Altered effective connectivity during working memory performance in schizophrenia: A study with fMRI and structural equation modeling

NeuroImage

Volumn 19, Issue 3, 2003, Pages 751-763

  Schlösser, Ralf ^a,b   Gesierich, Thomas ^a   Kaufmann, Bettina ^a   Vucurevic, Goran ^a   Hunsche, Stefan ^a   Gawehn, Joachim ^a   Stoeter, Peter ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Antipsychotics; Connectivity; fMRI; Frontal cortex; Schizophrenia

Indexed keywords

AMISULPRIDE; ATYPICAL ANTIPSYCHOTIC AGENT; HALOPERIDOL; OLANZAPINE;

ADULT; ARTICLE; ASSOCIATION CORTEX; CEREBELLUM CORTEX; CLINICAL ARTICLE; CONTROLLED STUDY; FEEDBACK SYSTEM; FEMALE; HEMISPHERE; HUMAN; MALE; MODEL; NUCLEAR MAGNETIC RESONANCE IMAGING; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA; TASK PERFORMANCE; THALAMUS; WORKING MEMORY;

EID: 0041669399     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1053-8119(03)00106-X     Document Type: Article

References (71)

1. Abboud, H.A., 1998, Super Lab Pro 1.06, Cedrus, Phoenix.
2. Alexander G., DeLong M., Strick P. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu. Rev. Neurosci. 9:1986;357-381.
3. Andreasen N.C., Arndt S., Swayze V. 2nd, Cizadlo T., Flaum M., O'Leary D., Ehrhardt J.C., Yuh W.T. Thalamic abnormalities in schizophrenia visualized through magnetic resonance image averaging. Science. 266:1994;294-298.
4. Andreasen N.C., Paradiso S., O'Leary D.S. "Cognitive dysmetria" as an integrative theory of schizophrenia a dysfunction in cortical-subcortical-cerebellar circuitry? Schizophr . Bull. 24:1998;203-218.
5. Bartlett E.J., Brodie J.D., Simkowitz P., Schlösser R., Dewey S.L., Lindenmayer J.P., Rusinek H., Wolkin A., Cancro R., Schiffer W. Effect of a haloperidol challenge on regional brain metabolism in neuroleptic-responsive and nonresponsive schizophrenic patients. Am. J. Psychiatry. 155:1998;337-343.
6. Bartlett E.J., Wolkin A., Brodie J.D., Laska E.M., Wolf A.P., Sanfilipo M. Importance of pharmacologic control in PET studies effects of thiothixene and haloperidol on cerebral glucose utilization in chronic schizophrenia . Psychiatry Res. 40:1991;115-124.
7. Bischoff S., Christen P., Vassout A. Blockade of hippocampal dopamine (DA) receptors a tool for antipsychotics with low extrapyramidal side effects . Prog. Neuropsychopharmacol. Biol. Psychiatry. 12:1988;455-467.
8. Bollen K.A. Structural Equations with Latent Variables. 1989;Wiley, New York.
9. Braver T.S., Cohen J.D., Nystrom L.E., Jonides J., Smith E.E., Noll D.C. A parametric study of prefrontal cortex involvement in human working memory. NeuroImage. 5:1997;49-62.
10. Brett M., Christoff K., Lancaster J. Using Talairach atlas with the MNI template. NeuroImage. 13:2001;S85.
11. Büchel C., Friston K.J. Modulation of connectivity in visual pathways by attention cortical interactions evaluated with structural equation modelling and fMRI . Cereb. Cortex. 7:1997;768-778.
12. Buchsbaum M.S., Hazlett E.A., Haznedar M.M., Spiegel-Cohen J., Wei T.C. Visualizing fronto-striatal circuitry and neuroleptic effects in schizophrenia. Acta Psychiatr. Scand. Suppl. 395:1999;129-137.
13. Bullmore E., Horwitz B., Honey G., Brammer M., Williams S., Sharma T. How good is good enough in path analysis of fMRI data? NeuroImage. 11:2000;289-301.
14. Cabeza R., Mclntosh A.R., Tulving E., Nyberg L., Grady C.L. Age-related differences in effective neural connectivity during encoding and recall. NeuroReport. 8:1997;3479-3483.
15. Callicott J.H., Bertolino A., Mattay V.S., Langheim F.J., Duyn J., Coppola R., Goldberg T.E., Weinberger D.R. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb. Cortex. 10:2000;1078-1092.
16. Callicott J.H., Ramsey N.F., Tallent K., Bertolino A., Knable M.B., Coppola R., Goldberg T., van Gelderen P., Mattay V.S., Frank J.A., Moonen C.T., Weinberger D.R. Functional magnetic resonance imaging brain mapping in psychiatry methodological issues illustrated in a study of working memory in schizophrenia . Neuropsychopharmacology. 18:1998;186-196.
17. Cohen M.S. Parametric analysis of fMRI data using linear systems methods. NeuroImage. 6:1997;93-103.
18. Cohen J., Forman S., Braver T., Casey B., Servan-Schreiber D., Noll D. Activation of prefrontal cortex in a non-spatial working memory task with functional MRI. Hum. Brain Mapp. 1:1994;293-304.
19. Coull J.T., Buchel C., Friston K.J., Frith C.D. Noradrenergically mediated plasticity in a human attentional neuronal network. NeuroImage. 10:1999;705-715.
20. Della-Maggiore V., Sekuler A.B., Grady C.L., Bennett P.J., Sekuler R., Mclntosh A.R. Corticolimbic interactions associated with performance on a short-term memory task are modified by age. J. Neurosci. 20:2000;8410-8416.
21. D'Esposito M., Postle B.R., Rypma B. Prefrontal cortical contributions to working memory evidence from event-related fMRI studies . Exp. Brain Res. 133:2000;3-11.
22. Dolan R.J., Fletcher P., Frith C.D., Friston K.J., Frackowiak R.S., Grasby P.M. Dopaminergic modulation of impaired cognitive activation in the anterior cingulate cortex in schizophrenia. Nature. 378:1995;180-182.
23. Fletcher P., McKenna P.J., Friston K.J., Frith C.D., Dolan R.J. Abnormal cingulate modulation of fronto-temporal connectivity in schizophrenia. NeuroImage. 9:1999;337-342.
24. Friston K., Ashburner J., Frith C., Poline J., Heather J., Frackowiak R. Spatial registration and normalization of images. Hum. Brain Mapp. 2:1995;165-189.
25. Friston K., Worsley K., Frackowiak R., Mazziotta J., Evans A. Assessing the significance of functional activations using their spatial extent. Hum. Brain Mapp. 1:1994;214-220.
26. Friston K.J., Fletcher P., Josephs O., Holmes A., Rugg M.D., Turner R. Event-related fMRI characterizing differential responses . NeuroImage. 7:1998;30-40.
27. Friston K.J., Frith C.D. Schizophrenia a disconnection syndrome? Clin. Neurosci. 3:1995;89-97.
28. Friston K.J., Jezzard P., Turner R. Analysis of functional MRI time series. Hum. Brain Mapp. 1:1994;153-171.
29. Gevins A., Cutillo B. Spatiotemporal dynamics of component processes in human working memory. Electroencephalogr. Clin. Neurophysiol. 87:1993;128-143.
30. Goldberg T.E., Gold J.M. Neurocognitive deficits in schizophrenia. Hirsch S.R., Weinberger D.R. Schizophrenia. 1995;146-162 Blackwell Sci. London.
31. Goldman Rakic P.S. Working memory dysfunction in schizophrenia. J. Neuropsychiatry Clin. Neurosci. 6:1994;348-357.
32. Goldman-Rakic P.S., Muly E.C. 3rd, Williams G.V. D(1) receptors in prefrontal cells and circuits. Brain Res. Brain Res. Rev. 31:2000;295-301.
33. Grafton S.T., Waters C., Sutton J., Lew M.F., Couldwell W. Pallidotomy increases activity of motor association cortex in Parkinson's disease a positron emission tomographic study . Ann. Neurol. 37:1995;776-783.
34. Green M.F., Marshall B.D. Jr., Wirshing W.C., Arnes D., Marder S.R., McGurk S., Kern R.S., Mintz J. Does risperidone improve verbal working memory in treatment-resistant schizophrenia? Am. J. Psychiatry. 154:1997;799-804.
35. Honey G.D., Bullmore E.T., Soni W., Varatheesan M., Williams S.C., Sharma T. Differences in frontal cortical activation by a working memory task after substitution of risperidone for typical antipsychotic drugs in patients with schizophrenia. Proc. Natl. Acad. Sci. USA. 96:1999;13432-13437.
36. Houk, J.C. 2001. Neurophysiology of frontal-subcortical loops, in: Lichter, D.G., Cumming, J.L. (Eds.), Frontal-Subcortical Circuits in Psychiatry and Neurology. Guilford, New York.
37. Jöreskog, K.G., and Sörborn, D. 1986. Analysis of linear structural relationships by the method of maximum likelihood. Scientific software, Mooresville, IN.
38. Lancaster J.L., Woldorff M.G., Parsons L.M., Liotti M., Freitas C.S., Rainey L., Kochunov P.V., Nickerson D., Mikiten S.A., Fox P.T. Automated Talairach atlas labels for functional brain mapping. Hum. Brain Mapp. 10:2000;120-131.
39. Loubinoux I., Boulanouar K., Ranjeva J.P., Carel C., Berry I., Rascol O., Celsis P., Chollet F. Cerebral functional magnetic resonance imaging activation modulated by a single dose of the monoamine neurotransmission enhancers fluoxetine and fenozolone during hand sensorimotor tasks. J. Cereb. Blood Flow Metab. 19:1999;1365-1375.
40. Manoach D.S., Gollub R.L., Benson E.S., Searl M.M., Goff D.C., Halpern E., Saper C.B., Rauch S.L. Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. Biol. Psychiatry. 48:2000;99-109.
41. Manoach D.S., Halpern E.F., Kramer T.S., Chang Y., Goff D.C., Rauch S.L., Kennedy D.N., Gollub R.L. Test-retest reliability of a functional MRI working memory paradigm in normal and schizophrenic subjects. Am. J. Psychiatry. 158:2001;955-958.
42. Manoach D.S., Press D.Z., Thangaraj V., Searl M.M., Goff D.C., Halpern E., Saper C.B., Warach S. Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biol. Psychiatry. 45:1999;1128-1137.
43. McGuire P.K., Frith C.D. Disordered functional connectivity in schizophrenia. Psychol. Med. 26:1996;663-667.
44. McIntosh A.R., Bookstein F.L., Haxby J.V., Grady C.L. Spatial pattern analysis of functional brain images using partial least squares. NeuroImage. 3:1996;143-157.
45. McIntosh A.R., Grady C.L., Ungerleider L.G., Haxby J.V., Rapoport S.I., Horwitz B. Network analysis of cortical visual pathways mapped with PET. J. Neurosci. 14:1994;655-666.
46. McIntosh A.R., Rajah M.N., Lobaugh N.J. Interactions of prefrontal cortex in relation to awareness in sensory learning. Science. 284:1999;1531-1533.
47. Meltzer H.Y. The mechanism of action of novel antipsychotic drugs. Schizophr. Bull. 17:1991;263-287.
48. Middleton F.A., Strick P.L. Basal ganglia and cerebellar loops motor and cognitive circuits . Brain Res. Brain Res. Rev. 31:2000;236-250.
49. Muller J.L., Roder C., Schuierer G., Klein H.E. Subcortical overactivation in untreated schizophrenic patients a functional magnetic resonance image finger-tapping study . Psychiatry Clin. Neurosci. 56:2002;77-84.
50. Oldfield R. The assessment and analysis of handedness The Edinburgh Inventory . Neuropsychologia. 9:1971;97-113.
51. Pandya D.N., Yeterian E.H. Comparison of prefrontal architecture and connections. Philos. Trans. R. Soc. London B Biol. Sci. 351:1996;1423-1432.
52. Pastor J., Lafon M., Trave-Massuyes L., Demonet J.F., Doyon B., Celsis P. Information processing in large-scale cerebral networks the causal connectivity approach . Biol. Cybern. 82:2000;49-59.
53. Petrides M. Frontal lobes and working memory evidence from investigations of the effects of cortical excisions in nonhuman primates . Boller F., Grafman J. Handbook of Neuropsychology. 1994;59-82 Elsevier, Amsterdam.
54. Petrides M. Specialized systems for the processing of mnemonic information within the primate frontal cortex. Philos. Trans. R. Soc. London B Biol. Sci. 351:1996;1455-1461. discussion 1461-1462.
55. Petrides M. Mapping prefrontal cortical systems for the control of cognition. Toga A., Mazziotta J.C. Brain Mapping The Systems . 2000;157-176 Academic Press, San Diego.
56. Postle B.R., Zarahn E., D'Esposito M. Using event-related fMRI to assess delay-period activity during performance of spatial and nonspatial working memory tasks. Brain Res. Brain Res. Protocols. 5:2000;57-66.
57. Rypma B., Berger J.S., D'Esposito M. The influence of working-memory demand and subject performance on prefrontal cortical activity. J. Cogn. Neurosci. 14:2002;721-731.
58. Schlösser R., Hunsche S., Gawehn J., Grunert P., Vucurevic G., Gesierich T., Kaufmann B., Rossbach W., Stoeter P. Characterization of BOLD-fMRI signal during a verbal fluency paradigm in patients with intracerebral tumors affecting the frontal lobe. Magn. Reson. Imaging. 20:2002;7-16.
59. Schlösser R., Hutchinson M., Joseffer S., Rusinek H., Saarimaki A., Stevenson J., Dewey S.L., Brodie J.D. Functional magnetic resonance imaging of human brain activity in a verbal fluency task. J. Neurol. Neurosurg. Psychiatry. 64:1998;492-498.
60. Schmahmann J., Pandya D. Trajectories of the prefrontal, premotor and precentral corticopontine fiber systems in the rhesus monkey. Soc. Neurosci. Abstr. 20:1994;985.
61. Schmahmann J.D., Pandya D.N. Prefrontal cortex projections to the basilar pons in rhesus monkey implications for the cerebellar contribution to higher function . Neurosci. Lett. 199:1995;175-178.
62. Schmahmann J.D., Pandya D.N. Anatomic organization of the basilar pontine projections from prefrontal cortices in rhesus monkey. J. Neurosci. 17:1997;438-458.
63. Schmahmann J.D., Pandya D.N. The cerebrocerebellar system. Int. Rev. Neurobiol. 41:1997;31-60.
64. Stephan K.E., Magnotta V.A., White T., Arndt S., Flaum M., O'Leary D.S., Andreasen N.C. Effects of olanzapine on cerebellar functional connectivity in schizophrenia measured by fMRI during a simple motor task. Psychol. Med. 31:2001;1065-1078.
65. Stern C.E., Owen A.M., Tracey I., Look R.B., Rosen B.R., Petrides M. Activity in ventrolateral and mid-dorsolateral prefrontal cortex during nonspatial visual working memory processing evidence from functional magnetic resonance imaging . NeuroImage. 11:2000;392-399.
66. Stevens A.A., Goldman-Rakic P.S., Gore J.C., Fulbright R.K., Wexler B.E. Cortical dysfunction in schizophrenia during auditory word and tone working memory demonstrated by functional magnetic resonance imaging. Arch. Gen. Psychiatry. 55:1998;1097-1103.
67. Talairach J., Tournoux P. Co-planar Stereotaxic Atlas of the Human Brain. 1988;Thieme, Stuttgart.
68. Volz H., Gaser C., Hager F., Rzanny R., Ponisch J., Mentzel H., Kaiser W.A., Sauer H. Decreased frontal activation in schizophrenics during stimulation with the continuous performance test - a functional magnetic resonance imaging study. Eur. Psychiatry. 14:1999;17-24.
69. Volz H., Gaser C., Sauer H. Supporting evidence for the model of cognitive dysmetria in schizophrenia - a structural magnetic resonance imaging study using deformation-based morphometry. Schizophr. Res. 46:2000;45-56.
70. Wiser A.K., Andreasen N.C., DS O.L., Watkins G.L., Boles Ponto L.L., Hichwa R.D. Dysfunctional cortico-cerebellar circuits cause 'cognitive dysmetria' in schizophrenia. NeuroReport. 9:1998;1895-1899.
71. Youngren K.D., Inglis F.M., Pivirotto P.J., Jedema H.P., Bradberry C.W., Goldman-Rakic P.S., Roth R.H., Moghaddam B. Clozapine preferentially increases dopamine release in the rhesus monkey prefrontal cortex compared with the caudate nucleus. Neuropsychopharmacology. 20:1999;403-412.