Recent advances in the understanding of the processing of APP to beta amyloid peptide

Annals of the New York Academy of Sciences

Volumn 920, Issue , 2000, Pages 206-208

  Sinha, S ^a   Anderson, J ^a   McConlogue, L ^a   Thorsett, E ^a   Schenk, D ^a  

^a ELAN PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; MALTOSE BINDING PROTEIN;

ALZHEIMER DISEASE; CONFERENCE PAPER; ENZYME PURIFICATION; MEMBRANE BINDING; MISSENSE MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; RECEPTOR AFFINITY; SENILE PLAQUE;

EID: 0034531478     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06923.x     Document Type: Conference Paper

References (10)

1. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants
2. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice
3. The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease
4. Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism
5. Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease
6. Purification and cloning of amyloid precursor protein β secretase from human brain
7. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
8. Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity
9. Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide