Eradication of human non-Hodgkin's lymphoma in SCID mice by BCL-2 antisense oligonucleotides combined with low-dose cyclophosphamide

Clinical Cancer Research

Volumn 6, Issue 6, 2000, Pages 2492-2500

  Klasa, Richard J ^a,b   Bally, Marcel B ^a   Ng, Rebecca ^a   Goldie, James H ^a   Gascoyne, Randy D ^a   Wong, Frances M P ^a,b  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CYCLOPHOSPHAMIDE; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B CELL LYMPHOMA; CELL DAMAGE; CONTROLLED STUDY; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; MALE; MOUSE; NATURAL KILLER CELL; NONHODGKIN LYMPHOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCID MOUSE;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BLOTTING, WESTERN; COMBINED MODALITY THERAPY; CYCLOPHOSPHAMIDE; DOWN-REGULATION; GENES, BCL-2; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOMA, NON-HODGKIN; MALE; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; OLIGONUCLEOTIDES, ANTISENSE; POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0034083410     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Zamecnik, P. C., and Stephenson, M. L. Inhibition of Rous sarcoma virus replication and cell transformation by anoligodeoxynucleotide. Proc. Natl. Acad. Sci. USA, 75: 280-284, 1978.
2. Stephenson, M. L., and Zamecnik, P. C. Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide. Proc. Natl. Acad. Sci. USA, 75: 285-288, 1978.
3. Cotter, F. E. Antisense therapy for lymphomas. Hematol. Oncol., 15: 3-11, 1997.
4. Ho, P. T., and Parkinson, R. Antisense oligonucleotides as therapeutics for malignant diseases. Semin. Oncol., 24: 187-202, 1997.
5. Wintersberger, U. Ribonucleases H of retroviral and cellular origin. Pharmacol. Ther., 48: 259-280, 1990.
6. Weiner, G. J., Liu, H. M., Wooldridge, J. E., Dahle, C. E., and Krieg, A. M. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc. Natl. Acad. Sci. USA, 94: 10833-10837, 1997.
7. Wooldridge, J. E., Ballas, Z., and Krieg, A. M. Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma. Blood, 89: 2994-2998, 1997.
8. Ballas, Z. K., Rasmussen, W. L., and Krieg, A. M. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol., 157: 1840-1845, 1996.
9. Krieg, A. M., Yi, A. K., Matson, S., Waldschmidt, T. J., Bishop, G. A., Teasdale, R., Koretzky, G. A., and Klinman, D. M. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature (Lond.), 374: 546-549, 1995.
10. Jansen, B., Schlagbauer-Wadl, H., Brown, B. D., Bryan, R. N., van Elsas, A., Muller, M., Wolff, K., Eichler, H., and Pehamberger, H. bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice. Nat. Med., 4: 232-234, 1998.
11. Monia, B. P., Johnston, J. F., Geiger, T., Muller, M., and Fabbro, D. Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide. Nat. Med., 2: 668-675, 1996.
12. Hijiya, N., Zhang, J., Ratajczak, M. Z., Kant, J. A., DeRiel, K., Herlyn, M., Zon, G., and Gewirtz, A. M. Biologic and therapeutic significance of MYB expression in human melanoma. Proc. Natl. Acad. Sci. USA, 91: 4499-4503, 1994.
13. Skorski, T., Nieborowska-Skorska, M., Nicolaides, N. C., Szczylik, C., Iversen, P., Iozzo, R. V., Zon, G., and Calabretta, B. Suppression of Philadelphia-1 leukemia cell growth in mice by BCR-ABL antisense oligonucleotide. Proc. Natl. Acad. Sci. USA, 91: 4504-4508, 1994.
14. Cotter, F. E., Johnson, P., Hall, P., Pocock, C., al Mahdi, N., Cowell, J. K., and Morgan, G. Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model. Oncogene, 9: 3049-3055, 1994.
15. Yang, E., and Korsmeyer, S. J. Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood, 88: 386-401, 1996.
16. Reed, J. C. Double identity for proteins of the Bcl-2 family. Nature (Lond.), 387: 773-776, 1997.
17. Agrawal, S., Temsamani, J., and Tang, J. Y. Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice. Proc. Natl. Acad. Sci. USA, 88: 7595-7599, 1991.
18. Raynaud, F. I., Orr, R. M., Goddard, P. M., Lacey, H. A., Lancashire, H., Judson, I. R., Beck, T., Bryan, B., and Cotter, F. Pharmacokinetics of G3139, a phosphorothioate oligodeoxynucleotide antisense to bcl-2, after intravenous administration or continuous subcutaneous infusion to mice. J. Pharmacol. Exp. Ther., 281: 420-427, 1997.
19. Webb, A., Cunningham, D., Cotter, F., Clarke, P. A., di Stefano, F., Ross, P., Corbo, M., and Dziewanowska, Z. BCL-2 antisense therapy in patients with non-Hodgkin lymphoma. Lancet, 349: 1137-1141, 1997.
20. Reed, J. C., Miyashita, T., Takayama, S., Wang, H. G., and Sato, T. BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy. J. Cell. Biochem., 60: 23-32, 1996.
21. Reed, J. C. Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies. Semin. Hematol., 34: 9-19, 1997.
22. Reed, J. C. Bcl-2: prevention of apoptosis as a mechanism of drug resistance. Hematol. Oncol. Clin. North Am., 9: 451-473, 1995.
23. Miyashita, T., and Reed, J. C. bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs. Cancer Res., 52: 5407-5411, 1992.
24. Miyashita, T., and Reed, J. C. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood, 81: 151-157, 1993.
25. Kamesaki, S., Kamesaki, H., Jorgensen, T. J., Tanizawa, A., Pommier, Y., and Cossman, J. bcl-2 protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase II-induced DNA strand breaks and their repair. Cancer Res., 53: 4251-4256, 1993.
26. Walton, M. I., Whysong, D., O'Connor, P. M., Hockenbery, D., Korsmeyer, S. J., and Kohn, K. W. Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis. Cancer Res., 53: 1853-1861, 1993.
27. Reed, J. C., Kitada, S., Takayama, S., and Miyashita, T. Regulation of chemoresistance by the bcl-2 oncoprotein in non-Hodgkin's and lymphocytic leukemia cell lines. Ann. Oncol., 5 (Suppl 1): 61-65, 1994.
28. Keith, F. J., Bradbury, D. A., Zhu, Y. M., and Russell, N. H. Inhibition of bcl-2 with antisense oligonucleotides induces apoptosis and increases the sensitivity of AML blasts to Ara-C. Leukemia (Baltimore), 9: 131-138, 1995.
29. Kluin-Nelemans, H. C., Limpens, J., Meerabux, J., Beverstock, G., Jansen, J. H., de Jong, D., and Kluin, P. A new non-Hodgkin's B-cell line (DoHH2) with a chromosomal translocation t(14;18)(q32;q21). Leukemia (Baltimore), 5: 221-224, 1991.
30. Dyer, M. J., Lillington, D. M., Bastard, C., Tilly, H., and Lens, D. Concurrent activation of MYC and BCL2 in B cell non-Hodgkin lymphoma cell lines by translocation of both oncogenes to the same immunoglobulin heavy chain locus. Leukemia (Baltimore), 10: 1198-1208, 1996.
31. Kronenwett, R., Steidl, U., Kirsch, M., Sczakiel, G., and Haas, R. Oligodeoxyribonucleotide uptake in primary human hematopoietic cells is enhanced by cationic lipids and depends on the hematopoietic cell subset. Blood, 91: 852-862, 1998.
32. Sambrook, J., Fritsch, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual. 2nd edition, Vol. 2. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1989.
33. Gascoyne, R. D., Adomat, S. A., Krajewski, S., Krajewska, M., Horsman. D. E., Tolcher, A. W., O'Reilly, S. E., Hoskins, P., Coldman, A. J., Reed, J. C., and Connors, J. M. Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma. Blood, 90: 244-251, 1997.
34. Horsman, D. E., Gascoyne, R. D., Coupland, R. W., Coldman, A. J., and Adomat, S. A. Comparison of cytogenetic analysis, southern analysis, and polymerase chain reaction for the detection of t(14;18) in follicular lymphoma. Am. J. Clin. Pathol., 103: 472-478, 1995.
35. de Kroon, J. F., Kluin, P. M., Kluin-Nelemans, H. C., Willemze, R., and Falkenburg, J. H. Homing and antigenic characterization of a human non-Hodgkin's B lymphoma in severe combined immunodeficient (SCID) mice. Leukemia (Baltimore), 8: 1385-1391, 1994.
36. Macpherson, N., Lesack, D., Klasa, R., Horsman, D., Connors, J. M., Barnett, M., and Gascoyne, R. Small noncleaved, non-Burkitt's (Burkit-Like) lymphoma: cytogenetics predict outcome and reflect clinical presentation. J. Clin. Oncol., 17: 1558-1567, 1999.