p53-independent induction of apoptosis in human melanoma cells by a bcl-2/bcl-xL bispecific antisense oligonucleotide

Clinical Cancer Research

Volumn 7, Issue 5, 2001, Pages 1446-1451

  Strasberg Rieber, Mary ^a   Rieber, Manuel ^a   Zangemeister Wittke, Uwe ^b  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN P53;

APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER RESISTANCE; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; ENZYME DEGRADATION; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; MELANOMA CELL; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

APOPTOSIS; BCL-X PROTEIN; CELL DIVISION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA FRAGMENTATION; DOWN-REGULATION; HUMANS; MELANOMA; MUTATION; OLIGONUCLEOTIDES, ANTISENSE; POLY(ADP-RIBOSE) POLYMERASES; PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0034896331     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Spontaneous development of drug resistance: Mismatch repair and p53 defects in resistance to cisplatin in human tumor cells
2. Emergence of p53 mutant cisplatin-resistant ovarian carcinoma cells following drug exposure: Spontaneously mutant selection
3. Paclitaxel selects for mutant or pseudo-null p53 in drug resistance associated with tubulin mutations in human cancer
4. Regulation of expression of the multidrug resistance protein MRP1 by p53 in human prostate cancer cells
5. An abnormality in the p53 pathway following γ irradiation in many wild type p53 human melanoma lines
6. p53-dependent apoptosis in melanoma cells after treatment with camptothecin
7. Overexpression of p53 is a late event in the development of malignant melanoma
8. p53 gene mutation and expression in naevi and melanomas
9. A novel bispecific antisense oligonucleotide inhibiting both bcl-2 and bcl-xL expression efficiently induces apoptosis in tumor cells
10. Apoptosis-inducing levels of UV radiation and proteasome inhibitors produce opposite effects on p21WAF1 in human melanoma cells
11. Induction of p53 without increase in p21WAF1 in betulinic acid-mediated cell death is preferential for human metastatic melanoma
12. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
13. DNA excision repair and DNA damage-induced apoptosis are linked to poly(ADP-ribosyl)ation but have different requirements for p53
14. Regulation of p21WAF1 by p53-independent pathways
15. Tumor-suppressor p53: Implications for tumor development and prognosis
16. Proteolysis of poly(ADP-ribose) polymerase by caspase 3: Kinetics of cleavage of mono(ADP-ribosyl)ated and DNA-bound substrates
17. p21Waf1/Cip1 acts in synergy with bcl-2 to confer multidrug resistance in a camptothecin-selected human lung-cancer cell line
18. Induction of apoptosis in lung cancer cells following bcl-xL antisense treatment
19. Oncogenic mutations of the p53 tumor suppressor; the demons of the guardian of the genome