Histopathologic correlate of hypointense lesions on T1-weighted spin- echo MRI in multiple sclerosis

Neurology

Volumn 50, Issue 5, 1998, Pages 1282-1288

  Van Walderveen, M A A ^a   Kamphorst, W ^a   Scheltens, P ^a   Van Waesberghe, J H T M ^a   Ravid, R ^b   Valk, J ^a   Polman, C H ^a   Barkhof, F ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NETHERLANDS BRAIN BANK   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN;

ADULT; AGED; ARTICLE; ASTROCYTE; CLINICAL ARTICLE; DEMYELINATION; FEMALE; GLIOSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; WHITE MATTER;

EID: 0031844371     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.50.5.1282     Document Type: Article

References (22)

1. Miller DH, Albert PS, Barkhof F, et al. Guidelines for the use of magnetic resonance techniques in monitoring the treatment of multiple sclerosis. Ann Neurol 1996;39:6-16.
2. Barkhof F, Filippi M. Can MRI be a predictor of long-term clinical outcome for MS? Int MS J 1995;2:4-9.
3. Dousset V, Grossman RI, Ramer KN, et al. Experimental allergic encephalomyelitis and multiple sclerosis: lesion characterization with magnetization transfer imaging. Radiology 1992;182:483-492.
4. Dousset V, Brochet B, Vital A, et al. Lysolecithin-induced demyelination in primates: preliminary in vivo study with MR and magnetization transfer. AJNR Am J Neuroradiol 1995;16: 225-231.
5. Davie CA, Barker GJ, Webb S, et al. Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axon loss. Brain 1995;118: 1583-1592.
6. van Walderveen MAA, Barkhof F, Hommes OR, et al. Correlating MRI and clinical disease activity in multiple sclerosis: relevance of hypointense lesions on short-TR/short-TE (T1-weighted) spin-echo images. Neurology 1995;45:1684-1690.
7. Truyen L, van Waesberghe JHTM, van Walderveen MAA, et al. Accumulation of hypointense lesion ("black holes") on T1 SE MRI in multiple sclerosis correlates with disease progression. Neurology 1996;47:1469-1476.
8. 1-weighted images. AJNR Am J Neuroradiol 1995; 16:69-77.
9. van Waesberghe JHTM, Castelijns JA, Scheltens P, et al. Comparison of four potential MR parameters for severe tissue destruction in multiple sclerosis lesions. Magn Reson Imaging 1997;15:155-162.
10. Stewart WA, Hall LD, Berry K, Paty DW. Correlation between NMR and brain slice: date in multiple sclerosis. Lancet 1984;ii:412.
11. Barkhof F, Scheltens P, Kamphorst W, et al. Pre- and post-mortem MR imaging of unsuspected multiple sclerosis in a patient with Alzheimer's disease. J Neurol Sci 1993;117: 175-178.
12. Kamman RL, Go KG, Stomp GP, et al. Changes of relaxation times T1 and T2 in rat tissue after biopsy and fixation. Magn Reson Imaging 1985;3:245-250.
13. Bö L, Mörk S, Kong PA, Nyland H, Pardo CA, Trapp BD. Detection of MHC class II-antigens on macrophages and microglia but not on astrocytes and endothelia in active multiple sclerosis lesions. J Neuroimmunol 1994;51:135-146.
14. Prineas WJ, Mc Donald WI. Demyelinating diseases. In: Graham DI, Lantos PL, eds. Greenfield's neuropathology. London: Edward Arnold, 1997:836-838.
15. Lassmann L, Suchanek G, Ozawa K. Histopathology and the blood-cerebrospinal fluid barrier in multiple sclerosis. Ann Neurol 1994;36:S42-S46.
16. Barnes D, Mc Donald WI, Johnson G, Tofts PS, Landon DN. Quantitative nuclear magnetic resonance imaging: characterization of experimental cerebral oedema. J Neurol Neurosurg Psychiatry 1987;50:125-133.
17. Barnes D, Munro PMG, Youl D, Prineas JW, McDonald WI. The longstanding MS lesion. A quantitative MRI and electron microscopic study. Brain 1991;114:1271-1280.
18. van Waesberghe JHTM, van Walderveen MAA, Castelijns JA, et al. Natural history of hypointense lesions in multiple sclerosis. J Neurol 1997;244(suppl 3):87.
19. Brown JJ, Hesselink JR, Rothrock JF. MR and CT of lacunar infarcts. AJR Am J Roentgenol 1988;15:367-372.
20. Marshall V, Bradley W, Marshall C, et al. Deep white matter infarction: correlation of MR imaging and histopathologic findings. Radiology 1988;167:517-522.
21. Lassmann H. Comparative neuropathology of chronic expertmental encephalomyelitis and multiple sclerosis. Berlin: Springer-Verlag, 1983.
22. Prineas JW, Barnard RO, Revesz, et al. Multiple sclerosis, pathology of recurrent lesions. Brain 1993;116:681-693.