Nitric oxide synthase expression and apoptotic cell death in brains of AIDS and AIDS dementia patients

AIDS

Volumn 13, Issue 3, 1999, Pages 317-326

  Vincent, Valérie A M ^a   De Groot, Corline J A ^b   Lucassen, Paul J ^c   Portegies, Peter ^d   Troost, Dirk ^d   Tilders, Fred J H ^a   Van Dam, Anne Marie ^a,e  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c LEIDEN UNIVERSITY   (Netherlands)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cerebral cortex; HIV; Immunocytochemistry; In situ end labelling; Neurodegeneration

Indexed keywords

NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; AGED; AIDS RELATED COMPLEX; APOPTOSIS; ARTICLE; ASTROCYTE; AUTOPSY; BRAIN CORTEX; CELL DEATH; CELLULAR DISTRIBUTION; CHEMICAL LABELING; CLINICAL ARTICLE; CONTROLLED STUDY; DEMENTIA; GRAY MATTER; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MACROPHAGE; MALE; MICROGLIA; PRIORITY JOURNAL; WHITE MATTER;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADULT; AGED; AIDS DEMENTIA COMPLEX; ANTIBODIES, MONOCLONAL; APOPTOSIS; AUTOPSY; CELL DEATH; CEREBRAL CORTEX; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MIDDLE AGED; NADPH DEHYDROGENASE; NITRIC OXIDE SYNTHASE;

EID: 0033044842     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199902250-00003     Document Type: Article

References (52)

1. Price RW, Brew B, Sidtis J, Rosenblum M, Scheck AC, Cleary P: The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science 1988, 239:568-592.
2. McArthur JC, Hoover DR, Bacellar H, et al.: Dementia in AIDS patients: incidence and risk factors. Neurology 1993, 43:2245-2252.
3. Power C, Johnson RT: HIV-1 associated dementia: clinical features and pathogenesis. Can J Neurol Sci 1995, 22:92-100.
4. Kure K, Pellena J, Lyman WD, et al.: Human immunodeficiency virus-1 infection of the nervous system. Hum Pathol 1991, 22:700-710.
5. Budka H, Costianzi G, Cristina A, et al.: Brain pathology induced by infection with the human immunodeficiency virus (HIV). A histological, immunocytochemical, and electron microscopical study of 100 autopsy cases. Acta Neuropathol 1987, 75:185-198.
6. McArthur JC, Beckor PS, Parisi JE, et al.: Neuropathological changes in early HIV-1 dementia. Ann Neurol 1989, 26:681-684.
7. Power C, Kong P, Crawford TO, et al.: Cerebral white matter changes in acquired immunodeficiency syndrome dementia: alterations of the blood-brain barrier. Ann Neurol 1993, 34:339-350.
8. Ketzler S, Weis S, Haug H, Budka H: Loss of neurons in the frontal cortex in AIDS brains. Acta Neuropathol 1990, 80:92-94.
9. Wiley CA, Masliah E, Morey M, et al.: Neocortical damage during HIV infection. Ann Neurol 1991, 29:651-657.
10. Masliah E, Morey M, DeTeresa R, Terry RD, Wiley CA: Cortical dendritic pathology in human immunodeficiency virus encephalitis. Lab Invest 1992, 66:285-291.
11. Adle-Biassette H, Levy Y, Colombel M, et al.: Neuronal apoptosis in HIV infection in adults. Neuropathol Appl Neurobiol 1995, 21:218-227.
12. Shi B, De Girolami U, He J, et al.: Apoptosis induced by HIV-1 infection of the central nervous system. J Clin Invest 1996, 98:1979-1990.
13. Nuovo GJ, Gallery F, MacConnell P, Braun A: In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acids and tumor necrosis factor-alpha RNA in the central nervous system. Am J Pathol 1994, 144:659-666.
14. Bagasra O, Lavi E, Bobroski L, et al.: Cellular reservoirs of HIV-1 in the central nervous system of infected individuals: identification by the combination of in situ polymerase chain reaction and immunohistochemistry. AIDS 1996, 10:573-585.
15. Budka H: Human immunodeficiency virus (HIV) envelope and core proteins in CNS tissues of patients with the acquired immune deficiency syndrome (AIDS). Acta Neuropathol 1990, 79:611-619.
16. Wiley CA, Schrier RD, Nelson JA, Lampert PW, Oldstone MBA: Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl Acad Sci USA 1986, 83:7089-7093.
17. Dawson TD, Dawson VI.: gp120 neurotoxicity in primary cortical cultures. Adv Neuroimmunol 1994, 4:167-173.
18. Lipton SA: Requirement for macrophages in neuronal injury induced by HIV envelope protein gp120. Neuroreport 1992, 3:913-915.
19. Genis P, Jett M, Bernton EW, et al.: Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease. J Exp Med 1992, 176:1703-1718.
20. Yeung MC, Pulliam L, Lau AS: The HIV envelope protein gp120 is toxic to human brain-cell cultures through the induction of interleukin-6 and tumor necrosis factor-α. AIDS 1995, 9:137-143.
21. Nuovo GJ, Lynn Alfieri M: AIDS dementia is associated with massive, activated HIV-1 infection and concomitant expression of several cytokines. Mol Med 1996, 2:358-366.
22. Dawson VL, Brahmbhatt HP, Mong JA, Dawson TM: Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures. Neuropharmacology 1994, 33:1425-1430.
23. Pietraforte D, Tritarelli E, Testa U, Minetti M: gp120 HIV envelope glycoprotein increases the production of nitric oxide in human monocyte-derived macrophages. J Leukoc Biol 1994, 55:175-182.
24. Giulian D, Wendt E, Vaca K, Noonan CA: The envelope glycoprotein of human immunodeficiency virus type 1 stimulates release of neurotoxins from monocytes. Proc Natl Acad Sci USA 1993, 90:2769-2773.
25. De Groot CJA, Ruuls SR, Theeuwes JWM, Dijkstra CD, Van der Valk P: Immunocytochemical characterization of the expression of inducible and constitutive isoforms of nitric oxide synthase in demyelinating multiple sclerosis lesions. J Neuropathol Exp Neurol 1997, 56:10-20.
26. Bagasra O, Michaels FH, Zheng YM, et al.: Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis. Proc Natl Acad Sci USA 1995, 92:12041-12045.
27. Adamson DC, Wildemann B, Sasaki M, et al.: Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41. Science 1996, 274:1917-1920.
28. Boje KM, Arora PK: Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res 1992, 587:250-256.
29. Dawson VL, Dawson TD, London ED, Bredt DS, Snyder SH: Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci USA 1991, 88:6368-6371.
30. Chao CC, Hu S, Molitor TW, Shaskan EG, Peterson PK: Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunol 1992, 149:2736-2741.
31. Price RW, Brew BJ: The AIDS dementia complex. J Infect Dis 1988, 158:1079-1083.
32. Hope B, Vincent S: Histochemical characterization of neuronal NADPH-diaphorase. J Histochem Cytochem 1989, 37:653-661.
33. Lucassen PJ, Chung WCJ, Vermeulen JP, Van Lookeren Campagne M, Van Dierendonk JH, Swaab DF: Microwave-enhanced in situ end-labeling of fragmented DNA: parametric studies in relation to postmortem delay and fixation of rat and human brain. J Histochem Cytochem 1995, 43:1163-1171.
34. Lucassen PJ, Chung WC, Kamphorst W, Swaab DF: DNA damage distribution in the human brain as shown by in situ end labeling: area-specific differences in aging and Alzheimer disease in the absence of apoptotic morphology. J Neuropathol Exp Neurol 1997, 56:887-900.
35. Lucassen PJ, Williams A, Chung WCJ, Fraser H: Detection of apoptosis in murine scrapie. Neurosci Lett 1995, 198:185-188.
36. Kerr JFR, Wyllie AH, Currie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972, 26:239-257.
37. Kressel M, Groscurth P: Distinction of apoptotic and necrotic cell death by in situ end labeling of fragmented DNA. Cell Tissue Res 1994, 278:549-556.
38. Li WP, Chan WY, Lai HWL, Yew DT: Terminal dUTP nick end labeling (TUNEL) positive cells in the different regions of the brain in normal aging and Alzheimer patients. J Mol Neurosci 1997, 8:75-82.
39. Lipton SA: Similarity of neuronal cell injury and death in AIDS dementia and focal cerebral ischemia: potential treatment with NMDA open-channel blockers and nitric oxide-related species. Brain Pathol 1996, 6:507-517.
40. Hunot S, Boissiere F, Faucheux B, et al.: Nitric oxide synthase and neuronal vulnerability in Parkinson's disease. Neuroscience 1996, 72:355-363.
41. Van Dam A-M, Bauer J, Man-A-Hing WK, Marquette C, Tilders FJ, Berkenbosch F: Appearance of inducible nitric oxide synthase in the rat central nervous system after rabies virus infection and during experimental allergic encephalomyelitis but not after peripheral administration of endotoxin. J Neurosci Res 1995, 40:251-260.
42. Koprowski H, Zheng YM, Heber-Katz E: In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases. Proc Natl Acad Sci USA 1993, 90:3024-3027.
43. Vodovotz Y, Lucia MS, Flanders C, et al.: Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease. J Exp Med 1996, 184:1425-1433.
44. Wallace MN, Geddes JG, Farquhar DA, Masson MR: Nitric oxide synthase in reactive astrocytes adjacent to beta-amyloid plaques. Exp Neurol 1997, 144:266-272.
45. Brosnan CF, Battistini L, Raine CS, Dickson DW, Casedevall A, Lee SC: Reactive nitrogen intermediates in human neuropathology: an overview. Dev Neurosci 1994, 16:152-161.
46. Lei DL, Yang DL, Liu HM: Local injection of kainic acid causes widespread degeneration of NADPH-d neurons and induction of NADPH-d in neurons, endothelial cells and reactive astrocytes. Brain Res 1996, 730:199-206.
47. Peng ZC, Pietra C, Sbarbati A, et al.: Induction of NADPH-diaphorase activity in the rat forebrain after middle cerebral artery occlusion. Exp Neurol 1996, 138:105-120.
48. Mitrovic B, Ignarro LJ, Montestruque S, Smoll A, Merrill JE: Nitric oxide as a potential pathological mechanism in demyelination: its differential effects on primary glial cells in vitro. Neuroscience 1994, 61:575-585.
49. Palluy O, Rigaud M: Nitric oxide induces cultured cortical neuron apoptosis. Neurosci Lett 1996, 208:1-4.
50. Leist M, Fava E, Montecucco C, Nicotera P: Peroxynitrite and nitric oxide donors induce neuronal apoptosis by eliciting autocrine excitotoxicity. Eur J Neurosci 1997, 9:1488-1498.
51. Esiri MM, Morris CS, Millard PR: Fate of oligodendrocytes in HIV-1 infection. AIDS 1991, 5:1081-1088.
52. Knox KK, Carrigan DR: Active human herpesvirus (HHV-6) infection of the central nervous system in patients with AIDS. J Acquir Immune Defic Syndr Hum Retrovirol 1995, 9:69-73.