Glia-related pathomechanisms in Alzheimer’s disease: A therapeutic target?

Mechanisms of Ageing and Development

Volumn 123, Issue 1, 2001, Pages 47-57

  Schubert, Peter ^a   Ogata, Tadanori ^b   Marchini, Cristina ^c   Ferroni, Stefano ^c  

^a MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^b EHIME UNIVERSITY   (Japan)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Acetylcholine deficiency; Alzheimer's dementia; Amyloid toxicity; In vitro studies; Oxidative damage; Pathological glia activation; Therapeutic interference

Indexed keywords

ADENOSINE; AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; CHOLINESTERASE INHIBITOR; CYCLIC CMP; INTERLEUKIN 1BETA; NITRIC OXIDE; OXYGEN RADICAL; PEROXYNITRITE; TUMOR NECROSIS FACTOR ALPHA;

ALZHEIMER DISEASE; ASTROCYTE; CELL ACTIVATION; CELL CULTURE; CELL DIFFERENTIATION; CONFERENCE PAPER; GLIA CELL; HOMEOSTASIS; MICROGLIA; NEGATIVE FEEDBACK; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; VITAMIN DEFICIENCY;

ALZHEIMER DISEASE; ANIMALS; ASTROCYTES; CYCLIC AMP; HUMANS; MICROGLIA; NEUROGLIA; SIGNAL TRANSDUCTION;

EID: 0034799913     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(01)00343-8     Document Type: Article

References (33)

1. Il-6 inhibits LPS-induced tumor necrosis factor production in cultured human monocytes
2. Astrocytes as mediators of immune and inflammatory responses in the CNS
3. Modulation of intracellular formation of reactive oxygen intermediates in peritoneal macrophages and microglia/brain macrophages by propentofylline
4. Astrocytic uptake of potassium by astrocytes
5. Hydrogen peroxide mediates amyloid β protein toxicity
6. Astrocyte-microglia interaction
7. Human APOE protein localized in brains of transgenic mice
8. Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system
9. Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner
10. Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1
11. Two distinct inward rectifying conductances are expressed in cultured rat cortical astrocytes after long term dibutyryl-cyclic-AMP treatment
12. Expression of amyloid precursor protein mRNAs in endothelial, neuronal and glial cells: Modulation by interleukin-1
13. Ameboid microglia as effector of inflammation in the central nervous system
14. A strategy for identifying immunosuppressive therapies for Alzheimer disease
15. Brain interleukine 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
16. Selective potentiation of NMDA induced neuronal injury following induction of astrocytic iNOS
17. Subacute NO generation induced by Alzheimer's (-amyloid in the living brain: Reversed by inhibition of the inducible NO synthase
18. Regulation by cAMP-dependent proteine kinease of a G-protein-mediated phospholipase C
19. Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of beta-protein into filaments
20. Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
21. Microglia in degenerative neurological disease
22. Activation of microglial cells by β-amyloid protein and interferon-γ
23. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors
24. 2+-related A1/A2 adenosine receptor cooperation
25. Nitric oxide-induced neurotoxicity is inhibited by propentofylline via cyclic GMP elevation
26. G-protein coupled signal transduction systems in the Alzheimer's disease brain
27. Apolipoprotein E distribution among different plaque types in Alzheimer's disease: Implications for its role in plaque progression
28. Differential regulation of microglial activation by propentofylline via cAMP signaling
29. Peroxinitrite inhibits glutamate transporter subtypes
30. Inhibition of endotoxin-induced oxide synthase production in microglial cells by the presence of astroglial cells: A role for transforming growth factor β
31. Cellular immune reactivity within the CNS
32. Apolipoprotein E: A pathological chaperone in patients with cerebral and systemic amyloid