Apolipoprotein-E allele-specific regulation of nitric oxide production

Annals of the New York Academy of Sciences

Volumn 962, Issue , 2002, Pages 212-225

  Colton, Carol A ^a   Brown, Candice M ^a   Czapiga, Meggan ^a   Vitek, Michael P ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Apolipoprotein E; Arginine transport; Nitric oxide production

Indexed keywords

3 NITROTYROSINE; APOLIPOPROTEIN E; APOLIPOPROTEIN E2; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; ARGININE; CARRIER PROTEIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ALLELE; ALZHEIMER DISEASE; AMINO ACID TRANSPORT; CONFERENCE PAPER; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HUMAN; MICROGLIA; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION;

FELIS CATUS; MUS MUSCULUS;

EID: 0036268903     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb04070.x     Document Type: Conference Paper

References (62)

1. The progression of Alzheimer's disease from limbic regions to the neocortex: Clinical,radiological and pathological relationships
2. Apolipoprotein E isoforms and the development of low and high Braak stages of Alzheimer's disease-related lesions
3. Alzheimer-related tau-pathology in the perforant path target zone and in the hippocampal stratum oriens and radiatum correlates with onset and degree of dementia
4. nNOS expressing neurons in the entorhinal cortex and hippocampus are affected in patients with Alzheimer's disease
5. Widespread peroxynitrite-mediated damage in Alzheimer's disease
6. Evidence for neuronal oxidative damage in Alzheimer's disease
7. Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain
8. Antibodies that recognize nitrotyrosine
9. Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation
10. Alterations of 3-nitrotyrosine concentrations in the cerebrospinal fluid during aging and in patients with Alzheimer's disease
11. Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer disease
12. Dimethylarginase, a nitric oxide regulatory protein, in Alzheimer disease
13. Arginine metabolism and the synthesis of nitric oxide in the nervous system
14. A web-accessible digital atlas of the distribution of nitric oxide synthase in the mouse brain
15. Neuronal nitric oxide synthase (nNOS) mRNA expression and NADPH-diaphorase staining in the frontal cortex, visual cortex and hippocampus of control and Alzheimer's disease brains
16. Expression and function of inducible nitric oxide synthase in neurons
17. Characterization and regional distribution of nitric oxide synthase in the human brain during normal ageing
18. Inducible nitric oxide synthase in tangle bearing neurons of patients with Alzheimer's disease
19. Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): Analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages
20. Nitric oxide synthase in reactive astrocytes adjacent to beta-amyloid plaques
21. Fibrillary beta-amyloid deposits are closely associated with atrophic nitric oxide synthase (NOS)-expressing neurons but do not upregulate the inducible NOS in transgenic Tg2576 mouse brain with Alzheimer pathology
22. Induction of superoxide anion and nitric oxide production in cultured microglia
23. Activation of microglial cells by b-amyloid protein and interferon-g
24. Subacute NO generation by Alzheimer's beta amyloid in the living brain: Reversal by inhibition of the inducible NO synthase
25. Nitric oxide synthase activity is elevated in brain microvessels in Alzheimer's disease
26. No association between the NOS3 codon 298 polymorphism and Alzheimer's disease in a sample from the United States
27. Relative sparing of nitric oxide synthase-containing neurons in the hippocampal formation in Alzheimer's disease
28. Histochemistry of nitric oxide synthase in the nervous system
29. Risk of Alzheimer disease with the epsilon 4 allele for apolipoprotein E in a population based study of men aged 62-73 years
30. Apolipoprotein E, a gene with complex biological interactions in the aging brain
31. Increased amyloid b-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease
32. Apolipoprotein E acts to increase NO production in macrophages by stimulating arginine transport
33. Modulation of nitric oxide production in human macrophages by apolipoprotein E and amyloid beta peptide
34. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E
35. Microglial activation in Alzheimer's disease: Association with APOE genotype
36. Apolipoprotein E inhibits platelet aggregration through the L-arginine: Nitric oxide pathway
37. Type III hyperlipoproteinemia and spontaneous athersclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe2
38. Nitric oxide biosynthesis, nitric oxide synthase inhibitors and arginase competition for L-arginine utilization
39. Arginine metabolism: Nitric oxide and beyond
40. Sustained NO production in macrophages requires the arginine transporter
41. Substrate supply for nitric oxide synthase in macrophages and endothelial cells: Role of cationic amino acid transporters
42. Peroxynitrite anion stimulates arginine release from cultured rat astrocytes
43. Nitric oxide, arginine transport and apolipoprotein E: A link between oxidative stress and the genetics of AD
44. Transporters for cationic amino acids in animal cells: Discovery, structure and function
45. Cloning and characterization of a brain specific cationic amino acid transporter
46. Roles of NMDA receptor activity and nitric oxide production in brain development
47. Nitric oxide: A novel neuronal messenger molecule
48. The role of nitric oxide and NMDA receptors in the development of motor neuron dendrites
49. B-amyloid protein dependent nitric oxide production from microglial cells and neurotoxicity
50. Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms
51. The chemical biology of nitric oxide
52. Cytotoxicity related to oxidative and nitrosatice stress by nitric oxide
53. Nitrosative capacity of macrophages is dependent on nitric-oxide synthase induction signals
54. Modulation of superoxide-dependent oxidation and hydroxylation reactions by nitric oxide
55. Beta-amyloid protein enhances macrophage production of oxygen free radicals and glutamate
56. Amyloid-b deposition in Alzheimer transgenic mice is associated with oxidative stress
57. Neuritic plaque evolution in Alzheimer's disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic
58. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
59. Expression of differential immune factors in temportal cortex and cerebellum: The role of a-1-antichymotrypsin, apolipoprotein E and reactive glia in the progression of Alzheimer's disease
60. Human apolipoprotein E2, E3 and E4 isoform specific transgenic mice: Human like pattern of glial and neuronal imunoreactivity in central nervous system not observed in wildtype mice
61. Protection from oxidation enhances the survival of cultured mesencephalic neurons
62. CAT2-mediated L-arginine transport and nitric oxide production in activated macrophages