Acute administration of antipsychotics modulates Homer striatal gene expression differentially

Molecular Brain Research

Volumn 98, Issue 1-2, 2002, Pages 124-129

  De Bartolomeis, Andrea ^a   Aloj, Luigi ^b   Ambesi Impiombato, Alberto ^a   Bravi, Daniele ^c   Caracò, Corradina ^b   Muscettola, Giovanni ^a   Barone, Paolo ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CNR   (Italy)

^c Eli Lilly Italia   (Italy)

Author keywords

Accumbens; Caudate putamen; Dopamine; Enkeliphalin; Haloperidol; In situ hybridization; mRNA; Olanzapine; Postsynaptic density protein

Indexed keywords

BRAIN PROTEIN; HALOPERIDOL; MESSENGER RNA; NEUROLEPTIC AGENT; OLANZAPINE; OPIATE RECEPTOR; POSTSYNAPTIC DENSITY PROTEIN 95; PREPROENKEPHALIN; PROTEIN HOMER; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CAUDATE NUCLEUS; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG EFFECT; FOREBRAIN; GENE EXPRESSION REGULATION; IMMEDIATE EARLY GENE; MALE; NERVE CELL PLASTICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; NUCLEUS ACCUMBENS; PARIETAL LOBE; PREFRONTAL CORTEX; PRIORITY JOURNAL; PUTAMEN; RAT; SYNAPSE;

ANIMALS; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; CARRIER PROTEINS; CAUDATE NUCLEUS; CORPUS STRIATUM; ENKEPHALINS; FRONTAL LOBE; HALOPERIDOL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; NEURONAL PLASTICITY; NEUROPEPTIDES; NUCLEUS ACCUMBENS; PARIETAL LOBE; PIRENZEPINE; PREFRONTAL CORTEX; PUTAMEN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; RNA, MESSENGER;

EID: 0037203851     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(01)00327-8     Document Type: Article

References (20)

1. Effect of chronic typical and atypical neuroleptic treatment on proenkephalin mRNA levels in the striatum and nucleus accumbens of the rat
2. Further evidence that behavioral tests and neuropeptide mRNA and tissue level alterations can differentiate between typical and atypical antipsychotic drugs
3. Homer: A protein that selectively binds metabotropic glutamate receptors
4. Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells
5. The inhibitory mGluR agonist, S-4-carboxy-3-hydroxy-phenylglycine selectively attenuates NMDA neurotoxicity and oxygen-glucose deprivation-induced neuronal death
6. The effects of D1 or D2 dopamine receptor blockade on zif/268 and preprodynorphin gene expression in rat forebrain following a short-term cocaine binge
7. Dopaminergic and peptidergic mRNA levels in juvenile rat brain after prenatal cocaine treatment
8. Dopamine-glutamate interactions in the striatum: Behaviourally relevant modification of excitotoxicity by dopamine receptor-mediated mechanisms
9. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95
10. Clozapine and haloperidol produce a differential pattern of immediate early gene expression in rat caudate-putamen, nucleus accumbens, lateral septum and islands of Calleja
11. The behavioral pharmacology of olanzapine, a novel 'atypical' antipsychotic agent
12. Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin
13. NMDA antagonists as neurotherapeutic drugs, psychotogens, neurotoxins, and research tools for studying schizophrenia
14. Metabotropic receptors in excitotoxicity: (S)-4-carboxy-3-hydroxyphenylglycine ((S)-4C3HPG) protects against rat striatal quinolinic acid lesions
15. Effects of olanzapine on regional C-Fos expression in rat forebrain
16. Sigma receptor ligands attenuate N-methyl-D-aspartate cytotoxicity in dopaminergic neurons of mesencephalic slice cultures
17. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins
18. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors
19. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins