Genetically altered transgenic models of Alzheimer's disease

Journal of Neural Transmission, Supplement

Volumn , Issue 59, 2000, Pages 175-183

  Masliah, E ^a,b   Rockenstein, E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; PLATELET DERIVED GROWTH FACTOR; PRESENILIN 1; PRION PROTEIN; TAU PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; GENE OVEREXPRESSION; MACROGLIA; MICROGLIA; NEURITE; NEUROFIBRILLARY TANGLE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SYNAPSE; TRANSGENIC ANIMAL; VASCULAR AMYLOIDOSIS; ANIMAL; DISEASE MODEL; GENETICS; HYBRIDIZATION; MOUSE; MOUSE MUTANT;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DISEASE MODELS, ANIMAL; HYBRIDIZATION, GENETIC; MICE; MICE, KNOCKOUT;

EID: 0033624421     PISSN: 03036995     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-7091-6781-6_20     Document Type: Review

References (42)

1. Aguzzi A, Brandner S, Marino S, Steinbach JP (1996) Transgenic and knockout mice in the study of neurodegenerative diseases. J Mol Med 74: 111-126
2. Andra K, Abramowski D, Duke M, Probst A, Wiederholt KH, Burki K, Goedert M, Sommer B, Staufenbiel M (1996) Expression of APP in transgenic mice: a comparison of neuron-specific promoters. Neurobiol Aging 17: 183-190
3. Arai H, Lee V-Y, Messinger ML, Greenberg BD, Lowery DE, Trojanowski JQ (1991) Expression patterns of β-amyloid precursor protein (β-APP) in neural and nonneural tissues from Alzheimer's disease and control subjects. Ann Neurol 30: 686-693
4. Bales KR, Verina T, Dodel RC, Du Y, Altstiel L, Bender M, Hyslop P, Johnstone EM, Little SP, Cummins DJ, Piccardo P, Ghetti B, Paul SM (1997) Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition. Nat Genet 17: 263-264
5. Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D (1996) Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron 17: 1005-1013
6. Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, Jenkins NA, Copeland NG, Price DL, Sisodia SS (1997) Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin I and amyloid precursor proteins. Neuron 19: 939-945
7. Carlson GA, Borchelt DR, Dake A, Turner S, Danielson V, Coffin JD, Eckman C, Meiners J, Nilsen SP, Younkin SG, Hsiao KK (1997) Genetic modifications of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice. Hum Mol Genet 6: 1951-1959
8. Clark RF, Goate AM (1993) Molecular genetics of Alzheimer's disease. Arch Neurol 50: 1164-1172
9. Cole GM, Masliah E, Huynh TV, DeTeresa R, Terry RD, Okudea C, Saitoh T (1989) An antiserum against amyloid β-protein precursor detects a unique peptide in Alzheimer brain. Neurosci Lett 100: 340-346
10. Cras P, Kawai M, Lowery D, Gonzalez-DeWhitt P, Greenberg B, Perry G (1991) Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein. PNAS USA 88: 7552-7556
11. Dickson DW, Farlo J, Davies P, Crystal H, Fuld P, Yen SC (1988) Alzheimer disease. A double immunohistochemical study of senile plaques. Am J Pathol 132: 86-101
12. Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemes J, Donaldson T, Gillespie F, Guido T, Hagopian S, Johnson-Wood K, Khan K, Lee M, Leibowitz P, Lieberburg I, Little S, Masliah E, McConlogue L, Montoya-Zavala M, Mucke L, Paganini L, Penniman E, Power M, Schenk D, Seubert P, Snyder B, Soriano F, Tan H, Vitale J, Wadsworth S, Wolozin B, Zhao J (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 373: 523-527
13. Games D, Masliah E, Lee M, Johnson-Wood K, Schenk D (1997) Neurodegenerative Alzheimer-like pathology in PDAPP 717V → F transgenic mice. In: Hyman BT, Duyckaerts C, Christen Y (eds) Connections, cognition and Alzheimer's disease. Springer, Berlin Heidelberg New York Tokyo, pp 105-119
14. Goate A, Chartier-Harlin M-C, Mullan M, Brown J, Crawford F, Fidani L, Guiffra L, Haynes A, Irving N, James L, Mant R, Newton P, Rooke K, Roques P, Talbot C, Williamson R, Rossor M, Owen M, Hardy J (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349: 704
15. Hof PR, Cox K, Morrison JH (1990) Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: I. Superior frontal and inferior temporal cortex. J Comp Neurol 301: 44-54
16. Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, Wright K, Saad I, Mueller R, Morgan D, Sanders P, Zehr C, O'Campo K, Hardy J, Prada C-M, Eckman C, Younkin S, Hsiao K, Duff K (1998) Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med 4: 97-100
17. Holtzman DM, Bales KR, Wu S, Bhat P, Parsadanian M, Fagan AM, Chang LK, Sun Y, Paul SM (1999) Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease. J Clin Invest 103: R15-R21
18. Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Correlative memory deficits, A beta elevation, and amyloid plaques in transgenic mice. Science 274: 99-102
19. Hyman BT, VanHoesen GW, Damasio AR, Barnes CL (1984) Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation. Science 225: 1168-1170
20. LaFerla FM, Tinkle BT, Bieberich CJ, Haudenschild CC, Jay G (1995) The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat Genet 9: 21-30
21. Martin LJ, Cork LC, Koo EH, Sisodia SS, Weidemann A, Beyreuther K, Masters C, Price DL (1989) Localization of amyloid precursor protein (APP) in brains of young and aged monkeys. Soc Neurosci Abstr 15: 23
22. Masliah E (1995) Mechanisms of synaptic dysfunction in Alzheimer's disease. Histol Histopathol 10: 509-519
23. Masliah E, Mallory M, Hansen L, Alford M, Albright T, Terry R, Shapiro P, Sundsmo M, Saitoh T (1991) Immunoreactivity of CD45, a protein phosphotyrosine phosphatase, in Alzheimer disease. Acta Neuropathol 83: 12-20
24. Masliah E, Mallory M, Ge N, Saitoh T (1992) Amyloid precursor protein is localized in growing neurites of neonatal rat brain. Brain Res 593: 323-328
25. Masliah E, Mallory M, Hansen L, Alford M, DeTeresa R, Terry R (1993) An antibody against phosphorylated neurofilaments identifies a subset of damaged association axons in Alzheimer's disease. Am J Pathol 142: 871-882
26. Masliah E, Sisk A, Mallory M, Mucke L, Schenk D, Games D (1996) Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F β-amyloid precursor protein and Alzheimer's disease. J Neurosci 16: 5795-5811
27. Masters CL, Multhaup G, Simms G, Pottglesser J, Martins RN, Beyreuther K (1985) Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO J 4: 2757-2763
28. Moechars D, Dewachter I, Lorent K, Reverse D, Baekelandt V, Naidu A, Tesseur I, Spittaels K, van den Haute C, Checler F, Godaux E, Cordell B, Van Leuven F (1999) Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J Biol Chem 274: 6483-6492
29. Mucke L, Yu G-Q, Abraham CR, McConlogue L, Rockenstein EM, Masliah E (1999) Potential role of alpha1-antichymotrypsin and alpha-synuclein in Alzheimer's disease pathogenesis assessed in bigenic mice expressin human amyloid precursor proteins. Soc Neurosci Abstr 25: 122.10
30. Nalbantoglu J, Tirado-Santiago G, Lahsaini A, Poirier J, Goncalves O, Verge G, Momoli F, Welner SA, Massicotte G, Julien JP (1997) Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature 387: 500-505
31. Palmer AM, Gershon S (1990) Is the neuronal basis of Alzheimer's disease cholinergic or glutamatergic? FASEB J 4: 2745-2752
32. Perry EK, Perry RH, Blessed G, Tomlinson BE (1977) Neurotransmitter enzyme abnormalities in senile dementia: CAT and GAD activities in necropsy tissue. J Neurol Sci 34: 247-265
33. Rockenstein EM, McConlogue L, Tan H, Power M, Masliah E, Mucke L (1995) Levels and alternative splicing of amyloid β protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease. J Biol Chem 270: 28257-28267
34. Rogers J, Luber-Narod J, Styren SD, Civin WH (1988) Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease. Neurobiol Aging 9: 339-349
35. Selkoe DJ (1989) Amyloid β-protein precursor and the pathogenesis of Alzheimer's disease. Cell 58: 611-612
36. Sisodia SS, Koo EH, Beyreuther K, Unterbeck A, Price DL (1990) Evidence that β-amyloid protein in Alzheimer's disease is not derived by normal processing. Science 248: 492-494
37. Sturchler-Pierrat C, Abramowski D, Duke M, Wiederholt KH, Mistl C, Rothacher S, Ledermann B, Burki K, Frey P, Paganetti PA, Waridel C, Calhoun ME, Jucker M, Probst A, Staufenbiel M, Sommer B (1997) Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci USA 94: 13287-13292
38. Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R (1991) Physical basis of cognitive alterations in Alzheimer disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30: 572-580
39. Terry RD, Hansen L, Masliah E (1994) Structural alterations in Alzheimer disease. In: Terry RD, Katzman R (eds), Alzheimer disease. Raven Press New York, pp 179-196
40. van Leeuwen FW, de Kleijn DP, van den Hurk HH, Neubauer A, Sonnemans MA, Sluijs JA, Keoyceau S, Ramdjielal R, Salehi A, Martens G, Grosveld FG, Peter J, Burbach H, Hol EM (1998) Frameshift mutants of beta amyloid precursor protein and ubiqutin-B in Alzheimer's and Down patients. Science 279: 242-247
41. Wilcock GK, Esiri MM, Bowen DM, Hughes AO (1988) The differential involvement of subcortical nuclei in senile dementia of Alzheimer's type. J Neurol Neurosurg Psych 51: 842-849
42. Wyss-Coray T, Masliah E, Mallory M, McConlogue L, Johnson-Wood K, Campagno F, Lin C, Samuels I, Mucke L (1997) Amyloidogenic role of transforming growth factor β1 in transgenic mice and Alzheimer's disease. Nature 389: 603-606