메뉴 건너뛰기




Volumn 6, Issue 6, 1996, Pages 858-867

Synapse maturation and structural plasticity at Drosophila neuromuscular junctions

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; GENE PRODUCT; ION CHANNEL;

EID: 0030469153     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(96)80038-9     Document Type: Article
Times cited : (93)

References (80)
  • 1
    • 0024359739 scopus 로고
    • Studies of nerve-muscle interactions in Xenopus cell culture: Fine structure of early functional contacts
    • Buchanan J, Sun Y, Poo M: Studies of nerve-muscle interactions in Xenopus cell culture: fine structure of early functional contacts. J Neurosci 1989, 9:1540-1554.
    • (1989) J Neurosci , vol.9 , pp. 1540-1554
    • Buchanan, J.1    Sun, Y.2    Poo, M.3
  • 2
    • 0025471377 scopus 로고
    • Neuromuscular junctions shrink and expand as muscle fiber size is manipulated: In vivo observations in the androgensensitive bulbocavernosus muscle of mice
    • Bailee-Gordon RJ, Breedlove SM, Bernstein S, Lichtman JW: Neuromuscular junctions shrink and expand as muscle fiber size is manipulated: in vivo observations in the androgensensitive bulbocavernosus muscle of mice. J Neurosci 1990, 10:2660-2671.
    • (1990) J Neurosci , vol.10 , pp. 2660-2671
    • Bailee-Gordon, R.J.1    Breedlove, S.M.2    Bernstein, S.3    Lichtman, J.W.4
  • 3
    • 0029926999 scopus 로고    scopus 로고
    • The Drosophila neuromuscular junction: A model system for studying synaptic development and function
    • Keshishian H, Broadie K, Chiba A, Bate M: The Drosophila neuromuscular junction: a model system for studying synaptic development and function. Annu Rev Neurosci 1996, 19:545-575. This comprehensive review summarizes data on myogenesis, pathfinding, and target recognition in Drosophila, which are not discussed in the present review.
    • (1996) Annu Rev Neurosci , vol.19 , pp. 545-575
    • Keshishian, H.1    Broadie, K.2    Chiba, A.3    Bate, M.4
  • 4
    • 0027480289 scopus 로고
    • Synaptic structure and development: The neuromuscular junction
    • Hall ZW, Sanes JR: Synaptic structure and development: the neuromuscular junction. Neuron 1993, 10:99-121.
    • (1993) Neuron , vol.10 , pp. 99-121
    • Hall, Z.W.1    Sanes, J.R.2
  • 5
    • 0028906099 scopus 로고
    • The assembly of the postsynaptic apparatus
    • Apel EO, Merlie JP: The assembly of the postsynaptic apparatus. Curr Opin Neurobiol 1995, 5:62-67.
    • (1995) Curr Opin Neurobiol , vol.5 , pp. 62-67
    • Apel, E.O.1    Merlie, J.P.2
  • 6
    • 0029978023 scopus 로고    scopus 로고
    • Clustering membrane proteins: Ifs all coming together with the PSD-95/SAP-90 protein family
    • Gomperts SN: Clustering membrane proteins: ifs all coming together with the PSD-95/SAP-90 protein family. Cell 1996, 84:659-662.
    • (1996) Cell , vol.84 , pp. 659-662
    • Gomperts, S.N.1
  • 7
    • 0030296378 scopus 로고    scopus 로고
    • Synaptic proteins and the assembly of synaptic junctions
    • Garner C, Kindler S: Synaptic proteins and the assembly of synaptic junctions. Trends Cell Biol 1996, 6:429-433.
    • (1996) Trends Cell Biol , vol.6 , pp. 429-433
    • Garner, C.1    Kindler, S.2
  • 8
    • 0024511443 scopus 로고
    • Stereotypic morphology of glutamatergic synapses on identified muscle cells of Drosophila larvae
    • Johansen J, Halpern ME, Johansen KM, Keshishian H: Stereotypic morphology of glutamatergic synapses on identified muscle cells of Drosophila larvae. J Neurosci 1989, 9:710-725.
    • (1989) J Neurosci , vol.9 , pp. 710-725
    • Johansen, J.1    Halpern, M.E.2    Johansen, K.M.3    Keshishian, H.4
  • 9
    • 0027301138 scopus 로고
    • Ultrastructure of neuromuscular junctions in Drosophila: Comparison of wild type and mutants with increased excitability
    • Jia X, Gorczyca M, Budnik V: Ultrastructure of neuromuscular junctions in Drosophila: comparison of wild type and mutants with increased excitability. J Neurobiol 1993, 24:1025-1044.
    • (1993) J Neurobiol , vol.24 , pp. 1025-1044
    • Jia, X.1    Gorczyca, M.2    Budnik, V.3
  • 10
    • 0027279409 scopus 로고
    • Insulin-like receptor and insulin-like peptide are localized at neuromuscular junctions in Drosophila
    • Gorczyca MG, Augart C, Budnik V: Insulin-like receptor and insulin-like peptide are localized at neuromuscular junctions in Drosophila. J Neurosci''1993, 13:3692-3704.
    • (1993) J Neurosci'' , vol.13 , pp. 3692-3704
    • Gorczyca, M.G.1    Augart, C.2    Budnik, V.3
  • 11
    • 0026453301 scopus 로고
    • SSB, an antigen that selectively labels morphologically distinct synaptic boutons at the Drosophila larval neuromuscular junctions
    • Budnik V, Gorczyca M: SSB, an antigen that selectively labels morphologically distinct synaptic boutons at the Drosophila larval neuromuscular junctions. J Neurobiol 1993, 23:1054-1056.
    • (1993) J Neurobiol , vol.23 , pp. 1054-1056
    • Budnik, V.1    Gorczyca, M.2
  • 12
    • 0024397595 scopus 로고
    • Embryonic development of axon pathways in the Drosophila CNS. II. Behavior of pioneer growth cones
    • Jacobs JR, Goodman CS: Embryonic development of axon pathways in the Drosophila CNS. II. Behavior of pioneer growth cones. J Neurosci 1989, 9:2412-2424.
    • (1989) J Neurosci , vol.9 , pp. 2412-2424
    • Jacobs, J.R.1    Goodman, C.S.2
  • 13
    • 0024801491 scopus 로고
    • Axonal guidance and the development of muscle fiber-specific innervation in Drosophila embryos
    • Johansen J, Halpern ME, Keshishian H: Axonal guidance and the development of muscle fiber-specific innervation in Drosophila embryos. J Neurosci 1989, 9:4318-4332.
    • (1989) J Neurosci , vol.9 , pp. 4318-4332
    • Johansen, J.1    Halpern, M.E.2    Keshishian, H.3
  • 14
    • 0026034901 scopus 로고
    • Location and connectivity of abdominal motor neurons in the embryo and larva of Drosophila melanogaster
    • Sink H, Whitington PM: Location and connectivity of abdominal motor neurons in the embryo and larva of Drosophila melanogaster. J Neurobiol 1991, 22:298-311.
    • (1991) J Neurobiol , vol.22 , pp. 298-311
    • Sink, H.1    Whitington, P.M.2
  • 15
    • 0025938588 scopus 로고
    • Growth cone behavior underlying the development of Stereotypic synaptic connections in Drosophila embryos
    • Halpern ME, Chiba A, Johansen J, Keshishian H: Growth cone behavior underlying the development of Stereotypic synaptic connections in Drosophila embryos. J Neurosci 1991, 11:3227-3238.
    • (1991) J Neurosci , vol.11 , pp. 3227-3238
    • Halpern, M.E.1    Chiba, A.2    Johansen, J.3    Keshishian, H.4
  • 16
    • 0025843536 scopus 로고
    • Pathfinding in the central nervous system and periphery by identified embryonic Drosophila motor axons
    • Sink H, Whitington PM: Pathfinding in the central nervous system and periphery by identified embryonic Drosophila motor axons. Development 1992, 112:307-316.
    • (1992) Development , vol.112 , pp. 307-316
    • Sink, H.1    Whitington, P.M.2
  • 17
    • 0027232876 scopus 로고
    • Genes that control neuromuscular specificity in Drosophila
    • Van Vactor D, Sink H, Fambrough D, Tsoo R, Goodman CS: Genes that control neuromuscular specificity in Drosophila. Cell 1993, 73:1137-1154.
    • (1993) Cell , vol.73 , pp. 1137-1154
    • Van Vactor, D.1    Sink, H.2    Fambrough, D.3    Tsoo, R.4    Goodman, C.S.5
  • 18
    • 0017149332 scopus 로고
    • L-glutamate as an excitatory transmitter at the Drosophila larval neuromuscular junction
    • Jan LY, Jan YN: L-glutamate as an excitatory transmitter at the Drosophila larval neuromuscular junction. J Physiol 1976, 262:215-236.
    • (1976) J Physiol , vol.262 , pp. 215-236
    • Jan, L.Y.1    Jan, Y.N.2
  • 19
    • 0023872497 scopus 로고
    • Identification of the neuropeptide transmitter proctolin in Drosophila larvae: Characterization of fiber-specific neuromuscular endings
    • Anderson MS, Halpern ME, Keshishian H: Identification of the neuropeptide transmitter proctolin in Drosophila larvae: characterization of fiber-specific neuromuscular endings. J Neurosci 1988, 8:242-255.
    • (1988) J Neurosci , vol.8 , pp. 242-255
    • Anderson, M.S.1    Halpern, M.E.2    Keshishian, H.3
  • 20
    • 0028958578 scopus 로고
    • A novel synaptic transmission mediated by a PACAP-like neuropeptide in Drosophila
    • Zhong Y, Pena LA: A novel synaptic transmission mediated by a PACAP-like neuropeptide in Drosophila. Neuron 1995, 14:527-536.
    • (1995) Neuron , vol.14 , pp. 527-536
    • Zhong, Y.1    Pena, L.A.2
  • 21
    • 0026671232 scopus 로고
    • Segmental peptidergic innervation of abdominal targets in larval and adult dipteran insects revealed with an antiserum against leucokinin I
    • Gantera R, Nässei DR: Segmental peptidergic innervation of abdominal targets in larval and adult dipteran insects revealed with an antiserum against leucokinin I. Cell Tissue Res 1992, 269:459-471.
    • (1992) Cell Tissue Res , vol.269 , pp. 459-471
    • Gantera, R.1    Nässei, D.R.2
  • 23
    • 0027325492 scopus 로고
    • Differential ultrastructure of synaptic terminals on ventral longitudinal abdominal muscles in Drosophila larvae
    • Atwood H, Govind CK, Wu C-F: Differential ultrastructure of synaptic terminals on ventral longitudinal abdominal muscles in Drosophila larvae. J Neurobiol 1993, 24:1008-1024.
    • (1993) J Neurobiol , vol.24 , pp. 1008-1024
    • Atwood, H.1    Govind, C.K.2    Wu, C.-F.3
  • 26
    • 0026718251 scopus 로고
    • Alternate neuromuscular target selection following the loss of single muscle fibers in Drosophila
    • Cash S, Chiba A, Keshishian H: Alternate neuromuscular target selection following the loss of single muscle fibers in Drosophila. J Neurosci 1992, 11:2051 -2064.
    • (1992) J Neurosci , vol.11 , pp. 2051-2064
    • Cash, S.1    Chiba, A.2    Keshishian, H.3
  • 27
    • 0027509877 scopus 로고
    • The growth cone choices of Drosophila motoneurons in response to muscle fiber mismatch
    • Chiba A, Hing H, Cash S, Keshishian H: The growth cone choices of Drosophila motoneurons in response to muscle fiber mismatch. J Neurosci 1993, 13:714-732.
    • (1993) J Neurosci , vol.13 , pp. 714-732
    • Chiba, A.1    Hing, H.2    Cash, S.3    Keshishian, H.4
  • 28
    • 0030273675 scopus 로고    scopus 로고
    • Presynaptic development at the Drosophila neuromuscular junction: Assembly and localization of presynaptic active zones
    • Prokop A, Landgraf M, Rushton E, Broadie K, Bate M: Presynaptic development at the Drosophila neuromuscular junction: assembly and localization of presynaptic active zones. Neuron 1996, 17:617-626. The authors show that presynaptic densities can develop in the absence of target muscles. However, certain aspects of presynaptic development require interactions with the muscle cell. In met mutants, in which myoblasts form but fail to differentiate, presynaptic densities fail to localize properly, and the association between the presynaptic terminal and the myoblast is abnormal.
    • (1996) Neuron , vol.17 , pp. 617-626
    • Prokop, A.1    Landgraf, M.2    Rushton, E.3    Broadie, K.4    Bate, M.5
  • 29
    • 0027384355 scopus 로고
    • Muscle development is independent of innervation during Drosophila embryogenesis
    • Broadie K, Bate M: Muscle development is independent of innervation during Drosophila embryogenesis. Development 1993, 119:533-543.
    • (1993) Development , vol.119 , pp. 533-543
    • Broadie, K.1    Bate, M.2
  • 30
    • 0030156251 scopus 로고    scopus 로고
    • The Drosophila tumor suppressor gene, dig, is involved in structural plasticity at a glutamatergic synapse
    • Guan B, Hartmann B, Kho Y-H, Gorczyca M, Budnik V: The Drosophila tumor suppressor gene, dig, is involved in structural plasticity at a glutamatergic synapse. Curr Bio/1996, 6:695-706. Traces the development of the postsynaptic apparatus during target muscle growth and the influence of dig on this process. Major findings are that the postsynaptic surfaces at fly NMJs increase dramatically in size, and that these changes are paralleled by similarly dramatic target muscle growth. Mutations in dig partially block this expansion, suggesting its role in structural synapse modification during development. Analysis of a temperature-sensitive allele of dig reveals that there are two stages likely to require DLG for postsynaptic expansion, embryogenesis and mid to late larval development.
    • (1996) Curr Bio , vol.6 , pp. 695-706
    • Guan, B.1    Hartmann, B.2    Kho, Y.-H.3    Gorczyca, M.4    Budnik, V.5
  • 32
    • 0027497693 scopus 로고
    • Innervation directs receptor synthesis and localization in Drosophila embryo synaptogenesis
    • Broadie K, Bate M: Innervation directs receptor synthesis and localization in Drosophila embryo synaptogenesis. Nature 1993, 361:350-353.
    • (1993) Nature , vol.361 , pp. 350-353
    • Broadie, K.1    Bate, M.2
  • 33
    • 0028088813 scopus 로고
    • Building synapses: Agrin and dystroglycan stick together
    • Fallen JR, Hall ZW: Building synapses: agrin and dystroglycan stick together. Trends Neurosci 1994, 17:469-473.
    • (1994) Trends Neurosci , vol.17 , pp. 469-473
    • Fallen, J.R.1    Hall, Z.W.2
  • 34
    • 0029044590 scopus 로고
    • The inhibitory glycine receptor: Architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex
    • Khuse J, Betz H, Kirsch J: The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex. Curr Opin Neurobiol 1995, 5:318-323.
    • (1995) Curr Opin Neurobiol , vol.5 , pp. 318-323
    • Khuse, J.1    Betz, H.2    Kirsch, J.3
  • 35
    • 0029046771 scopus 로고
    • Drosophila glutamate receptor RNA expression in embryonic and larval muscle fibers
    • Currie DA, Truman JW, Burden Si: Drosophila glutamate receptor RNA expression in embryonic and larval muscle fibers. Dev Dyn 1995, 203:311 -316.
    • (1995) Dev Dyn , vol.203 , pp. 311-316
    • Currie, D.A.1    Truman, J.W.2    Si, B.3
  • 36
    • 0028871230 scopus 로고
    • Regulation of the acetylcholine receptor epsilon subunit gene by recombinant ARIA: An in vitro model for transynaptic gene regulation
    • Chu GC, Moscosso LM, Sliwkowski MX, Merlie JP: Regulation of the acetylcholine receptor epsilon subunit gene by recombinant ARIA: an in vitro model for transynaptic gene regulation. Neuron 1995, 14:329-339.
    • (1995) Neuron , vol.14 , pp. 329-339
    • Chu, G.C.1    Moscosso, L.M.2    Sliwkowski, M.X.3    Merlie, J.P.4
  • 37
    • 0027527614 scopus 로고
    • Activity-dependent development of the neuromuscular synapse during Drosophila embryogenesis
    • Broadie K, Bate M: Activity-dependent development of the neuromuscular synapse during Drosophila embryogenesis. Neuron 1993, 11:607-619.
    • (1993) Neuron , vol.11 , pp. 607-619
    • Broadie, K.1    Bate, M.2
  • 38
    • 0027768992 scopus 로고
    • ZO-1, DLGA and PSD-95/SAP-90: Homologous proteins in tight, septate and synaptic cell junctions
    • Woods DF, Bryant PJ: ZO-1, DLGA and PSD-95/SAP-90: homologous proteins in tight, septate and synaptic cell junctions. Mech Dev 1993, 44:85-89.
    • (1993) Mech Dev , vol.44 , pp. 85-89
    • Woods, D.F.1    Bryant, P.J.2
  • 39
    • 0030604722 scopus 로고    scopus 로고
    • Crystal structures of a complexed and peptide-free membrane protein-binding domain: Molecular basis of peptide recognition by PDZ
    • Doyle DA, Lee A, Lewis J, Kirn E, Sheng E: Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell 1996,85:1067-1076.
    • (1996) Cell , vol.85 , pp. 1067-1076
    • Doyle, D.A.1    Lee, A.2    Lewis, J.3    Kirn, E.4    Sheng, E.5
  • 40
    • 0029098659 scopus 로고
    • Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95
    • Kornau H-C, Schenker LT, Kennedy MB, Seeburg PH: Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science 1995, 269:1737-1740.
    • (1995) Science , vol.269 , pp. 1737-1740
    • Kornau, H.-C.1    Schenker, L.T.2    Kennedy, M.B.3    Seeburg, P.H.4
  • 41
    • 0028882810 scopus 로고
    • Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases
    • Kim E, Niethammer M, Rothschild A, Jan YN, Sheng M: Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. Nature 1995, 378:85-88.
    • (1995) Nature , vol.378 , pp. 85-88
    • Kim, E.1    Niethammer, M.2    Rothschild, A.3    Jan, Y.N.4    Sheng, M.5
  • 42
    • 0029946167 scopus 로고    scopus 로고
    • Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD95 family of membrane-associated guanylate kinases
    • Niethammer M, Kim E, Sheng M: Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD95 family of membrane-associated guanylate kinases. J Neurosci 1996, 16:2157-2163.
    • (1996) J Neurosci , vol.16 , pp. 2157-2163
    • Niethammer, M.1    Kim, E.2    Sheng, M.3
  • 43
    • 0030200438 scopus 로고    scopus 로고
    • Heteromultimerization and NMDA receptor clustering activity of chapsyn-110, a member of the PSD-95 family of synaptic proteins
    • Kim E, Cho K-O, Rothschild AR, Sheng M: Heteromultimerization and NMDA receptor clustering activity of chapsyn-110, a member of the PSD-95 family of synaptic proteins. Neuron 1996, 17:103-113.
    • (1996) Neuron , vol.17 , pp. 103-113
    • Kim, E.1    Cho, K.-O.2    Rothschild, A.R.3    Sheng, M.4
  • 44
    • 0031034750 scopus 로고    scopus 로고
    • Essential role for dig in synaptic clustering of Shaker K+ channels in vivo
    • in press
    • Tejedor FJ, Bokhari A, Rogero O, Zhang JW, Gorczyca M, Kim E, Sheng M, Budnik V: Essential role for dig in synaptic clustering of Shaker K+ channels in vivo. J Neurosci 1996, 17:in press. At the fly larval NMJ, Shaker K+ channels are found to be clustered at synaptic boutons in co-localization with DLG. The two-hybrid system and heterologous transfection experiments are used to demonstrate direct interactions between DLG and Shaker K+ channel in vivo. Moreover, for the first time, genetic evidence for a role of DLG in clustering Shaker channels in the intact animal is provided - domain-specific mutations in dig or Shaker are shown to lead to either a lack or abnormal clustering of Shaker channels at synaptic boutons.
    • (1996) J Neurosci , vol.17
    • Tejedor, F.J.1    Bokhari, A.2    Rogero, O.3    Zhang, J.W.4    Gorczyca, M.5    Kim, E.6    Sheng, M.7    Budnik, V.8
  • 45
    • 0025941465 scopus 로고
    • The disc-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions
    • Woods DF, Bryant PJ: The disc-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell 1991, 66:451-464.
    • (1991) Cell , vol.66 , pp. 451-464
    • Woods, D.F.1    Bryant, P.J.2
  • 46
    • 0028091586 scopus 로고
    • The Drosophila tumor suppressor gene dig is required for normal synaptic bouton structure
    • Lahey T, Gorczyca M, Jia X, Budnik V: The Drosophila tumor suppressor gene dig is required for normal synaptic bouton structure. Neuron 1994, 13:823-835.
    • (1994) Neuron , vol.13 , pp. 823-835
    • Lahey, T.1    Gorczyca, M.2    Jia, X.3    Budnik, V.4
  • 47
    • 33646070787 scopus 로고    scopus 로고
    • From growth control to synaptic structure: Rat membraneassociated guanylate kinase homologs SAP97 and SAP102 can functionally replace the Drosophila tumor suppressor protein DlgA
    • in press
    • Thomas U, Phannavong B, Müller B, Garner CC, Gundetfinger ED: From growth control to synaptic structure: rat membraneassociated guanylate kinase homologs SAP97 and SAP102 can functionally replace the Drosophila tumor suppressor protein DlgA. Mech Dev 1997, in press. The authors use the Gal4 enhancer trap method to introduce and to target the expression of the mammalian dig homologs SAP97 and SAP102. It is suggested that these mammalian proteins are indeed functional dig homologs, because they can rescue dig mutant abnormalities in epithelial tissues and synapses. In addition, the authors characterize at the light microscopical level a dig mutant allele that shows presynaptic abnormalities.
    • (1997) Mech Dev
    • Thomas, U.1    Phannavong, B.2    Müller, B.3    Garner, C.C.4    Gundetfinger, E.D.5
  • 48
    • 0025411428 scopus 로고
    • A voltage-clamp analysis of genedosage effects of the Shaker locus on larval muscle potassium currents in Drosophila
    • Haugland FN, Wu C-F: A voltage-clamp analysis of genedosage effects of the Shaker locus on larval muscle potassium currents in Drosophila. J Neurosci 1990, 10:1357-1371.
    • (1990) J Neurosci , vol.10 , pp. 1357-1371
    • Haugland, F.N.1    Wu, C.-F.2
  • 49
    • 0021025105 scopus 로고
    • Neurogenetic analysis of potassium currents in Drosophila: Synergistic effects on neuromuscular transmission in double mutants
    • Ganetzky B, Wu C-F: Neurogenetic analysis of potassium currents in Drosophila: synergistic effects on neuromuscular transmission in double mutants. J Neurogenet 1983, 1:17-28.
    • (1983) J Neurogenet , vol.1 , pp. 17-28
    • Ganetzky, B.1    Wu, C.-F.2
  • 51
    • 0023990491 scopus 로고
    • Shaker encodes a family of putative potassium channel proteins in the nervous system of Drosophila
    • Pongs O, Kecskemethy N, Muller R, Krah-Jentgens l, Baumann A, Kiltz HH, Canal l, Llamazares S, Ferrus A: Shaker encodes a family of putative potassium channel proteins in the nervous system of Drosophila. EMBO J 1988, 7:1087-1096.
    • (1988) EMBO J , vol.7 , pp. 1087-1096
    • Pongs, O.1    Kecskemethy, N.2    Muller, R.3    Baumann, A.4    Kiltz, H.H.5    Llamazares, S.6    Ferrus, A.7
  • 52
    • 0024285862 scopus 로고
    • Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila
    • Schwarz TL, Tempel BL, Papazian DM, Jan YN, Jan LY: Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila. Nature 1988, 331:137-142.
    • (1988) Nature , vol.331 , pp. 137-142
    • Schwarz, T.L.1    Tempel, B.L.2    Papazian, D.M.3    Jan, Y.N.4    Jan, L.Y.5
  • 53
    • 0024426041 scopus 로고
    • The interference of truncated with normal potassium channel subunits leads to abnormal behaviour in transgenic Drosophila melanogaster
    • Gisselman G, Sewing S, Madsen BW, Mallart A, Angaut-Petit D, Miiller-Holtkamp F, Ferrüs A, Pongs O: The interference of truncated with normal potassium channel subunits leads to abnormal behaviour in transgenic Drosophila melanogaster. EMBO J 1989, 8:2359-2364.
    • (1989) EMBO J , vol.8 , pp. 2359-2364
    • Gisselman, G.1    Sewing, S.2    Madsen, B.W.3    Mallart, A.4    Angaut-Petit, D.5    Miiller-Holtkamp, F.6    Ferrüs, A.7    Pongs, O.8
  • 54
    • 0024344416 scopus 로고
    • Molecular cloning of the lethald discslarge-1 oncogene of Drosophila
    • Woods DF, Bryant PJ: Molecular cloning of the lethald) discslarge-1 oncogene of Drosophila. Dev Biol 1989, 134:222-235.
    • (1989) Dev Biol , vol.134 , pp. 222-235
    • Woods, D.F.1    Bryant, P.J.2
  • 55
    • 0029819449 scopus 로고    scopus 로고
    • The Dig protein is required for junction structure, cell polarity and proliferation control in Drosophila epithelia
    • Woods DF, Hough C, Peel D, Callaini G, Bryant P: The Dig protein is required for junction structure, cell polarity and proliferation control in Drosophila epithelia. J Cell Biol 1996, 134:1469-1482.
    • (1996) J Cell Biol , vol.134 , pp. 1469-1482
    • Woods, D.F.1    Hough, C.2    Peel, D.3    Callaini, G.4    Bryant, P.5
  • 56
    • 0028096801 scopus 로고
    • Cloning and characterization of hdlg: The human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1
    • Lue RA, Marfatia SM, Branton D, Chrishti AH: Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1. Proc Natl Acad Sei USA 1994, 91:9818-9822.
    • (1994) Proc Natl Acad Sei USA , vol.91 , pp. 9818-9822
    • Lue, R.A.1    Marfatia, S.M.2    Branton, D.3    Chrishti, A.H.4
  • 57
    • 0028325048 scopus 로고
    • A Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene
    • Fehon RG, Dawson IA, Artavanis-Tsakonas S: A Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene. Development 1994, 120:545-557.
    • (1994) Development , vol.120 , pp. 545-557
    • Fehon, R.G.1    Dawson, I.A.2    Artavanis-Tsakonas, S.3
  • 58
    • 0026095585 scopus 로고
    • Molecular cloning of an invertebrate glutamate receptor subunit, expressed in Drosophila muscle
    • Schuster CM, Ultsch A, Schloss P, Cox JA, Schmitt B, Betz H: Molecular cloning of an invertebrate glutamate receptor subunit, expressed in Drosophila muscle. Science 1991, 254:112-114.
    • (1991) Science , vol.254 , pp. 112-114
    • Schuster, C.M.1    Ultsch, A.2    Schloss, P.3    Cox, J.A.4    Schmitt, B.5    Betz, H.6
  • 59
    • 0030273505 scopus 로고    scopus 로고
    • Regulation of synapse structure and function by the Drosophila tumor suppressor gene discs-large
    • Budnik V, Guan B, Kho Y-H, Hartmann B, Hough C, Woods D, Gorczyca M: Regulation of synapse structure and function by the Drosophila tumor suppressor gene discs-large. Neuron 1996, 17:627-640. Investigates the mechanisms underlying structural and functional synaptic alterations in dig mutants. The Gal4 enhancer trap method is use to selectively target DLG expression in pre- or postsynaptic cells. The most significant conclusions are that levels of DLG in the muscle can upregulate or downregulate the size of the postsynaptic specialization at type I synapses. However, the postsynaptic abnormalities observed in dig mutants are also rescued by selective presynaptic DLG targeting, showing that postsynaptic development depends on signaling mechanisms from the presynaptic cell. Voltage clamp analysis of synaptic currents demonstrates that in dig mutants, the amount of glutamate released by the presynaptic cell is increased. Models to account for these observations are proposed.
    • (1996) Neuron , vol.17 , pp. 627-640
    • Budnik, V.1    Guan, B.2    Kho, Y.-H.3    Hartmann, B.4    Hough, C.5    Woods, D.6    Gorczyca, M.7
  • 60
    • 0027160708 scopus 로고    scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • Brand A, Perrimon N: Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. De/e/opmenM993, 118:401-415.
    • De/e/opmenM993 , vol.118 , pp. 401-415
    • Brand, A.1    Perrimon, N.2
  • 61
    • 0028147879 scopus 로고
    • Ectopic and increased expression of fasciclin II alters motor neuron growth cone guidance
    • Lin DM, Goodman CS: Ectopic and increased expression of fasciclin II alters motor neuron growth cone guidance. Neuron 1994, 13:673-687.
    • (1994) Neuron , vol.13 , pp. 673-687
    • Lin, D.M.1    Goodman, C.S.2
  • 62
    • 0028170211 scopus 로고
    • Ectopic expression of connectin reveals a repulsive function during growth cone guidance and synapse formation
    • Nose A, Takeichi M, Goodman CS: Ectopic expression of connectin reveals a repulsive function during growth cone guidance and synapse formation. Neuron 1994, 13:525-539.
    • (1994) Neuron , vol.13 , pp. 525-539
    • Nose, A.1    Takeichi, M.2    Goodman, C.S.3
  • 63
    • 0027523669 scopus 로고
    • Developmental mechanisms that generate precise patterns of neuronal connectivity
    • Goodman CS, Shatz CJ: Developmental mechanisms that generate precise patterns of neuronal connectivity. Neuron 1993, 10:77-98.
    • (1993) Neuron , vol.10 , pp. 77-98
    • Goodman, C.S.1    Shatz, C.J.2
  • 64
    • 0029590041 scopus 로고
    • Role of neural activity during synaptogenesis in Drosophila
    • Jarecki J, Keshishian H: Role of neural activity during synaptogenesis in Drosophila. J Neurosci 1995, 15:8177-8190. Genetic variants and pharmacological agents that affect ion channel function are used to study patterns of connectivity at the fly NMJ during embryogenesis and early larval stages. Presynaptic but not postsynaptic activity blockade results in collateral sprouting, which is maintained through larval life. The authors suggest that in flies, electrical activity is not required for pathfinding and target recognition, but for refining patterns of connectivity.
    • (1995) J Neurosci , vol.15 , pp. 8177-8190
    • Jarecki, J.1    Keshishian, H.2
  • 65
    • 0029047691 scopus 로고
    • The Drosophila Toll gene functions zygotically and is necessary for proper motor neuron and muscle development
    • Halfon M, Hashimoto C, Keshishian H: The Drosophila Toll gene functions zygotically and is necessary for proper motor neuron and muscle development Dev Biol 1995, 169:151-167.
    • (1995) Dev Biol , vol.169 , pp. 151-167
    • Halfon, M.1    Hashimoto, C.2    Keshishian, H.3
  • 66
    • 0021368380 scopus 로고
    • Sprouting of motor nerves in adult muscles: A recapitulation of ontogeny
    • Brown MC: Sprouting of motor nerves in adult muscles: a recapitulation of ontogeny. Trends Neurosci 1984, 7:10-14.
    • (1984) Trends Neurosci , vol.7 , pp. 10-14
    • Brown, M.C.1
  • 67
    • 0025513585 scopus 로고
    • Morphological plasticity of motor axon terminals in Drosophila mutants with altered excitability
    • Budnik V, Zhong Y, Wu C-F: Morphological plasticity of motor axon terminals in Drosophila mutants with altered excitability. J Neurosci 1990, 10:3754-3768.
    • (1990) J Neurosci , vol.10 , pp. 3754-3768
    • Budnik, V.1    Zhong, Y.2    Wu, C.-F.3
  • 68
    • 0026544119 scopus 로고
    • Synaptic plasticity in Drosophila memory and hyperexcitable mutants: Role of cAMP cascade
    • Zhong Y, Budnik V, Wu C-F: Synaptic plasticity in Drosophila memory and hyperexcitable mutants: role of cAMP cascade. J Neurosci 1992, 12:644-651.
    • (1992) J Neurosci , vol.12 , pp. 644-651
    • Zhong, Y.1    Budnik, V.2    Wu, C.-F.3
  • 69
    • 0029906425 scopus 로고    scopus 로고
    • Physiology and biochemistry of Drosophila learning mutants
    • Davis RL: Physiology and biochemistry of Drosophila learning mutants. Physiol Rev 1996, 76:299-317.
    • (1996) Physiol Rev , vol.76 , pp. 299-317
    • Davis, R.L.1
  • 70
    • 0025974558 scopus 로고
    • Altered synaptic plasticity in Drosophila memory mutants with a defective cyclic AMP cascade
    • Zhong Y, Wu C-F: Altered synaptic plasticity in Drosophila memory mutants with a defective cyclic AMP cascade. Science 1991, 251:198-201.
    • (1991) Science , vol.251 , pp. 198-201
    • Zhong, Y.1    Wu, C.-F.2
  • 71
    • 0027104631 scopus 로고
    • K+-channel blockers restore synaptic plasticity in the neuromuscular junction of dunce, a Drosophila learning and memory mutant
    • Delgado R, Latorre R, Labarca P: K+-channel blockers restore synaptic plasticity in the neuromuscular junction of dunce, a Drosophila learning and memory mutant Proc R Soc Lond IBiol] 1992, 250:181-185.
    • (1992) Proc R Soc Lond IBiol , vol.250 , pp. 181-185
    • Delgado, R.1    Latorre, R.2    Labarca, P.3
  • 72
    • 0024393433 scopus 로고
    • An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation
    • Malenka RC, Kauer JA, Perkel DJ, Mauk MD, Kelly PT, Nicoll RA, Waxham MN: An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation. Nature 1989, 340:554-557.
    • (1989) Nature , vol.340 , pp. 554-557
    • Malenka, R.C.1    Kauer, J.A.2    Perkel, D.J.3    Mauk, M.D.4    Kelly, P.T.5    Nicoll, R.A.6    Waxham, M.N.7
  • 73
    • 0027538509 scopus 로고
    • Inhibition of calcium/calmodulin-dependent protein kinase in Drosophila disrupts behavioral plasticity
    • Griffith LC, Wang J, Zhong Y, Wu C-F, Greenspan RJ: Inhibition of calcium/calmodulin-dependent protein kinase in Drosophila disrupts behavioral plasticity. Neuron 1993, 10:501-509.
    • (1993) Neuron , vol.10 , pp. 501-509
    • Griffith, L.C.1    Wang, J.2    Zhong, Y.3    Wu, C.-F.4    Greenspan, R.J.5
  • 74
    • 0028578762 scopus 로고
    • Concomitant alterations of physiological and developmental plasticity in Drosophila CaM kinase ll-inhibited synapses
    • Wang J, Renger JJ, Griffith LC, Greenspan RJ, Wu C-F: Concomitant alterations of physiological and developmental plasticity in Drosophila CaM kinase ll-inhibited synapses. Neuron 1994, 13:1373-1384.
    • (1994) Neuron , vol.13 , pp. 1373-1384
    • Wang, J.1    Renger, J.J.2    Griffith, L.C.3    Greenspan, R.J.4    Wu, C.-F.5
  • 75
    • 0029948786 scopus 로고    scopus 로고
    • Homeostasis of synaptic transmission in Drosophila with genetically altered nerve terminal morphology
    • Stewart BA, Schuster CM, Goodman CS, Atwood HL: Homeostasis of synaptic transmission in Drosophila with genetically altered nerve terminal morphology. J Neurosci 1996, 16:3877-3886. That cell adhesion molecules may affect both synapse function and structure is illustrated in this and the following paper [76]. Fly larval NMJs were examined in hypomorphic fas II mutants, which are found to contain a decreased number of NMJ boutons compared to controls. In spite of this phenotype, synaptic strength is maintained as a result of an enhancement of transmitter released by individual synaptic boutons. At the ultrastructural level, this is reflected by an increase in the size of synaptic boutons and in the number of active zones. The authors suggest that morphological parameters of nerve endings are adjusted in the intact organism to maintain optimal synaptic transmission.
    • (1996) J Neurosci , vol.16 , pp. 3877-3886
    • Stewart, B.A.1    Schuster, C.M.2    Goodman, C.S.3    Atwood, H.L.4
  • 76
    • 0028808056 scopus 로고
    • Altered nerve terminal arborization and synaptic transmission in Drosophila mutants of cell adhesion molecule fasciclin I
    • Zhong Y, Shanley J: Altered nerve terminal arborization and synaptic transmission in Drosophila mutants of cell adhesion molecule fasciclin I. J Neurosci 1995, 15:6679-6687. Examines anatomical and electrophysiological NMJ properties in null fas I mutants and fly strains with Fas I overexpression. fas I null mutants are found to have an enhanced number of boutons and NMJ arborizations, while the opposite is observed in Fas I overexpressers. Similarly, the amplitude of synaptic currents is increased in the fas I mutant, and this alteration appears to be consequence of a larger quantal content. These results suggest that fas I may be involved in fine-tuning nerve terminal arborizations. The observation that NMJ overgrowth is similar to that found in hyperexcitable mutants, and that neurotransmitter release is also enhanced, raises the interesting possibility that fas I may be involved in activity-dependent synapse modification.
    • (1995) J Neurosci , vol.15 , pp. 6679-6687
    • Shanley, Z.Y.1
  • 77
    • 0027538548 scopus 로고
    • Structural changes accompanying memory storage
    • Bailey CH, Kandel ER: Structural changes accompanying memory storage. Annu Rev Physiol 1993, 55:397-426.
    • (1993) Annu Rev Physiol , vol.55 , pp. 397-426
    • Bailey, C.H.1    Kandel, E.R.2
  • 80
    • 0030273772 scopus 로고    scopus 로고
    • Genetic dissection of structural and functional components of synaptic plasticity. III. CREB is necessary for presynaptic functional plasticity
    • Davis GW, Schuster CM, Goodman CS: Genetic dissection of structural and functional components of synaptic plasticity. III. CREB is necessary for presynaptic functional plasticity. Neuron 1996, 17:669-679.
    • (1996) Neuron , vol.17 , pp. 669-679
    • Davis, G.W.1    Schuster, C.M.2    Goodman, C.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.