메뉴 건너뛰기




Volumn 14, Issue 6, 2004, Pages 805-818

Bcl-2-targeted cancer therapeutics

Author keywords

Antimycin; Antisense; Apoptosis; Bcl 2; Bcl XL; BH3; BH3I 1; BH3I 2; Cancer; Chelerythrine; Gossypol; HA14 1; Oblimersen; Small molecule; Therapy; Tumour

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; ANTIMYCIN A1; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CHELERYTHRINE; CISPLATIN; CYCLOPHOSPHAMIDE; DACARBAZINE; DOCETAXEL; DOXORUBICIN; ETOPOSIDE; FAS ANTIBODY; GOSSYPOL; HA 141; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; OBLIMERSEN; OLIGOMYCIN; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE C INHIBITOR; ROTENONE; STAUROSPORINE; TERPHENYL DERIVATIVE; TETROCARCIN A; UNCLASSIFIED DRUG; UNINDEXED DRUG; US 6548536;

EID: 3042842776     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.14.6.805     Document Type: Review
Times cited : (2)

References (99)
  • 1
    • 0036205587 scopus 로고    scopus 로고
    • Mechanisms of caspase activation and inhibition during apoptosis
    • SHI Y: Mechanisms of caspase activation and inhibition during apoptosis. Mol. Cell (2002) 9:459-470.
    • (2002) Mol. Cell , vol.9 , pp. 459-470
    • Shi, Y.1
  • 2
    • 0036716281 scopus 로고    scopus 로고
    • The Bcl-2 family: Regulators of the cellular life-or-death switch
    • CORY S, ADAMS JM: The Bcl-2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer (2002) 2:647-656.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 647-656
    • Cory, S.1    Adams, J.M.2
  • 3
    • 0036728834 scopus 로고    scopus 로고
    • Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
    • LETAI A, BASSIK M, WALENSKY L, SORCINELLI M, WEILER S, KORSMEYER S: Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell (2002) 2:183-192.
    • (2002) Cancer Cell , vol.2 , pp. 183-192
    • Letai, A.1    Bassik, M.2    Walensky, L.3    Sorcinelli, M.4    Weiler, S.5    Korsmeyer, S.6
  • 4
    • 0029033866 scopus 로고
    • Regulation of Bcl-2 expression by oncogenic Ras protein in hematopoietic cells
    • KINOSHITA T, YOKOTA T, ARAI K, MIYAJIMA A: Regulation of Bcl-2 expression by oncogenic Ras protein in hematopoietic cells. Oncogene (1995) 10:2207-2212.
    • (1995) Oncogene , vol.10 , pp. 2207-2212
    • Kinoshita, T.1    Yokota, T.2    Arai, K.3    Miyajima, A.4
  • 5
    • 0035898449 scopus 로고    scopus 로고
    • Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-κB, Bad, or caspase activation
    • LIU H, PERLMAN H, PAGLIARI LJ, POPE RM: Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-κB, Bad, or caspase activation. J. Exp. Med. (2001) 194:113-126.
    • (2001) J. Exp. Med. , vol.194 , pp. 113-126
    • Liu, H.1    Perlman, H.2    Pagliari, L.J.3    Pope, R.M.4
  • 6
    • 0033877297 scopus 로고    scopus 로고
    • Met/HGF receptor modulates bcl-w expression and inhibits apoptosis in human colorectal cancers
    • KITAMURA S, KONDO S, SHINOMURA Yet al.: Met/HGF receptor modulates bcl-w expression and inhibits apoptosis in human colorectal cancers. Br. J. Cancer (2000) 83:668-673.
    • (2000) Br. J. Cancer , vol.83 , pp. 668-673
    • Kitamura, S.1    Kondo, S.2    Shinomura, Y.3
  • 7
    • 0023877768 scopus 로고
    • Expression in non Hodgkin's lymphoma of the bcl-2 protein associated with the t(14;18) chromosomal translocation
    • NGAN BY, CHEN-LEVY Z, WEISS LM, WARNKE RA, CLEARY ML: Expression in non Hodgkin's lymphoma of the bcl-2 protein associated with the t(14;18) chromosomal translocation. N. Engl. J. Med. (1988) 318:1638-1644.
    • (1988) N. Engl. J. Med. , vol.318 , pp. 1638-1644
    • Ngan, B.Y.1    Chen-Levy, Z.2    Weiss, L.M.3    Warnke, R.A.4    Cleary, M.L.5
  • 8
    • 1642618055 scopus 로고    scopus 로고
    • Molecular and pharmacokinetic properties associated with the therapeutics of Bcl-2 antisense oligonucleotide G3139 combined with free and liposomal doxorubicin
    • LOPES DE, MENEZES DE, HUDON N, MCINTOSH N, MAYER LD: Molecular and pharmacokinetic properties associated with the therapeutics of Bcl-2 antisense oligonucleotide G3139 combined with free and liposomal doxorubicin. Clin. Cancer Res. (2000) 6:2891-2902.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2891-2902
    • Lopes, D.E.1    Menezes, D.E.2    Hudon, N.3    Mcintosh, N.4    Mayer, L.D.5
  • 9
    • 0032741282 scopus 로고    scopus 로고
    • Progression to androgen independence is delayed by adjuvant treatment with antisense Bcl-2 oligodeoxynucleotides after castration in the LNCaP prostate tumor model
    • GLEAVE M, TOLCHER A, MIYAKE H et al.: Progression to androgen independence is delayed by adjuvant treatment with antisense Bcl-2 oligodeoxynucleotides after castration in the LNCaP prostate tumor model. Clin. Cancer Res. (1999) 5:2891-2898.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 2891-2898
    • Gleave, M.1    Tolcher, A.2    Miyake, H.3
  • 10
    • 0034083410 scopus 로고    scopus 로고
    • Eradication of human non-Hodgkin's lymphoma in SCID mice by BCL-2 antisense oligonucleotides combined with low-dose cyclophosphamide
    • KLASA RJ, BALLY MB, NG R, GOLDIE JH, GASCOYNE RD, WONG FM: Eradication of human non-Hodgkin's lymphoma in SCID mice by BCL-2 antisense oligonucleotides combined with low-dose cyclophosphamide. Clin. Cancer Res. (2000) 6:2492-2500.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2492-2500
    • Klasa, R.J.1    Bally, M.B.2    Ng, R.3    Goldie, J.H.4    Gascoyne, R.D.5    Wong, F.M.6
  • 11
    • 0031907428 scopus 로고    scopus 로고
    • Bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice
    • JANSEN B, SCHLAGBAUER-WADL H, BROWN BD et al.: Bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice. Nat. Med. (1998) 4:232-234.
    • (1998) Nat. Med. , vol.4 , pp. 232-234
    • Jansen, B.1    Schlagbauer-Wadl, H.2    Brown, B.D.3
  • 12
    • 0033993970 scopus 로고    scopus 로고
    • Bcl-2 antisense oligonucleotides (G3139) inhibit Merkel cell carcinoma growth in SCID mice
    • SCHLAGBAUER-WADL H, KLOSNER G, HEERE-RESS E et al.: Bcl-2 antisense oligonucleotides (G3139) inhibit Merkel cell carcinoma growth in SCID mice. J. Invest. Dermatol. (2000) 114:725-730.
    • (2000) J. Invest. Dermatol. , vol.114 , pp. 725-730
    • Schlagbauer-wadl, H.1    Klosner, G.2    Heere-ress, E.3
  • 13
    • 0033902003 scopus 로고    scopus 로고
    • Bcl-xl antisense treatment induces apoptosis in breast carcinoma cells
    • SIMOES-WUSTA AP, OLIE RA, GAUTSCHI O et al.: Bcl-xl antisense treatment induces apoptosis in breast carcinoma cells. Int. J. Cancer (2000) 87:582-590.
    • (2000) Int. J. Cancer , vol.87 , pp. 582-590
    • Simoes-Wusta, A.P.1    Olie, R.A.2    Gautschi, O.3
  • 14
    • 0033748335 scopus 로고    scopus 로고
    • Effects of Bcl-2 modulation with G3139 antisense oligonucleotide on human breast cancer cells are independent of inherent Bcl-2 protein expression
    • CHI KN, WALLIS AE, LEE CH et al.: Effects of Bcl-2 modulation with G3139 antisense oligonucleotide on human breast cancer cells are independent of inherent Bcl-2 protein expression. Breast Cancer Res. Treat. (2000) 63:199-212.
    • (2000) Breast Cancer Res. Treat. , vol.63 , pp. 199-212
    • Chi, K.N.1    Wallis, A.E.2    Lee, C.H.3
  • 15
    • 0028066802 scopus 로고
    • Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model
    • COTTER FE, JOHNSON P, HALL P et al.: Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model. Oncogene (1994) 9:3049-3055.
    • (1994) Oncogene , vol.9 , pp. 3049-3055
    • Cotter, F.E.1    Johnson, P.2    Hall, P.3
  • 17
    • 0033574578 scopus 로고    scopus 로고
    • The role of antiapoptotic Bcl-2 family members in endothelial apoptosis elucidated with antisense oligonucleotides
    • ACKERMANN EJ, TAYLOR JK, NARAYANA R, BENNETT CF.: The role of antiapoptotic Bcl-2 family members in endothelial apoptosis elucidated with antisense oligonucleotides. J. Biol. Chem. (1999) 274:11245-11252.
    • (1999) J. Biol. Chem. , vol.274 , pp. 11245-11252
    • Ackermann, E.J.1    Taylor, J.K.2    Narayana, R.3    Bennett, C.F.4
  • 19
    • 0036121142 scopus 로고    scopus 로고
    • L antisense oligonucleotides induce apoptosis in melanoma cells of different clinical stages
    • L antisense oligonucleotides induce apoptosis in melanoma cells of different clinical stages. J. Invest. Dermatol. (2002) 118:505-512.
    • (2002) J. Invest. Dermatol. , vol.118 , pp. 505-512
    • Olie, R.A.1    Hafner, C.2    Kuttel, R.3
  • 20
    • 0032422475 scopus 로고    scopus 로고
    • L might be the crucial member of the Bcl-2 gene family in colorectal cancer
    • L might be the crucial member of the Bcl-2 gene family in colorectal cancer. Dig. Dis. Sci. (1998) 43:2641-2648.
    • (1998) Dig. Dis. Sci. , vol.43 , pp. 2641-2648
    • Maurer, C.A.1    Friess, H.2    Buhler, S.S.3
  • 21
    • 0033989678 scopus 로고    scopus 로고
    • Bcl-w expression in colorectal adenocarcinoma
    • WILSON JW, NOSTRO MC, BALZI M et al.: Bcl-w expression in colorectal adenocarcinoma. Br. J. Cancer (2000) 82:178-185.
    • (2000) Br. J. Cancer , vol.82 , pp. 178-185
    • Wilson, J.W.1    Nostro, M.C.2    Balzi, M.3
  • 25
    • 0029795396 scopus 로고    scopus 로고
    • Elevated levels of apoptosis regulator proteins p53 and Bcl-2 are independent prognostic biomarkers in surgically treated clinically localized prostate cancer
    • BAUER JJ, SESTERHENN IA, MOSTOFI FK, MCLEOD DG, SRIVASTAVA S, MOUL JW: Elevated levels of apoptosis regulator proteins p53 and Bcl-2 are independent prognostic biomarkers in surgically treated clinically localized prostate cancer. J. Urol. (1996) 156:1511-1516.
    • (1996) J. Urol. , vol.156 , pp. 1511-1516
    • Bauer, J.J.1    Sesterhenn, I.A.2    Mostofi, F.K.3    Mcleod, D.G.4    Srivastava, S.5    Moul, J.W.6
  • 26
    • 0028894034 scopus 로고
    • Bcl-2 protein expression in cutaneous malignant melanoma and benign melanocytic nevi
    • CERRONI L, SOYER HP, KERL H: Bcl-2 protein expression in cutaneous malignant melanoma and benign melanocytic nevi. Am. J. Dematopathol. (1995) 17:7-11.
    • (1995) Am. J. Dematopathol. , vol.17 , pp. 7-11
    • Cerroni, L.1    Soyer, H.P.2    Kerl, H.3
  • 27
    • 0033970414 scopus 로고    scopus 로고
    • Simultaneous detection of BCL-2 protein, trisomy 12, retinoblastoma and P53 monoallelic gene deletions in B-cell chronic lymphocytic leukemia by fluorescence in situ hybridization (FISH): Relation to disease status
    • LAZARIDOU A, MIRAXTSI C, KORANTZIS J, ELEFTHERIADIS N, CHRISTAKIS JI: Simultaneous detection of BCL-2 protein, trisomy 12, retinoblastoma and P53 monoallelic gene deletions in B-cell chronic lymphocytic leukemia by fluorescence in situ hybridization (FISH): relation to disease status. Leuk. Lymphoma (2000) 36:503-512.
    • (2000) Leuk. Lymphoma , vol.36 , pp. 503-512
    • Lazaridou, A.1    Miraxtsi, C.2    Korantzis, J.3    Eleftheriadis, N.4    Christakis, J.I.5
  • 28
    • 0031889769 scopus 로고    scopus 로고
    • High expression of bcl-2 mRNA as a determinant of poor prognosis in acute myeloid leukemia
    • KARAKAS T, MAURER U, WEIDMANN E, MIETHING CC, HOELZER D, BERGMANN L: High expression of bcl-2 mRNA as a determinant of poor prognosis in acute myeloid leukemia. Ann. Oncol. (1998) 9:129-130.
    • (1998) Ann. Oncol. , vol.9 , pp. 129-130
    • Karakas, T.1    Maurer, U.2    Weidmann, E.3    Miething, C.C.4    Hoelzer, D.5    Bergmann, L.6
  • 29
    • 0032890640 scopus 로고    scopus 로고
    • Association of Bcl-2 protein expression with gallbladder carcinoma differentiation and progression and its relation to apoptosis
    • MIKAMI T, YANAGISAWA N, BABA H, KOIKE M, OKAYASU I: Association of Bcl-2 protein expression with gallbladder carcinoma differentiation and progression and its relation to apoptosis. Cancer (1999) 85:318-325.
    • (1999) Cancer , vol.85 , pp. 318-325
    • Mikami, T.1    Yanagisawa, N.2    Baba, H.3    Koike, M.4    Okayasu, I.5
  • 30
    • 0032527649 scopus 로고    scopus 로고
    • Expression of Bcl-2 in testicular carcinoma: Correlation with tumor progression and MDR1/Pgp
    • EID H, GULYAS M, GECZI L, BODROGI I, INSTITORIS E, BAK M: Expression of Bcl-2 in testicular carcinoma: correlation with tumor progression and MDR1/Pgp. Cancer (1998) 83:331-336.
    • (1998) Cancer , vol.83 , pp. 331-336
    • Eid, H.1    Gulyas, M.2    Geczi, L.3    Bodrogi, I.4    Institoris, E.5    Bak, M.6
  • 32
    • 0033965759 scopus 로고    scopus 로고
    • BCL-2 family protein expression and platinum drug resistance in ovarian carcinoma
    • BEALE PJ, ROGERS P, BOXALL F, SHARP SY, KELLAND LR: BCL-2 family protein expression and platinum drug resistance in ovarian carcinoma. Br. J. Cancer (2000) 82:436-440.
    • (2000) Br. J. Cancer , vol.82 , pp. 436-440
    • Beale, P.J.1    Rogers, P.2    Boxall, F.3    Sharp, S.Y.4    Kelland, L.R.5
  • 33
    • 0036568524 scopus 로고    scopus 로고
    • Bcl-X(L) is a chemoresistance factor in human melanoma cells that can be inhibited by antisense therapy
    • HEERE-RESS E, THALLINGER C, LUCAS T et al: Bcl-X(L) is a chemoresistance factor in human melanoma cells that can be inhibited by antisense therapy. Int. J. Cancer (2002) 99:29-34.
    • (2002) Int. J. Cancer , vol.99 , pp. 29-34
    • Heere-Ress, E.1    Thallinger, C.2    Lucas, T.3
  • 34
    • 0037138267 scopus 로고    scopus 로고
    • L in a human ovarian carcinoma cell line: Paradoxic effects on chemosensitivity in vitro versus in vivo
    • L in a human ovarian carcinoma cell line: paradoxic effects on chemosensitivity in vitro versus in vivo. Int. J. Cancer (2002) 97:858-863.
    • (2002) Int. J. Cancer , vol.97 , pp. 858-863
    • Rogers, P.M.1    Beale, P.J.2    Al-Moundhri, M.3
  • 35
    • 0028060247 scopus 로고
    • Reversal of chemoresistance of lymphoma cells by antisense-mediated reduction of bcl-2 gene expression
    • KITADA S, TAKAYAMA S, DE RIEL K, TANAKA S, REED JC: Reversal of chemoresistance of lymphoma cells by antisense-mediated reduction of bcl-2 gene expression. Antisense Res. Dev. (1994) 4:71-79.
    • (1994) Antisense Res. Dev. , vol.4 , pp. 71-79
    • Kitada, S.1    Takayama, S.2    De Riel, K.3    Tanaka, S.4    Reed, J.C.5
  • 36
    • 0034606686 scopus 로고    scopus 로고
    • Chemosensitization and delayed androgen-independent recurrence of prostate cancer with the use of antisense Bcl-2 of oligodeoxynucleotides
    • MIAYAKE H, TOLCHER A, GLEAVE ME. Chemosensitization and delayed androgen-independent recurrence of prostate cancer with the use of antisense Bcl-2 of oligodeoxynucleotides. J. Natl. Cancer Inst. (2000) 92:34-41.
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 34-41
    • Miayake, H.1    Tolcher, A.2    Gleave, M.E.3
  • 37
    • 0033855710 scopus 로고    scopus 로고
    • L antisense sensitizes human colon cancer cell line to 5-fluorouracil
    • L antisense sensitizes human colon cancer cell line to 5-fluorouracil. Jpn. J. Cancer Res. (2000) 91(8):825-32.
    • (2000) Jpn. J. Cancer Res. , vol.91 , Issue.8 , pp. 825-832
    • Nita, M.E.1    Ono-Nita, S.K.2    Tsuno, N.3
  • 38
    • 0038154168 scopus 로고    scopus 로고
    • L down-regulation switches the response to topoisomerase I inhibition from senescence to apoptosis in colorectal cancer cells, enhancing global cytotoxicity
    • L down-regulation switches the response to topoisomerase I inhibition from senescence to apoptosis in colorectal cancer cells, enhancing global cytotoxicity. Clin. Cancer Res. (2003) 9:2856-2865.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 2856-2865
    • Hayward, R.I.1    Macpherson, J.S.2    Cummings, J.3
  • 39
    • 0036730430 scopus 로고    scopus 로고
    • L antisense oligonucleotides chemosensitize human glioblastoma cells
    • L antisense oligonucleotides chemosensitize human glioblastoma cells. Chemotherapy (2002) 48:189-195.
    • (2002) Chemotherapy , vol.48 , pp. 189-195
    • Guensberg, P.1    Wacheck, V.2    Lucas, T.3
  • 40
    • 0034326272 scopus 로고    scopus 로고
    • L in prostate cancer cells: Effects of over-expression and down-regulation on chemosensitivity
    • L in prostate cancer cells: effects of over-expression and down-regulation on chemosensitivity. Cancer Res. (2000) 60:6052-6060.
    • (2000) Cancer Res. , vol.60 , pp. 6052-6060
    • Lebedeva, I.1    Rando, R.2    Ojwang, J.3    Cossum, P.4    Stein, C.A.5
  • 41
    • 0035866339 scopus 로고    scopus 로고
    • L underlies the molecular basis for resistance to staurosporine-induced apoptosis in PC-3 cells
    • L underlies the molecular basis for resistance to staurosporine-induced apoptosis in PC-3 cells. Cancer Res. (2001) 61:1699-1706.
    • (2001) Cancer Res. , vol.61 , pp. 1699-1706
    • Li, X.1    Marani, M.2    Mannucci, R.3
  • 43
    • 0031018994 scopus 로고    scopus 로고
    • Relationship of p53, Bcl-2, and tumor proliferation to clinical drug resistance in non-Hodgkin's lymphomas
    • WILSON WH, TERUYA-FELDSTEIN J, FEST T et al.: Relationship of p53, Bcl-2, and tumor proliferation to clinical drug resistance in non-Hodgkin's lymphomas. Blood (1997) 89:601-609.
    • (1997) Blood , vol.89 , pp. 601-609
    • Wilson, W.H.1    Teruya-Feldstein, J.2    Fest, T.3
  • 44
    • 0030029443 scopus 로고    scopus 로고
    • Prognostic significance of Bcl-2 protein expression in aggessive non-Hodgkin's lymphoma
    • Groupe d'Etude des Lymphomes de l'Adulte (GELA)
    • HERMINE O, HAIOUN C, LEPAGE E et al.: Prognostic significance of Bcl-2 protein expression in aggessive non-Hodgkin's lymphoma. Groupe d'Etude des Lymphomes de l'Adulte (GELA). Blood (1996) 87:265-272.
    • (1996) Blood , vol.87 , pp. 265-272
    • Hermine, O.1    Haioun, C.2    Lepage, E.3
  • 45
    • 0030951877 scopus 로고    scopus 로고
    • Bcl-2, p53, and response to tamoxifen in estrogen receptor-positive metastatic breast cancer a Southwest Oncology Group study
    • ELLEDGE RM, GREEN S, HOWES L et al.: Bcl-2, p53, and response to tamoxifen in estrogen receptor-positive metastatic breast cancer a Southwest Oncology Group study. J. Clin. Oncol (1997) 15:1916-1922.
    • (1997) J. Clin. Oncol , vol.15 , pp. 1916-1922
    • Elledge, R.M.1    Green, S.2    Howes, L.3
  • 47
    • 1542269161 scopus 로고    scopus 로고
    • Progress in antisense technology
    • CROOKE ST: Progress in antisense technology. Ann. Rev. Med (2004) 55:61-95.
    • (2004) Ann. Rev. Med. , vol.55 , pp. 61-95
    • Crooke, S.T.1
  • 48
    • 0036846993 scopus 로고    scopus 로고
    • Antisense therapy for cancer - The time of truth
    • JANSEN B, ZANGEMEISTER-WITTKE U: Antisense therapy for cancer - the time of truth. Lancet Oncol. (2002) 3:672-683.
    • (2002) Lancet Oncol. , vol.3 , pp. 672-683
    • Jansen, B.1    Zangemeister-Wittke, U.2
  • 49
    • 0141790036 scopus 로고    scopus 로고
    • BCL-2 antisense oligonucleotide genasense is active against imatinib-resistant BCR-ABL-positive cells
    • TAUCHI T, SUMI M, NAKAJIMA A et al.: BCL-2 antisense oligonucleotide genasense is active against imatinib-resistant BCR-ABL-positive cells. Clin. Cancer Res. (2003) 9:4267-4273.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 4267-4273
    • Tauchi, T.1    Sumi, M.2    Nakajima, A.3
  • 50
    • 0030888664 scopus 로고    scopus 로고
    • Bcl-2 antisense therapy in patients with non-Hodgkin lymphoma
    • WEBB A, CUNNINGHAM D, COTTER F et al.: Bcl-2 antisense therapy in patients with non-Hodgkin lymphoma. Lancet (1997) 349:1137-1141.
    • (1997) Lancet , vol.349 , pp. 1137-1141
    • Webb, A.1    Cunningham, D.2    Cotter, F.3
  • 51
    • 0034015672 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma
    • WATERS JS, WEBB A, CUNNINGHAM D et al.: Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma. J. Clin. Oncol. (2000) 18:1812-1823.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 1812-1823
    • Waters, J.S.1    Webb, A.2    Cunningham, D.3
  • 52
    • 0034684471 scopus 로고    scopus 로고
    • Chemosensitisation of malignant melanoma by Bcl-2 antisense therapy
    • JANSEN B, WACHECK V, HEERE-RESS E et al.: Chemosensitisation of malignant melanoma by Bcl-2 antisense therapy. Lancet (2000) 356:1728-1733.
    • (2000) Lancet , vol.356 , pp. 1728-1733
    • Jansen, B.1    Wacheck, V.2    Heere-Ress, E.3
  • 53
    • 0030900680 scopus 로고    scopus 로고
    • Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma
    • WOOLDRIDGE JE, BALLAS Z, KRIEG AM, WEINER GJ: Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma. Blood (1997) 89:2994-2998.
    • (1997) Blood , vol.89 , pp. 2994-2998
    • Wooldridge, J.E.1    Ballas, Z.2    Krieg, A.M.3    Weiner, G.J.4
  • 54
    • 0036975955 scopus 로고    scopus 로고
    • Antitumor effect of G3139 Bcl-2 antisense oligonucleotide is independent of its immune stimulation by CpG motifs in SCID mice
    • WACHECK V, KREPLER C, STROMMER S et al.: Antitumor effect of G3139 Bcl-2 antisense oligonucleotide is independent of its immune stimulation by CpG motifs in SCID mice. Antisense Nucleic Acid Drug Dev. (2002) 12:359-367.
    • (2002) Antisense Nucleic Acid Drug Dev. , vol.12 , pp. 359-367
    • Wacheck, V.1    Krepler, C.2    Strommer, S.3
  • 55
    • 0242719919 scopus 로고    scopus 로고
    • Cellular pharmacology of P-ethoxy antisense oligonucleotides targeted to Bcl-2 in a follicular lymphoma cell line
    • GUTIERREZ-PUENTE Y, TARI AM, FORD RJ et al.: Cellular pharmacology of P-ethoxy antisense oligonucleotides targeted to Bcl-2 in a follicular lymphoma cell line. Leuk. Lymphoma (2003) 44:1979-1985.
    • (2003) Leuk. Lymphoma , vol.44 , pp. 1979-1985
    • Gutierrez-Puente, Y.1    Tari, A.M.2    Ford, R.J.3
  • 56
    • 0031664988 scopus 로고    scopus 로고
    • Synergistic cytotoxicity of the Bcl-2 antisense oligodeoxynucleotides and etoposide, doxorubicin and cisplatin on small-cell lung cancer cell lines
    • ZANGEMEISTER-WITTK U, SCHENKER T, LUEDKE GH, STAHEL RA. Synergistic cytotoxicity of the Bcl-2 antisense oligodeoxynucleotides and etoposide, doxorubicin and cisplatin on small-cell lung cancer cell lines. Br. J. Cancer (1998) 78:1035-1042
    • (1998) Br. J. Cancer , vol.78 , pp. 1035-1042
    • Zangemeister-Wittk, U.1    Schenker, T.2    Luedke, G.H.3    Stahel, R.A.4
  • 57
    • 0030759409 scopus 로고    scopus 로고
    • The antisense Bcl-2-IgH transcript is an optimal target for synthetic oligonucleotides
    • MORELLI S, DELIA D, CAPACCIOLI A et al.: The antisense Bcl-2-IgH transcript is an optimal target for synthetic oligonucleotides. Proc. Natl. Acad. Sci. USA (1997) 94:8150-8155.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 8150-8155
    • Morelli, S.1    Delia, D.2    Capaccioli, A.3
  • 58
  • 59
    • 0035925537 scopus 로고    scopus 로고
    • L-bispecific antisense oligonucleotide against tumors of diverse histologic origins
    • L-bispecific antisense oligonucleotide against tumors of diverse histologic origins. J. Natl. Cancer Inst. (2001) 93:463-471.
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 463-471
    • Gautschi, O.1    Tschopp, S.2    Olie, R.A.3
  • 61
    • 0037312522 scopus 로고    scopus 로고
    • L, epidermal growth factor receptor, and protein kinase A Type I causes potent antitumor, apoptotic, and antiangiogenic activity
    • L, epidermal growth factor receptor, and protein kinase A Type I causes potent antitumor, apoptotic, and antiangiogenic activity. Clin. Cancer Res. (2003) 9:866-871.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 866-871
    • Tortora, G.1    Caputo, R.2    Damiano, V.3
  • 62
    • 0038806293 scopus 로고    scopus 로고
    • Mcl-1 antisense therapy chemosensitizes human melanoma in a SCID mouse xenotransplantation model
    • THALLINGER C, WOLSCHEK MF, WACHECK V et al.: Mcl-1 antisense therapy chemosensitizes human melanoma in a SCID mouse xenotransplantation model. J. Invest. Dermatol. (2003) 120:1081-1086.
    • (2003) J. Invest. Dermatol. , vol.120 , pp. 1081-1086
    • Thallinger, C.1    Wolschek, M.F.2    Wacheck, V.3
  • 63
    • 0035816232 scopus 로고    scopus 로고
    • Induction of apoptosis in prostate carcinoma cells by BH3 peptides which inhibit Bak/Bcl-2 interactions
    • FINNEGAN NM, CURTIN JF, PREVOST G, MORGAN B, COTTER TG: Induction of apoptosis in prostate carcinoma cells by BH3 peptides which inhibit Bak/Bcl-2 interactions. Br. J. Cancer (2001) 85:115-121.
    • (2001) Br. J. Cancer , vol.85 , pp. 115-121
    • Finnegan, N.M.1    Curtin, J.F.2    Prevost, G.3    Morgan, B.4    Cotter, T.G.5
  • 64
    • 0034654522 scopus 로고    scopus 로고
    • Cell permeable Bcl-2 binding peptides: A chemical approach to apoptosis induction in tumor cells
    • WANG JL, ZHANG ZJ, CHOKSI S et al.: Cell permeable Bcl-2 binding peptides: a chemical approach to apoptosis induction in tumor cells. Cancer Res. (2000) 60:1498-1502.
    • (2000) Cancer Res. , vol.60 , pp. 1498-1502
    • Wang, J.L.1    Zhang, Z.J.2    Choksi, S.3
  • 65
    • 0037050253 scopus 로고    scopus 로고
    • The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1-overexpressing breast cancer cell lines
    • RADETZKI S, KOHNE CH, VON HAEFEN C et al.: The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1-overexpressing breast cancer cell lines. Oncogene (2002) 21:227-238.
    • (2002) Oncogene , vol.21 , pp. 227-238
    • Radetzki, S.1    Kohne, C.H.2    Von Haefen, C.3
  • 66
    • 0019205610 scopus 로고
    • Tetrocarcins, novel antitumor antibiotics. I. Producing organism, fermentation and antimicrobial activity
    • TOMITA F, TAMAOKI T: Tetrocarcins, novel antitumor antibiotics. I. Producing organism, fermentation and antimicrobial activity. J. Antibiot. (1980) 33:946-950.
    • (1980) J. Antibiot. , vol.33 , pp. 946-950
    • Tomita, F.1    Tamaoki, T.2
  • 67
    • 0019137520 scopus 로고
    • Tetrocarcins, novel antitumor antibiotics. II. Isolation, characterization and antitumor activity
    • TAMAOKI T, KASAI M, SHIRAHATA K et al.: Tetrocarcins, novel antitumor antibiotics. II. Isolation, characterization and antitumor activity. J. Antibiot. (1980) 33:940-945.
    • (1980) J. Antibiot. , vol.33 , pp. 940-945
    • Tamaoki, T.1    Kasai, M.2    Shirahata, K.3
  • 68
    • 0020415474 scopus 로고
    • Tetrocarcins, new antitumor antibiotics. III. Antitumor activity of tetrocarcin A
    • MORIMOTO M, FUKUI M, OHKUBO S, TAMAOKI T. TOMITA F: Tetrocarcins, new antitumor antibiotics. III. Antitumor activity of tetrocarcin A. J. Antibiot. (1982) 35:1033-1037.
    • (1982) J. Antibiot. , vol.35 , pp. 1033-1037
    • Morimoto, M.1    Fukui, M.2    Ohkubo, S.3    Tamaoki, T.4    Tomita, F.5
  • 69
    • 0034162983 scopus 로고    scopus 로고
    • Tetrocarcin A inhibits mitochondrial functions of Bcl-2 and suppresses its antiapoptotic activity
    • NAKASHIMA T, MIURA M, HARA M: Tetrocarcin A inhibits mitochondrial functions of Bcl-2 and suppresses its antiapoptotic activity. Cancer Res. (2000) 60:1229-1235.
    • (2000) Cancer Res. , vol.60 , pp. 1229-1235
    • Nakashima, T.1    Miura, M.2    Hara, M.3
  • 70
    • 0035832097 scopus 로고    scopus 로고
    • Synthesis of tetrocarcin derivatives with specific inhibitory activity towards Bcl-2 functions
    • KANEKO M, NAKASHIMA T, UOSAKI Y, HARA M, IKEDA S, KANDA Y: Synthesis of tetrocarcin derivatives with specific inhibitory activity towards Bcl-2 functions. Bioorg. Med. Chem. Lett. (2001) 11:887-890.
    • (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 887-890
    • Kaneko, M.1    Nakashima, T.2    Uosaki, Y.3    Hara, M.4    Ikeda, S.5    Kanda, Y.6
  • 72
    • 0030867866 scopus 로고    scopus 로고
    • Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria
    • XIA D, YU CA, KIM H et al.: Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria. Science (1997) 277:60-66.
    • (1997) Science , vol.277 , pp. 60-66
    • Xia, D.1    Yu, C.A.2    Kim, H.3
  • 73
    • 0035147650 scopus 로고    scopus 로고
    • Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3
    • TZUNG SP, KIM KM, BASANEZ G et al.: Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3. Nat. Cell. Biol. (2001) 3:183-191.
    • (2001) Nat. Cell. Biol. , vol.3 , pp. 183-191
    • Tzung, S.P.1    Kim, K.M.2    Basanez, G.3
  • 74
    • 0035942324 scopus 로고    scopus 로고
    • Biophysical characterization of recombinant human Bcl-2 and its interaction with an inhibitory ligand, antimycin A
    • KIM KM, GIEDT CD, BASANEZ Get al.: Biophysical characterization of recombinant human Bcl-2 and its interaction with an inhibitory ligand, antimycin A. Biochemistry (2001) 40:4911-4922.
    • (2001) Biochemistry , vol.40 , pp. 4911-4922
    • Kim, K.M.1    Giedt, C.D.2    Basanez, G.3
  • 75
    • 0034691130 scopus 로고    scopus 로고
    • Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
    • WANG J-L, LIU D, ZHANG Z-J et al.: Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc. Natl. Acad. Sci. USA (2000) 97:7124-7129.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 7124-7129
    • Wang, J.-L.1    Liu, D.2    Zhang, Z.-J.3
  • 76
    • 0036566242 scopus 로고    scopus 로고
    • Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia
    • MILELLA M, ESTROV Z, KORNBLAU SM et al.: Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia. Blood (2002) 99:3461-3464.
    • (2002) Blood , vol.99 , pp. 3461-3464
    • Milella, M.1    Estrov, Z.2    Kornblau, S.M.3
  • 77
    • 3042766027 scopus 로고    scopus 로고
    • The apoptotic effect of HA14-1, a Bcl-2-interacting small molecule compound, requires Bax translocation and is enhanced by PK11195
    • CHEN J, FREEMAN A, LIU J, DAI Q, LEE R: The apoptotic effect of HA14-1, a Bcl-2-interacting small molecule compound, requires Bax translocation and is enhanced by PK11195. Mol. Cancer Ther. (2002) 1:981-987.
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 981-987
    • Chen, J.1    Freeman, A.2    Liu, J.3    Dai, Q.4    Lee, R.5
  • 78
    • 0142244338 scopus 로고    scopus 로고
    • The proteosome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA 14-1 in multiple myeloma cells
    • PEI X-Y, DAI Y, GRANT S: The proteosome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA 14-1 in multiple myeloma cells. Leukemia (2003) 17:2036-2045.
    • (2003) Leukemia , vol.17 , pp. 2036-2045
    • Pei, X.-Y.1    Dai, Y.2    Grant, S.3
  • 80
    • 0037138678 scopus 로고    scopus 로고
    • A novel approach for characterizing protein ligand complexes: Molecular basis for specificity of small-molecule Bcl-2 inhibitors
    • LUGOVSKOY AA. DEGTEREV AI, Fahmy AF et al.: A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors. J. Am. Chem. Soc. (2002) 124:1234-1240.
    • (2002) J. Am. Chem. Soc. , vol.124 , pp. 1234-1240
    • Lugovskoy, A.A.1    Degterev, A.I.2    Fahmy, A.F.3
  • 81
    • 0035818885 scopus 로고    scopus 로고
    • Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening
    • ENYEDY IJ, LING YL, NACRO K et al.: Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening. J. Med. Chem. (2001) 44:4313-4324.
    • (2001) J. Med. Chem. , vol.44 , pp. 4313-4324
    • Enyedy, I.J.1    Ling, Y.L.2    Nacro, K.3
  • 82
    • 0034801374 scopus 로고    scopus 로고
    • Toward proteomics: Terphenyl derivatives as structural and functional mimics of extended regions of an α-helix
    • ORNER BP, ERNST JT, HAMILTON AD: Toward proteomics: Terphenyl derivatives as structural and functional mimics of extended regions of an α-helix. J. Am. Chem. Soc. (2001) 123:5382-5383.
    • (2001) J. Am. Chem. Soc. , vol.123 , pp. 5382-5383
    • Orner, B.P.1    Ernst, J.T.2    Hamilton, A.D.3
  • 83
    • 0037126834 scopus 로고    scopus 로고
    • Design of a protein surface antagonist based on a-helix mimicry: Inhibition of gp41 assembly and viral fusion
    • ERNST JT, KUTZKI O, DEBNATH AK, JIANG S, LU H, HAMITLON AD: Design of a protein surface antagonist based on a-helix mimicry: inhibition of gp41 assembly and viral fusion.Angew. Chem. Int. Ed. (2002) 41:278-281.
    • (2002) Angew. Chem. Int. Ed. , vol.41 , pp. 278-281
    • Ernst, J.T.1    Kutzki, O.2    Debnath, A.K.3    Jiang, S.4    Lu, H.5    Hamitlon, A.D.6
  • 84
    • 0030614915 scopus 로고    scopus 로고
    • L-Bak peptide complex: Recognition between regulators of apoptosis
    • L-Bak peptide complex: recognition between regulators of apoptosis. Science (1997) 275:983-986.
    • (1997) Science , vol.275 , pp. 983-986
    • Sattler, M.1    Liang, H.2    Nettesheim, D.3
  • 86
    • 0024394011 scopus 로고
    • An overview of the clinical pharmacology and therapeutic potential of gossypol as a male contraceptive agents and gynaecological disease
    • WU D: An overview of the clinical pharmacology and therapeutic potential of gossypol as a male contraceptive agents and gynaecological disease. Drugs (1989) 38:333-341.
    • (1989) Drugs , vol.38 , pp. 333-341
    • Wu, D.1
  • 87
    • 0022899737 scopus 로고
    • Antiviral activities of gossypol and its derivatives against herpes simplex virus Type II
    • RADLOFF RJ, DECK LM, ROYER RE, VANDER JAGT DL: Antiviral activities of gossypol and its derivatives against herpes simplex virus Type II. Pharmacol. Res. Commun. (1986) 18:1063-1073.
    • (1986) Pharmacol. Res. Commun. , vol.18 , pp. 1063-1073
    • Radloff, R.J.1    Deck, L.M.2    Royer, R.E.3    Vander Jagt, D.L.4
  • 89
    • 0028151457 scopus 로고
    • Induction of neutrophil Mac-1 integrin expression and superoxide production by the medicinal plant extract gossypol
    • BENHAIM P, MATHES SJ, HUNT TK, SCHEUENSTUHL H, BENZ CC: Induction of neutrophil Mac-1 integrin expression and superoxide production by the medicinal plant extract gossypol. Inflammation (1994) 18:443-458.
    • (1994) Inflammation , vol.18 , pp. 443-458
    • Benhaim, P.1    Mathes, S.J.2    Hunt, T.K.3    Scheuenstuhl, H.4    Benz, C.C.5
  • 90
    • 0027460576 scopus 로고
    • Oral gossypol in the treatment of matastatic adrenal cancer
    • FLACK MR, PYLE RG, MULLEN NM et al.: Oral gossypol in the treatment of matastatic adrenal cancer. J. Clin. Endocrinol. Metab. (1993) 76:1019-1024.
    • (1993) J. Clin. Endocrinol. Metab. , vol.76 , pp. 1019-1024
    • Flack, M.R.1    Pyle, R.G.2    Mullen, N.M.3
  • 92
    • 0032780442 scopus 로고    scopus 로고
    • Gossypol treatment of recurrent adult malignant gliomas
    • BUSHUNOW P, REIDENBERG MM, WASENKO J et al.: Gossypol treatment of recurrent adult malignant gliomas. J. Neurooncol. (1999) 42:79-86.
    • (1999) J. Neurooncol. , vol.42 , pp. 79-86
    • Bushunow, P.1    Reidenberg, M.M.2    Wasenko, J.3
  • 93
    • 0034922672 scopus 로고    scopus 로고
    • Oral gossypol in the treatment of patients with refractory matastatic breast cancer: A Phase I/II clinical trial
    • VAN POZNAK C, SEIDMAN AD, REIDENBERG MM et al.: Oral gossypol in the treatment of patients with refractory matastatic breast cancer: a Phase I/II clinical trial. Breast Cancer Res. Treat. (2001) 66:239-248.
    • (2001) Breast Cancer Res. Treat. , vol.66 , pp. 239-248
    • Van Poznak, C.1    Seidman, A.D.2    Reidenberg, M.M.3
  • 94
    • 0034692871 scopus 로고    scopus 로고
    • Cytotoxic effect of gossypol on colon carcinoma cells
    • WANG X, WANG J, WONG SCH et al.: Cytotoxic effect of gossypol on colon carcinoma cells. Life Sci. (2000) 67:2663-2671.
    • (2000) Life Sci. , vol.67 , pp. 2663-2671
    • Wang, X.1    Wang, J.2    Wong, S.C.H.3
  • 95
    • 0038682166 scopus 로고    scopus 로고
    • Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells
    • ZHANG M, LIU H, GUO R et al.: Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. Biochem. Pharmacol. (2003) 66:93-103.
    • (2003) Biochem. Pharmacol. , vol.66 , pp. 93-103
    • Zhang, M.1    Liu, H.2    Guo, R.3
  • 96
    • 0030815108 scopus 로고    scopus 로고
    • Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation
    • CHMURA SJ, MAUCERI H, ADVANI S et al.: Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation. Cancer Res. (1997) 57:4340-4347.
    • (1997) Cancer Res. , vol.57 , pp. 4340-4347
    • Chmura, S.J.1    Mauceri, H.2    Advani, S.3
  • 97
    • 0033961302 scopus 로고    scopus 로고
    • In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo
    • CHMURA SJ, DOLAN ME, CHA A et al.: In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo. Clin. Cancer Res. (2000) 6:737-742.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 737-742
    • Chmura, S.J.1    Dolan, M.E.2    Cha, A.3
  • 99
    • 0031931014 scopus 로고    scopus 로고
    • Inhibition of neointimal cell Bcl-X expression induces apoptosis and regression of vascular disease
    • POLLMAN MJ, HALL JL, MANN MJ, ZHANG L, GIBBONS GH: Inhibition of neointimal cell Bcl-X expression induces apoptosis and regression of vascular disease. Nat. Med. (1998) 4:222-227.
    • (1998) Nat. Med. , vol.4 , pp. 222-227
    • Pollman, M.J.1    Hall, J.L.2    Mann, M.J.3    Zhang, L.4    Gibbons, G.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.