male contraceptive agents and gynaecological disease. Drugs (1989) 38:333-341.
-
(1989)
Drugs
, vol.38
, pp. 333-341
-
-
Wu, D.1
-
87
-
-
0022899737
-
Antiviral activities of gossypol and its derivatives against herpes simplex virus Type II
-
RADLOFF RJ, DECK LM, ROYER RE, VANDER JAGT DL: Antiviral activities of gossypol and its derivatives against herpes simplex virus Type II. Pharmacol. Res. Commun. (1986) 18:1063-1073.
-
(1986)
Pharmacol. Res. Commun.
, vol.18
, pp. 1063-1073
-
-
Radloff, R.J.1
Deck, L.M.2
Royer, R.E.3
Vander Jagt, D.L.4
-
88
-
-
0019940628
-
Inhibitory action of gossypol on enzymes and growth of Trypansoma cruzi
-
MONTAMAT EE, BURGOS C, GEREZ DE BURGOS NM, ROVAI LE, BLANCO A, SEGURA EL: Inhibitory action of gossypol on enzymes and growth of Trypansoma cruzi. Science (1982) 218:288-289.
-
(1982)
Science
, vol.218
, pp. 288-289
-
-
Montamat, E.E.1
Burgos, C.2
Gerez De Burgos, N.M.3
Rovai, L.E.4
Blanco, A.5
Segura, E.L.6
-
89
-
-
0028151457
-
Induction of neutrophil Mac-1 integrin expression and superoxide production by the medicinal plant extract gossypol
-
BENHAIM P, MATHES SJ, HUNT TK, SCHEUENSTUHL H, BENZ CC: Induction of neutrophil Mac-1 integrin expression and superoxide production by the medicinal plant extract gossypol. Inflammation (1994) 18:443-458.
-
(1994)
Inflammation
, vol.18
, pp. 443-458
-
-
Benhaim, P.1
Mathes, S.J.2
Hunt, T.K.3
Scheuenstuhl, H.4
Benz, C.C.5
-
90
-
-
0027460576
-
Oral gossypol in the treatment of matastatic adrenal cancer
-
FLACK MR, PYLE RG, MULLEN NM et al.: Oral gossypol in the treatment of matastatic adrenal cancer. J. Clin. Endocrinol. Metab. (1993) 76:1019-1024.
-
(1993)
J. Clin. Endocrinol. Metab.
, vol.76
, pp. 1019-1024
-
-
Flack, M.R.1
Pyle, R.G.2
Mullen, N.M.3
-
92
-
-
0032780442
-
Gossypol treatment of recurrent adult malignant gliomas
-
BUSHUNOW P, REIDENBERG MM, WASENKO J et al.: Gossypol treatment of recurrent adult malignant gliomas. J. Neurooncol. (1999) 42:79-86.
-
(1999)
J. Neurooncol.
, vol.42
, pp. 79-86
-
-
Bushunow, P.1
Reidenberg, M.M.2
Wasenko, J.3
-
93
-
-
0034922672
-
Oral gossypol in the treatment of patients with refractory matastatic breast cancer: A Phase I/II clinical trial
-
VAN POZNAK C, SEIDMAN AD, REIDENBERG MM et al.: Oral gossypol in the treatment of patients with refractory matastatic breast cancer: a Phase I/II clinical trial. Breast Cancer Res. Treat. (2001) 66:239-248.
-
(2001)
Breast Cancer Res. Treat.
, vol.66
, pp. 239-248
-
-
Van Poznak, C.1
Seidman, A.D.2
Reidenberg, M.M.3
-
94
-
-
0034692871
-
Cytotoxic effect of gossypol on colon carcinoma cells
-
WANG X, WANG J, WONG SCH et al.: Cytotoxic effect of gossypol on colon carcinoma cells. Life Sci. (2000) 67:2663-2671.
-
(2000)
Life Sci.
, vol.67
, pp. 2663-2671
-
-
Wang, X.1
Wang, J.2
Wong, S.C.H.3
-
95
-
-
0038682166
-
Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells
-
ZHANG M, LIU H, GUO R et al.: Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. Biochem. Pharmacol. (2003) 66:93-103.
-
(2003)
Biochem. Pharmacol.
, vol.66
, pp. 93-103
-
-
Zhang, M.1
Liu, H.2
Guo, R.3
-
96
-
-
0030815108
-
Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation
-
CHMURA SJ, MAUCERI H, ADVANI S et al.: Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation. Cancer Res. (1997) 57:4340-4347.
-
(1997)
Cancer Res.
, vol.57
, pp. 4340-4347
-
-
Chmura, S.J.1
Mauceri, H.2
Advani, S.3
-
97
-
-
0033961302
-
In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo
-
CHMURA SJ, DOLAN ME, CHA A et al.: In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo. Clin. Cancer Res. (2000) 6:737-742.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 737-742
-
-
Chmura, S.J.1
Dolan, M.E.2
Cha, A.3
-
99
-
-
0031931014
-
Inhibition of neointimal cell Bcl-X expression induces apoptosis and regression of vascular disease
-
POLLMAN MJ, HALL JL, MANN MJ, ZHANG L, GIBBONS GH: Inhibition of neointimal cell Bcl-X expression induces apoptosis and regression of vascular disease. Nat. Med. (1998) 4:222-227.
-
(1998)
Nat. Med.
, vol.4
, pp. 222-227
-
-
Pollman, M.J.1
Hall, J.L.2
Mann, M.J.3
Zhang, L.4
Gibbons, G.H.5
|