Possible contributions of myelin and oligodendrocyte dysfunction to schizophrenia

International Review of Neurobiology

Volumn 59, Issue , 2004, Pages 381-424

  Stewart, Daniel G ^a   Davis, Kenneth L ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 3; GELSOLIN; MYELIN ASSOCIATED GLYCOPROTEIN; TRANSFERRIN;

AGE; ANIMAL; DEMYELINATING DISEASE; DIAGNOSTIC IMAGING; GENE EXPRESSION; GENETIC LINKAGE; GENETICS; GLIA; HUMAN; LYMPHOCYTE; METABOLISM; METHODOLOGY; MYELIN SHEATH; OLIGODENDROGLIA; PATHOLOGY; PHYSIOLOGY; REVIEW; SCHIZOPHRENIA;

AGE FACTORS; ANIMALS; DEMYELINATING DISEASES; DIAGNOSTIC IMAGING; GELSOLIN; GENE EXPRESSION; HUMANS; LINKAGE (GENETICS); LYMPHOCYTES; MYELIN SHEATH; MYELIN-ASSOCIATED GLYCOPROTEIN; NEUROGLIA; OLIGODENDROGLIA; RECEPTOR, ERBB-3; SCHIZOPHRENIA; TRANSFERRIN;

EID: 2342461665     PISSN: 00747742     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0074-7742(04)59015-3     Document Type: Article

References (369)

1. Abney, E. R., Bartlett, P. P., et al. (1981). Astrocytes, ependymal cells, and oligodendrocytes develop on schedule in dissociated cell cultures of embryonic rat brain. Dev. Biol. 83(2), 301-310.
2. Adlkofer, K., and Lai, C. (2000). Role of neuregulins in glial cell development. Glia 29(2), 104-111.
3. Agartz, I., Andersson, J. L., et al. (2001). Abnormal brain white matter in schizophrenia: A diffusion tensor imaging study. Neuroreport 12(10), 2251-2254.
4. Akbarian, S., Kim, J. J., et al. (1995). Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Arch. Gen. Psychiat. 52(4), 258-266.
5. Akbarian, S., Kim, J. J., et al. (1996). Maldistribution of interstitial neurons in prefrontal white matter of the brains of schizophrenic patients. Arch. Gen. Psychiat. 53(5), 425-436.
6. Akers, R. F., and Routtenberg, A. (1985). Protein kinase G phosphorylates a 47 Mr protein (F1) directly related to synaptic plasticity. Brain Res. 334, 147-151.
7. Akil, M., and Lewis, D. A. (1996). Reduced dopaminergic innervation of the prefrontal cortex in schizophrenia. Soc. Neurosci. 22, 1679. [Abstract]
8. Allen, H. L., and Iversen, L. L. (1990). Phencyclidine, dizocilpine, and cerebrocortical neurons. Science 247(4939), 221.
9. Alonso, M. A., Barton, D. E., et al. (1988). Assignment of the T-cell differentiation gene MAL to human chromosome 2, region cen-q13. Immunogenetics 27(2), 91-95.
10. Alves, D., Pires, M. M., et al. (1986). Four cases of late onset metachromatic leucodystrophy in a family: Clinical, biochemical and neuropathological studies. J. Neurol. Neurosurg. Psychiat. 49(12), 1417-1422.
11. Anand, A., Charney, D. S., et al. (2000). Attenuation of the neuropsychiatric effects of ketamine with lamotrigine: Support for hyperglutamatergic effects of N-methyl-D-aspartate receptor antagonists. Arch. Gen. Psychiat. 57(3), 270-276.
12. Anderson, S. A., Volk, D. W., et al. (1996). Increased density of microtubule associated protein 2-immunoreactive neurons in the prefrontal white matter of schizophrenic subjects. Schizophr. Res. 19(2-3), 111-119.
13. Andreasen, N. C., Flashman, L., et al. (1994). Regional brain abnormalities in schizophrenia measured with magnetic resonance imaging. JAMA 272(22), 1763-1769.
14. Andreasen, N. C., O'Leary, D. S., et al. (1997). Hypofrontality in schizophrenia: Distributed dysfunctional circuits in neuroleptic-naive patients. Lancet 349(9067), 1730-1734.
15. Andreasen, N. C., Paradiso, S., et al. (1998). "Cognitive dysmetria" as an integrative theory of schizophrenia: A dysfunction in cortical-subcortical-cerebellar circuitry? Schizophr. Bull. 24(2), 203-218.
16. Araque, A., Parpura, V., et al. (1999). Tripartite synapses: Glia, the unacknowledged partner. Trends Neurosci. 22(5), 208-215.
17. Arnett, P. A., Rao, S. M., et al. (1994). Relationship between frontal lobe lesions and Wisconsin card sorting test performance in patients with multiple sclerosis. Neurology 44(3 Pt 1), 420-425.
18. Arnold, S. E. (1999). Cognition and neuropathology in schizophrenia. Acta Psychiat. Scand Suppl. 395, 41-50.
19. Arquint, M., Roder, J., et al. (1987). Molecular cloning and primary structure of myelin-associated glycoprotein. Proc. Natl. Acad. Sci. USA 84(2), 600-604.
20. Auer, D. P., Wilke, M., et al. (2001). Reduced NAA in the thalamus and altered membrane and glial metabolism in schizophrenic patients detected by 1H-MRS and tissue segmentation. Schizophr. Res. 52(1-2), 87-99.
21. Bahr, M., and Bonhoeffer, F. (1994). Perspectives on axonal regeneration in the mammalian CNS. Trends Neurosci. 17(11), 473-479.
22. Bailer, U., Leisch, F., et al. (2000). Genome scan for susceptibility loci for schizophrenia. Neuropsychobiology 42(4), 175-182.
23. Barres, B. A., Hart, I. K., et al. (1992). Cell death and control of cell survival in the oligodendrocyte lineage. Cell 70(1), 31-46.
24. Barres, B. A., Lazar, M. A., et al. (1994). A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development. Development 120(5), 1097-1108.
25. Barres, B. A., and Raff, M. C. (1993). Proliferation of oligodendrocyte precursor cells depends on electrical activity in axons. Nature 361(6409), 258-260.
26. Barres, B. A., Raff, M. C., et al. (1994a). A crucial role for neurotrophin-3 in oligodendrocyte development. Nature 367(6461), 371-375.
27. Bartha, R., al-Semaan, Y. M., et al. (1999). A short echo proton magnetic resonance spectroscopy study of the left mesial-temporal lobe in first-onset schizophrenic patients. Biol. Psychiat. 45(11), 1403-1411.
28. Bartsch, S., Montag, D., et al. (1997). Increased number of unmyelinated axons in optic nerves of adult mice deficient in the myelin-associated glycoprotein (MAG). Brain Res. 762(1-2), 231-234.
29. Bartsch, U. (1996). Myelination and axonal regeneration in the central nervous system of mice deficient in the myelin-associated glycoprotein. J. Neurocytol. 25(5), 303-313.
30. Bartsch, U., Kirchhoff, F., et al. (1989). Immunohistological localization of the adhesion molecules L1, N-CAM, and MAG in the developing and adult optic nerve of mice. J. Camp. Neurol. 284(3), 451-462.
31. Bartzokis, G., Beckson, M., et al. (2001). Age-related changes in frontal and temporal lobe volumes in men: A magnetic resonance imaging study. Arch. Gen. Psychiat. 58(5), 461-465.
32. Bartzokis, G., Nuechterlein, K. H., et al. (2003). Dysregulated brain development in adult men rath schizophrenia: A magnetic resonance imaging study. Biol. Psychiat. 53(5), 412-421.
33. Baumann, N., and Pham-Dinh, D. (2001). Biology of oligodendrocyte and myelin in the mammalian central nervous system. Psysiol. Rev. 81(2), 871-927.
34. Beatty, W. W. (1993). Cognitive and emotional disturbances in multiple sclerosis. Neurol. Clin. 11(1), 189-204.
35. Beck, K. D., Powell-Braxton, L., et al. (1995). Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons. Neuron 14(4), 717-730.
36. Benes, F. M. (1989). Myelination of cortical-hippocampal relays during late adolescence. Schizophr. Bull. 15(4), 585-593.
37. Benes, F. M., Turtle, M., et al. (1994). Myelination of a key relay zone in the hippocampal formation occurs in the human brain during childhood, adolescence, and adulthood. Arch. Gen. Psychiat. 51(6), 477-484.
38. Benes, F. M., Vincent, S. L., et al. (1992). Increased GABAA receptor binding in superficial layers of cingulate cortex in schizophrenics. J. Neurosci. 12(3), 924-929.
39. Benes, F. M., Vincent, S. L., et al. (1996). Up-regulation of GABAA receptor binding on neurons of the prefrontal cortex in schizophrenic subjects. Neuroscience 75(4), 1021-1031.
40. Bergles, D. E., Roberts, J. D., et al. (2000). Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus. Nature 405(6783), 187-191.
41. Bertolino, A., Breier, A., et al. (2000). The relationship between dorsolateral prefrontal neuronal N-acetylaspartate and evoked release of striatal dopamine in schizophrenia. Neuropsychopharmacology 22(2), 125-132.
42. Bertolino, A., Callicott, J. H., et al. (1998a). Regionally specific neuronal pathology in untreated patients with schizophrenia: A proton magnetic resonance spectroscopic imaging study. Biol. Psychiat. 43(9), 641-648.
43. Bertolino, A., Callicott, J. H., et al. (1998b). Reproducibility of proton magnetic resonance spectroscopic imaging in patients with schizophrenia. Neuropsychopharmacology 18(1), 1-9.
44. Bertolino, A., Callicott, J. H., et al. (2001). The effect of treatment with antipsychotic drugs on brain N-acetylaspartate measures in patients with schizophrenia. Biol. Psychiat. 49(1), 39-46.
45. Bertolino, A., Knable, M. B., et al. (1999). The relationship between dorsolateral prefrontal N-acetylaspartate measures and striatal dopamine activity in schizophrenia. Biol. Psychiat. 45(6), 660-667.
46. Bertolino, A., Nawroz, S., et al. (1996). Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multislice proton magnetic resonance spectroscopic imaging. Am. J. Psychiat. 153(12), 1554-1563.
47. Biffiger, K., Bartsch, S., et al. (2000). Severe hypomyelination of the murine CNS in the absence of myelin-associated glycoprotein and fyn tyrosine kinase. J. Neurosci. 20(19), 7430-7437.
48. Bloch, B., Popovici, T., et al. (1985). Transferrin gene expression visualized in oligodendrocytes of the rat brain by using in situ hybridization and immunohistochemistry. Proc. Natl. Acad. Sci. USA 82(19), 6706-6710.
49. Block, W., Bayer, T. A., et al. (2000). Decreased frontal lobe ratio of N-acetyl aspartate to choline in familial schizophrenia: A proton magnetic resonance spectroscopy study. Neurosci. Lett. 289(2), 147-151.
50. Bogerts, B., Meertz, E., et al. (1985). Basal ganglia and limbic system pathology in schizophrenia: A morphometric study of brain volume and shrinkage. Arch. Gen. Psychiat. 42(8), 784-791.
51. Bogler, O., Wren, D., et al. (1990). Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells. Proc. Natl. Acad. Sci. USA 87(16), 6368-6372.
52. Bongarzone, E. R., Howard, S. G., et al. (1998). Identification of the dopamine D3 receptor in oligodendrocyte precursors: Potential role in regulating differentiation and myelin formation. J. Neurosci. 18(14), 5344-5353.
53. Braun, P. E., Sandillon, F., et al. (1988). Immunocytochemical localization by electron microscopy of 2′,3′-cyclic nucleotide 3′-phosphodiesterase in developing oligodendrocytes of normal and mutant brain. J. Neurosci. 8(8), 3057-3066.
54. Braus, D. F., Ende, G., et al. (2002). Functioning and neuronal viability of the anterior cingulate neurons following antipsychotic treatment: MR-spectroscopic imaging in chronic schizophrenia. Eur. Neuropsychopharmacol. 12(2), 145-152.
55. Breier, A., Buchanan, R. W., et al. (1992). Brain morphology and schizophrenia: A magnetic resonance imaging study of limbic, prefrontal cortex, and caudate structures. Arch. Gen. Psychiat. 49(12), 921-926.
56. Brown, R., Colter, N., et al. (1986). Postmortem evidence of structural brain changes in schizophrenia: Differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder. Arch. Gen. Psychiat. 43(1), 36-42.
57. Browning, M. D., Dudek, E. M., et al. (1993). Significant reductions in synapsin but not synaptophysin specific activity in the brains of some schizophrenics. Biol. Psychiat. 34(8), 529-535.
58. Brzustowicz, L. M., Hodgkinson, K. A., et al. (2000). Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. Science 288(5466), 678-682.
59. Buchanan, R. W., Vladar, K., et al. (1998). Structural evaluation of the prefrontal cortex in schizophrenia. Am. J. Psychiat. 155(8), 1049-1055.
60. Buchsbaum, M. S., Tang, C. Y., et al. (1998). MRI white matter diffusion anisotropy and PET metabolic rate in schizophrenia. Neuroreport 9(3), 425-430.
61. Bullmore, E. T., Woodruff, P. W., et al. (1998). Does dysplasia cause anatomical dysconnectivity in schizophrenia? Schizophr. Res. 30(2), 127-135.
62. Burnashev, N. (1996). Calcium permeability of glutamate-gated channels in the central nervous system. Curr. Opin. Neurobiol 6(3), 311-317.
63. Butt, A. M., Ibrahim, M., et al. (1995). Biochemical subtypes of oligodendrocyte in the anterior medullary velum of the rat as revealed by the monoclonal antibody Rip. Glia 14(3), 185-197.
64. Callicott, J. H., Bertolino, A., et al. (2000a). Selective relationship between prefrontal N-acetylaspartate measures and negative symptoms in schizophrenia. Am. J. Psychiat. 157(10), 1646-1651.
65. Callicott, J. H., Bertolino, A., et al. (2000b). Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb. Cortex 10(11), 1078-1092.
66. Callicott, J. H., Egan, M. F., et al. (1998). Hippocampal N-acetyl aspartate in unaffected siblings of patients with schizophrenia: A possible intermediate neurobiological phenotype. Biol. Psychiat. 44(10), 941-950.
67. Callicott, J. H., Egan, M. F., et al. (2003). Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia. Am. J. Psychiat. 160(4), 709-719.
68. Cannon, T. D., van Erp, T. G., et al. (1998). Regional gray matter, white matter, and cerebrospinal fluid distributions in schizophrenic patients, their siblings, and controls. Arch. Gen. Psychiat. 55(12), 1084-1091.
69. Canoll, P. D., Kraemer, R., et al. (1999). GGF/neuregulin induces a phenotypic reversion of oligodcndrocytes. Mol. Cell Neurosci. 13(2), 79-94.
70. Canoll, P. D., Musacchio, J. M., et al. (1996). GGF/neuregulin is a neuronal signal that promotes the proliferation and survival and inhibits the differentiation of oligodendrocyte progenitors. Neuron 17(2), 229-243.
71. Carson, M. J., Behringer, R. R., et al. (1993). Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic mice. Neuron 10(4), 729-740.
72. Casanova, M. F. (1997). Functional and anatomical aspects of prefrontal pathology in schizophrenia. Schizophr. Bull. 23(3), 517-519.
73. Cassia, R., Besnard, L., et al. (1997). Transferrin is an early marker of hepatic differentiation, and its expression correlates with the postnatal development of oligodendrocytes in mice. J. Neurosci. Res. 50(3), 421-432.
74. Cecil, K. M., Lenkinski, R. E., et al. (1999). Proton magnetic resonance spectroscopy in the frontal and temporal lobes of neuroleptic naive patients with schizophrenia. Neuropsychopharmacology 20(2), 131-140.
75. Cerizza, M., Nemni, R., et al. (1987). Adult metachromatic leucodystrophy: An underdiagnosed disease? J. Neurol. Neurosurg. Psychiat. 50(12), 1710-1712.
76. Cheng, C. M., Joncas, G., et al. (1998). Biochemical and morphometric analyses show that myelination in the insulin-like growth factor 1 null brain is proportionate to its neuronal composition. J. Neurosci. 18(15), 5673-5681.
77. Choe, B. Y., Kim, K. T., et al. (1994). 1H magnetic resonance spectroscopy characterization of neuronal dysfunction in drug-naive, chronic schizophrenia. Acad Radiol. 1(3), 211-216.
78. Choe, B. Y., Suh, T. S., et al. (1996). Observation of metabolic changes in chronic schizophrenia after neuroleptic treatment by in vivo hydrogen magnetic resonance spectroscopy. Invest. Radiol. 31(6), 345-352.
79. Choi, D. W. (1992). Excitotoxic cell death. J. Neurobiol. 23(9), 1261-1276.
80. Choi, D. W., Maulucci-Gedde, M., et al. (1987). Glutamate neurotoxicity in cortical cell culture. J. Neurosci. 7(2), 357-368.
81. Coetzee, T., Dupree, J. L., et al. (1998). Demyelination and altered expression of myelin-associated glycoprotein isoforms in the central nervous system of galactolipid-deficient mice. J. Neurosd. Res. 54(5), 613-622.
82. Comi, G., Filippi, M., et al. (1995). Brain MRI correlates of cognitive impairment in primary and secondary progressive multiple sclerosis. J. Neurol. Sci. 132(2), 222-227.
83. Connor, J. R., and Fine, R. E. (1987). Development of transferrin-positive oligodendrocytes in the rat central nervous system. J. Neurosci. Res. 17(1), 51-59.
84. Connor, J. R., and Menzies, S. L. (1996). Relationship of iron to oligodendrocytes and myelination. Glia 17(2), 83-93.
85. Cooper, J. A., Bryan, J., et al. (1987). Microinjection of gelsolin into living cells. J. Cell Biol. 104(3), 491-501.
86. Corfas, G., Rosen, K. M., et al. (1995). Differential expression of ARIA isoforms in the rat brain. Neuron 14(1), 103-115.
87. Corso, T. D., Neafsey, E. J., et al. (1994). Neuron necrotizing properties of phencyclidine. Soc. Neurosci. 20, 1531[Abstract].
88. Corso, T. D., Sesma, M. A., et al. (1997). Multifocal brain damage induced by pheneyclidine is augmented by pilocarpine. Brain Res. 752(1-2), 1-14.
89. Cotter, D. R., Pariante, C. M., et al. (2001). Glial cell abnormalities in major psychiatric disorders: The evidence and implications. Brain Res. Bull. 55(5), 585-595.
90. Davis, K. L., Buchsbaum, M. S., et al. (1998). Ventricular enlargement in poor-outcome schizophrenia. Biol. Psychiat. 43(11), 783-793.
91. Davis, K. L., Stewart, D. G., et al. (2003). White matter changes in schizophrenia: Evidence for myelin-related dysfunction. Arch. Gen. Psychiat. 60(5), 443-456.
92. Daviss, S. R., and Lewis, D. A. (1995). Local circuit neurons of the prefrontal cortex in schizophrenia: Selective increase in the density of calbindin-immunorcactive neurons. Psychiat. Res. 59(1-2), 81-96.
93. De Angelis, D. A., and Braun, P. E. (1994). Isoprenylation of brain 2′,3′-cyclic nucleotide 3′-phosphodiesterase modulates cell morphology. J. Neurosci. Res. 39(4), 386-397.
94. De Angelis, D. A., and Braun, P. E. (1996). 2′,3′-Cyclic nucleotide 3′-phosphodiesterase binds to actin-based cytoskeletal elements in an isoprenylation-independent manner. J. Neurochem 67(3), 943-951.
95. De Angelis, D. A., and Braun, P. E. (1996). Binding of 2′,3′-cyclic nucleotide 3′-phosphodiesterase to myelin: An in vitro study. J. Neurochem. 66(6), 2523-2531.
96. Deakin, J. F., Slater, P., et al. (1990). Hyperinnervation of orbital frontal cortex in schizophrenia. Br. J. Psychiat. 157, 459-460.
97. Deicken, R. F., Calabrese, G., et al. (1994). 31 phosphorus magnetic resonance spectroscopy of the frontal and parietal lobes in chronic schizophrenia. Biol. Psychiat. 36(8), 503-510.
98. Delamillieure, P., Constans, J., et al. (2000). Proton magnetic resonance spectroscopy (1H-MRS) of the thalamus in schizophrenia. Eur. Psychiat. 15(8), 489-491.
99. Demaree, H. A., Gaudino, E. A., et al. (2000). Learning impairment is associated with recall ability in multiple sclerosis. J. Clin. Exp. Neuropsychol. 22(6), 865-873.
100. Dickinson, T. K., and Connor, J. R. (1994). Histological analysis of selected brain regions of hypotransferrinemic mice. Brain Res. 635(1-2), 169-178.
101. Dousset, V., Gayou, A., et al. (1998). Early structural changes in acute MS lesions assessed by serial magnetization transfer studies. Neurology 51(4), 1150-1155.
102. Dracheva, S., Gluck, M. G., et al. (2001). Glutamate synthesis and NMDA receptor and PSD-95 expression in DLPFC and occipital cortices of schizophrenics. Abstr. Soc. Neurosci. 27, 335.
103. Eastwood, S. L., Burnet, P. W., et al. (1995). Altered synaptophysin expression as a marker of synaptic pathology in schizophrenia. Neuroscience 66(2), 309-319.
104. Eastwood, S. L., Burnet, P. W., et al. (1994). Synaptophysin gene expression in human brain: A quantitative in situ hybridization and immunocytochemical study. Neuroscience 59(4), 881-892.
105. Eastwood, S. L., and Harrison, P. J. (1995). Decreased synaptophysin in the medial temporal lobe in schizophrenia demonstrated using immunoautoradiography. Neuroscience 69(2), 339-343.
106. Eastwood, S. L., and Harrison, P. J. (1999). Detection and quantification of hippocampal synaptophysin messenger RNA in schizophrenia using autoclaved, formalin-fixed, paraffin wax-embedded sections. Neuroscience 93(1), 99-106.
107. Ekelund, J., Lichtermann, D., et al. (2000). Genome-wide scan for schizophrenia in the Finnish population: Evidence for a locus on chromosome 7q22. Hum. Mol. Genet. 9(7), 1049-1057.
108. Erkwoh, R., Sabri, O., et al. (1999). Aspects of cerebral connectivity in schizophrenia: A comparative CBF study on treated schizophrenics before and after medication. Fortschr. Neurol. Psychiat. 67(7), 318-326.
109. Escobar Cabrera, O. E., Zakin, M. M., et al. (1997). Single intracranial injection of apotransferrin in young rats increases the expression of specific myelin protein mRNA. J. Neurosci. Res. 47(6), 603-608.
110. Espinosa de los Monteros, A., and Foucaud, B. (1987). Effect of iron and transferrin on pure oligodendrocytes in culture; characterization of a high-affinity transferrin receptor at different ages. Brain Res. 432(1), 123-130.
111. Espinosa de los Monteros, A. E., Pena, L. A., et al. (1989). Does transferrin have a special role in the nervous system? J. Neurosci. Res. 24, 125-136.
112. Falkai, P., and Bogerts, B. (1986). Cell loss in the hippocampus of schizophrenics. Eur Arch. Psychiat. Neurol. Sci. 236(3), 154-161.
113. Falkai, P., Bogerts, B., et al. (1988). Limbic pathology in schizophrenia: The entorhinal region-A morphometric study. Biol. Psychiat. 24(5), 515-521.
114. Faraone, S. V., Matise, T., et al. (1998). Genome scan of European-American schizophrenia pedigrees: Results of the NIMH Genetics Initiative and Millennium Consortium. Am. J. Med. Genet. 81(4), 290-295.
115. Farber, N., Price, M. T., et al. (1992). Age dependency of NMDA antagonist neurotoxicity. Soc. Neurosci. 18, 1148[Abstract].
116. Farber, N. B., Wozniak, D. F., et al. (1995). Age-specific neurotoxicity in the rat associated with NMDA receptor blockade: potential relevance to schizophrenia? Biol. Psychiat. 38(12), 788-796.
117. Feinberg, I. (1982). Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence? J. Psychiat. Res. 17(4), 319-334.
118. Filbin, M. T. (1995). Myelin-associated glycoprotein: A role in myelination and in the inhibition of axonal regeneration? Curr. Opin. Neurobiol. 5(5), 588-595.
119. Filippi, C. G., Ulug, A. M., et al. (2001). Diffusion tensor imaging of patients with HIV and normal-appearing white matter on MR images of the brain. AJNR Am. J. Neuroradiol. 22(2), 277-283.
120. Filippi, M., Cercignani, M., et al. (2001a). Diffusion tensor magnetic resonance imaging in multiple sclerosis. Neurology 56(3), 304-311.
121. Finelli, P. F. (1985). Metachromatic leukodystrophy manifesting as a schizophrenic disorder: Computed tomographic correlation. Ann. Neurol. 18(1), 94-95.
122. Fix, A. S., Horn, J. W., et al. (1993). Neuronal vacuolization and necrosis induced by the noncompctitive N-methyl-D-aspartate (NMDA) antagonist MK(+)801 (dizocilpine malcate): A light and electron microscopic evaluation of the rat retrosplenial cortex. Exp. Neurol. 123(2), 204-215.
123. Foong, J., Maier, M., et al. (2000a). In vivo investigation of white matter pathology in schizophrenia with magnetisation transfer imaging. J. Neurol. Neurosurg. Psychiat. 68(1), 70-74.
124. Foong, J., Maier, M., et al. (2000b). Neuropathological abnormalities of the corpus callosum in schizophrenia: A diffusion tensor imaging study. J. Neurol. Neurosurg. Psychiat. 68(2), 242-244.
125. Foong, J., Rozewicz, L., et al. (1997). Executive function in multiple sclerosis: The role of frontal lobe pathology. Brain 120(Pt. 1), 15-26.
126. Foong, J., Symms, M. R., et al. (2001). Neuropathological abnormalities in schizophrenia: Evidence from magnetization transfer imaging. Brain 124(Pt.5), 882-892.
127. Frandsen, A., and Schousboe, A. (1990). Development of excitatory amino acid induced cytotoxicity in cultured neurons. Int. J. Dev. Neurosci. 8(2), 209-216.
128. Frank, M. (2000). MAL, a proteolipid in glycosphingolipid enriched domains: Functional implications in myelin and beyond. Prog. Neurobiol. 60(6), 531-544.
129. Frank, M., Schaeren-Wiemers, N., et al. (1999). Developmental expression pattern of the myelin proteolipid MAL indicates different functions of MAL for immature Schwann cells and in a late step of CNS myelinogenesis. J. Neurochem. 73(2), 587-597.
130. Frank, M., van der Haar, M. E., et al. (1998). rMAL is a glycosphingolipid-associated protein of myelin and apical membranes of epithelial cells in kidney and stomach. J. Neurosci. 18(13), 4901-4913.
131. Friston, K. J. (1996). Theoretical neurobiology and schizophrenia. Br. Med. Bull. 52(3), 644-655.
132. Friston, K. J., and Frith, C. D. (1995). Schizophrenia: A disconnection syndrome? Clin. Neurosci. 3(2), 89-97.
133. Frith, C., and Dolan, R. (1996). The role of the prefrontal cortex in higher cognitive functions. Brain Res. Cogn. Brain Res. 5(1-2), 175-181.
134. Frith, G. D., Friston, K. J., et al. (1995). Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task. Br. J. Psychiat. 167(3), 343-349.
135. Fukutani, Y., Noriki, Y., et al. (1999). Adult-type mctachromatic leukodystrophy with a compound heterozygote mutation showing character change and dementia. Psychiat. Clin. Neurosci. 53(3), 425-128.
136. Furukawa, K., Fu, W., et al. (1997). The actin-severing protein gelsolin modulates calcium channel and NMDA receptor activities and vulnerability to excitotoxicity in hippocampal neurons. J. Neurosci. 17(21), 8178-8186.
137. Gabriel, S. M., Haroutunian, V., et al. (1997). Increased concentrations of presynaptic proteins in the cingulate cortex of subjects with schizophrenia. Arch. Gen. Psychiat. 54(6), 559-566.
138. Gallhofer, B., Lis, S., et al. (1999). Cognitive dysfunction in schizophrenia: A new set of tools for the assessment of cognition and drug effects. Acta Psychiat. Scand. Suppl. 395, 118-128.
139. Gallo, V., and Ghiani, G. A. (2000). Glutamate receptors in glia: New cells, new inputs and new functions. Trends Pharmacol. Sci. 21(7), 252-258.
140. Gallo, V., Zhou, J. M., et al. (1996). Oligodendrocyte progenitor cell proliferation and lineage progression are regulated by glutamate receptor-mediated K+ channel block. J. Neurosci. 16(8), 2659-2670.
141. Gard, A. L., Maughon, R. H., et al. (1996). In vitro oligodendrogliotrophic properties of cell adhesion molecules in the immunoglobulin superfamily: Myelin-associated glycoprotein and N-CAM. J. Neurosci. Res. 46(4), 415-426.
142. Gass, A., Barker, G. J., et al. (1994). Correlation of magnetization transfer ratio with clinical disability in multiple sclerosis. Ann. Neurol. 36(1), 62-67.
143. Gaudino, E. A., Chiaravalloti, N. D., et al. (2001). A comparison of memory performance in relapsing-remitting, primary progressive and secondary progressive, multiple sclerosis. Neuropsychiat. Neuropsychol. Behav. Neurol. 14(1), 32-44.
144. Giedd, J. N., Blumenthal, J., et al. (1999). Brain development during childhood and adolescence: A longitudinal MRI study. Nature Neurosci. 2(10), 861-863.
145. Gimenez, M., Junque, C., et al. (2003). Basal ganglia N-acetylaspartate correlates with the performance in the procedural task "Tower of Hanoi" of neuroleptic-naive schizophrenic patients Neurosci. Lett. 347(2), 97-100.
146. Giometto, B., Bozza, F., et al. (1990). Transferrin receptors in rat central nervous system: An immunocytochemical study. J. Neurol. Sci. 98(1), 81-90.
147. Glantz, L. A., and Lewis, D. A. (1997). Reduction of synaptophysin immunoreactivity in the prefrontal cortex of subjects with schizophrenia: Regional and diagnostic specificity [corrected and republished article originally appeared in Arch. Gen. Psychiat. 54(7) 660-669(1997)]. Arch. Gen. Psychiat. 54(10), 943-952.
148. Gluck, M. R., Thomas, R. G., et al. (2002). Implications for altered glutamate and GABA metabolism in the dorsolateral prefrontal cortex of aged schizophrenic patients. Am. J. Psychiat. 159(7), 1165-1173.
149. Goldberg, T. E., Hyde, T. M., et al. (1993). Course of schizophrenia: Neuropsychological evidence for a static encephalopathy. Schizophr. Bull. 19(4), 797-804.
150. Goldman-Rakic, P. S., and Selemon, L. D. (1997). Functional and anatomical aspects of prefrontal pathology in schizophrenia. Schizophr. Bull. 23(3), 437-458.
151. Gravel, M., Peterson, J., et al. (1996). Overexpression of 2′,3′-cyclic nucleotide 3′-phosphodiesterase in transgenic mice alters oligodendrocyte development and produces aberrant myelination. Mol. Cell. Neurosci. 7(6), 453-466.
152. Green, T., Heinemann, S. F., et al. (1998). Molecular neurobiology and genetics: Investigation of neural function and dysfunction. Neuron 20(3), 427-444.
153. Grinspan, J. B., and Franceschini, B. (1995). Platelet-derived growth factor is a survival factor for PSA-NCAM+ oligodendrocyte pre-progenitor cells. J. Neurosci. Res. 41(4), 540-551.
154. Grosche, J., Matyash, V., et al. (1999). Microdomains for neuron-glia interaction: Parallel fiber signaling to Bergmann glial cells. Nature Neurosci, 2(2), 139-143.
155. Gruzelier, J. H. (1999). Functional neuropsychophysiological asymmetry in schizophrenia: A review and reorientation. Schizophr. Bull. 25(1), 91-120.
156. Guidotti, A., Auta, J., et al. (2000). Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: A postmortem brain study. Arch. Gen. Psychiat. 57(11), 1061-1069.
157. Gurling, H. M., Kalsi, G., et al. (2001). Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23. Am. J. Hum. Genet. 68(3), 661-673.
158. Hageman, A. T., Gabreels, F. J., et al. (1995). Clinical symptoms of adult metachromatic leukodystrophy and arylsulfatase A pseudodeficiency. Arch. Neurol. 52(4), 408-413.
159. Hagino, H., Suzuki, M., et al. (2002). Proton magnetic resonance spectroscopy of the inferior frontal gyrus and thalamus and its relationship to verbal learning task performance in patients with schizophrenia: A preliminary report. Psychiat. Clin. Neurosci. 56(5), 499-507.
160. Hakak, Y., Walker, J. R., et al. (2001). Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc. Natl. Acad. Sci. USA 98(8), 4746-4751.
161. Hamos, J. E., DeGennaro, L. J., et al. (1989). Synaptic loss in Alzheimer's disease and other dementias. Neurology 39(3), 355-361.
162. Hardy, R., and Reynolds, R. (1993). Neuron-oligodendroglial interactions during central nervous system development. J. Neurosci. Res. 36(2), 121-126.
163. Hargreaves, R. J., Rigby, M., et al. (1993). Competitive as well as uncompetitive N-methyl-D-aspartate receptor antagonists affect cortical neuronal morphology and cerebral glucose metabolism. Neurochem. Res. 18(12), 1263-1269.
164. Harrison, P. J. (1999). The neuropathology of schizophrenia: A critical review of the data and their interpretation. Brain 122(Pt. 4), 593-624.
165. Harvey, P. D., Parrella, M., et al. (1999). Convergence of cognitive and adaptive decline in late-life schizophrenia. Schizophr. Res. 35(1), 77-84.
166. Harvey, P. D., Silverman, J. M., et al. (1999a). Cognitive decline in late-life schizophrenia: A longitudinal study of geriatric chronically hospitalized patients. Biol. Psychiat. 45(1), 32-40.
167. Haug, H. (1987). Brain sizes, surfaces, and neuronal sizes of the cortex cerebri: A stereological investigation of man and his variability and a comparison with some mammals (primates, whales, marsupials, insectivores, and one elephant). Am. J. Anal. 180(2), 126-142.
168. Haydon, P. G. (2001). GLIA: Listening and talking to the synapse. Mature Rat. Neurosci. 2(3), 185-193.
169. Ho, B. C., Andreasen, N. C., et al. (2003). Progressive structural brain abnormalities and their relationship to clinical outcome: A longitudinal magnetic resonance imaging study early in schizophrenia. Arch. Gen. Psychiat. 60(5), 585-594.
170. Hof, P. R., Haroutunian, V., et al. (2003). Loss and altered spatial distribution of oligodendrocytes in the superior frontal gyrus in schizophrenia. Biol. Psychiat. 53(12), 1075-1085.
171. Hohol, M. J., Guttmann, C. R., et al. (1997). Serial neuropsychological assessment and magnetic resonance imaging analysis in multiple sclerosis. Arch. Neurol. 54(8), 1018-1025.
172. Honer, W. G., Hurwitz, T., et al. (1987). Temporal lobe involvement in multiple sclerosis patients with psychiatric disorders. Arch. Neurol. 44(2), 187-190.
173. Howard, R., Cox, T., et al. (1995). White matter signal hyperintensities in the brains of patients with late paraphrenia and the normal, community-living elderly. Biol. Psychiat. 38(2), 86-91.
174. Howard, S., Landry, C., et al. (1998). Postnatal localization and morphogenesis of cells expressing the dopaminergic D2 receptor gene in rat brain: Expression in nonneuronal cells. J. Comp. Neurol. 391(1), 87-98.
175. Hulshoff Pol, H. E., Hoek, H. W., et al. (2000). Prenatal exposure to famine and brain morphology in schizophrenia. Am. J. Psychiat. 157(7), 1170-1172.
176. Huttenlocher, P. R. (1979). Synaptic density in human frontal cortex: Developmental changes and effects of aging. Brain Res. 163(2), 195-205.
177. Huttenlocher, P. R., and de Courten, C. (1987). The development of synapses in striate cortex of man. Hum. Neurobiol. 6(1), 1-9.
178. Hyde, T. M., Ziegler, J. C., et al. (1992). Psychiatric disturbances in metachromatic leukodystrophy: Insights into the neurobiology of psychosis. Arch. Neurol. 49(4), 401-406.
179. Ito, R., Melhem, E. R., et al. (2001). Diffusion tensor brain MR imaging in X-linked cerebral adrenoleukodystrophy. Neurology 56(4), 544-547.
180. Jacobson, R. D., Virag, I., et al. (1986). A protein associated with axon growth, GAP-43, is widely distributed and developmentally regulated in rat CNS. J. Neurosci. 6(6), 1843-1855.
181. Jahn, R., and Sudhof, T. C. (1994). Synaptic vesicles and exocytosis. Annu. Rev. Neurosci. 17, 219-246.
182. Janmey, P. A., and Stossel, T. P. (1987). Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate. Nature 325(6102), 362-364.
183. Jeste, D. V., McAdams, L. A., et al. (1998). Relationship of neuropsychological and MRI measures to age of onset of schizophrenia. Acta Psychiat. Scand. 98(2), 156-164.
184. Johannsen, P., Ehlers, L., et al. (2001). Dementia with impaired temporal glucose metabolism in late-onset metachromatic leukodystrophy. Dement. Geriatr. Cogn. Disord. 12(2), 85-88.
185. Johnson, P. W., Abramow-Newerly, W., et al. (1989). Recombinant myelin-associated glycoprotein confers neural adhesion and neurite outgrowth function. Neuron 3(3), 377-385.
186. Jordan, C., Friedrich, V., Jr., et al. (1989). In situ hybridization analysis of myelin gene transcripts in developing mouse spinal cord. J. Neurosci. 9(1), 248-257.
187. Karson, C. N., Mrak, R. E., et al. (1999). Alterations in synaptic
188. Kaufmann, C. A., Suarez, B., et al. (1998). NIMH Genetics Initiative Millenium Schizophrenia Consortium: Linkage analysis of African-American pedigrees. Am. J. Med. Genet. 81(4), 282-289.
189. Keefe, R. S., Mohs, R. C., et al. (1989). Premorbid sociosexual functioning and long-term outcome in schizophrenia. Am. J. Psychiat. 146(2), 206-211.
190. Keshavan, M. S., Diwadkar, V. A., et al. (2002). A preliminary functional magnetic resonance imaging study in offspring of schizophrenic parents. Prog. Neuropsychopharmacol. Biol. Psychiat. 26(6), 1143-1149.
191. Keshavan, M. S., Rosenberg, D., et al. (1998). Decreased caudate volume in neuroleptic-naive psychotic patients. Am. J. Psychiat. 155(6), 774-778.
192. Keynes, R., and Cook, G. M. (1995). Axon guidance molecules. Cell 83(2), 161-169.
193. Keynes, R. J., and Cook, G. M. (1995). Repulsive and inhibitory signals. Curr. Opin. Neurobiol. 5(1), 75-82.
194. Kidd, G. J., Hauer, P. E., et al. (1990). Axons modulate myelin protein messenger RNA levels during central nervous system myelination in vivo. J. Neurosci. Res. 26(4), 409-418.
195. Kim, T., Fiedler, K., et al. (1995). Cloning and characterization of MVP17: A developmentally regulated myelin protein in oligodendrocytes. J. Neurosci. Res. 42(3), 413-122.
196. Kirkpatrick, B., Conley, R. C., et al. (1999). Interstitial cells of the white matter in the inferior parietal cortex in schizophrenia: An unbiased cell-counting study. Synapse 34(2), 95-102.
197. Koshy, K. M., and Boggs, J. M. (1996). Investigation of the calcium-mediated association between the carbohydrate head groups of galactosylceramide and galactosylceramide 13 sulfate by electrospray ionization mass spectrometry. J. Biol. Chem. 271(7), 3496-3499.
198. Krull, A. J., Press, G., et al. (1991). Brain imaging in late-onset schizophrenia and related psychoses. Int. J. Geriatr. Psychiat. 6, 651-658.
199. Kwiatkowski, D. J., Mehl, R., et al. (1988a). Muscle is the major source of plasma gelsolin. J. Biol. Chem. 263(17), 8239-8243.
200. Kwiatkowski, D. J., Mehl, R., et al. (1988). Genomic organization and biosynthesis of secreted and cytoplasmic forms of gelsolin. J. Cell Biol. 106(2), 375-384.
201. Lai, C., Watson, J. B., et al. (1987). Neural protein IB236/myelin-associated glycoprotein (MAG) defines a subgroup of the immunoglobulin superfamily. Immunol. Rev. 100, 129-151.
202. Landen, M., Davidsson, P., et al. (1999). Reduction of the small synaptic vesicle protein synaptophysin but not the large dense core chromogranins in the left thalamus of subjects with schizophrenia. Biol. Psychiat. 46(12), 1698-1702.
203. Lassmann, H., Bartsch, U., et al. (1997). Dying-back oligodendrogliopathy: A late sequel of myelin-associated glycoprotein deficiency. Glia 19(2), 104-110.
204. Law, A. (2003). Schizophrenia, IV: Neuregulin-1 in the human brain. Am. J. Psychiat. 160(8), 1392.
205. Lawrie, S. M., Bucchel, C., et al. (2002). Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations. Biol. Psychiat. 51(12), 1008-1011.
206. Lena, J. Y., Legrand, C., et al. (1994). High gelsolin content of developing oligodcndrocytes. Int. J. Dev. Neurosci. 12(5), 375-386.
207. Lesser, I. M., Miller, B. L., et al. (1991). Brain injury and cognitive function in late-onset psychotic depression. J. Neuropsychiat. Clin. Neurosci. 3(1), 33-40.
208. Levinson, D. F., Mahtani, M. M., et al. (1998). Genome scan of schizophrenia. Am. J. Psychiat. 155(6), 741-750.
209. +-dependent glutamate uptake. J. Neurosci. 18(23), 9620-9628.
210. Lewis, D. A., Woo, T.-U., et al. (1997). Schizophrenia and subclasses of local circuit neurons in the prefrontal cortex. Schizophr. Res. 24, 38-39.
211. Li, C., Trapp, B., et al. (1998). Myelin associated glycoprotein modulates glia-axon contact in vivo. J. Neurosci. Res. 51(2), 210-217.
212. Li, C., Tropak, M. B., et al. (1994). Myelination in the absence of myelin-associated glycoprotein. Nature 369(6483), 747-750.
213. Liddle, P. F. (1996). Functional imaging: Schizophrenia. Br. Med. Bull. 52(3), 486-194.
214. Lim, K. O., Hedehus, M., et al. (1999). Compromised white matter tract integrity in schizophrenia inferred from diffusion tensor imaging. Arch. Gen. Psychiat. 56(4), 367-374.
215. Lim, K. O., Tew, W., et al. (1996). Cortical gray matter volume deficit in patients with first-episode schizophrenia. Am. J. Psychiat. 153(12), 1548-1553.
216. Lintner, R. N., and Dyer, C. A. (2000). Redistribution of cholesterol in oligodendrocyte membrane sheets after activation of distinct signal transduction pathways. J. Neurosci. Res. 60(4), 437-449.
217. LoTurco, J. J. (2000). Neural circuits in the 21st century: Synaptic networks of neurons and glia. Proc. Natl. Acad. Sci. USA 97(15), 8196-8197.
218. Lovinger, D. M., Akers, R. F., Nelson, R. B., Barnes, C. A., McNaughton, B. L., and Routtenberg, A. (1985). A selective increase in phosphorylation of protein F1, a protein kinase C substrate, directly related to three day growth of long-term synaptic enhancement. Brain Res. 343, 137-143.
219. Lovinger, D. M., and McCool, B. A. (1995). Metabotropic glutamate receptor-mediated presynaptic depression at corticostriatal synapses involves mGLuR2 or 3. J. Neurophysiol. 73(3), 1076-1083.
220. Ludwin, S. K. (1997). The pathobiology of the oligodendrocyte. J. Neuropathol. Exp. Neurol. 56(2), 111-124.
221. Ludwin, S. K., and Johnson, E. S. (1981). Evidence for a "dying-back" gliopathy in demyelinating diseased. Ann. Neurol. 9(3), 301-305.
222. Maier, M., and Ron, M. A. (1996). Hippocampal age-related changes in schizophrenia: A proton magnetic resonance spectroscopy study. Schizophr. Res. 22(1), 5-17.
223. Manoach, D. S. (2003). Prefrontal cortex dysfunction during working memory performance in schizophrenia: Reconciling discrepant findings. Schizophr. Res. 60(2-3), 285-298.
224. Manoach, D. S., Gollub, R. L., et al. (2000). Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. Biol. Psychiat. 48(2), 99-109.
225. Manoach, D. S., Press, D. Z., et al. (1999). Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biol. Psychiat. 45(9), 1128-1137.
226. Marshall, B. E., and Longnecker, D. E. (1990). General anesthetics. In "The Pharmacological Basis of Therapeutics" (L. S. Goodman, A. Gilman, T. W. Rall, A. S. Niess, and P. Tayplor, Eds.), Pergamon Press, Elmsford, NY.
227. Martini, R., and Schachner, M. (1986). Immunoelectron microscopic localization of neural cell adhesion molecules (LI, N-CAM, and MAG) and their shared carbohydrate epitope and myelin basic protein in developing sciatic nerve. J. Cell Biol. 103(6 Pt. 1), 2439-2448.
228. Masliah, E., Terry, R. D., et al. (1990). Quantitative immunohistochemistry of synaptophysin in human neocortex: An alternative method to estimate density of presynaptic terminals in paraffin sections. J. Histochem. Cytochem. 38(6), 837-844.
229. Mason, J. L., Ye, P., et al. (2000). Insulin-like growth factor-1 inhibits mature oligodendrocyte apoptosis during primary demyelination. J. Neurosci. 20(15), 5703-5708.
230. Matute, C. (1998). Characteristics of acute and chronic kainate excitotoxic damage to the optic nerve. Proc. Natl. Acad. Sci. USA 95(17), 10229-10234.
231. Matute, C., Alberdi, E., et al. (2001). The link between excitotoxic oligodendroglial death and demyelinating diseases. Trends Neurosci. 24(4), 224-230.
232. Matute, C., Sanchez-Gomez, M. V., et al. (1997). Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes. Proc. Natl. Acad. Sci. USA 94(16), 8830-8835.
233. Mayer, M., Bogler, O., et al. (1993). The inhibition of oligodendrocytic differentiation of O-2A progenitors caused by basic fibroblast growth factor is overridden by astrocytes. Glia 8(1), 12-19.
234. McClure, R. J., Keshavan, M. S., et al. (1998). Chemical and physiologic brain imaging in schizophrenia. Psychiat. Clin. North Am. 21(1), 93-122.
235. McDonald, J. W., Levine, J. M., et al. (1998). Multiple classes of the oligodendrocyte lineage are highly vulnerable to excitotoxicity. Neuroreport 9(12), 2757-2762.
236. McGlashan, T. H., and Hoffman, R. E. (2000). Schizophrenia as a disorder of developmentally reduced synaptic connectivity. Arch. Gen. Psychiat. 57(7), 637-648.
237. McMorris, F. A., and Dubois-Dalcq, M. (1988). Insulin-like growth factor I promotes cell proliferation and oligodendroglial commitment in rat glial progenitor cells developing in vitro. J. Neurosci. Res. 21(2-4), 199-209.
238. McTigue, D. M., Horner, P. J., et al. (1998). Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord. J. Neurosci. 18(14), 5354-5365.
239. Medaer, R., Nelissen, E., et al. (1987). Magnetic resonance imaging and cognitive functioning in multiple sclerosis. J. Neurol. 235(2), 86-89.
240. Melkersson, K. I., Hulting, A. L., et al. (2001). Dose requirement and prolactin elevation of antipsychotics in male and female patients with schizophrenia or related psychoses. Br. J. Clin. Phamacol. 51(4), 317-324.
241. Miller, B. L., Benson, D. F., et al. (1986). Late-life paraphrenia: An organic delusional syndrome. J. Clin. Psychiat. 47(4), 204-207.
242. Miller, B. L., Lesser, I. M., et al. (1989). Brain white-matter lesions and psychosis. Br. J. Psychiat. 155, 73-78.
243. Miller, B. L., Lesser, I. M., et al. (1991). Brain lesions and cognitive function in late-life psychosis. Br. J. Psychiat. 158, 76-82.
244. Miyakawa, T., Sumiyoshi, S., et al. (1972). Electron microscopic study on schizophrenia: Mechanism of pathological changes. Acta Neuropathol. (Berl) 20(1), 67-77.
245. Moghaddam, B., Adams, B., et al. (1997). Activation of glutamatergic neurotransmission by ketamine: A novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J. Neurosci. 17(8), 2921-2927.
246. Moghaddam, B., and Adams, B. W. (1998). Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science 281(5381), 1349-1352.
247. Moises, H. W., Zoega, T., et al. (2002). The glial growth factors deficiency and synaptic dcstabilization hypothesis of schizophrenia. BMC Psychiat. 2(1), 8.
248. Montag, D., Giese, K. P., et al. (1994). Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin. Neuron 13(1), 229-246.
249. Moore, R. Y., and Bernstein, M. E. (1989). Synaptogenesis in the rat suprachiasmatic nucleus demonstrated by electron microscopy and synapsin I immunoreactivity. J. Neurosci. 9(6), 2151-2162.
250. Mori, S., and Leblond, C. P. (1970). Electron microscopic identification of three classes of oligodendrocytes and a preliminary study of their proliferative activity in the corpus callosum of young rats. J. Comp. Neurol. 139(1), 1-28.
251. Mowry, B. J., Ewen, K. R., et al. (2000). Second stage of a genome scan of schizophrenia: Study of five positive regions in an expanded sample. Am. J. Med. Genet. 96(6), 864-869.
252. Niculescu, A. B., 3rd, Segal, D. S., et al. (2000). Identifying a series of candidate genes for mania and psychosis: A convergent functional genomics approach. Physiol. Genomics 4(1), 83-91.
253. O'Donovan, M. (2002). Personal communication.
254. Oifa, A. I., and Uranova, N. A. (1991). Electron-microscopic analysis of cytoarchitectonic disorders in the cerebral cortex in schizophrenia. Zh. Neuropathol. Psikhiatr. Im S S Korsakova 91(10), 48-52.
255. Okada, F., Tokumitsu, Y., et al. (1994). Impaired interhemispheric integration in brain oxygenation and hemodynamics in schizophrenia. Eur. Arch. Psychiat. Clin. Neurosci. 244(1), 17-25.
256. Olney, J. W., and Farber, N. B. (1995a). Glutamate receptor dysfunction and schizophrenia. Arch. Gen. Psychiat. 52(12), 998-1007.
257. Olney, J. W., and Farber, N. B. (1995b). NMDA antagonists as neurotherapeutic drugs, psychotogens, neurotoxins, and research tools for studying schizophrenia. Neuropsychopharmacology 13(4), 335-345.
258. Olney, J. W., Labruyere, J., et al. (1989). Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 244(4910), 1360-1362.
259. Olney, J. W., Labruyere, J., et al. (1991). NMDA antagonist neurotoxicity. Mechanism and prevention. Science 254(5037), 1515-1518.
260. O'Neill, R. C., Minuk, J., et al. (1997). CNP2 mRNA directs synthesis of both CNP1 and CNP2 polypeptides. J. Neurosci. Res. 50(2), 248-257.
261. Pakkenberg, B. (1987). Post-mortem study of chronic schizophrenic brains. Br. J. Psychiat. 151, 744-752.
262. Pakkenberg, B. (1993). Total nerve cell number in neocortex in chronic schizophrenics and controls estimated using optical disectors. Biol. Psychiat. 34(11), 768-772.
263. Park, J. P., Mocschler, J. B., et al. (1991). Schizophrenia and mental retardation in an adult male with a de novo interstitial deletion 9(q32q34.1). J. Med. Genet. 28(4), 282-283.
264. Parpura, V., and Haydon, P. G. (2000). Physiological astrocytic calcium levels stimulate glutamate release to modulate adjacent neurons. Proc. Natl. Acad. Sci. USA 97(15), 8629-8634.
265. Pearlson, G. D. (1999). New insights on the neuroanatomy of schizophrenia. Curr. Psychiat. Rep. 1(1), 41-45.
266. Perrone-Bizzozero, N. I., Sower, A. C., et al. (1996). Levels of the growth-associated protein GAP-43 arc selectively increased in association cortices in schizophrenia. Proc. Natl. Acad. Sci. USA 93(24), 14182-14187.
267. Persaud, R., Russow, H., Harvey, I., Lewis, S. W., Ron, M., Murray, R. M., and du Boulay, G. (1997). Focal signal hyperintensities in schizophrenia. Schizophr. Res. 27, 55-64.
268. Peters, A., Leahu, D., et al. (1994). The effects of aging on area 46 of the frontal cortex of the rhesus monkey. Cereb Cortex 4(6), 621-635.
269. Peyser, J. M., Rao, S. M., et al. (1990). Guidelines for neuropsychological research in multiple sclerosis. Arch. Neurol. 47(1), 94-97.
270. Pfefferbaum, A., Sullivan, E. V., et al. (1999). Brain gray and white matter transverse relaxation time in schizophrenia. Psychiat. Res. 91(2), 93-100.
271. Poltorak, M., Sadoul, R., et al. (1987). Myelin-associated glycoprotein, a member of the L2/HNK-1 family of neural cell adhesion molecules, is involved in neuron-oligodendrocyte and oligodendrocyte-oligodendrocyte interaction. J. Cell Biol. 105(4), 1893-1899.
272. Pomara, N., Crandall, D. T., et al. (2001). White matter abnormalities in HIV-1 infection: A diffusion tensor imaging study. Psychiat. Res. 106(1), 15-24.
273. Quarles, R. H. (1983). Myelin-associated glycoprotein in development and disease. Dev. Neurosci. 6(6), 285-303.
274. Quarles, R. H., and Trapp, B. D. (1984). Localization of myelin-associated glycoprotein. J. Neurochem. 43(6), 1773-1777.
275. Raabe, T. D., Clive, D. R., et al. (1997). Neonatal oligodendrocytes contain and secrete neuregulins in vitro. J. Neurochem. 69(5), 1859-1863.
276. Rajkowska, G., Halaris, A., et al. (2001). Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder. Biol. Psychiat. 49(9), 741-752.
277. Rajkowska, G., Selemon, L. D., et al. (1998). Neuronal and glial somal size in the prefrontal cortex: A postmortem morphometric study of schizophrenia and Huntington disease. Arch. Gen. Psychiat. 55(3), 215-224.
278. Rao, S. M., Leo, G. J., et al. (1991). Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology 41(5), 685-691.
279. Rao, S. M., Leo, G. J., et al. (1989). Correlation of magnetic resonance imaging with neuropsychological testing in multiple sclerosis. Neurology 39(2 Pt 1), 161-166.
280. Reischies, F. M., Baum, K., et al. (1988). Cerebral magnetic resonance imaging findings in multiple sclerosis: Relation to disturbance of affect, drive, and cognition. Arch. Neurol. 45(10), 1114-1116.
281. Riley, B. P., Tahir, E., et al. (1997). A linkage study of the N-methyl-D-aspartate receptor subunit gene loci and schizophrenia in southern African Bantu-speaking families. Psychiat. Genet. 7(2), 57-74.
282. Rivkin, P., Kraut, M., et al. (2000). White matter hyperintensity volume in late-onset and early-onset schizophrenia. Int. J. Geriat. Psychiat. 15(12), 1085-1089.
283. Roberts, R. C., Conley, R., et al. (1996). Reduced striatal spine size in schizophrenia: A postmortem ultrastructural study. Neuroreport 7(6), 1214-1218.
284. Rodriguez, M., Prayoomviwat, N., et al. (1994). Proteolipid protein gene expression in demyelination and remyelination of the central nervous system: A model for multiple sclerosis. J. Neuropathol. Exp. Neurol. 53(2), 136-143.
285. Rodriguez, M., and Scheithauer, B. (1994). Ultrastructure of multiple sclerosis. Ultrastruct. Pathol. 18(1-2), 3-13.
286. Rodriguez, M., Scheithauer, B. W., et at. (1993). Oligodendrocyte injury is an early event in lesions of multiple sclerosis. Mayo Clin. Proc. 68(7), 627-636.
287. Rosahl, T. W., Geppert, M., et al. (1993). Short-term synaptic plasticity is altered in mice lacking synapsin I. Cell 75(4), 661-670.
288. Rugg-Gunn, F. J., Symms, M. R., et al. (2001). Diffusion imaging shows abnormalities after blunt head trauma when conventional magnetic resonance imaging is normal. J. Neurol. Neurosurg. Psychiat. 70(4), 530-533.
289. Sachdev, P., and Brodaty, H. (1999). Quantitative study of signal hyperintensities on T2-weighted magnetic resonance imaging in late-onset schizophrenia. Am. J. Psychiat. 156(12), 1958-1967.
290. Sachdev, P., Cathcart, S., Shnier, R., Wen, W., and Brodaty, H. (1999). Reliability and validity of ratings of signal hyperintensities on MRI by visual inspection and computerized measurement. Psychiatry Res. 92, 103-115.
291. Salzer, J. L., Holmes, W. P., et al. (1987). The amino acid sequences of the myelin-associated glycoproteins: Homology to the immunoglobulin gene superfamily. J. Cell Biol. 104(4), 957-965.
292. Salzer, J. L., Pedraza, L., et al. (1990). Structure and function of the myelin-associated glycoproteins. Ann. N. Y. Acad. Sci. 605, 302-312.
293. Sanchez, I., Hassinger, L., et al. (1996). Oligodendroglia regulate the regional expansion of axon caliber and local accumulation of neurofilaments during development independently of myelin formation. J. Neurosci. 16(16), 5095-5105.
294. Sanchez, I., Hassinger, L., et al. (2000). Local control of neurofilament accumulation during radial growth of myelinating axons in vivo: Selective role of site-specific phosphorylation. J. Cell Biol. 151(5), 1013-1024.
295. Sanchez-Gomez, M. V., and Matute, C. (1999). AMPA and kainate receptors each mediate excitotoxicity in oligodendroglial cultures. Neurobiol. Dis. 6(6), 475-485.
296. Sanfilipo, M., Lafargue, T., et al. (2000). Volumetric measure of the frontal and temporal lobe regions in schizophrenia: Relationship to negative symptoms. Arch. Gen. Psychiat. 57(5), 471-480.
297. Schachner, M., and Bartsch, U. (2000). Multiple functions of the myelin-associated glycoprotein MAG (siglec-4a) in formation and maintenance of myelin. Glia 29(2), 154-165.
298. Schaumburg, H. H., Powers, J. M., et al. (1975). Adrenoleukodystrophy: A clinical and pathological study of 17 cases. Arch. Neurol. 32(9), 577-591.
299. Scheibel, A. B., and Kovelman, J. A. (1981). Disorientation of the hippocampal pyramidal cell and its processes in the schizopohrenic patient. Biol. Psychiat. 16, 101-102.
300. Schlosser, R., Gesierich, T., et al. (2003). Altered effective connectivity during working memory performance in schizophrenia: A study with fMRI and structural equation modeling. Neuroimage 19(3), 751-763.
301. Sclemon, L. D., and Goldman-Rakic, P. S. (1999). The reduced neuropil hypothesis: A circuit based model of schizophrenia. Biol. Psychiat. 45(1), 17-25.
302. Selemon, L. D., Rajkowska, G., et al. (1995). Abnormally high neuronal density in the schizophrenic cortex: A morphometric analysis of prefrontal area 9 and occipital area 17. Arch. Gen. Psychiat. 52(10), 805-818; discussion 819-820.
303. Selemon, L. D., Rajkowska, G., et al. (1998). Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: Application of a three-dimensional, stereologic counting method. J. Comp. Meurol. 392(3), 402-412.
304. Shapiro, E. G., Lockman, L. A., et al. (1991). Characteristics of the dementia in late-onset metachromatic leukodystrophy. Neurology 44(4), 662-665.
305. Sharp, F. R., Butman, M., et al. (1994). Phencyclidine induction of the hsp 70 stress gene in injured pyramidal neurons is mediated via multiple receptors and voltage gated calcium channels. Neuroscience 62(4), 1079-1092.
306. Shihabuddin, L., Buchsbaum, M. S., et al. (2000). Diffusion tensor imaging in schizophrenia and schizophrenia spectrum disorders. Biol. Psychiat. 47(Suppl.), 97S.
307. Siesjo, B. K. (1993). Basic mechanisms of traumatic brain damage. Ann. Emerg. Med. 22(6), 959-969.
308. Sigmundsson, T., Suckling, J., et al. (2001). Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms. Am. J. Psychiat. 158(2), 234-243.
309. Skomer, C., Stears, J., et al. (1983). Metachromatic leukodystrophy (MLD). XV. Adult MLD with focal lesions by computed tomography. Arch. Neurol. 40(6), 354-355.
310. Small, R. K., Riddle, P., et al. (1987). Evidence for migration of oligodendrocyte: Type-2 astrocyte progenitor cells into the developing rat optic nerve. Nature 328(6126), 155-157.
311. Smith, S. J. (1994). Neural signalling: Neuromodulatory astrocytes. Curr. Biol. 4(9), 807-810.
312. Spence, S. A., Liddle, P. F., et al. (2000). Functional anatomy of verbal fluency in people with schizophrenia and those at genetic risk: Focal dysfunction and distributed disconnectivity reappraised. Br. J. Psychiat. 176, 52-60.
313. Sperling, R. A., Guttmann, C. R., et al. (2001). Regional magnetic resonance imaging lesion burden and cognitive function in multiple sclerosis: A longitudinal study. Arch. Neurol. 58(1), 115-121.
314. Srinivasan, J., Schachner, M., et al. (1998). Interaction of voltage-gated sodium channels with the extracellular matrix molecules tenascin-C and tenascin-R. Proc. Natl. Acad. Sci. USA 95(26), 15753-15757.
315. Steel, R. M., Bastin, M. E., et al. (2001). Diffusion tensor imaging (DTI) and proton magnetic resonance spectroscopy (1H MRS) in schizophrenic subjects and normal controls. Psychiat. Res. 106(3), 161-170.
316. Stefansson, H., Sarginson, J., et al. (2003). Association of neuregulin 1 with schizophrenia confirmed in a Scottish population. Am. J. Hum. Genet. 72(1), 83-87.
317. Stefansson, H., Sigurdsson, E., et al. (2002). Neuregulin 1 and susceptibility to schizophrenia. Am. J. Hum. Genet. 71(4), 877-892.
318. Stefansson, H., Thorgeirsson, T. E., et al. (2003). Neuregulin 1 in schizophrenia: Out of Iceland. Mol. Psychiat. 8(7), 639-640.
319. Sternberger, N. H., Quarles, R. H., et al. (1979). Myelin-associated glycoprotein demonstrated immunocytochemically in myelin and myelin-forming cells of developing rat. Proc. Natl. Acad. Sci. USA 76(3), 1510-1514.
320. Stewart, R. J., and Boggs, J. M. (1993). A carbohydrate-carbohydrate interaction between galactosylceramide-containing liposomes and cerebroside sulfate-containing liposomes: Dependence on the glycolipid ceramide composition. Biochemisly 32(40), 10666-10674.
321. Stober, G., Saar, K., et al. (2000). Splitting schizophrenia: Periodic catatonia-susceptibility locus on chromosome 15q15. Am. J. Hum. Genet. 67(5), 1201-1207.
322. Sullivan, E. V., Shear, P. K., et al. (1996). Cognitive and motor impairments are related to gray matter volume deficits in schizophrenia. Biol. Psychia. 39(4), 234-240.
323. Suirsky-Sacchetti, T., Mitchell, D. R., et al. (1992). Neuropsychological and structural brain lesions in multiple sclerosis: A regional analysis. Neurology 42(7), 1291-1295.
324. Symonds, L. L., Olichney, J. M., et al. (1997). Lack of clinically significant gross structural abnormalities in MRIs of older patients with schizophrenia and related psychoses. J. Neuropsychiat. Clin. Neurosci. 9(2), 251-258.
325. Taber, K. H., Pierpaoli, C., et al. (2002). The future for diffusion tensor imaging in neuropsychiatry. J. Neuropsychiat. Clin. Neurosci. 14(1), 1-5.
326. Tanaka, J., Kira, M., et al. (1993). Gelsolin is localized in neuronal growth cones. Brain Res. Dev. Brain Res. 76(2), 268-271.
327. Tcherepanov, A. A., and Sokolov, B. P. (1997). Age-related abnormalities in expression of mRNAs encoding synapsin IA, synapsin IB, and synaptophysin in the temporal cortex of schizophrenics. J. Neurosci. Res. 49(5), 639-644.
328. Terry, R. D., DeTeresa, R., et al. (1987). Neocortical cell counts in normal human adult aging. Ann. Neurol. 21(6), 530-539.
329. Tessier-Lavigne, M., and Goodman, C. S. (1996). The molecular biology of axon guidance. Science 274(5290), 1123-1133.
330. Thorpe, J. W., Barker, G. J., et al. (1995). Magnetisation transfer ratios and transverse magnetisation decay curves in optic neuritis: Correlation with clinical findings and electrophysiology. J. Neurol. Neurosurg. Psychiat. 59(5), 487-492.
331. Tonkonogy, J. M., and Geller, J. L. (1999). Late-onset paranoid psychosis as a distinct clinicopathologic entity: Magnetic resonance imaging data in elderly patients with paranoid psychosis of late onset and schizophrenia of early onset. Neuropsychiat. Neuropsychol. Behav. Neurol. 12(4), 230-235.
332. Trapp, B. D., Andrews, S. B., et al. (1989). The myelin-associated glycoprotein is enriched in multivesicular bodies and periaxonal membranes of actively myelinating oligodendrocytes. J. Cell Eiol. 109(5), 2417-2426.
333. Trapp, B. D., Bernier, L., et al. (1988). Cellular and subcellular distribution of 2′,3′-cyclic nucleotide 3′-phosphodiesterase and its mRNA in the rat central nervous system. J. Neurochem. 51(3), 859-868.
334. Ulug, A. M., Moore, D. F., et al. (1999). Clinical use of diffusion-tensor imaging for diseases causing neuronal and axonal damage. AJNR Am. J. Neuroradiol. 20(6), 1044-1048.
335. Uranova, N., Orlovskaya, D., et al. (2001a). Electron microscopy of oligodendroglia in severe mental illness. Brain Res. Bull. 55(5), 597-610.
336. Uranova, N. A. (1988). Structural changes in the neuropil of the frontal cortex in schizophrenia. Zh Neuropatol Psikhiatr Im S S Korsakova 88(7), 52-58.
337. Uranova, N. A., Orlovskaia, D. D., et al. (2001b). Morphometric study of ultrastructural changes in oligodendroglial cells in the postmortem brain in endogenous psychoses. Vestn Ross Akad. Med. Nauk. 7, 42-48.
338. Valat, J., Privat, A., et al. (1988). Experimental modifications of postnatal differentiation and fate of glial cells related to axo-glial relationships. Int. J. Dev. Neurosci. 6(3), 245-260.
339. van Walderveen, M. A., Kamphorst, W., et al. (1998). Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis. Neurology 50(5), 1282-1288.
340. Vartanian, T., Corfas, G., et al. (1994). A role for the acetylcholine receptor-inducing protein ARIA in oligodendrocyte development. Proc. Natl. Acad. Sci. USA 91(24), 11626-11630.
341. Vartanian, T., Fischbach, G., et al. (1999). Failure of spinal cord oligodendrocyte development in mice lacking neuregulin. Proc. Natl. Acad. Sci. USA 96(2), 731-735.
342. Ventura, R., and Harris, K. M. (1999). Three-dimensional relationships between hippocampal synapses and astrocytes. J. Neurosci. 19(16), 6897-6906.
343. Verity, M. A. (1992). Ca(2+)-dependent processes as mediators of neurotoxicity. Neurotoxicology 13(1), 139-147.
344. Vogel, U. S., and Thompson, R. J. (1988). Molecular structure, localization, and possible functions of the myelin-associated enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase. J. Neurochem. 50(6), 1667-1677.
345. Volk, D. W., Austin, M. C., et al. (2000). Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia. Arch. Gen. Psychiat. 57(3), 237-245.
346. Walaas, S. I., Jahn, R., et al. (1988). Quantitation of nerve terminal populations: Synaptic vesicle-associated proteins as markers for synaptic density in the rat neostriatum. Synapse 2(5), 516-520.
347. Wang, S., Sdrulla, A. D., et al. (1998). Notch receptor activation inhibits oligodendrocyte differentiation. Neuron 21(1), 63-75.
348. Ward, K. E., Friedman, L., et al. (1996). Meta-analysis of brain and cranial size in schizophrenia. Schizophr. Res. 22(3), 197-213.
349. Weiss, M. D., Hammer, J., et al. (2000). Oligodendrocytes in aging mice lacking myelin-associated glycoprotein are dystrophic but not apoptotic. J. Neurosci. Res. 62(6), 772-780.
350. Wiedenmann, B., and Franke, W. W. (1985). Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles. Cell 41(3), 1017-1028.
351. Williams, N. M., Preece, A., et al. (2003). Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia. Mol. Psychiat. 8(5), 485-487.
352. Williams, N. M., Rees, M. I., et al. (1999). A two-stage genome scan for schizophrenia susceptibility genes in 196 affected sibling pairs. Hum. Mol. Genel. 8(9), 1729-1739.
353. Williams, R. W., and Rakic, P. (1988). Elimination of neurons from the rhesus monkey's lateral geniculate nucleus during development. J. Comp. Neurol. 272(3), 424-436.
354. Williamson, P., Pelz, D., et al. (1991). Correlation of negative symptoms in schizophrenia with frontal lobe parameters on magnetic resonance imaging. Br. J. Psychiat. 159, 130-134.
355. Wolkin, A., Choi, S. J., et al. (2003). Inferior frontal white matter anisotropy and negative symptoms of schizophrenia: A diffusion tensor imaging study. Am. J. Psychiat. 160(3), 572-574.
356. Woo, T. U., Whitehead, R. E., et al. (1998). A subclass of prefrontal gamma-aminobutyric acid axon terminals are selectively altered in schizophrenia. Proc. Natl. Acad. Sci. USA 95(9), 5341-5346.
357. Woodruff, P. W., Phillips, M. L., Rushe, T., Wright, I. C., Murray, R. M., and David, A. S. (1997). Corpus callosum size and inter-hemispheric function in schizophrenia. Schizophr. Res. 23, 189-196.
358. Wozniak, D. F., McEwen, M., et al. (1993). MK-801 induces extensive neuronal necrosis in posterior cingulate/retrosplenial cortices. Soc. Neurosci. 12, 1770. [Abstract]
359. Wright, I. C., Rabe-Hesketh, S., et al. (2000). Meta-analysis of regional brain volumes in schizophrenia. Am. J. Psychiat. 157(1), 16-25.
360. Yakovlev, A. Y., and Lecours, A. R. (1967). "Regional Development of the Brain in Early Life." Blackwell Scientific Press, Oxford.
361. Yang, H., Xiao, Z. C., et al. (1999). Role for myelin-associated glycoprotein as a functional tenascin-R receptor. J. Neurosci. Res. 55(6), 687-701.
362. Yang, J. Z., Si, T. M., et al. (2003). Association study of neuregulin 1 gene with schizophrenia. Mol. Psychiat. 8(7), 706-709.
363. 2+ control of actin filament length: Effects of macrophage gelsolin on actin polymerization. J. Biol. Chem. 256(18), 9693-9697.
364. Yin, X., Crawford, T. O., et al. (1998). Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons. J. Neurosci. 18(6), 1953-1962.
365. Yoshioka, A., Bacskai, B., et al. (1996). Pathophysiology of oligodendroglial excitotoxicity. J. Neurosci. Res. 46(4), 427-437.
366. Young, C. E., Arima, K., et al. (1998). SNAP-25 deficit and hippocampal connectivity in schizophrenia. Cereb. Cortex 8(3), 261-268.
367. Yuan, X., Eisen, A. M., et al. (1998). A role for glutamate and its receptors in the regulation of oligodendrocyte development in cerebellar tissue slices. Development 125(15), 2901-2914.
368. Zerangue, N., and Kavanaugh, M. P. (1996). Flux coupling in a neuronal glutamate transporter. Nature 383(6601), 634-637.
369. Zipursky, R. B., Lim, K. O., et al. (1992). Widespread cerebral gray matter volume deficits in schizophrenia. Arch. Gen. Psychiat. 49(3), 195-205.