Molecular constituents and phosphorylation-dependent regulation of the post-synaptic density

Mass Spectrometry Reviews

Volumn 21, Issue 4, 2002, Pages 266-286

  Yamauchi, Takashi ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

(CaM KII); Ca2+ calmodulin dependent protein kinase II; Glutamate receptor; Long term potentiation; Phosphorylation; Post synaptic density; Proteomics analysis; Synaptic plasticity

Indexed keywords

BIOCHEMISTRY; CELL MEMBRANES; ENZYMES; FUNCTIONAL NEURAL STIMULATION; GENETIC ENGINEERING; NEUROLOGY;

POST SYNAPTIC DENSITY; PROTEIN KINASES; PROTEIN PHOSPHORYLATION; PROTEOMIC ANALYSIS; SIGNAL TRANSDUCTION PATHWAYS; SYNAPTIC PLASTICITY;

MOLECULAR BIOLOGY;

NERVE PROTEIN; POSTSYNAPTIC DENSITY PROTEINS; PROTEIN KINASE (CALCIUM,CALMODULIN);

ANIMAL; CLASSIFICATION; HUMAN; LONG TERM POTENTIATION; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEOMICS; REVIEW; SIGNAL TRANSDUCTION; SYNAPSE;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; HUMANS; LONG-TERM POTENTIATION; MAP KINASE SIGNALING SYSTEM; NERVE TISSUE PROTEINS; PHOSPHORYLATION; PROTEOMICS; SYNAPSES;

EID: 0036629572     PISSN: 02777037     EISSN: None     Source Type: Journal    
DOI: 10.1002/mas.10033     Document Type: Article

References (121)

1. Abbott MA, Wells DG, Fallon JR. 1999. The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses. J Neurosci 19:7300-7308.
2. Adams JP, Anderson AE, Varga AW, Dineley KT, Cook RG, Pfaffinger PJ, Sweatt JD. 2000. The A-type potassium channel K4.2v is a substrate for the mitogen-activated protein kinase ERK. J Neurochem 75:2277-2287.
3. Ahn S, Maudsley S, Luttrell LM, Lefkowitz RJ, Daaka Y. 1999. Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling. J Biol Chem 274:1185-1188.
4. Airas JM, Betz H, Far OE. 2001. PKC phosphorylation of a conserved serine residue in the C-terminus of group III metabotropic glutamate receptors inhibits calmodulin binding. FEBS Lett 494:60-63.
5. Anderson AE, Adams JP, Qian Y, Cook RG, Pfaffinger PJ, Sweatt JD. 2000 Kv4.2 phosphorylation by cyclic AMP-dependent protein kinase. J Biol Chem. 275:5337-5346.
6. Apperson ML, Moon IS, Kennedy MB. 1996. Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family. J Neurosci 16:6839-6852.
7. 2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in the α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate-type glutamate receptor. J Biol Chem 272:32727-32730.
8. Barria A, Muller D, Derkach V, Griffith LC, Soderling TR. 1997. Regulatory phosphorylation of AMPA-type glutamate receptor by CaM-KII during long-term potentiation. Science 276:2042-2045.
9. Bayer KU, Konlnck PD, Leonard AS, Hell JW, Schulman H. 2001 Interaction with the NMDA receptor locks CaMKII in an active conformation. Nature 411:801-805.
10. Beesley PW, Mummery R, Tibaldi J. 1994. N-cadherin is a major glycoprotein component of isolated rat forebrain postsynaptic densities. J Neurochem 64:2288-2294.
11. Boeckers TM, Kreutz MR, Winter C, Zuschratter W, Smalla KH, Sanmarti-Vila L, Wex H, Langnaese K, Bockmann J, Garner CC, Gundelfinger ED. 1999. Proline-rich synapse-associated protein-1/cortacium binding protein 1 (ProSAP1/CortBP1) is a PDZ-domain protein highly enriched in the postsynaptic density. J Neurosci 19:6506-6518.
12. Boeckers TM, Bockmann J, Kreutz MR, Gundelfinger ED. 2002. ProSAP/Shank proteins - A family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease. J Neurochem 81:903-910.
13. Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL, Worley PF. 1997. Homer: A protein that selectively binds metabotropic glutamate receptors. Nature 386:284-288.
14. Braun AP, Schulman H. 1995. The multifunctional calcium/calmodulin-dependent protein kinase: From form to function. Annu Rev Physiol 57:417-445.
15. Bredt DS, Ferris CC, Snyder SH. 1992. Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin-dependent protein kinase; identification of flavin and calmodulin binding sites. J Biol Chem 267:10976-10981.
16. Carr DW, Stofko-Hahn RE, Fraser ID, Cone RD, Scott JD. 1992. Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79. J Biol Chem 267:16816-16823.
17. Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB. 1998. A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II. Neuron 20:895-904.
18. Cho KO, Hunt CA, Kennedy MB. 1992. The rat brain post-synaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron 9:929:942.
19. Choi J, Ko J, Park E, Lee JR, Yoon J, Lim S, Kim E. 2002. Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95. J Biol Chem 277:12359-12363.
20. Chung HJ, Xia J, Scannevin RH, Zhang X, Huganir RL. 2000. Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates it interaction with PDZ domain-containing proteins. J Neurosci 20:7258-7267.
21. + channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation. Neuron 17:759-767.
22. Cotman CW, Banker G, Churchil L, Taylor D. 1974. Isolation of postsynaptic densities from rat brain. J Cell Biol 63:441-455.
23. Craven SE, Bredt DS. 1998. PDZ proteins organize synaptic signaling pathways. Cell 93:495-498.
24. Dalva MB, Takaku MA, Lin MZ, Shamah SM, Hu L, Gale NW, Greenberg ME. 2000. EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. Cell 103:945-956.
25. Deguchi M, Hata Y, Takeuchi M, Ide N, Hirao K, Yao I, Irie M, Toyoda A, Takai Y. 1998. BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP-90-binding protein. J Biol Chem 273:26269-26272.
26. Dev KK, Nakajima Y, Kitano J, Braithwaite SP, Henley JM, Nikanishi S. 2000. PICK interacts with and regulates PKC phosphorylation of mGluR7. J Neurosci 20:7252-7257.
27. Dong H, O'Brien RJ, Fung ET, Lanahan AA, Worley PF, Huganir RL. 1997. GRIP: A synaptic PDZ domain-containing protein that interacts with AMPA receptors. Nature 386:279-284.
28. Dosemeci A, Reese TS. 1993. Inhibition of endogenous phosphatase in a postsynaptic density fraction allows extensive phosphorylation of the major postsynaptic density protein. J Neurochem 61:550-555.
29. Earnest S, Khokhlatchev A, Albanesi JP, Barylko B. 1996. Phosphorylation of dynamin by ERK2 inhibits the dynamin-microtubule interaction. FEBS Lett 396:62-66.
30. Ehlers MD. 2002. Molecular morphogens for dendritic spines. Trends Neurosci 25:64-67.
31. 2+ pathway by phosphorylation of the receptor-G protein-coupling domain. Proc Natl Acad Sci USA 97:6185-6190.
32. Furuyashiki T, Fujisawa K, Fujita A, Madaule P, Uchino S, Mishina M, Bito H, Narumiya S. 1999. Citron, a Rho-target interacts with PSD-95/SAP-90 at glutamatergic synapse in the thalamus. J Neurosci 19: 109-118.
33. Gardoni F, Bellone C, Cattabeni F, Luca MD. 2001a. Protein kinase C activation modulates α-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex. J Biol Chem. 276:7609-7613.
34. 2+/calmodulin-dependent protein kinase II and postsynaptic density 95 for binding to the NR2A subunit of the NMDA receptor. J Neurosci 21:1501-1509.
35. Goldenring JR, McGuire JS, DeLorenzo RJ. 1984. Identification of the major postsynaptic density protein as homologous with the major calmodulin-binding subunit of a calmodulin-dependent protein kinase. J Neurochem 42:1077-1084.
36. Grunwald IC, Korte M, Wolfer D, Wilkinson GA, Unsicker K, Lipp HP, Bonhoeffer T, Klein R. 2001. Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity. Neuron 32:1027-1040.
37. Hayashi Y, Nishio M, Naito Y, Yokokura H, Nimura Y, Hidaka H, Watanabe Y. 1999. Regulation of neuronal nitric-oxide synthase by calmodulin kinases. J Biol Chem 274:20597-20602.
38. Hayashi Y, Shi SH, Esteban JA, Piccini A, Poncer JC, Malinow R. 2000. Driving AMPA receptors into synapses by LTP and CaMKII: Requirement for GluR1 and PDZ domain interaction. Science 287:2262-2267.
39. Heidinger V, Manzerra P, Wang XQ, Strasser U, Yu SP, Choi DW, Behrens MM. 2002. Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: Mediation through the Pyk2/Src-family kinase pathway in cortical neurons. J Neurosci 22:5452-5461.
40. Henderson JT, Georgiou J, Jia Z, Robertson J, Elowe S, Roder JC, Pawson T. 2001. Receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function. Neuron 32:1041-1056.
41. Hollmann M, Heinemann S. 1994. Cloned glutamate receptors. Annu Rev Neurosci 17:31-108.
42. Huang YZ, Wang Q, Xiong WC, Mei L. 2001. Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95. J Biol Chem 276:19318-19326.
43. Hung AY, Sheng M. 2002. PDZ domains: Structural modules for protein complex assembly. J Biol Chem 277:5699-5702.
44. Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SGN. 2000. Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. Nat Neurosci 3:661-669.
45. Jo K, Derin R, Li M, Bredt DS. 1999. Characterization of MALS/Velis-1, -2, and -3: A family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex. J Neurosci 18:4189-4199.
46. Kandel ER, Schwartz JH, Jessell TM. 2000. Principles of neuronal science. Fourth edition. New York: McGraw-Hill. 210 p.
47. Kelly PT, Cotman CW. 1978. Synaptic proteins: Characterization of tubulin and actin and identification of a distinct postsynaptic density polypeptide. J Cell Biol 79:173-183.
48. 2+/calmodulin dependent protein kinase. Proc Natl Acad Sci USA 81:945-949.
49. Kennedy MB. 1993. The postsynaptic density. Curr Opin Neurobiol 3:732-737.
50. Kennedy MB. 1997. The postsynaptic density at glutamatergic synapses. Trends Neurosci 20:264-268.
51. Kennedy MB. 1998. Signal transduction molecules at the glutamatergic postsynaptic membrane. Brain Res Rev 26:243-257.
52. Kennedy MB. 2000. Signal-processing machines at the postsynaptic density. Science 290:750-754.
53. Kennedy MB, Bennett MK, Erondu NE. 1983. Biochemical and immunochemical evidence that "the major postsynaptic density protein" is a subunit of a calmodulin-dependent protein kinase. Proc Natl Acad Sci USA 80:7357-7361.
54. Kim TW, Wu K, Xu JL, Black IB. 1992. Detection of dystrophin in the postsynaptic density of rat brain and deficiency in a mouse model of Duchenne muscular dystrophy. Proc Natl Acad Sci USA 89:11642-11644.
55. Kim E, Cho KO, Rothschild A, Sheng M. 1996. Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins. Neuron 17:103-113.
56. Kim E, Naisbitt S, Hsueh YP, Rao A, Rothschild A, Craig AM, Sheng M. 1997. GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP-90 family of channel clustering molecules. J Cell Biol 136:669-678.
57. Kim JH, Liao D, Lau LF, Huganir RL. 1998. SynGAP: A synaptic RasGAP that associates with the PSD-95/SAP-90 protein family. Neuron 20:683-691.
58. Kistner U, Wenzel BM, Veh RW, Cases-Langhoff C, Garner AM, Appeltauer U, Voss B, Gundelfinger ED, Garner CC. 1993. SAP-90, a rat postsynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A. J Biol Chem 268:4580-4583.
59. Lee HK, Barbarosie M, Kameyama K, Bear MF, Huganir RL. 2000. Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity. Nature 405:955-959.
60. Lim S, Sala C, Yoon J, Park S, Kuroda S, Sheng M, Kim E. 2001. Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins. Mol Cell Neurosci 17:385-397.
61. Lin JW, Wyszynski M, Madhavan R, Sealock R, Kim JU, Sheng M. 1998. Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1. J Neurosci 18:2017-2027.
62. Lisman J, Schulman H, Cline H. 2002. The molecular basis of CaMKII function in synaptic and behavioral memory. Nature Rev Neurosci 3:175-190.
63. Luscher C, Nicoll RA, Malenka RC, Muller D. 2000. Synaptic plasticity and dynamic modulation of the postsynaptic membrane. Nat Neurosci 3:545-550.
64. Lyford GL, Yamagata K, Kaufmann WE, Barnes CA, Sanders LK, Copeland NG, Gilbert DJ, Jenkins NA, Lanahan AA, Worley PF. 1995. Arc, a growth factor and activity regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. Neuron 14:433-445.
65. Mammen AL, Kameyama K, Roche KW, Huganir RL. 1997. Phosphorylation of the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II. J Biol Chem 272:32528-32533.
66. Minturn JE, Fryer HJL, Geschwind DH, Hockfield S. 1995. TOAD-64, a gene expressed early in neuronal differentiation in the rat, is related to unc-33, a C. elegans gene involved in axon outgrowth. J Neurosci 15:6757-6766.
67. Moon RT, McMahon AP. 1990. Generation of diversity in nonerythroid spectrins. Multiple polypeptides are predicted by sequence analysis of cDNAs encompassing the coding regio human nonerythroid α-spectrin. J Biol Chem 265:4427-4433.
68. Moon IS, Apperson ML, Kennedy MB. 1994. The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B. Proc Natl Acad Sci USA 91:3954-3958.
69. Muller BM, Kistner U, Kindler S, Chung WJ, Kuhlendahl S, Fenster SD, Lau LF, Veh RW, Huganir RL, Gundelfinger ED, Garner CC, 1997. SAP102, a novel postsynaptic protein that interacts with NMDA receptor complex in vivo. Neuron 17:255-265.
70. Naisbitt S, Kim E, Tu JC, Xiao B, Sala C, Valtschanoff J, Weinberg RJ, Worley PF, Scheng M, 1999. Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. Neutron 23:569-582.
71. Nakazawa T, Komai S, Tezuka T, Hisatsune C, Umemori H, Semba K, Mishina M, Manabe T, Yamamoto T. 2001. Characterization of Fyn-mediated tyrosine phosphorylation sites on GluRεr (NR2B) subunit of the N-methyl-D-aspartate receptor. J Biol Chem 276:693-699.
72. Niethammer M, Valtshanoff JG, Kapoor TM, Allison DW, Weinberg RJ, Craig AM, Sheng M. 1998. CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP-90. Neuron 20:693-707.
73. 2+/calmodulin-dependent protein kinase II in the postsynaptic density of the rat brain. Brain Res 610:97-107.
74. Omkumar RV, Kiely MJ, Rosenstein AJ, Min KT, Kennedy MB. 1996. Identification of a phosphorylation site for calcium/calmodulin-dependent protein kinase Ilinthe NR2B subunit of the N-methyl-D-aspartate receptor. J Biol Chem 271:31670-31678.
75. Park DTS, Yang S, Rudolph-Correia S, Kim E, Sheng M. 2001. Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. Neuron 31:289-303.
76. Pei L, Teves RL, Wallace MC, Gurd JW. 2001. Transient cerebral ischemia increases tyrosine phosphorylation of the synaptic RAS-GTPase activating protein, SynGAP. J Cereb Blood Flow Metab 21:955-963.
77. Penzes P, Johnson RC, Alam MR, Kambampati V, Mains RE, Eipper BA. 2000. An isoform of kalirin, a brain-specific GDP/GTP exchange factor, is enriched in the postsynaptic density fraction. J Biol Chem 275:6395-6403.
78. Powell KA, Valova VA, Malladi CS, Jensen ON, Larsen MR, Robinson PJ. 2000. Phosphorylation of dynamin I on Ser-795 by protein kinase c block its association with phospholipids. J Biol Chem 275:11610-11617.
79. Raymond LA, Blackstone CD, Huganir RL. 1993. Phosphorylation and modulation of recombinant GluR6 glutamate receptors by cAMP-dependent protein kinase. Nature 361:637-641.
80. 2+/calmodluin-dependent protein kinase. J Neurosci 17:3379-3391.
81. Scot DB, Blanpied TA, Swanson GT, Zhang C, Ehlers MD. 2001. An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing. J Neurosci 21:3063-3072.
82. Shen K, Meyer T. 1999. Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation. Science 284:162-166.
83. Sheng M. 2001. Molecular organization of the postsynaptic specialization. Proc Natl Acad Sci USA 98:7058-7061.
84. Sheng M, Lee SH. 2001. AMPA receptor trafficking and the control of synaptic transmission. Cell 105:825-828.
85. Sheng M, Sala C 2001. PDZ domains and the organization of supramolecular complexes. Annu Rev Neurosci 24:1-29.
86. Soderling TR, Derkach VA. 2000. Postsynaptic protein phosphorylation and LTP. Trends Neurosci 23:75-80.
87. Srivastava S, Osten P, Villim FS, Khatri L, Inman G, States B, Daly C, DeSouza S, Abagyan R, Valstchanoff JG, Weinberg RJ, Ziff EB. 1998. Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP. Neuron 21:581-591.
88. Stack S, Colbran RJ. 1998. Autophosphorylation-dependent targeting of calcium/calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl-D-aspartate receptor. J Biol Chem 273:20689-20692.
89. 2+/calmodulin-dependent protein kinase II by protein phosphatase 1 and 2A. J Neurochem 68:2119-2128.
90. Strack S, Choi S, Lovinge DM, Colbran RJ. 1997b. Translocation of autophosphorylated calcium/calmodulin-dependent protein kinase II to the postsynaptic density. J Biol Chem 272:13467-13470.
91. Suzuki T, Okumura-Noji K. 1995. NMDA receptor subunits epsilon 1 (NR2A) and epsilon 2 (NR2B) are substrates for Fyn in the postsynaptic density fraction isolated from the rat brain. Biochem Biophys Res Commun 216:582-588.
92. 2+/calmodulin-dependent protein kinase II into postsynaptic density after decapitation. J Neurochem 63:1529-1537.
93. Suzuki T, Mitake S, Okumura-Noji K, Shimizu H, Tada T, Fujii T. 1997. Excitable membranes and synaptic transmission: Postsynaptic mechanisms. Localization of α-internexin in the postsynaptic density of the rat brain. Brain Res 765:74-80.
94. Suzuki T, Mitake S, Murata S. 1999. Presence of up-stream and downstream components of a mitogen-activated protein kinase pathway in the PSD of the rat forebrain. Brain Res 840:36-44.
95. Suzuki T, Usuda N, Murata S, Nakazawa A, Ohtsuka K, Takagi H. 1999. Presence of molecular chaperones, heat shock cognate (Hsc) to and heat shock proteins (Hsp) 40, in the post-synaptic structures of rat brain. Biochem Biophys Res Commun 816:99-110.
96. Takaku MA, Dalva MB, Zigmond RE, Greenberg ME. 2002. Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors. Science 295: 491-495.
97. Takeuchi M, Hata Y, Hirao K, Toyoda A, Irie M, Takai Y, 1997. SAPAPs: A family of PSD-95/SAP-90-associated proteins localized at postsynaptic density. J Biol Chem 272:11943-11951.
98. Thomas U. 2002. Modulation of synaptic signaling complexes by Homer proteins. J Neurochem 81, 407-413.
99. Tingley WG, Ehlers MD, Kameyama K, Doherty C, Ptak JB, Riley CT, Huganir RL. 1997. Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NRI subunit using phosphorylation site-specific antibodies. J Biol Chem 272:5157-5166.
100. Torres R, Firestein BL, Dong H, Staudinger J, Olson EN, Huganir RL, Bredt DS, Gale NW, Yancopoulos GD. 1998. PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron 21:1453-1463.
101. Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF. 1998. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron 21:717-726.
102. Tu JC, Xiao B, Naisbitt S, Yuan JP, Petralia RS, Brakeman P, Doan A, Aakalu VK, Lanahan AA, Sheng M, Worley PF. 1999. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron 23:583-592.
103. Walikonis RS, Jensen ON, Mann M, Provance DW, Jr., Mercer JA, Kennedy MB. 2000. Identification of proteins in the postsynaptic density fraction by mass spectrometry. J Neurosci 20:4069-4080.
104. 2+/calmodulin-dependent protein kinase II and α actinin. J Neurosci 21:423-433.
105. Walsh MJ, Kuruc N. 1992. The postsynaptic density: Constituent and associated proteins characterized by electrophoresis, immunoblotting, and peptide sequencing. J Neurochem 59:667-678.
106. Wang LY, Taverna FA, Hunang XP, MacDonald JF, Hampson DR. 1993. Phosphorylation and modulation of a kainate receptor (GluR6) by cAMP-dependent protein kinase. Science 259:1173-1175.
107. Westphal RS, Tavalin SJ, Lin JW, Alto NM, Fraser IDC, Langeberg LK, Shen M, Scott JD. 1999. Regulation of NMDA-receptors by an associated phosphatase-kinase signaling complex. Science 285:93-96.
108. Wolf M, Burgess S, Misra UK, Sahyoun N. 1986. Postsynaptic densities contain a subtype of protein kinase C. Biochem Biophys Res Commun 140:691-698.
109. 2+/calmodulin. Proc Natl Acad Sci USA 89:8686-8690.
110. Wu K, Xu JL, Suen PC, Levine E, Huang YY, Mount HT, Lin SY, Black IB. 1996. Functional trkB neurotrophin receptors are intrinsic components of the adult brain postsynaptic density. Mol Brain Res 43:286-290.
111. Wu L, Wells D, Tay J, Mendis D, Abbott MA, Barnitt A, Quinlan E, Heynen A, Fallon JR, Richter JD. 1998. CPEB-mediated cytoplasmic polyadenylation and the regulation of experience-dependent translation of α-CaMKII mRNA at synapses. Neuron 21:1129-1139.
112. Xia J, Zhang X, Staudinger J, Huganir RL. 1999. Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICKI. Neuron 22:179-187.
113. Yeh TC, Ogawa W, Danielson AG, Roth RA. 1996. Characterization and cloning of a 58/53-kDa substrate of the insulin receptor tyrosine kinase. J Biol Chem 271:2921-2928
114. 2+/calmodulin-dependent protein kinase II with the postsynaptic densities. J Biol Chem 272:26354-26359.
115. 2+/calmodulin-dependent protein kinase II from the postsynaptic density in the rat forebrain. J Biochem (Tokyo) 119:268-273.
116. 2+/calmodulin-dependent protein kinase II from postsynaptic densities. FEBS Lett 446:239-242.
117. 2+/calmodulin-dependent protein kinase II translocated to the postsynaptic density. Mol Brain Res 81:118-128.
118. 2+/calmodulin-dependent protein kinase II in the postsynaptic density by protein sequencing and mass spectrometry. Biochem Biophys Res Commun 290:948-954.
119. Zhang W, Vazquez L, Apperson M, Kennedy MB. 1999. Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus. J Neurosci 19:96-108.
120. Zheng F, Gingrich MB, Traynelis SF, Conn PJ. 1998. Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition. Nat Neurosci 1:185-191.
121. Ziff EB. 1997. Enlightening the postsynaptic density. Neuron 19:1163-1174.