Leu-574 of HIF-1α is essential for the von Hippel-Lindau (VHL)-mediated degradation pathway

Journal of Biological Chemistry

Volumn 277, Issue 44, 2002, Pages 41750-41755

  Eric Huang, L ^a,b,c   Pete, Erin A ^b   Schau, Maureen ^b   Milligan, Justine ^b   Gu, Jie ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c Functional Genetics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIODEGRADATION; DRUG THERAPY; GENES; HYDROXYLATION; MUTAGENESIS; OXYGEN;

TRANSCRIPTIONAL ACTIVATION;

PROTEINS;

HYPOXIA INDUCIBLE FACTOR 1ALPHA; LEUCINE; PROTEASOME; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; GENE DELETION; GENE TARGETING; HOMEOSTASIS; HUMAN; HUMAN CELL; HYDROXYLATION; HYPOXIA; OXYGEN CONSUMPTION; OXYGEN TRANSPORT; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STABILITY; TRANSCRIPTION INITIATION; VON HIPPEL LINDAU DISEASE;

HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LEUCINE; LIGASES; OXYGEN; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 0036828845     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M207280200     Document Type: Article

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