Postsynaptic density scaffolding proteins at excitatory synapse and disorders of synaptic plasticity: Implications for human behavior pathologies

International Review of Neurobiology

Volumn 59, Issue , 2004, Pages 221-254

  De Bartolomeis, Andrea ^a   Fiore, Germano ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; DLG1 PROTEIN, HUMAN; HOMER PROTEIN; MEMBRANE PROTEIN; NERVE PROTEIN; NEUROPEPTIDE; POSTSYNAPTIC DENSITY PROTEINS; SAPAP PROTEINS; SHANK2 PROTEIN, RAT; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL; CHEMISTRY; HUMAN; MENTAL DISEASE; METABOLISM; NERVE CELL PLASTICITY; PHYSIOLOGY; REVIEW; SYNAPSE; SYNAPTIC TRANSMISSION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CARRIER PROTEINS; HUMANS; MEMBRANE PROTEINS; MENTAL DISORDERS; NERVE TISSUE PROTEINS; NEURONAL PLASTICITY; NEUROPEPTIDES; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 2342627958     PISSN: 00747742     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0074-7742(04)59009-8     Document Type: Article

References (184)

1. Aarts, M., Liu, Y., Liu, L., Besshoh, S., Arundine, M., Gurd, J. W., Wang, Y. T., Salter, M. W., and Tymianski, M. (2002). Treatment of ischemic brain damage by perturbing NMDA receptor-PSD-95 protein interactions. Science 298, 846-850.
2. Ageta, H., Kato, A., Fukazawa, Y., Inokuchi, K., and Sugiyama, H. (2001). Effects of proteasome inhibitors on the synaptic localization of Vesl-1S/Homer-1a proteins. Brain Res. Mol. Brain Res. 97, 186-189.
3. Ammon, S., Mayer, P., Riechert, U., Tischmeyer, H., and Hollt, V. (2003). Microarray analysis of genes expressed in the frontal cortex of rats chronically treated with morphine and after naloxone precipitated withdrawal. Brain Res. Mol. Brain Res. 112, 113-125.
4. Ango, F., Pin, J. P., Tu, J. C., Xiao, B., Worley, P. F., Bockaert, J., and Fagni, L. (2000). Dendritic and axonal targeting of type 5 metabotropic glutamate receptor is regulated by homer1 proteins and neuronal excitation. J. Neurosci. 20, 8710-8716.
5. Ango, F., Prezeau, L., Muller, T., Tu, J. C., Xiao, B., Worley, P. F., Pin, J. P., Bockaert, J., and Fagni, L. (2001). Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature 411, 962-965.
6. Ango, F., Robbe, D., Tu, J. C., Xiao, B., Worley, P. F., Pin, J. P., Bockaert, J., and Fagni, L. (2002). Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons. Mol. Cell Neurosci. 20, 323-329.
7. Bagrodia, S., and Cerione, R. A. (1999). Pak to the future. Trends Cell Biol. 9, 350-355.
8. Banke, T. G., Bowie, D., Lee, H., Huganir, R. L., Schousboe, A., and Traynelis, S. F. (2000). Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase. J. Neurosci. 20, 89-102.
9. Bassand, P., Bernard, A., Rafiki, A., Gayet, D., and Khrestchatisky, M. (1999). Differential interaction of the tSXV motifs of the NR1 and NR2A NMDA receptor subunits with PSD-95 and SAP97. Eur. J. Neurosci. 11, 2031-2043.
10. Bear, M. F., and Malenka, R. C. (1994). Synaptic plasticity: LTP and LTD. Curr. Opin. Neurobiol. 4, 389-399.
11. Beique, J. C., and Andrade, R. (2003). PSD-95 regulates synaptic transmission and plasticity in rat cerebral cortex. J. Physiol. 546, 859-867.
12. Blanpied, T. A., Scott, D. B., and Ehlers, M. D. (2002). Dynamics and regulation of clathrin coats at specialized endocytic zones of dendrites and spines. Neuron 36, 435-449.
13. Bockmann, J., Kreutz, M. R., Gundelfinger, E. D., and Bockers, T. M. (2002). ProSAP/Shank postsynaptic density proteins interact with insulin receptor tyrosine kinase substrate IRSp53. J. Neurochem. 83, 1013-1017.
14. Boeckers, T. M., Winter, C., Smalla, K. H., Kreutz, M. R., Bockmann, J., Seidenbecher, C., Garner, C. C., and Gundelfinger, E. D. (1999). Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family. Biochem. Biophys. Res. Commun. 264, 247-252.
15. Bonaglia, M. C., Giorda, R., Borgatti, R., Felisari, G., Gagliardi, C., Selicorni, A., and Zuffardi, O. (2001). Disruption of the ProSAP2 gene in a t(12;22)(q24.1;q13.3) is associated with the 22q13.3 deletion syndrome. Am. J. Hum. Genet. 69, 261-268.
16. Bottai, D., Guzowski, J. F., Schwarz, M. K., Kang, S. H., Xiao, B., Lanahan, A., Worley, P. F., and Seeburg, P. H. (2002). Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression. J. Neurosci. 22, 167-175.
17. Brakeman, P. R., Lanahan, A. A., O'Brien, R., Roche, K., Barnes, C. A., Huganir, R. L., and Worley, P. F. (1997). Homer: A protein that selectively binds metabotropic glutamate receptors. Nature 386, 284-288.
18. Brenman, J. E., Chao, D. S., Gee, S. H., McGee, A. W., Craven, S. E., Santillano, D. R., Wu, Z., Huang, F., Xia, H., Peters, M. F., Froehner, S. C., and Bredt, D. S. (1996a). Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. Cell 84, 757-767.
19. Brenman, J. E., Christopherson, K. S., Craven, S. E., McGee, A. W., and Bredt, D. S. (1996b). Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting protein. J. Neurosci. 16, 7407-7415.
20. Bruckner, K., Pablo Labrador, J., Scheiflele, P., Herb, A., Seeburg, P. H., and Klein, R. (1999). EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron 22, 511-524.
21. Budnik, V. (1996). Synapse maturation and structural plasticity at Drosophila neuromuscular junctions. Curr. Opin. Neurobiol. 6, 858-867.
22. Cai, C., Coleman, S. K., Niemi, K., and Keinanen, K. (2002). Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3- methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif. J. Biol. Chem. 277, 31484-31490.
23. Carlin, R. K., Bartelt, D. C., and Siekevitz, P. (1983). Identification of fodrin as a major calmodulin-binding protein in postsynaptic density preparations. J. Cell. Biol. 96, 443-448.
24. Caruana, G., and Bernstein, A. (2001). Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene. Mol. Cell. Biol. 21, 1475-1483.
25. Chen, H. J., Rojas-Soto, M., Oguni, A., and Kennedy, M. B. (1998). A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II. Neuron 20, 895-904.
26. Chen, L., Chetkovich, D. M., Petralia, R. S., Sweeney, N. T., Kawasaki, Y., Wenthold, R. J., Bredt, D. S., and Nicoll, R. A. (2000). Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature 408, 936-943.
27. Cho, K. O., Hunt, C. A., and Kennedy, M. B. (1992). The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron 9, 929-942.
28. Choquet, D., and Triller, A. (2003). The role of receptor diffusion in the organization of the postsynaptic membrane. Nature Rev. Neurosci. 4, 251-265.
29. Christopherson, K. S., Hillier, B. J., Lim, W. A., and Bredt, D. S. (1999). PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain. J. Biol. Chem. 274, 27467-27473.
30. Ciruela, F., Soloviev, M. M., Chan, W. Y., and McIlhinney, R. A. (2000). Homer-1c/Vesl-IL modulates the cell surface targeting of metabotropic glutamate receptor type 1alpha: Evidence for an anchoring function. Mol. Cell Neurosci. 15, 36-50.
31. Ciruela, F., Soloviev, M. M., and McIlhinney, R. A. (1999). Co-expression of metabotropic glutamate receptor type 1alpha with homer-1a/Vesl-1S increases the cell surface expression of the receptor. Biochem. J. 341, (Pt. 3), 795-803.
32. Cochran, S. M., Fujimura, M., Morris, B. J., and Pratt, J. A. (2002). Acute and delayed effects of phencyclidine upon mRNA levels of markers of glutamatergic and GABAergic neurotransmitter function in the rat brain. Synapse 46, 206-214.
33. Colledge, M., Dean, R. A., Scott, G. K., Langeberg, L. K., Huganir, R. L., and Scott, J. D. (2000). Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex. Neuron 27, 107-119.
34. Colledge, M., and Scott, J. D. (1999). AKAPs: From structure to function. Trends Cell Biol. 9, 216-221.
35. Contractor, A., Rogers, C., Maron, C., Henkemeyer, M., Swanson, G. T., and Heinemann, S. F. (2002). Trans-synaptic Eph receptor-ephrin signaling in hippocampal mossy fiber LTP. Science 296, 1864-1869.
36. Coutinho, V., Kavanagh, I., Sugiyama, H., Tones, M. A., and Henley, J. M. (2001). Characterization of a metabotropic glutamate receptor type 5-green fluorescent protein chimera (mGluR5-GFP): Pharmacology, surface expression, and differential effects of Homer-1a and Homer-1c. Mol. Cell Neurosci. 18, 296-306.
37. Craven, S. E., El-Husseini, A. E., and Bredt, D. S. (1999). Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs. Neuron 22, 497-509.
38. de Bartolomeis, A., Aloj, L., Ambesi-Impiombato, A., Bravi, D., Caraco, C., Muscettola, G., and Barone, P. (2002). Acute administration of antipsychotics modulates Homer striatal gene expression differentially. Brain Res. Mol. Brain Res. 98, 124-129.
39. 2+ stores. Neuron 36, 787-790.
40. Diagana, T. T., Thomas, U., Prokopenko, S. N., Xiao, B., Worley, P. F., and Thomas, J. B. (2002). Mutation of Drosophila homer disrupts control of locomotor activity and behavioral plasticity. J. Neurosci 22, 428-136.
41. Dong, H., O'Brien, R. J., Fung, E. T., Lanahan, A. A., Worley, P. F., and Huganir, R. L. (1997). GRIP: A synaptic PDZ domain-containing protein that interacts with AMPA receptors. Nature 386, 279-284.
42. Dong, H., Zhang, P., Liao, D., and Huganir, R. L. (1999). Characterization, expression, and distribution of GRIP protein. Ann. N. Y. Acad. Sci. 868, 535-540.
43. Dracheva, S., Marras, S. A., Elhakem, S. L., Kramer, F. R., Davis, K. L., and Haroutunian, V. (2001). N-methyl-D-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia. Am. J. Pychiat. 158, 1400-1410.
44. Du, Y., Weed, S. A., Xiong, W. C., Marshall, T. D., and Parsons, J. T. (1998). Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons. Mol. Cell. Biol. 18, 5838-5851.
45. Ehlers, M. D., Mammen, A. L., Lau, L. F., and Huganir, R. L. (1996). Synaptic targeting of glutamate receptors. Curr. Opin. Cell Biol. 8, 484-189.
46. El-Husseini, A. E., Schnell, E., Chetkovich, D. M., Nicoll, R. A., and Bredt, D. S. (2000). PSD-95 involvement in maturation of excitatory synapses. Science 290, 1364-1368.
47. El-Husseini Ael, D., Schnell, E., Dakoji, S., Sweeney, N., Zhou, Q., Prange, O., Gauthier-Campbell, C., Aguilera-Moreno, A., Nicoll, R. A., and Bredt, D. S. (2002). Synaptic strength regulated by palmitate cycling on PSD-95. Cell 108, 849-863.
48. Feng, W., Tu, J., Yang, T., Vernon, P. S., Allen, P. D., Worley, P. F., and Pessah, I. N. (2002). Homer regulates gain of ryanodine receptor type 1 channel complex. J. Biol. Chem. 277, 44722-14730.
49. Foa, L., Rajan, I., Haas, K., Wu, G. Y., Brakeman, P., Worley, P., and Cline, H. (2001). The scaffold protein, Homer1 b/c, regulates axon pathfinding in the central nervous system in vivo. Nature Neurosci. 4, 499-506.
50. Garcia, E. P., Mehta, S., Blair, L. A., Wells, D. G., Shang J., Fukushima, T., Fallon J. R., Garner, C. G., and Marshall, J. (1998). SAP90 binds and clusters kainate receptors causing incomplete desensitization. Neuron 21, 727-739.
51. Gardoni, F., Bellone, G., Viviani, B., Marinovich, M., Meli, E., Pellegrini-Giampietro, D. E., Cattabeni, F., and Di Luca, M. (2002). Lack of PSD-95 drives hippocampal neuronal cell death through activation of an alpha CaMKII transduction pathway. Eur. J. Neurosci. 16, 777-786.
52. Garner, C. C., Nash, J., and Huganir, R. L. (2000). PDZ domains in synapse assembly and signalling. Trends Cell Biol. 10, 274-280.
53. Garry, E. M., Moss, A., Delaney, A., O'Neill, F., Blakemore, J., Bowen, J., Husi, H., Mitchell, R., Grant, S. G., and Fleetwood-Walker, S. M. (2003). Neuropathic sensitization of behavioral reflexes and spinal NMDA receptor/CaM kinase II interactions are disrupted in PSD-95 mutant mice. Curr. Biol. 13, 321-328.
54. Glenney, J. R., Jr., Glenney, P., and Weber, K. (1983). Mapping the fodrin molecule with monoclonal antibodies: A general approach for rod-like multidomain proteins. J. Mol. Biol. 167, 275-293.
55. Goff, D. G., Henderson, D. C., Evins, A. E., and Amico, E. (1999a). A placebo-controlled crossover trial of D-cycloserine added to clozapine in patients with schizophrenia. Biol. Psychiat. 45, 512-514.
56. Goff, D. C., Tsai, G., Levitt, J., Amico, E., Manoach, D., Schoenfeld, D. A., Hayden, D. L., McCarley, R., and Coyle, J. T. (1999b). A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophrenia. Arch. Gen. Pychiat. 56, 21-27.
57. Grant, S. G., and O'Dell, T. J. (2001). Multiprotein complex signaling and the plasticity problem. GOT. Opin. Neurobiol. 11, 363-368.
58. Gray, N. W., Fourgeaud, L., Huang, B., Chen, J., Cao, H., Oswald, B. J., Hemar, A., and McNiven, M. A. (2003). Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer. Curr. Biol. 13, 510-515.
59. Hibino, H., Inanobe, A., Tanemoto, M., Fujita, A., Doi, K., Kubo, T., Hata, Y., Takai, Y., and Kurachi, Y. (2000). Anchoring proteins confer G protein sensitivity to an inward-rectifier K(+) channel through the GK domain. EMBO J. 19, 78-83.
60. Hsueh, Y. P., Kim, E., and Sheng, M. (1997). Disulfide-linked head-to-head multimerization in the mechanism of ion channel clustering by PSD-95. Neuron 18, 803-814.
61. Hu, B. R., Park, M., Martone, M. E., Fischer, W. H., Ellisman, M. H., and Zivin, J. A. (1998). Assembly of proteins to postsynaptic densities after transient cerebral ischemia. J. Neurosci. 18, 625-633.
62. Huntington's Disease Collaborative Research Group. (1993). A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72, 971-983.
63. Imamura, F., Maeda, S., Doi, T., and Fujiyoshi, Y. (2002). Ligand binding of the second PDZ domain regulates clustering of PSD-95 with the Kv1.4 potassium channel. J. Biol. Chem. 277, 3640-3646.
64. + channels composed of Kir3.2 subunits in dopaminergic neurons of the substantia nigra. J. Neurosci. 19, 1006-1017.
65. Irie, M., Hata, Y., Takeuchi, M., Ichtchenko, K., Toyoda, A., Hirao, K., Takai, Y., Rosahl, T. W., and Sudhof, T. C. (1997). Binding of neuroligins to PSD-95. Science 277, 1511-1515.
66. Javitt, D. C., and Zukin, S. R. (1991). Recent advances in the phencyclidine model of schizophrenia. Am. J. Pychiat. 148, 1301-1308.
67. Jo, K., Derin, R., Li, M., and Bredt, D. S. (1999). Characterization of MALS/Velis-1, -2, and -3: A family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex. J. Neurosci. 19, 4189-4199.
68. Kammermeier, P. J., Xiao, B., Tu, J. C., Worley, P. F., and Ikeda, S. R. (2000). Homer proteins regulate coupling of group I metabotropic glutamate receptors to N-type calcium and M-type potassium channels. J. Neurosci. 20, 7238-7245.
69. Karnak, D., Lee, S., and Margolis, B. (2002). Identification of multiple binding partners for the amino-terminal domain of synapse-associated protein 97. J. Biol. Chem. 277, 46730-46735.
70. Kato, A., Ozawa, F., Saitoh, Y., Fukazawa, Y., Sugiyama, H., and Inokuchi, K. (1998). Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptors. J. Biol. Chem. 273, 23969-23975.
71. Kennedy, M. B. (1997). The postsynaptic density at glutamatergic synapses. Trends Neurosci. 20, 264-268.
72. Kennedy, M. B. (1998). Signal transduction molecules at the glutamatergic postsynaptic membrane. Brain Res. Brain Res. Rev. 26, 243-257.
73. Kennedy, M. B. (2000). Signal-processing machines at the postsynaptic density. Science 290, 750-754.
74. Kim, E., Cho, K. O., Rothschild, A., and Sheng, M. (1996). Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins. Neuron 17, 103-113.
75. Kim, E., Naisbitt, S., Hsueh, Y. P., Rao, A., Rothschild, A., Craig, A. M., and Sheng, M. (1997). GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules. J. Cell Biol. 136, 669-678.
76. + channels by interaction with a family of membrane-associated guanylate kinases. Nature 378, 85-88.
77. Kim, J. H., Liao, D., Lau, L. F., and Huganir, R. L. (1998). SynGAP: A synaptic RasGAP that associates with the PSD-95/SAP90 protein family. Neuron 20, 683-691.
78. Kistner, U., Wenzel, B. M., Veh, R. W., Cases-Langhoff, C., Garner, A. M., Appeltauer, U., Voss, B., Gundelfinger, E. D., and Garner, C. C. (1993). SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A. J. Biol. Chem. 268, 4580-4583.
79. Klocker, N., Bunn, R. C., Schnell, E., Caruana, G., Bernstein, A., Nicoll, R. A., and Bredt, D. S. (2002). Synaptic glutamate receptor clustering in mice lacking the SH3 and GK domains of SAP97. Eur. J. Neurosci. 16, 1517-1522.
80. Komeima, K., Hayashi, Y., Naito, Y., and Watanabe, Y. (2000). Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase Halpha through Scr847 phosphorylation in NG108-15 neuronal cells. J. Biol. Chem. 275, 28139-28143.
81. Komiyama, N. H., Watabe, A. M., Carlisle, H. J., Porter, K., Charlesworth, P., Monti, J., Strathdee, D. J., O'Carroll, C. M., Martin, S. J., Morris, R. G., O'Dell, T. J., and Grant, S. G. (2002). SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. J. Neurosci. 22, 9721-9732.
82. Kornau, H. C., Schenker, L. T., Kennedy, M. B., and Seeburg, P. H. (1995). Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science 269, 1737-1740.
83. Kornau, H. C., Seeburg, P. H., and Kennedy, M. B. (1997). Interaction of ion channels and receptors with PDZ domain proteins. Curr. Opin. Neurobiol. 7, 368-373.
84. Kreienkamp, H. J., Zitzer, H., Gundelfinger, E. D., Richter, D., and Bockers, T. M. (2000). The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. J. Biol. Chem. 275, 32387-32390.
85. Krystal, J. H., Karper, L. P., Seibyl, J. P., Freeman, G. K., Delaney, R., Bremner, J. D., Heninger, G. R., Bowers, M. B., Jr., and Charney, D. S. (1994). Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch. Gen. Pychiat. 51, 199-214.
86. Krystal, J. H., D'Souza, D. C., Karper, L. P., Bennett, A., Abi-Dargham, A., Abi-Saab, D., Cassello, K., Bowers, M. B., Jr., Vegso, S., Heninger, G. R., and Charney, D. S. (1999). Interactive effects of subanesthetic ketamine and haloperidol in healthy humans. Pychopharmacology (Berl.) 145, 193-204.
87. Lahti, A. C., Koffel, B., LaPorte, D., and Tamminga, G. A. (1995). Subanesthetic doses of ketamine stimulate psychosis in schizophrenia. Neuropychopharmacology 13, 9-19.
88. Lee, H. K., Barbarosie, M., Kameyama, K., Bear, M. F., and Huganir, R. L. (2000). Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity. Nature 405, 955-959.
89. Lee, S., Fan, S., Makarova, O., Straight, S., and Margolis, B. (2002). A novel and conserved protein-protein interaction domain of mammalian Lin-2/CASK binds and recruits SAP97 to the lateral surface of epithelia. Mol. Cell. Biol. 22, 1778-1791.
90. Leonard, A. S., Davare, M. A., Horne, M. C., Garner, C. C., and Hell, J. W. (1998). SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole- 4-propionic acid receptor GluR1 subunit. J. Biol. Chem. 273, 19518-19524.
91. Leonoudakis, D., Mailliard, W., Wingerd, K., Clegg, D., and Vandenberg, C. (2001). Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97. J. Cell Sci. 114, 987-998.
92. Lim, S., Naisbitt, S., Yoon, J., Hwang, J. I., Suh, P. G., Sheng, M., and Kim, E. (1999). Characterization of the Shank family of synaptic proteins: Multiple genes, alternative splicing, and differential expression in brain and development. J. Biol. Chem. 274, 29510-29518.
93. Lim, S., Sala, C., Yoon, J., Park, S., Kuroda, S., Sheng, M., and Kim, E. (2001). Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins. Mol. Cell Neurosci. 17, 385-397.
94. Lin, J. W., Wyszynski, M., Madhavan, R., Sealock, R., Kim, J. U., and Sheng, M. (1998). Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1. J. Neurosci. 18, 2017-2027.
95. Linden, A. M., Vasanen, J., Storvik, M., Lakso, M., Korpi, E. R., Wong, G., and Castren, E. (2001). Uncompetitive antagonists of the N-methyl-D-aspartate (NMDA) receptors alter the mRNA expression of proteins associated with the NMDA receptor complex. Pharmacol. Toxicol. 88, 98-105.
96. Long, J. F., Tochio, H., Wang, P., Fan, J. S., Sala, C., Niethammer, M., Sheng, M., and Zhang, M. (2003). Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95. J. Mol. Biol. 327, 203-214.
97. Lue, R. A., Marfatia, S. M., Branton, D., and Chishti, A. H. (1994). Cloning and characterization of hdlg: The human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1. Proc. Natl. Acad. Sci. USA 91, 9818-9822.
98. Luo, L. (2000). Rho GTPases in neuronal morphogenesis. Nature Rev. Neurosci. 1, 173-180.
99. + channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons. Neuron 19, 687-695.
100. Malhotra, A. K., Adler, C. M., Kennison, S. D., Elman, I., Pickar, D., and Breier, A. (1997). Clozapine blunts N-methyl-D-aspartate antagonist-induced psychosis: A study with ketamine. Biol. Pychiat. 42, 664-668.
101. Manser, E., Loo, T. H., Koh, C. G., Zhao, Z. S., Chen, X. Q., Tan, L., Tan, I., Leung, T., and Lim, L. (1998). PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Mol. Cell 1, 183-192.
102. Martin, J. B., and Gusella, J. F. (1986). Huntington's disease: Pathogenesis and management. N. Engl. J. Med. 315, 1267-1276.
103. Masuko, N., Makino, K., Kuwahara, H., Fukunaga, K., Sudo, T., Araki, N., Yamamoto, H., Yamada, Y., Miyamoto, E., and Saya, H. (1999). Interaction of NE-dlg/SAP102, a neuronal and endocrine tissue-specific membrane-associated guanylate kinase protein, with calmodulin and PSD-95/SAP90: A possible regulatory role in molecular clustering at synaptic sites. J. Biol. Chem. 274, 5782-5790.
104. Matrisciano, F., Storto, M., Ngomba, R. T., Cappuccio, I., Caricasole, A., Scaccianoce, S., Riozzi, B., Melchiorri, D., and Nicoletti, F. (2002). Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus. Neuropharmacology 42, 1008-1015.
105. McGee, A. W., Dakoji, S. R., Olsen, O., Bredt, D. S., Lim, W. A., and Prehoda, K. E. (2001). Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins. Mol. Cell 8, 1291-1301.
106. Means, A. R. (2000). Regulatory cascades involving calmodulin-dependent protein kinases. Mol. Endocrinol. 14, 4-13.
107. Mehta, S., Wu, H., Garner, C. C., and Marshall, J. (2001). Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97. J. Biol. Chem. 276, 16092-16099.
108. Migaud, M., Charlesworth, P., Dempster, M., Webster, L. C., Watabe, A. M., Makhinson, M., He, Y., Ramsay, M. F., Morris, R. G., Morrison, J. H., O'Dell, T. J., and Grant, S. G. (1998). Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein. Nature 396, 433-139.
109. Morioka, R., Kato, A., Fueta, Y., and Sugiyama, H. (2001). Expression of vesl-1S/homer-1a, a gene associated with long-term potentiation, in the brain of the epileptic EI mouse. Meurosci Lett. 313, 99-101.
110. Muller, B. M., Kistner, U., Veh, R. W., Cases-Langhoff, C., Becker, B., Gundelfinger, E. D., and Garner, C. C. (1995). Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein. J. Neurosci. 15, 2354-2366.
111. Naisbitt, S., Kim, E., Tu, J. C., Xiao, B., Sala, C., Valtschanoff, J., Weinberg, R. J., Worley, P. F., and Sheng, M. (1999). Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. Neuron 23, 569-582.
112. Nakanishi, S. (1994). Metabotropic glutamate receptors: Synaptic transmission, modulation, and plasticity. Neuron 13, 1031-1037.
113. Nesslinger, N. J., Gorski, J. L., Kurczynski, T. W., Shapira, S. K., Siegel-Bartelt, J., Dumanski, J. P., Cullen, R. F., Jr., French, B. N., and McDermid, H. E. (1994). Clinical, cytogenetic, and molecular characterization of seven patients with deletions of chromosome 22q13.3. Am. J. Hum. Genet. 54, 464-472.
114. Nielsen, H. S., Georg, B., Hannibal, J., and Fahrenkrug, J. (2002). Homer-1 mRNA in the rat suprachiasmatic nucleus is regulated differentially by the retinohypothalamic tract transmitters pituitary adenylate cyclase activating polypeptide and glutamate at time points where light phase-shifts the endogenous rhythm. Brain Res. Mol. Brain Res. 105, 79-85.
115. Niethammer, M., Kim, E., and Sheng, M. (1996). Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. J. Neurosci. 16, 2157-2163.
116. Niethammer, M., Valtschanoff, J. G., Kapoor, T. M., Allison, D. W., Weinberg, T. M., Craig, A. M., and Sheng, M. (1998). CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90. Neuron 20, 693-707.
117. O'Brien, R. J., Xu, D., Petralia, R. S., Steward, O., Huganir, R. L., and Worley, P. (1999). Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp. Neuron 23, 309-323.
118. Ohnuma, T., Kato, H., Arai, H., Faull, R. L., McKenna, P. J., and Emson, P. C. (2000). Gene expression of PSD95 in prefrontal cortex and hippocampus in schizophrenia. Neuroreport 11, 3133-3137.
119. Okamoto, P. M., Gamby, C., Wells, D., Fallon, J., and Vallee, R. B. (2001). Dynamin isoform-specific interaction with the shank/ProSAP scaffolding proteins of the postsynaptic density and actin cytoskeleton. J. Biol. Chem. 276, 48458-18165.
120. Olney, J. W., and Farber, N. B. (1995). Glutamate receptor dysfunction and schizophrenia. Arch. Gen. Pychiat. 52, 998-1007.
121. 2+ calmodulin and the synapse-associated protein SAP97 requires the SH3 domain-guanylate kinase domain-connecting HOOK region. J. Biol. Chem. 277, 40832-40838.
122. Park, E., Na, M., Choi, J., Kim, S., Lee, J. R., Yoon, J., Park, D., Sheng, M., and Kim, E. (2003). The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the β PIX guanine nucleotide exchange factor for Rac1 and Cdc42. J. Biol. Chem. 278, 19220-19229.
123. Park, H. T., Kang, E. K., and Bae, K. W. (1997). Light regulates Homer mRNA expression in the rat suprachiasmatic nucleus. Brain Res. Mol. Brain Res. 52, 318-322.
124. Peiretti, F., Deprez-Beauclair, P., Bonardo, B., Aubert, H., Juhan-Vague, I., and Nalbone, G. (2003). Identification of SAP97 as an intracellular binding partner of TACE. J. Cell Sci. 116, 1949-1957.
125. Polese, D., de Serpis, A. A., Ambesi-Impiombato, A., Muscettola, G., and de Bartolomeis, A. (2002). Homer 1a gene expression modulation by antipsychotic drugs: Involvement of the glutamate metabotropic system and effects of D-cycloserine. Neuropychopharmacology 27, 906-913.
126. Potschka, H., Krupp, E., Ebert, U., Gumbel, C., Leichtlein, C., Lorch, B., Pickert, A., Kramps, S., Young, K., Grune, U., Keller, A., Welschof, M., Vogt, G., Xiao, B., Worley, P. F., Loscher, W, and Hiemisch, H. (2002). Kindling-induced overexpression of Homer 1A and its functional implications for epileptogenesis. Eur. J. Neurosci. 16, 2157-2165.
127. Prasad, C.; Prasad, A. N., Chodirker, B. N., Lee, C., Dawson, A. K., Jocelyn, L. J., and Chudley, A. E. (2000). Genetic evaluation of pervasive developmental disorders: The terminal 22q13 deletion syndrome may represent a recognizable phenotype. Clin. Genet. 57, 103-109.
128. Rao, A., Kim, E., Sheng, M., and Craig, A. M. (1998). Heterogeneity in the molecular composition of excitatory postsynaptic sites during development of hippocampal neurons in culture. J. Neurosci. 18, 1217-1229.
129. Rasband, M. N., Park, E. W., Zhen, D., Arbuckle, M. I., Poliak, S., Peles, E., Grant, S. G., and Trimmer, J. S. (2002). Clustering of neuronal potassium channels is independent of their interaction with PSD-95. J. Cell Biol. 159, 663-672.
130. Roche, K. W., Tu, J. C., Petralia, R. S., Xiao, B., Wenthold, R. J., and Worley, P. F. (1999). Homer 1b regulates the trafficking of group I metabotropic glutamate receptors. J. Biol. Chem. 274, 25953-25957.
131. Saito, H., Kimura, M., Inanobe, A., Ohe, T., and Kurachi, Y. (2002). An N-terminal sequence specific for a novel Homer1 isoform controls trafficking of group I metabotropic glutamate receptor in mammalian cells. Biochem. Biophys. Res. Commun. 296, 523-529.
132. Sala, C., Piech, V., Wilson, N. R., Passafaro, M., Ou, G., and Sheng, M. (2001). Regulation of dendritic spine morphology and synaptic function by Shank and Homer. Neuron 31, 115-130.
133. Sandona, D., Tibaldo, E., and Volpe, P. (2000). Evidence for the presence of two homer 1 transcripts in skeletal and cardiac muscles. Biochem. Biophys. Res. Commun. 279, 348-353.
134. Sanes, J. R., and Lichtman, J. W. (1999). Can molecules explain long-term potentiation? Nature Neurosci. 2, 597-604.
135. Sans, N., Racca, G., Petralia, R. S., Wang, Y. X., McCallum, J., and Wenthold, R. J. (2001). Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway. J. Neurosci. 21, 7506-7516.
136. Sattler, R., Xiong, Z., Lu, W. Y., Hafner, M., MacDonald, J. F., and Tymianski, M. (1999). Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Science 284, 1845-1848.
137. Scannevin, R. H., and Huganir, R. L. (2000). Postsynaptic organization and regulation of excitatory synapses. Mature Rev. Neurosci. 1, 133-141.
138. Schnell, E., Sizemore, M., Karimzadegan, S., Chen, L., Bredt, D. S., and Nicoll, R. A. (2002). Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. Proc. Natl. Acad. Sci. USA 99, 13902-13907.
139. Serge, A., Fourgeaud, L., Hemar, A., and Choquet, D. (2002). Receptor activation and homer differentially control the lateral mobility of metabotropic glutamate receptor 5 in the neuronal membrane. J. Neurosci 22, 3910-3920.
140. Sheng, M. (1996). PDZs and receptor/channel clustering: Rounding up the latest suspects. Neuron 17, 575-578.
141. Sheng, M., and Kim, E. (2000). The Shank family of scaffold proteins. J. Cell Sci. 113, (Pt. 11), 1851-1856.
142. Sheng, M., and Kim, M. J. (2002). Postsynaptic signaling and plasticity mechanisms. Science 298, 776-780.
143. Sheng, M., and Pak, D. T. (2000). Ligand-gated ion channel interactions with cytoskeletal and signaling proteins. Annu. Rev. Physiol. 62, 755-778.
144. Shiraishi, Y., Mizutani, A., Bito, H., Fujisawa, K., Narumiya, S., Mikoshiba, K., and Furuichi, T. (1999). Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is expressed in developing mouse cerebellar granule cells. J. Neurosci. 19, 8389-8400.
145. Soderling, T. R. (2000). CaM-kinases: Modulators of synaptic plasticity. Curr. Opin. Neurobiol. 10, 375-380.
146. Soloviev, M. M. (2000). Detection of a surface-exposed PEST like sequence in the metabotropic glutamate receptor mGluR1 alpha. Bioinformatics 16, 837-838.
147. Soloviev, M. M., Ciruela, F., Chan, W. Y., and McIlhinney, R. A. (2000). Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing. J. Mol. Biol. 295, 1185-1200.
148. Soltau, M., Richter, D., and Kreienkamp, H. J. (2002). The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42. Mol. Cell Neurosci. 21, 575-583.
149. Sprengel, R., Suchanek, B., Amico, C., Brusa, R., Burnashev, N., Rozov, A., Hvalby, O., Jensen, V., Paulsen, O., Andersen, P., Kim, J. J., Thompson, R. F., Sun, W., Webster, L. C., Grant, S. G., Eilers, J., Konnerth, A., Li, J., McNamara, J. O., and Seeburg, P. H. (1998). Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell 92, 279-289.
150. Srivastava, S., Osten, P., Vilim, F. S., Khatri, L., Inman, G., States, B., Daly, C., DeSouza, S., Abagyan, R., Valtschanoff, J. G., Weinberg, R. J., and Ziff, E. B. (1998). Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP. Neuron 21, 581-591.
151. Steigenwald, F., Schulz, T. W., Schenker, L. T., Kennedy, M. B., Seeburg, P. H., and Kohr, G. (2000). C-Terminal truncation of NR2A subunits impairs synaptic but not extrasynaptic localization of NMDA receptors. J. Neurosci. 20, 4573-4581.
152. Sun, J., Tadokoro, S., Imanaka, T., Murakami, S. D., Nakamura, M., Kashiwada, K., Ko, J., Nishida, W., and Sobue, K. (1998). Isolation of PSD-Zip45, a novel Homer/vesl family protein containing leucine zipper motifs, from rat brain. FEBS Lett. 437, 304-308.
153. Sun, Y., Savanenin, A., Reddy, P. H., and Liu, Y. F. (2001). Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate
154. Tadokoro, S., Tachibana, T., Imanaka, T., Nishida, W., and Sobue, K. (1999). Involvement of unique leucine-zipper motif of PSD-Zip45 (Homer 1c/vesl-IL) in group 1 metabotropic glutamate receptor clustering. Proc. Natl. Acad. Sci. USA 96, 13801-13806.
155. Takagi, N., Logan, R., Teves, L., Wallace, M. C., and Gurd, J. W. (2000). Altered interaction between PSD-95 and the NMDA receptor following transient global ischemia. J. Neurochem. 74, 169-178.
156. Tavalin, S. J., Colledge, M., Hell, J. W., Langeberg, L. K., Huganir, R. L., and Scott, J. D. (2002). Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression. J. Neurosci. 22, 3044-3051.
157. + channels in vivo. J. Neurosci. 17, 152-159.
158. Thomas, U. (2002). Modulation of synaptic signalling complexes by Homer proteins. J. Neurochem. 81, 407-113.
159. + channel Kv1.4. Neuron 20, 125-134.
160. Tovar, K. R., and Westbrook, G. L. (2002). Mobile NMDA receptors at hippocampal synapses. Neuron 34, 255-264.
161. Toyooka, K., Iritani, S., Makifuchi, T., Shirakawa, O., Kitamura, N., Maeda, K., Nakamura, R., Niizato, K., Watanabe, M., Kakita, A., Takahashi, H., Someya, T., and Nawa, H. (2002). Selective reduction of a PDZ protein, SAP-97, in the prefrontal cortex of patients with chronic schizophrenia. J. Neurochem. 83, 797-806.
162. Tu, J. C., Xiao, B., Naisbitt, S., Yuan, J. P., Petralia, R. S., Brakeman, P., Doan, A., Aakalu, V. K., Lanahan, A. A., Sheng, M., and Worley, P. F. (1999). Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron 23, 583-592.
163. Tu, J. G., Xiao, B., Yuan, J. P., Lanahan, A. A., Leoffert, K., Li, M., Linden, D. J., and Worley, P. F. (1998). Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron 21, 717-726.
164. Valtschanoff, J. G., Burette, A., Davare, M. A., Leonard, A. S., Hell, J. W., and Weinberg, R. J. (2000). SAP97 concentrates at the postsynaptic density in cerebral cortex. Eur. J. Neurosci. 12, 3605-3614.
165. Vazdarjanova, A., McNaughton, B. L., Barnes, C. A., Worley, P. F., and Guzowski, J. F. (2002). Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networks. J. Neurosci. 22, 10067-10071.
166. Watanabe, Y., Song, T., Sugimoto, K., Horii, M., Araki, N., Tokumitsu, H., Tezuka, T., Yamamoto, T., and Tokuda, M. (2003). Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase. Biochem. J. 372, 465-471.
167. Weed, S. A., Du, Y., and Parsons, J. T. (1998). Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1. J. Cell Sci. 111, (Pt. 16), 2433-2443.
168. Wells, A. L., Lin, A. W., Chen, L. Q., Safer, D., Cain, S. M., Hasson, T., Carragher, B. O., Milligan, R. A., and Sweeney, H. L. (1999). Myosin VI is an actin-based motor that moves backwards. Nature 401, 505-508.
169. Wong, A. C., King, Y., Flint, J., Clark, K., Dumanski, J. P., Ledbetter, D. H., and McDermid, H. E. (1997). Molecular characterization of a 130-kb terminal microdeletion at 22q in a child with mild mental retardation. Am. J. Hum. Genet. 60, 113-120.
170. Wu, H., Nash, J. E., Zamorano, P., and Garner, C. C. (2002). Interaction of SAP97 with minus-end-directed actin motor myosin M. Implications for AMPA receptor trafficking. J. Biol. Chem. 277, 30928-30934.
171. Wu, H., and Parsons, J. T. (1993). Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex. J. Cell Biol. 120, 1417-1426.
172. Wu, H., Reissner, C., Kuhlendahl, S., Coblentz, B., Reuver, S., Kindler, S., Gundelfinger, E. D., and Garner, C. C. (2000). Intramolecular interactions regulate SAP97 binding to GKAP. EMBO J. 19, 5740-5751.
173. Wu, J., Wang, Y., Rowan, M. J., and Anwyl, R. (1997). Evidence for involvement of the neuronal isoform of nitric oxide synthase during induction of long-term potentiation and long-term depression in the rat dentate gyrus in vitro. Neuroscience 78, 393-398.
174. Wyneken, U., Smalla, K. H., Marengo, J. J., Soto, D., de la Cerda, A., Tischmcyer, W., Grimm, R., Boeckers, T. M., Wolf, G., Orrego, F., and Gundelfinger, E. D. (2001). Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities. Neuroscience 102, 65-74.
175. Xia, J., Zhang, X., Staudinger, J., and Huganir, R. L. (1999). Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1. Neuron 22, 179-187.
176. Xiao, B., Tu, J. C., Petralia, R. S., Yuan, J. P., Doan, A., Breder, C. D., Ruggiero, A., Lanahan, A. A., Wenthold, R. J., and Worley, P. F. (1998). Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron 21, 707-716.
177. Yamada, M., Inanobe, A., and Kurachi, Y. (1998). G protein regulation of potassium ion channels. Pharmacol. Rev. 50, 723-760.
178. Yamada, Y., Chochi, Y., Ko, J. A., Sobue, K., and Inui, M. (1999). Activation of channel activity of the NMDA receptor-PSD-95 complex by guanylate kinase-associated protein (GKAP). FEBS Lett. 458, 295-298.
179. Yamada, Y., Chochi, Y., Takamiya, K., Sobue, K., and Inui, M. (1999). Modulation of the channel activity of the epsilon2/zeta1-subtype N-methyl D-aspartate receptor by PSD-95. J. Biol. Chem. 274, 6647-6652.
180. Yamada, Y., Iwamoto, T., Watanabe, Y., Sobue, K., and Inui, M. (2002). PSD-95 eliminates Src-induced potentiation of NR1/NR2A-subtype NMDA receptor channels and reduces high-affinity zinc inhibition. J. Neurochem. 81, 758-764.
181. Yamauchi, T. (2002). Molecular constituents and phosphorylation-dependent regulation of the postsynaptic density. Mass Spectrom. Rev. 21, 266-286.
182. Ziff, E. B. (1997). Enlightening the postsynaptic density. Neuron 19, 1163-1174.
183. Zitzer, H., Honck, H. H., Bachner, D., Richter, D., and Kreienkamp, H. J. (1999a). Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain. J. Biol. Chem. 274, 32997-33001.
184. Zitzer, H., Richter, D., and Kreienkamp, H. J. (1999b). Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1. J. Biol. Chem. 274, 18153-18156.