Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI

Biological Psychiatry

Volumn 45, Issue 9, 1999, Pages 1128-1137

  Manoach, Dara S ^a   Press, Daniel Z ^a   Thangaraj, Venkatassen ^a   Searl, Meghan M ^a   Goff, Donald C ^a   Halpern, Elkan ^a   Saper, Clifford B ^a   Warach, Steven ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Functional brain mapping; Functional magnetic resonance imaging; Neuropsychology; Prefrontal cortex; Schizophrenia; Working memory

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; MALE; NEUROPSYCHIATRY; NUCLEAR MAGNETIC RESONANCE IMAGING; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA; TASK PERFORMANCE; WORKING MEMORY;

ADULT; BRAIN MAPPING; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MEMORY; PREFRONTAL CORTEX; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; TASK PERFORMANCE AND ANALYSIS;

EID: 0033134961     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(98)00318-7     Document Type: Article

References (37)

1. Andreasen N.C., Rezai K., Alliger R., et al. Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophrenia. Arch Gen Psychiatry. 49:1992;943-958.
2. Baddeley A. Working memory. Science. 255:1992;556-559.
3. Bandettini P.A., Jesmanowicz A., Wong E.C., et al. Processing strategies for time-course data sets in functional MRI of the human brain. Magn Reson Med. 30:1993;161-173.
4. Barch D.M., Braver T.S., Nystrom L.E., et al. Dissociating working memory from task difficulty in human prefrontal cortex. Neuropsychologia. 35:1997;1373-1380.
5. Berman K., Zec R., Weinberger D. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. Arch Gen Psychiatry. 43:1986;126-135.
6. Blair J.R., Spreen O. Predicting premorbid IQ a revision of the National Adult Reading Test . Clin Neuropsychologist. 3:1989;129-136.
7. Braver T.S., Cohen J.D., Nystrom L.E., et al. A parametric study of prefrontal cortex involvement in human working memory. Neuroimage. 5:1997;49-62.
8. Callicott J.H., Ramsey N.F., Tallent K., et al. Functional magnetic resonance imaging brain mapping in psychiatry methodological issues illustrated in a study of working memory in schizophrenia . Neuropsychopharmacology. 18:1998;186-196.
9. Caviness V.S.J., Meyer J., Makris N., et al. MRI-based topographic parcellation of human neocortex An anatomically specified method with estimate of reliability . J Cognit Neurosci. 8:1996;566-587.
10. Cohen J.D., Braver T.S., O'Reilly R.C. A computational approach to prefrontal cortex, cognitive control and schizophrenia recent developments and current challenges . Philos Trans R Soc Lond B Biol Sci. 351:1996;1515-1527.
11. Ebmeier K.P., Lawrie S.M., Blackwood D., et al. Hypofrontality revisited a high resolution single photon emission computed tomography study in schizophrenia . J Neurol Neurosurg Psychiatry. 58:1995;452-456.
12. Friedman H.R., Goldman-Rakic P.S. Coactivation of prefrontal cortex and inferior parietal cortex in working memory tasks revealed by 2DG functional mapping in the rhesus monkey. J Neurosci. 14:1994;2775-2788.
13. Frith C.D., Friston K.J., Herold S., et al. Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task. Br J Psychiatry. 167:1995;343-349.
14. Goff D.C., Tsai G., Manoach D.S., et al. Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia. Am J Psychiatry. 152:1995;1213-1215.
15. Goff D.C., Tsai G., Manoach D.S., et al. D-cycloserine added to clozapine for patients with schizophrenia. Am J Psychiatry. 153:1996;1628-1630.
16. Goldberg T.E., Berman K.F., Fleming K., et al. Uncoupling cognitive workload and prefrontal cortical physiology a PET rCBF study . Neuroimage. 7:1998;296-303.
17. Goldman-Rakic P. Prefrontal cortical dysfunction in schizophrenia the relevance of working memory . Carroll B.J., Barrett J.E. Psychopathology and the Brain. 1991;1-23 Raven Press, Ltd, New York.
18. Heckers S., Rauch S.L., Goff D., et al. Impaired recruitment of the hippocampus during conscious recollection in schizophrenia. Nature Neurosci. 1:1998;318-323.
19. Hollingshead A.B. Two factor index of social position. 1965;Yale University Press, New Haven, CT.
20. Kay S.R., Fiszbein A., Opler L.A. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 13:1987;261-276.
21. Manoach D.S., Gollub R.L., Searl M.M., et al. Schizophrenics are not hypofrontal on a working memory task as measured by fMRI. Fourth International Conference on Functional Mapping of the Human Brain, Montreal, Canada. Neuroimage. 7:(suppl 4):1998;S893.
22. Manoach D.S., Schlaug G., Siewert B., et al. Prefrontal cortex fMRI signal changes are correlated with working memory load. Neuroreport. 8:1997;545-549.
23. National Institute of Mental Health: Abnormal Involuntary Movement Scale (AIMS), US Public Health Service Publication. Washington, DC: US Government Printing Office.
24. Overall J.E., Gorham D.R. The brief psychiatric rating scale. Psychol Rep. 10:1962;799-812.
25. Park S., Holzman P.S. Schizophrenics show spatial working memory deficits. Arch Gen Psychiatry. 49:1992;975-982.
26. Petrides M., Alivisatos B., Evans A.C., et al. Dissociation of human mid-dorsolateral from posterior dorsolateral frontal cortex in memory processing. Proc Natl Acad Sci U S A. 90:1993;873-877.
27. Petrides M., Alivisatos B., Meyer E., et al. Functional activation of the human prefrontal cortex during the performance of verbal working memory tasks. Proc Natl Acad Sci U S A. 90:1993;878-882.
28. Rajkowska G., Goldman-Rakic P.S. Cytoarchitectonic definition of prefrontal areas in the normal human cortex: II. Variability in locations of areas 9 and 46 and relationship to the Talairach coordinate system. Cereb Cortex. 5:1995;323-337.
29. Rubin P., Holm S., Friberg L., et al. Altered modulation of prefrontal and subcortical brain activity in newly diagnosed schizophrenia and schizophreniform disorder. Arch Gen Psychiatry. 48:1991;987-995.
30. Simpson G.M., Angus J.W.S. A rating scale for extrapyramidal side effects. Acta Psychiatr Scand Suppl. 212:1970;11-19.
31. Spitzer R.L., Williams J.B., Gibbon M., et al. The Structured Clinical Interview for DSM-III-R (SCID). I History, rationale, and description . Arch Gen Psychiatry. 49:1992;624-629.
32. Sternberg S. High-speed scanning in human memory. Science. 153:1966;652-654.
33. Watanabe M. Reward expectancy in primate prefrontal neurons. Nature. 382:1996;629-632.
34. Weinberger D.R., Berman K.F. Prefrontal function in schizophrenia confounds and controversies . Philos Trans R Soc Lond B Biol Sci. 351:1996;1495-1503.
35. Weinberger D.R., Berman K.F., Zec R.F. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence (see comments). Arch Gen Psychiatry. 43:1986;114-124.
36. White K., Ashton R. Handedness assessment inventory. Neuropsychologia. 14:1976;261-264.
37. Yurgelun-Todd D.A., Waternaux C.M., Cohen B.M., et al. Functional magnetic resonance imaging of schizophrenic patients and comparison subjects during word production. Am J Psychiatry. 153:1996;200-205.