메뉴 건너뛰기




Volumn 62, Issue 24, 2005, Pages 3057-3066

siRNA-mediated transcriptional gene silencing: The potential mechanism and a possible role in the histone code

Author keywords

DNMT3A; Histone code; RNAi; siRNA; Transcriptional gene silencing

Indexed keywords

DNA METHYLTRANSFERASE; DOUBLE STRANDED RNA; HISTONE; RNA POLYMERASE; SMALL INTERFERING RNA;

EID: 29344463071     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-005-5182-4     Document Type: Review
Times cited : (78)

References (86)
  • 1
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • Egger G., Liang G., Aparicio A. and Jones P. A. (2004) Epigenetics in human disease and prospects for epigenetic therapy. Nature 429: 457-463
    • (2004) Nature , vol.429 , pp. 457-463
    • Egger, G.1    Liang, G.2    Aparicio, A.3    Jones, P.A.4
  • 2
    • 1542715330 scopus 로고    scopus 로고
    • Epigenetic heredity in evolution
    • Jablonka E. and Lamb M. J. (2003) [Epigenetic heredity in evolution]. Tsitologiia 45: 1057-1072
    • (2003) Tsitologiia , vol.45 , pp. 1057-1072
    • Jablonka, E.1    Lamb, M.J.2
  • 3
    • 1542680530 scopus 로고    scopus 로고
    • Epigenetic inheritance and its possible role in the evolution of plant species
    • Lavrov S. A. and Mavrodiev E. V. (2003) Epigenetic inheritance and its possible role in the evolution of plant species. Zh. Obshch. Biol. 64: 403-420
    • (2003) Zh. Obshch. Biol. , vol.64 , pp. 403-420
    • Lavrov, S.A.1    Mavrodiev, E.V.2
  • 4
    • 0038505671 scopus 로고    scopus 로고
    • Epigenomic replication: Linking epigenetics to DNA replication
    • McNairn A. J. and Gilbert D. M. (2003) Epigenomic replication: linking epigenetics to DNA replication. Bioessays 25: 647-656
    • (2003) Bioessays , vol.25 , pp. 647-656
    • McNairn, A.J.1    Gilbert, D.M.2
  • 5
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double stranded RNA in Caenorhabditis elegans
    • Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., Mello C.C. (1998) Potent and specific genetic interference by double stranded RNA in Caenorhabditis elegans. Nature 391: 806-811
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 8
    • 0032417618 scopus 로고    scopus 로고
    • RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans
    • Montgomery M. K., Xu M.A., Fire A. (1998) RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans. Proc. Natl. Acad. Sci. 95: 15502-15507
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 15502-15507
    • Montgomery, M.K.1    Xu, M.A.2    Fire, A.3
  • 9
    • 0035900635 scopus 로고    scopus 로고
    • A short primer on RNAi: RNA-directed RNA polymerase acts as a key catalyst
    • Nishikura K. (2001) A short primer on RNAi: RNA-directed RNA polymerase acts as a key catalyst. Cell 107: 415-418
    • (2001) Cell , vol.107 , pp. 415-418
    • Nishikura, K.1
  • 10
    • 0035281741 scopus 로고    scopus 로고
    • RNA interference
    • Sharp P. A. (2001) RNA interference. Gen. Dev. 15: 485-490
    • (2001) Gen. Dev. , vol.15 , pp. 485-490
    • Sharp, P.A.1
  • 12
    • 4644336023 scopus 로고    scopus 로고
    • Revealing the world of RNA interference
    • Mello C. C. and Conte D. Jr (2004) Revealing the world of RNA interference. Nature 431: 338-342
    • (2004) Nature , vol.431 , pp. 338-342
    • Mello, C.C.1    Conte Jr., D.2
  • 13
    • 13944266785 scopus 로고    scopus 로고
    • A potential role for RNA interference in controlling the activity of the human LINE-1 retrotransposon
    • Soifer H. S., Zaragoza A., Peyvan M., Behlke M. A. and Rossi J. J. (2005) A potential role for RNA interference in controlling the activity of the human LINE-1 retrotransposon. Nucleic Acids Res. 33: 846-856
    • (2005) Nucleic Acids Res. , vol.33 , pp. 846-856
    • Soifer, H.S.1    Zaragoza, A.2    Peyvan, M.3    Behlke, M.A.4    Rossi, J.J.5
  • 14
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein E., Caudy A. A., Hammond S. M. and Hannon G. J. (2001) Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409: 363-366
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 15
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir S. M., Harborth J., Lendeckel W., Yalcin A., Weber K. and Tuschl T. (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 16
    • 0034737298 scopus 로고    scopus 로고
    • RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
    • Zamore P. D., Tuschl T., Sharp P. A. and Bartel D. P. (2000) RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101: 25-33
    • (2000) Cell , vol.101 , pp. 25-33
    • Zamore, P.D.1    Tuschl, T.2    Sharp, P.A.3    Bartel, D.P.4
  • 17
    • 14644393684 scopus 로고    scopus 로고
    • Perspective: Machines for RNAi
    • Tomari Y. and Zamore P. D. (2005) Perspective: machines for RNAi. Genes Dev. 19: 517-29
    • (2005) Genes Dev. , vol.19 , pp. 517-529
    • Tomari, Y.1    Zamore, P.D.2
  • 18
    • 0034673638 scopus 로고    scopus 로고
    • An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
    • Hammond S. M., Bernstein E., Beach D. and Hannon G. J. (2000) An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 404: 293-296
    • (2000) Nature , vol.404 , pp. 293-296
    • Hammond, S.M.1    Bernstein, E.2    Beach, D.3    Hannon, G.J.4
  • 19
    • 0035839109 scopus 로고    scopus 로고
    • Argonaute2, a link between genetic and biochemical analyses of RNAi
    • Hammond S. M., Boettcher S., Caudy A. A., Kobayashi R. and Hannon G. J. (2001) Argonaute2, a link between genetic and biochemical analyses of RNAi. Science 293: 1146-1150
    • (2001) Science , vol.293 , pp. 1146-1150
    • Hammond, S.M.1    Boettcher, S.2    Caudy, A.A.3    Kobayashi, R.4    Hannon, G.J.5
  • 21
    • 0037663944 scopus 로고    scopus 로고
    • Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages
    • Song E., Lee S., S. Dykxhoorn S., Novina C., Zhang D., Crawford K. et al. (2003) Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages. J. Virol. 77: 7174-7181
    • (2003) J. Virol. , vol.77 , pp. 7174-7181
    • Song, E.1    Lee, S.2    S. Dykxhoorn, S.3    Novina, C.4    Zhang, D.5    Crawford, K.6
  • 22
    • 0036245743 scopus 로고    scopus 로고
    • Expanding small RNA interference
    • Tuschl T. (2002) Expanding small RNA interference. Nat. Biotechnol. 20: 446-448
    • (2002) Nat. Biotechnol. , vol.20 , pp. 446-448
    • Tuschl, T.1
  • 23
    • 0036074161 scopus 로고    scopus 로고
    • RNA interference in human cells is restricted to the cytoplasm
    • Zeng Y. and Cullen B. R. (2002). RNA interference in human cells is restricted to the cytoplasm. RNA 8: 855-860
    • (2002) RNA , vol.8 , pp. 855-860
    • Zeng, Y.1    Cullen, B.R.2
  • 24
    • 22144478256 scopus 로고    scopus 로고
    • MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies
    • Liu J., Valencia-Sanchez M. A., Hannon G. J. and Parker R. (2005) MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat. Cell. Biol. 7: 719-723
    • (2005) Nat. Cell. Biol. , vol.7 , pp. 719-723
    • Liu, J.1    Valencia-Sanchez, M.A.2    Hannon, G.J.3    Parker, R.4
  • 25
    • 0035916831 scopus 로고    scopus 로고
    • Transcriptional and posttranscriptional gene silencing are mechansitically related
    • Sijen T., Vign G. J., Rebocho A., Blokland R., Roelofs D., Mol J. and Kooter J. (2001). Transcriptional and posttranscriptional gene silencing are mechansitically related. Curr. Biol. 11: 436-440
    • (2001) Curr. Biol. , vol.11 , pp. 436-440
    • Sijen, T.1    Vign, G.J.2    Rebocho, A.3    Blokland, R.4    Roelofs, D.5    Mol, J.6    Kooter, J.7
  • 26
    • 0000213492 scopus 로고
    • Reversible methylation and inactivation of marker genes in sequentially transformed tobacco plants
    • Matzke M. A., Primig M., Trnovsky J. and Matzke A. J. M. (1989) Reversible methylation and inactivation of marker genes in sequentially transformed tobacco plants. EMBO J. 8: 643-649
    • (1989) EMBO J. , vol.8 , pp. 643-649
    • Matzke, M.A.1    Primig, M.2    Trnovsky, J.3    Matzke, A.J.M.4
  • 27
    • 0028031830 scopus 로고
    • RNA-directed de novo methylation of genomic sequences in plants
    • Wassenegger M., Graham M. W. and Wang M. D. (1994). RNA-directed de novo methylation of genomic sequences in plants. Cell 76: 567-576
    • (1994) Cell , vol.76 , pp. 567-576
    • Wassenegger, M.1    Graham, M.W.2    Wang, M.D.3
  • 28
    • 0034596989 scopus 로고    scopus 로고
    • Transcriptional silencing and promoter methylation triggered by double-stranded RNA
    • Mette M. F., Aufsatz W., Van der Winden J., Matzke A. J. M. and Matzke M.A. (2000) Transcriptional silencing and promoter methylation triggered by double-stranded RNA. EMBO J. 19: 5194-5201
    • (2000) EMBO J. , vol.19 , pp. 5194-5201
    • Mette, M.F.1    Aufsatz, W.2    Van Der Winden, J.3    Matzke, A.J.M.4    Matzke, M.A.5
  • 29
    • 0037009520 scopus 로고    scopus 로고
    • Two classes of short interfering RNA in RNA silencing
    • Hamilton A., Voinnet O., Chappell L. and Baulcombe D. (2002) Two classes of short interfering RNA in RNA silencing. EMBO J. 21: 4671-4679
    • (2002) EMBO J. , vol.21 , pp. 4671-4679
    • Hamilton, A.1    Voinnet, O.2    Chappell, L.3    Baulcombe, D.4
  • 30
    • 0037474126 scopus 로고    scopus 로고
    • ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation
    • Zilberman D., Cao X. and Jacobsen S. E. (2003) ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. Science 299: 716-719
    • (2003) Science , vol.299 , pp. 716-719
    • Zilberman, D.1    Cao, X.2    Jacobsen, S.E.3
  • 31
    • 0037072661 scopus 로고    scopus 로고
    • Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi
    • Volpe T. A., Kidner C., Hall I. M., Teng G., Grewal S. I. S., Martienssen R. A. (2002) Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science 297: 1833-1837
    • (2002) Science , vol.297 , pp. 1833-1837
    • Volpe, T.A.1    Kidner, C.2    Hall, I.M.3    Teng, G.4    Grewal, S.I.S.5    Martienssen, R.A.6
  • 33
    • 10944248935 scopus 로고    scopus 로고
    • Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs
    • Motamedi M. R., Verdel A., Colmenares S. U., Gerber S. A., Gygi S. P. and Moazed D. (2004) Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. Cell 119: 789-802
    • (2004) Cell , vol.119 , pp. 789-802
    • Motamedi, M.R.1    Verdel, A.2    Colmenares, S.U.3    Gerber, S.A.4    Gygi, S.P.5    Moazed, D.6
  • 34
    • 22344434734 scopus 로고    scopus 로고
    • RNA Polymerase II is Required for RNAi-Dependent Heterochromatin Assembly
    • Kato H., Goto D. B., Martienssen R. A., Urano T., Furukawa K. and Murakami Y. (2005) RNA Polymerase II is Required for RNAi-Dependent Heterochromatin Assembly. Science 309: 467-469
    • (2005) Science , vol.309 , pp. 467-469
    • Kato, H.1    Goto, D.B.2    Martienssen, R.A.3    Urano, T.4    Furukawa, K.5    Murakami, Y.6
  • 35
    • 21744462775 scopus 로고    scopus 로고
    • RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription
    • Schramke V., Sheedy D. M., Denli A. M., Bonila C., Ekwall K., Hannon G. J. et al. (2005) RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription. Nature 435: 1275-1279
    • (2005) Nature , vol.435 , pp. 1275-1279
    • Schramke, V.1    Sheedy, D.M.2    Denli, A.M.3    Bonila, C.4    Ekwall, K.5    Hannon, G.J.6
  • 36
    • 0036775704 scopus 로고    scopus 로고
    • Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1alpha
    • Muchardt C., Guilleme M., Seeler J. S., Trouche D., Dejean A. and Yaniv M. (2002) Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1alpha. EMBO Rep 3: 975-981
    • (2002) EMBO Rep , vol.3 , pp. 975-981
    • Muchardt, C.1    Guilleme, M.2    Seeler, J.S.3    Trouche, D.4    Dejean, A.5    Yaniv, M.6
  • 38
    • 4344705410 scopus 로고    scopus 로고
    • Small interfering RNA-induced transcriptional gene silencing in human cells
    • Morris K. V., Chan S. W., Jacobsen S. E. and Looney D. J. (2004) Small interfering RNA-induced transcriptional gene silencing in human cells. Science 305: 1289-1292
    • (2004) Science , vol.305 , pp. 1289-1292
    • Morris, K.V.1    Chan, S.W.2    Jacobsen, S.E.3    Looney, D.J.4
  • 39
    • 0032410928 scopus 로고    scopus 로고
    • Double-stranded RNA induces mRNA degradation in Trypanosoma brucei
    • Ngo H., Tschudi C., Gull K. and Ullu E. (1998) Double-stranded RNA induces mRNA degradation in Trypanosoma brucei. Proc. Natl. Acad. Sci. 95: 14687-14692
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 14687-14692
    • Ngo, H.1    Tschudi, C.2    Gull, K.3    Ullu, E.4
  • 40
    • 20844435197 scopus 로고    scopus 로고
    • Short hairpin RNA-directed cytosine (CpG) methylation of the RASSF1A gene promoter in HeLa cells
    • Castanotto D., Tommasi S., Li M., Li H., Yanow S., Pfeifer G. P. et al. (2005) Short hairpin RNA-directed cytosine (CpG) methylation of the RASSF1A gene promoter in HeLa cells. Mol. Ther. 12: 179-183
    • (2005) Mol. Ther. , vol.12 , pp. 179-183
    • Castanotto, D.1    Tommasi, S.2    Li, M.3    Li, H.4    Yanow, S.5    Pfeifer, G.P.6
  • 41
    • 4544242851 scopus 로고    scopus 로고
    • Induction of DNA methylation and gene silencing by short interfering RNAs in human cells
    • Kawasaki H. and Taira K. (2004) Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature 9: 211-217
    • (2004) Nature , vol.9 , pp. 211-217
    • Kawasaki, H.1    Taira, K.2
  • 42
    • 23044507007 scopus 로고    scopus 로고
    • Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation
    • Ting A. H., Schuebel K. E., Herman J. G. and Baylin S. B. (2005). Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation. Nat. Genet. 37: 906-910
    • (2005) Nat. Genet. , vol.37 , pp. 906-910
    • Ting, A.H.1    Schuebel, K.E.2    Herman, J.G.3    Baylin, S.B.4
  • 43
    • 20844434177 scopus 로고    scopus 로고
    • Transcriptional silencing of nonsense codon-containing immunoglobulin minigenes
    • Buhler M., Mohn F., Stalder L. and Muhlemann O. (2005) Transcriptional silencing of nonsense codon-containing immunoglobulin minigenes. Mol. Cell 18: 307-317
    • (2005) Mol. Cell , vol.18 , pp. 307-317
    • Buhler, M.1    Mohn, F.2    Stalder, L.3    Muhlemann, O.4
  • 44
    • 24944589860 scopus 로고    scopus 로고
    • siRNA Induced Transcriptional Gene Silencing in Mammalian Cells
    • Kawasaki H., Taira K. and Morris K. V. (2005) siRNA Induced Transcriptional Gene Silencing in Mammalian Cells. Cell Cycle 4: 442-448
    • (2005) Cell Cycle , vol.4 , pp. 442-448
    • Kawasaki, H.1    Taira, K.2    Morris, K.V.3
  • 46
    • 0035859046 scopus 로고    scopus 로고
    • Gene silencing as an adaptive defence against viruses
    • Waterhouse P. M., Wang M. B. and Lough T. (2001). Gene silencing as an adaptive defence against viruses. Nature 411: 834-842
    • (2001) Nature , vol.411 , pp. 834-842
    • Waterhouse, P.M.1    Wang, M.B.2    Lough, T.3
  • 47
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • Okano M., Bell D. W., Haber D. A. and Li E. (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99: 247-57
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 48
    • 0035962632 scopus 로고    scopus 로고
    • DNA methylation, chromatin inheritance and cancer
    • Rountree M. R., Bachman K. E., Herman J. G. and Baylin S. B. (2001) DNA methylation, chromatin inheritance and cancer. Oncogene 20: 3156-3165
    • (2001) Oncogene , vol.20 , pp. 3156-3165
    • Rountree, M.R.1    Bachman, K.E.2    Herman, J.G.3    Baylin, S.B.4
  • 49
    • 0032769445 scopus 로고    scopus 로고
    • Cloning, expression and chromosome locations of the human DNMT3 gene family
    • Xie S., Wang Z., Okano M., Nogami M., Li Y., He W. W. et al. (1999). Cloning, expression and chromosome locations of the human DNMT3 gene family. Gene 236: 87-95
    • (1999) Gene , vol.236 , pp. 87-95
    • Xie, S.1    Wang, Z.2    Okano, M.3    Nogami, M.4    Li, Y.5    He, W.W.6
  • 50
    • 0031662164 scopus 로고    scopus 로고
    • Transcription of IAP endogenous retroviruses is constrained by cytosine methylation
    • Walsh C. P., Chaillet J. R. and Bestor T. H. (1998) Transcription of IAP endogenous retroviruses is constrained by cytosine methylation. Nat. Genet. 20: 116-117
    • (1998) Nat. Genet. , vol.20 , pp. 116-117
    • Walsh, C.P.1    Chaillet, J.R.2    Bestor, T.H.3
  • 51
    • 0027535235 scopus 로고
    • Effects of DNA methylation on DNA-binding proteins and gene expression
    • Tate P. H. and Bird A. P. (1993) Effects of DNA methylation on DNA-binding proteins and gene expression. Curr. Opin. Genet. Dev. 3: 226-231
    • (1993) Curr. Opin. Genet. Dev. , vol.3 , pp. 226-231
    • Tate, P.H.1    Bird, A.P.2
  • 52
    • 0344630574 scopus 로고
    • Chromatin structure is required to block transcription of the methylated herpes simplex virus thymidine kinase gene
    • USA
    • Buschhausen G., Wittig B., Graessmann M. and Graessmann A. (1987) Chromatin structure is required to block transcription of the methylated herpes simplex virus thymidine kinase gene. Proc. Natl. Acad. Sci. USA 84: 1177-1181
    • (1987) Proc. Natl. Acad. Sci. , vol.84 , pp. 1177-1181
    • Buschhausen, G.1    Wittig, B.2    Graessmann, M.3    Graessmann, A.4
  • 53
    • 0031618962 scopus 로고    scopus 로고
    • DNA methylation, nucleosomes and the inheritance of chromatin structure and function
    • Kass S. U. and Wolffe A. P. (1998) DNA methylation, nucleosomes and the inheritance of chromatin structure and function. Novartis Found. Symp. 214: 22-35; discussion 36-50
    • (1998) Novartis Found. Symp. , vol.214 , pp. 22-35
    • Kass, S.U.1    Wolffe, A.P.2
  • 54
    • 0035943709 scopus 로고    scopus 로고
    • Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin
    • Bachman K. E., Rountree M. R., and Baylin S. B. (2001) Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin. J. Biol. Chem. 276: 32282-32287
    • (2001) J. Biol. Chem. , vol.276 , pp. 32282-32287
    • Bachman, K.E.1    Rountree, M.R.2    Baylin, S.B.3
  • 55
    • 1342306395 scopus 로고    scopus 로고
    • Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription
    • Ling Y., Sankpal U. T., Robertson A. K., McNally J. G., Karpova T. and Robertson K. D. (2004) Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription. Nucleic Acids Res. 32: 598-610
    • (2004) Nucleic Acids Res. , vol.32 , pp. 598-610
    • Ling, Y.1    Sankpal, U.T.2    Robertson, A.K.3    McNally, J.G.4    Karpova, T.5    Robertson, K.D.6
  • 56
    • 0037376690 scopus 로고    scopus 로고
    • Biochemical fractionation reveals association of DNA methyltransferase (Dnmt) 3b with Dnmt1 and that of Dnmt 3a with a histone H3 methyltransferase and Hdac1
    • Datta J., Ghoshal K., Sharma S. M., Tajima S. and Jacob S. T. (2003) Biochemical fractionation reveals association of DNA methyltransferase (Dnmt) 3b with Dnmt1 and that of Dnmt 3a with a histone H3 methyltransferase and Hdac1. J. Cell. Biochem. 88: 855-864
    • (2003) J. Cell. Biochem. , vol.88 , pp. 855-864
    • Datta, J.1    Ghoshal, K.2    Sharma, S.M.3    Tajima, S.4    Jacob, S.T.5
  • 57
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein T. and Allis D. S. (2001) Translating the histone code. Science 293: 1074-1080
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, D.S.2
  • 58
    • 0032948005 scopus 로고    scopus 로고
    • Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
    • Cameron E. E., Bachman K. E., Myohanen S., Herman J. G. and Baylin S. B. (1999) Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat. Genet. 21: 103-107
    • (1999) Nat. Genet. , vol.21 , pp. 103-107
    • Cameron, E.E.1    Bachman, K.E.2    Myohanen, S.3    Herman, J.G.4    Baylin, S.B.5
  • 59
    • 4143149753 scopus 로고    scopus 로고
    • Dicer is essential for formation of the heterochromatin structure in vertebrate cells
    • Fukagawa T., Nogami M., Yoshikawa M., Ikeno M., Okazaki T., Takami Y. et al. (2004) Dicer is essential for formation of the heterochromatin structure in vertebrate cells. Nat. Cell. Biol. 6: 784-791
    • (2004) Nat. Cell. Biol. , vol.6 , pp. 784-791
    • Fukagawa, T.1    Nogami, M.2    Yoshikawa, M.3    Ikeno, M.4    Okazaki, T.5    Takami, Y.6
  • 60
    • 13844294261 scopus 로고    scopus 로고
    • Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing
    • Kanellopoulou C., Muljo S. A., Kung A. L., Ganesan S., Drapkin R., Jenuwein T. et al. (2005) Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Gen. Dev. 19: 489-501
    • (2005) Gen. Dev. , vol.19 , pp. 489-501
    • Kanellopoulou, C.1    Muljo, S.A.2    Kung, A.L.3    Ganesan, S.4    Drapkin, R.5    Jenuwein, T.6
  • 61
    • 10644221797 scopus 로고    scopus 로고
    • RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing
    • Noma K. I., Sugiyama T., Cam H., Verdel A., Zofall M., Jia S. et al. (2004). RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing. Nat. Genet. 36: 1174-1180
    • (2004) Nat. Genet. , vol.36 , pp. 1174-1180
    • Noma, K.I.1    Sugiyama, T.2    Cam, H.3    Verdel, A.4    Zofall, M.5    Jia, S.6
  • 64
    • 0036779319 scopus 로고    scopus 로고
    • Acetylated, methylated, remodeled: Chromatin states for gene regulation
    • Lusser A. (2002) Acetylated, methylated, remodeled: chromatin states for gene regulation. Curr. Opin. Plant Biol. 5: 437-43
    • (2002) Curr. Opin. Plant Biol. , vol.5 , pp. 437-443
    • Lusser, A.1
  • 65
    • 0033592999 scopus 로고    scopus 로고
    • Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in tetrahymena
    • In Process Citation. USA
    • StrahlB. D., Ohba, Cook R. G. and Allis C. D. (1999) Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in tetrahymena [In Process Citation]. Proc. Natl. Acad. Sci. USA 96: 14967-14972
    • (1999) Proc. Natl. Acad. Sci. , vol.96 , pp. 14967-14972
    • Strahlb, D.1    Ohba2    Cook, R.G.3    Allis, C.D.4
  • 66
    • 0033848849 scopus 로고    scopus 로고
    • Histone acetylation and an epigenetic code
    • Turner B. M. (2000). Histone acetylation and an epigenetic code. Bioessays 22: 836-845
    • (2000) Bioessays , vol.22 , pp. 836-845
    • Turner, B.M.1
  • 67
    • 0035815360 scopus 로고    scopus 로고
    • Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly
    • Nakayama J., Rice J. C., Strahl B. D., Allis C. D. and Grewal S. I. (2001) Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science 292: 110-113
    • (2001) Science , vol.292 , pp. 110-113
    • Nakayama, J.1    Rice, J.C.2    Strahl, B.D.3    Allis, C.D.4    Grewal, S.I.5
  • 68
    • 0036337759 scopus 로고    scopus 로고
    • Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes
    • Boggs B. A., Cheung P., Heard E., Spector D. L., Chinault A. C. and Allis C. D. (2002) Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes. Nat. Genet. 30: 73-76
    • (2002) Nat. Genet. , vol.30 , pp. 73-76
    • Boggs, B.A.1    Cheung, P.2    Heard, E.3    Spector, D.L.4    Chinault, A.C.5    Allis, C.D.6
  • 69
    • 0033118322 scopus 로고    scopus 로고
    • Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31
    • Aagaard L., Laible G., Selenko P., Schmid M., Dorn R., Schotta G. et al. (1999) Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J. 18: 1923-1938
    • (1999) EMBO J. , vol.18 , pp. 1923-1938
    • Aagaard, L.1    Laible, G.2    Selenko, P.3    Schmid, M.4    Dorn, R.5    Schotta, G.6
  • 71
    • 0035282573 scopus 로고    scopus 로고
    • Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
    • Lachner M., O'Carroll D., Rea S., Mechtler K. and Jenuwein T. (2001) Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410: 116-120
    • (2001) Nature , vol.410 , pp. 116-120
    • Lachner, M.1    O'Carroll, D.2    Rea, S.3    Mechtler, K.4    Jenuwein, T.5
  • 72
    • 0036787922 scopus 로고    scopus 로고
    • Association of class II histone deacetylases with heterochromatin protein 1: Potential role for histone methylation in control of muscle differentiation
    • Zhang C. L., McKinsey T. A. and Olson E. N. (2002). Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation. Mol. Cell. Biol. 22: 7302-7312
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 7302-7312
    • Zhang, C.L.1    McKinsey, T.A.2    Olson, E.N.3
  • 73
    • 0033838255 scopus 로고    scopus 로고
    • Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: Direct chromoshadow domain-KAP-1 corepressor interaction is essential
    • Lechner M. S., Begg G. E., Speicher D. W. and Rauscher III F. J. (2000) Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: Direct chromoshadow domain-KAP-1 corepressor interaction is essential. Mol. Cell. Biol. 20: 6449-6465
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 6449-6465
    • Lechner, M.S.1    Begg, G.E.2    Speicher, D.W.3    Rauscher III, F.J.4
  • 74
    • 0033571206 scopus 로고    scopus 로고
    • Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family
    • Nielsen A. L., Ortiz J. A., You J., Oulad-Abdelghani M., Khechumian R., Gansmuller A. et al. (1999) Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family. EMBO J. 18: 6385-6395
    • (1999) EMBO J. , vol.18 , pp. 6385-6395
    • Nielsen, A.L.1    Ortiz, J.A.2    You, J.3    Oulad-Abdelghani, M.4    Khechumian, R.5    Gansmuller, A.6
  • 75
    • 0033013868 scopus 로고    scopus 로고
    • KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: A potential role for Kruppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing. Mol
    • Ryan R. F., Schultz D. C., Ayyanathan K., Singh P. B., Friedman J. R., Fredericks W. J. et al. (1999) KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Kruppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing. Mol. Cell. Biol. 19: 4366-4378
    • (1999) Cell. Biol. , vol.19 , pp. 4366-4378
    • Ryan, R.F.1    Schultz, D.C.2    Ayyanathan, K.3    Singh, P.B.4    Friedman, J.R.5    Fredericks, W.J.6
  • 76
    • 10344250458 scopus 로고    scopus 로고
    • Components of the DNA methylation system of chromatin control are RNA-binding proteins
    • Jeffery L. and Nakielny D. S. (2004) Components of the DNA methylation system of chromatin control are RNA-binding proteins. J. Biol. Chem. 279: 49479-49487
    • (2004) J. Biol. Chem. , vol.279 , pp. 49479-49487
    • Jeffery, L.1    Nakielny, D.S.2
  • 77
    • 0035873225 scopus 로고    scopus 로고
    • Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription
    • Fuks F., Burgers W. A., Godin N., Kasai M. and Kouzarides T. (2001) Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. EMBO J. 20: 2536-2544
    • (2001) EMBO J. , vol.20 , pp. 2536-2544
    • Fuks, F.1    Burgers, W.A.2    Godin, N.3    Kasai, M.4    Kouzarides, T.5
  • 78
    • 0038412822 scopus 로고    scopus 로고
    • The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase
    • Fuks F., Hurd P. J., Deplus R. and Kouzarides T. (2003) The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. Nucleic Acids Res. 31: 2305-2312
    • (2003) Nucleic Acids Res. , vol.31 , pp. 2305-2312
    • Fuks, F.1    Hurd, P.J.2    Deplus, R.3    Kouzarides, T.4
  • 79
    • 0033180082 scopus 로고    scopus 로고
    • Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation
    • Zhang Y., Ng H. H., Erdjument-Bromage H., Tempst P., Bird A. and Reinberg D. (1999) Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. 13: 1924-1935
    • (1999) Genes Dev. , vol.13 , pp. 1924-1935
    • Zhang, Y.1    Ng, H.H.2    Erdjument-Bromage, H.3    Tempst, P.4    Bird, A.5    Reinberg, D.6
  • 80
    • 0034968451 scopus 로고    scopus 로고
    • Emerging connections between DNA methylation and histone acetylation
    • Dobosy J. R. and Selker E. U. (2001) Emerging connections between DNA methylation and histone acetylation. Cell. Mol. Life Sci. 58: 721-727
    • (2001) Cell. Mol. Life Sci. , vol.58 , pp. 721-727
    • Dobosy, J.R.1    Selker, E.U.2
  • 81
    • 0033616710 scopus 로고    scopus 로고
    • Genetic analysis of the mouse X inactivation center defines an 80-kb multifunction domain
    • USA
    • Lee J. Lu N., Han Y. (1999) Genetic analysis of the mouse X inactivation center defines an 80-kb multifunction domain. Proc. Natl. Acad. Sci. USA 96: 3836-3841
    • (1999) Proc. Natl. Acad. Sci. , vol.96 , pp. 3836-3841
    • Lee, J.1    Lu, N.2    Han, Y.3
  • 82
    • 0035147369 scopus 로고    scopus 로고
    • Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases
    • Taddei A., Maison C., Roche D. and Almouzni G. (2001) Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases. Nat. Cell. Biol. 3: 114-120
    • (2001) Nat. Cell. Biol. , vol.3 , pp. 114-120
    • Taddei, A.1    Maison, C.2    Roche, D.3    Almouzni, G.4
  • 83
    • 4444302947 scopus 로고    scopus 로고
    • Crystal structure of Argonaute and its implications for RISC slicer activity
    • Song J. J., Smith S. K., Hannon G. J. and Joshua-Tor L. (2004) Crystal structure of Argonaute and its implications for RISC slicer activity. Science 305: 1434-1437
    • (2004) Science , vol.305 , pp. 1434-1437
    • Song, J.J.1    Smith, S.K.2    Hannon, G.J.3    Joshua-Tor, L.4
  • 84
    • 84984758049 scopus 로고    scopus 로고
    • Inhibiting gene expression at transcription start sites in chromosomal DNA with antigene RNAs
    • Janowski B. A., Huffman K. E., Schwartz J. C., Ram R., Hardy D., Shames D. S. et al. (2005) Inhibiting gene expression at transcription start sites in chromosomal DNA with antigene RNAs. Nat. Chem. Biol. 1: 210-215
    • (2005) Nat. Chem. Biol. , vol.1 , pp. 210-215
    • Janowski, B.A.1    Huffman, K.E.2    Schwartz, J.C.3    Ram, R.4    Hardy, D.5    Shames, D.S.6
  • 85
    • 0141843656 scopus 로고    scopus 로고
    • The nuclear RNase III Drosha initiates microRNA processing
    • Lee Y., Ahn C., Han J., Choi H., Kim J., Yim J. et al. (2003) The nuclear RNase III Drosha initiates microRNA processing. Nature 425: 415-419
    • (2003) Nature , vol.425 , pp. 415-419
    • Lee, Y.1    Ahn, C.2    Han, J.3    Choi, H.4    Kim, J.5    Yim, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.