Intramolecular interactions regulate SAP97 binding to GKAP

EMBO Journal

Volumn 19, Issue 21, 2000, Pages 5740-5751

  Wu, Hongju ^a   Reissner, Carsten ^b   Kuhlendahl, Sven ^a   Coblentz, Blake ^a   Reuver, Susanne ^a   Kindler, Stefan ^c   Gundelfinger, Eckart D ^b   Garner, Craig C ^a  

^a University of Alabama at Birmingham   (United States)

^b LEIBNIZ INSTITUTE FOR NEUROBIOLOGY   (Germany)

^c UNIVERSITY OF HAMBURG   (Germany)

Author keywords

Cell adhesion; GKAP; Molecular modeling; SAP97; SH3

Indexed keywords

GUANYLATE KINASE; GUANYLATE KINASE ASSOCIATED PROTEIN; SYNAPSE ASSOCIATED PROTEIN 97; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL ADHESION; CELL JUNCTION; CRYSTAL STRUCTURE; ENZYME CONFORMATION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SEQUENCE HOMOLOGY;

EID: 0034329470     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.21.5740     Document Type: Article

References (45)

1. Regulatory intra-molecular association in a tyrosine kinase of the Tec family
2. Structure and mechanism of DNA topoisomerase II
3. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A
4. Synapse maturation and structural plasticity at Drosophila neuromuscular junctions
5. BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein
6. What is Drosophila telling us about cancer?
7. Crystal structures of a complexed and peptide-free membrane protein-binding domain: Molecular basis of peptide recognition by PDZ
8. PDZ domains and the formation of protein networks at the plasma membrane
9. Modelling protein docking using shape complementarity, electrostatics, and biochemical information
10. SAP90 binds and clusters kainate receptors causing incomplete desensitization
11. PDZ domains in synapse assembly and signalling
12. SWISS-MODEL and the Swiss-Pdb Viewer: An environment for comparative protein modeling
13. Synaptic PDZ domaincontaining proteins
14. GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules
15. Functional analysis of the guanylate kinase-like domain in the synapse-associated protein SAP97
16. AQUA and PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMR
17. Cloning and characterization of hdlg: The human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1
18. Identification of an intra-molecular interaction between the SH3 and guanylate kinase domains of PSD-95
19. Crystal structure of the mammalian Grb2 adaptor
20. Human homologue of the Drosophila discs large tumor suppressor protein forms an oligomer in solution. Identification of the self-association site
21. The folding transition state between SH3 domains is conformationally restricted and evolutionarily conserved
22. Interaction of NE-dlg/SAP102, a neuronal and endocrine tissue-specific membrane-associated guanylate kinase protein, with calmodulin and PSD-95/SAP90
23. Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement
24. Crystal structure of a PDZ domain
25. Identification of brain-specific splicing variants of the hDlg1 gene and altered splicing neuroblastoma cell lines
26. Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs large tumor suppressor protein
27. Molecular mechanisms of glutamate receptor clustering at excitatory synapses
28. Signaling through scaffold, anchoring, and adaptor proteins
29. HPV E6 targeted degradation of the discs large protein: Evidence for the involvement of a novel ubiquitin ligase
30. E-cadherin mediated cell adhesion recruits SAP97 into the cortical cytoskeleton
31. A developmental change in NMDA receptor-associated proteins at hippocampal synapses
32. DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95
33. An intra-molecular interaction between src homology 3 domain and guanylate kinase-like domain required for channel clustering by postsynaptic density-95/SAP90
34. Crystal structure of the Src family tyrosine kinase Hck
35. Refined structure of the complex between guanylate kinase and its substrate GMP at 2.0 Å resolution
36. SAPAPs, a family of PSD-95/SAP90-associated proteins localized at postsynaptic density
37. Kinases of the Src family: Structure and functions
38. Functional expression of rat synapse-associated proteins SAP97 and SAP102 in Drosophila dlg-1 mutants: Effects on tumor suppression and synaptic bouton structure
39. Synaptic targeting and localization of DLG is a stepwise process that is controlled by multiple domains
40. Solution structure and backbone dynamics of the second PDZ domain of postsynaptic density-95
41. WHAT IF: A molecular modeling and drug design program
42. Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia
43. Subcellular targeting and cytoskeletal attachment of SAP97 to the epithelial lateral membrane
44. Nucleoside monophosphate kinases: Structure, mechanism, and substrate specificity