-
1
-
-
0028915081
-
BCR/ABL signal transduction
-
Tauchi, T., and Broxmeyer, H. E. BCR/ABL signal transduction, Int. J. Hematol., 61: 105-112, 1995.
-
(1995)
Int. J. Hematol.
, vol.61
, pp. 105-112
-
-
Tauchi, T.1
Broxmeyer, H.E.2
-
2
-
-
0021674862
-
An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity
-
Konopka, J. B., Watanabe, S. M., and Witte, O. N. An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity. Cell, 37: 1035-1042, 1984.
-
(1984)
Cell
, vol.37
, pp. 1035-1042
-
-
Konopka, J.B.1
Watanabe, S.M.2
Witte, O.N.3
-
3
-
-
0021926819
-
The human cellular abl gene product in the chronic myelogenous leukemia cell line K562 has an associated tyrosine protein kinase activity
-
Kloetzer, W., Kurzrock, R., Smith, L., Talpaz, M., Spiller, M., Gutterman, J., and Arlinghaus, R. The human cellular abl gene product in the chronic myelogenous leukemia cell line K562 has an associated tyrosine protein kinase activity. Virology, 140: 230-238, 1985.
-
(1985)
Virology
, vol.140
, pp. 230-238
-
-
Kloetzer, W.1
Kurzrock, R.2
Smith, L.3
Talpaz, M.4
Spiller, M.5
Gutterman, J.6
Arlinghaus, R.7
-
4
-
-
0034330931
-
Efficacy of STI571, an abl tyrosine kinase inhibitor, in conjunction with other antileukemic agents against bcr-abl-positive cells
-
Thiesing, J. T., Ohno-Jones, S., Kolibaba, K. S., and Druker, B. J. Efficacy of STI571, an abl tyrosine kinase inhibitor, in conjunction with other antileukemic agents against bcr-abl-positive cells. Blood, 96: 3195-3199, 2000.
-
(2000)
Blood
, vol.96
, pp. 3195-3199
-
-
Thiesing, J.T.1
Ohno-Jones, S.2
Kolibaba, K.S.3
Druker, B.J.4
-
5
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of BCR-ABL positive cells
-
Druker, B. J., Tamura, S., Buchdunger, E., Ohno, S., Segal, G. M., Fanning, S., Zimmermann, J., and Lydon, N. B. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of BCR-ABL positive cells. Nat. Med., 2: 561-566, 1996.
-
(1996)
Nat. Med.
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
Ohno, S.4
Segal, G.M.5
Fanning, S.6
Zimmermann, J.7
Lydon, N.B.8
-
6
-
-
0034988035
-
ABL-specific tyrosine kinase inhibitor, STI571 in vitro, affects Ph-positive acute lymphoblastic leukemia and chronic myelogenous leukemia in blastic crisis
-
Nakajima, A., Tauchi, T., and Ohyashiki, K. ABL-specific tyrosine kinase inhibitor, STI571 in vitro, affects Ph-positive acute lymphoblastic leukemia and chronic myelogenous leukemia in blastic crisis. Leukemia (Baltimore), 15: 989-990, 2001.
-
(2001)
Leukemia (Baltimore)
, vol.15
, pp. 989-990
-
-
Nakajima, A.1
Tauchi, T.2
Ohyashiki, K.3
-
7
-
-
0037186924
-
Imatinib mesylate - A new oral targeted therapy
-
Savage, D. G., and Antman, K. H. Imatinib mesylate - a new oral targeted therapy. N. Engl. J. Med., 346: 683-693, 2002.
-
(2002)
N. Engl. J. Med.
, vol.346
, pp. 683-693
-
-
Savage, D.G.1
Antman, K.H.2
-
8
-
-
0028066802
-
Antisense oligonucleotides suppress B-cell lymphoma growth in SCID-hu mouse model
-
Cotter, F. E., Johnson, P., Hall, P., Pocock, C., al Mahdi, N., Cowell, J. K., and Morgan, G. Antisense oligonucleotides suppress B-cell lymphoma growth in SCID-hu mouse model. Oncogene, 9: 3049-3055, 1994.
-
(1994)
Oncogene
, vol.9
, pp. 3049-3055
-
-
Cotter, F.E.1
Johnson, P.2
Hall, P.3
Pocock, C.4
Al Mahdi, N.5
Cowell, J.K.6
Morgan, G.7
-
9
-
-
0034975774
-
Mouse models of cell death
-
Ranger, A. M., Malynn, B. A., and Korsmeyer, S. J. Mouse models of cell death. Nat. Genet., 28: 113-118, 2001.
-
(2001)
Nat. Genet.
, vol.28
, pp. 113-118
-
-
Ranger, A.M.1
Malynn, B.A.2
Korsmeyer, S.J.3
-
10
-
-
0032580361
-
Subcellular and submitochondrial model of action of Bcl-2 like oncoprotein
-
Zamzami, N., Brenner, C., Marzo, I., Susin, S. A., and Kroemer, G. Subcellular and submitochondrial model of action of Bcl-2 like oncoprotein. Oncogene, 16: 2265-2282, 1998.
-
(1998)
Oncogene
, vol.16
, pp. 2265-2282
-
-
Zamzami, N.1
Brenner, C.2
Marzo, I.3
Susin, S.A.4
Kroemer, G.5
-
11
-
-
0027389763
-
Bcl-2 oncoprotein blocks chemotherapeutic-induced apoptosis in a human leukemia cell line
-
Miyashita, T., and Reed, J. C. Bcl-2 oncoprotein blocks chemotherapeutic-induced apoptosis in a human leukemia cell line. Blood, 81: 151-157, 1993.
-
(1993)
Blood
, vol.81
, pp. 151-157
-
-
Miyashita, T.1
Reed, J.C.2
-
12
-
-
0028958030
-
Bcl-2 prevention of apoptosis as a mechanism of drug resistance
-
Reed, J. C. Bcl-2 prevention of apoptosis as a mechanism of drug resistance. Hematol. Oncol. Clin. N. Am., 9: 451-473, 1995.
-
(1995)
Hematol. Oncol. Clin. N. Am.
, vol.9
, pp. 451-473
-
-
Reed, J.C.1
-
13
-
-
9044225527
-
Bcl-2 family proteins: Regulators of cell death involved in the pathogenesis of cancer and resistance to therapy
-
Reed, J. C., Miyashita, T., Takayama, S., Wang, H. G., and Sato, T., Krajewski, S., Aime-Sempe, C., Bodrug, S., Kitada, S., and Hanada, M. Bcl-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy. J. Cell. Biochem., 60: 23-32, 1996.
-
(1996)
J. Cell. Biochem.
, vol.60
, pp. 23-32
-
-
Reed, J.C.1
Miyashita, T.2
Takayama, S.3
Wang, H.G.4
Sato, T.5
Krajewski, S.6
Aime-Sempe, C.7
Bodrug, S.8
Kitada, S.9
Hanada, M.10
-
14
-
-
0034662158
-
Versatility of BCR-ABL-expressing leukemic cells in circumventing proapoptotic BAD effects
-
Salomoni, P., Condorelli, F., Sweeney, S. M., and Calabretta, B. Versatility of BCR-ABL-expressing leukemic cells in circumventing proapoptotic BAD effects. Blood, 96: 676-684, 2000.
-
(2000)
Blood
, vol.96
, pp. 676-684
-
-
Salomoni, P.1
Condorelli, F.2
Sweeney, S.M.3
Calabretta, B.4
-
15
-
-
0034548831
-
Bcl-2 expression restores the leukemogenetic potential of a BCR-ABL mutant defective in transformation
-
Cirinna, M., Trotta, R., Salomoni, P., Kossev, P., Wasik, M., Perrotti, D., and Calabretta, B. Bcl-2 expression restores the leukemogenetic potential of a BCR-ABL mutant defective in transformation. Blood, 96: 3915-3921, 2000.
-
(2000)
Blood
, vol.96
, pp. 3915-3921
-
-
Cirinna, M.1
Trotta, R.2
Salomoni, P.3
Kossev, P.4
Wasik, M.5
Perrotti, D.6
Calabretta, B.7
-
16
-
-
0031007491
-
Pharmacokinetics of G3139, a phosphorothioate oligodeoxynucleotide antisense of bcl-2, after intravenous administration or continuous subcutaneous infusion to mice
-
Raynaud, F. I., Orr, R. M., Goddard, P. M., Lacey, H. A., Lancashire, H., Judson, I. R., Beck, T., Bryan, B., and Cotter, F. E. Pharmacokinetics of G3139, a phosphorothioate oligodeoxynucleotide antisense of bcl-2, after intravenous administration or continuous subcutaneous infusion to mice. J. Pharmacol. Exp. Ther., 281: 420-427, 1997.
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.281
, pp. 420-427
-
-
Raynaud, F.I.1
Orr, R.M.2
Goddard, P.M.3
Lacey, H.A.4
Lancashire, H.5
Judson, I.R.6
Beck, T.7
Bryan, B.8
Cotter, F.E.9
-
17
-
-
0030888664
-
BCL-2 antisense therapy in patients with non-Hodgkin lymphoma
-
Webb, A., Cunningham, D., Cotter, F., Clarke, P. A., di Stefano, F., Ross, P., Corbo, M., and Dziewanowska, Z. BCL-2 antisense therapy in patients with non-Hodgkin lymphoma. Lancet, 349: 1137-1141, 1997.
-
(1997)
Lancet
, vol.349
, pp. 1137-1141
-
-
Webb, A.1
Cunningham, D.2
Cotter, F.3
Clarke, P.A.4
Di Stefano, F.5
Ross, P.6
Corbo, M.7
Dziewanowska, Z.8
-
18
-
-
0031907428
-
Bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice
-
Jansen, B., Schlagbauer-Wadl, H., Brown, B. D., Bryan, R. N., van Elsas, A., Muller, M., Wolff, K., Eichler, H. G., and Pehamberger, H. bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice. Nat. Med., 4: 232-234, 1998.
-
(1998)
Nat. Med.
, vol.4
, pp. 232-234
-
-
Jansen, B.1
Schlagbauer-Wadl, H.2
Brown, B.D.3
Bryan, R.N.4
Van Elsas, A.5
Muller, M.6
Wolff, K.7
Eichler, H.G.8
Pehamberger, H.9
-
19
-
-
0034684471
-
Chemosensitisation of malignant melanoma by BCL-2 antisense therapy
-
Jansen, B., Wacheck, V., Heere-Ress, E., Schlagbauer-Wadl, H., Hoeller, C., Lucas, T., Hoermann, M., Wolff, K., and Pehamberger, H. Chemosensitisation of malignant melanoma by BCL-2 antisense therapy. Lancet, 356: 1728-1733, 2000.
-
(2000)
Lancet
, vol.356
, pp. 1728-1733
-
-
Jansen, B.1
Wacheck, V.2
Heere-Ress, E.3
Schlagbauer-Wadl, H.4
Hoeller, C.5
Lucas, T.6
Hoermann, M.7
Wolff, K.8
Pehamberger, H.9
-
20
-
-
1642618055
-
Molecular and pharmacokinetic properties associated with the therapeutics of bcl-2 antisense oligonucleotide G3139 combined with free and liposomal doxorubicin
-
Lopes de Menezes, D. E., Hudon, N., McIntosh, N., and Mayer, L. D. Molecular and pharmacokinetic properties associated with the therapeutics of bcl-2 antisense oligonucleotide G3139 combined with free and liposomal doxorubicin. Clin. Cancer Res., 6: 2891-2902, 2000.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 2891-2902
-
-
Lopes de Menezes, D.E.1
Hudon, N.2
McIntosh, N.3
Mayer, L.D.4
-
21
-
-
0034606686
-
Chemosentisization and delayed androgen-independent recurrence of prostate cancer with the use of antisense Bcl-2 oligodeoxynucleotides
-
Miyake, H., Tolcher, A., and Gleave, M. E. Chemosentisization and delayed androgen-independent recurrence of prostate cancer with the use of antisense Bcl-2 oligodeoxynucleotides. J. Natl. Cancer Inst., 92: 34-41, 2000.
-
(2000)
J. Natl. Cancer Inst.
, vol.92
, pp. 34-41
-
-
Miyake, H.1
Tolcher, A.2
Gleave, M.E.3
-
22
-
-
0034784534
-
Bcl-2 antisense oligonucleotides chemosensitize human gastric cancer in a SCID mouse xenotransplantation model
-
Wacheck, V., Heere-Ress, E., Halaschek-Wiener, J., Lucas, T., Meyer, H., Eichler, H. G., and Jansen, B. Bcl-2 antisense oligonucleotides chemosensitize human gastric cancer in a SCID mouse xenotransplantation model. J. Mol. Med., 79: 587-593, 2001.
-
(2001)
J. Mol. Med.
, vol.79
, pp. 587-593
-
-
Wacheck, V.1
Heere-Ress, E.2
Halaschek-Wiener, J.3
Lucas, T.4
Meyer, H.5
Eichler, H.G.6
Jansen, B.7
-
23
-
-
0035678781
-
A phase I dose-finding study of combined treatment with an antisense Bcl-2 oligonucleotide (Genasense) and mitoxantrone in patients with metastatic hormone-refractory prostate cancer
-
Chi, K. N., Gleave, M. E., Klasa, R., Murray, N., Bryce, C., Lopes de Menezes, D. E., D'Aloisio, S., and Tolcher, A. W. A phase I dose-finding study of combined treatment with an antisense Bcl-2 oligonucleotide (Genasense) and mitoxantrone in patients with metastatic hormone-refractory prostate cancer. Clin. Cancer Res., 7: 3920-3927, 2001.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 3920-3927
-
-
Chi, K.N.1
Gleave, M.E.2
Klasa, R.3
Murray, N.4
Bryce, C.5
Lopes de Menezes, D.E.6
D'Aloisio, S.7
Tolcher, A.W.8
-
24
-
-
0036137646
-
Phamacokinetics of Bcl-2 antisense oligonucleotide (G3139) combined with doxorubicin in SCID mice bearing human breast cancer solid tumor xenografts
-
Lopes, D., and Mayer, L. D. Phamacokinetics of Bcl-2 antisense oligonucleotide (G3139) combined with doxorubicin in SCID mice bearing human breast cancer solid tumor xenografts. Cancer Chemother. Pharmacol., 49: 57-68, 2002.
-
(2002)
Cancer Chemother. Pharmacol.
, vol.49
, pp. 57-68
-
-
Lopes, D.1
Mayer, L.D.2
-
25
-
-
0036236808
-
A pilot trial of G3139, a bcl-2 antisense oligonucleotide, and paclitaxel in patients with chemorefractory small-cell lung cancer
-
Rudin, C. M., Otterson, G. A., Mauer, A. M., Villalona-Calero, M. A., Tomek, R., Prange, B., Geoge, C. M., Szeto, L., and Vokes, E. E. A pilot trial of G3139, a bcl-2 antisense oligonucleotide, and paclitaxel in patients with chemorefractory small-cell lung cancer. Ann. Oncol., 13: 539-545, 2002.
-
(2002)
Ann. Oncol.
, vol.13
, pp. 539-545
-
-
Rudin, C.M.1
Otterson, G.A.2
Mauer, A.M.3
Villalona-Calero, M.A.4
Tomek, R.5
Prange, B.6
Geoge, C.M.7
Szeto, L.8
Vokes, E.E.9
-
26
-
-
0037438586
-
Phase I pharmacodynamic studies of G3139, a bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia
-
Marcucci, G., Byrd, J. C., Dai, G., Klisovic, M. I., Youg, D. C., Cataland, S. R., Fisher, D. B., Lucas, D., Chan, K. K., Porcu, P., Lin, Z. P., Farag, S. F., Frankel, S. R., Zweibel, J. A., Kraut, E. H., Balcerzak, S. P., Bloomfield, C. D., Grever, M. R., and Caligiuri, M. A. Phase I and pharmacodynamic studies of G3139, a bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia. Blood, 102: 425-432, 2003.
-
(2003)
Blood
, vol.102
, pp. 425-432
-
-
Marcucci, G.1
Byrd, J.C.2
Dai, G.3
Klisovic, M.I.4
Youg, D.C.5
Cataland, S.R.6
Fisher, D.B.7
Lucas, D.8
Chan, K.K.9
Porcu, P.10
Lin, Z.P.11
Farag, S.F.12
Frankel, S.R.13
Zweibel, J.A.14
Kraut, E.H.15
Balcerzak, S.P.16
Bloomfield, C.D.17
Grever, M.R.18
Caligiuri, M.A.19
-
27
-
-
0030813877
-
SH2-containing phosphotyrosine phosphatase SHP-1 is involved in BCR-ABL signal transduction pathways
-
Tauchi, T., Ohyashiki, K., Yamashita, Y., Sugimoto, S., and Toyama, K. SH2-containing phosphotyrosine phosphatase SHP-1 is involved in BCR-ABL signal transduction pathways. Int. J. Oncol., 11: 471-475, 1997.
-
(1997)
Int. J. Oncol.
, vol.11
, pp. 471-475
-
-
Tauchi, T.1
Ohyashiki, K.2
Yamashita, Y.3
Sugimoto, S.4
Toyama, K.5
-
28
-
-
0035108553
-
CIS1, a cytokine-inducible SH2 protein, suppresses BCR/ABL-mediated transformation: Involvement of the ubiquitin proteasome pathway
-
Tauchi, T., Yoshimura, A., and Ohyashiki, K. CIS1, a cytokine-inducible SH2 protein, suppresses BCR/ABL-mediated transformation: Involvement of the ubiquitin proteasome pathway. Exp. Hematol., 29: 356-361, 2001.
-
(2001)
Exp. Hematol.
, vol.29
, pp. 356-361
-
-
Tauchi, T.1
Yoshimura, A.2
Ohyashiki, K.3
-
29
-
-
0036845833
-
Inhibition of human telomerase enhances the effect of the tyrosine kinase inhibitor, imatinib, in BCR-ABL-positive leukemia cells
-
Tauchi, T., Nakajima, A., Sashida, G., Shimamoto, T., Ohyashiki, J. H., Abe, K., Yamamoto, K., and Ohyashiki, K. Inhibition of human telomerase enhances the effect of the tyrosine kinase inhibitor, imatinib, in BCR-ABL-positive leukemia cells. Clin. Cancer Res., 8: 3341-3347, 2002.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 3341-3347
-
-
Tauchi, T.1
Nakajima, A.2
Sashida, G.3
Shimamoto, T.4
Ohyashiki, J.H.5
Abe, K.6
Yamamoto, K.7
Ohyashiki, K.8
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