Cortical gray matter volume deficit in patients with first-episode schizophrenia

American Journal of Psychiatry

Volumn 153, Issue 12, 1996, Pages 1548-1553

  Lim, Kelvin O ^a   Tew, William ^b   Kushner, Maureen ^b   Chow, Kenneth ^b   Matsumoto, Brian ^b   DeLisi, Lynn E ^b  

^a VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BRAIN SIZE; BRAIN VENTRICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GRAY MATTER; HUMAN; IMAGE ANALYSIS; INTERVIEW; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RATING SCALE; SCHIZOPHRENIA;

EID: 0029951232     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.153.12.1548     Document Type: Article

References (41)

1. Marsh L, Suddath RL, Higgins N, Weinberger DR: Medial temporal lobe structures in schizophrenia: relationship of size to duration of illness. Schizophr Res 1994; 11:225-238
2. Zipursky R, Lim KO, Dement S, Marsh L, Murphy GM, Pfefferhaum A: Volumetric MRI assessment of temporal lobe morphology in schizophrenic patients with widespread gray matter volume deficit (abstract). Biol Psychiatry 1992; 31:124A
3. Lim KO, Beal M, Harvey RL Jr, Myers T, Lane B, Sullivan EV, Faustman WO, Pfefferbaum A: Brain dysmorphology in adults with congenital rubella plus schizophrenia-like symptoms. Biol Psychiatry 1995; 37:764-776
4. Lim KO, Harris D, Beal M, Minn K, Hoff A, Csernansky J, Faustman W, Marsh L, Sullivan EV, Pfefferbaum A: Gray matter volume deficits in young onset schizophrenia are independent of age of onset. Biol Psychiatry 1996; 40:4-13
5. Harvey I, Ron M, du Bouley G, Wicks D, Lewis S, Murray RM: Reduction of cortical volume in schizophrenia on magnetic resonance imaging. Psychol Med 1993; 23:591-604
6. DeLisi LE, Hoff AL, Schwartz JE, Shields GW, Halthore SN, Gupta SM, Henn FA, Anand AK: Brain morphology in first-episode schizophrenic-like psychotic patients: a quantitative magnetic resonance imaging study. Biol Psychiatry 1991; 29:159-175; correction, 29:519
7. Vita A, Giobbio GM, Dieci M, Garbarini M, Morganti C, Comazzi M, Invernizzi G: Stability of cerebral ventricular size from the appearance of the first psychotic symptoms to the later diagnosis of schizophrenia. Biol Psychiatry 1994; 35:960-962
8. Weinberger DR, DeLisi LE, Perman GP, Targum S, Wyatt RJ: Computed tomography in schizophreniform disorder and other acute psychiatric disorders. Arch Gen Psychiatry 1982; 39:778-783
9. Lieberman J, Bogerts B, Degreef G, Ashtari M, Lantos G, Alvir J: Qualitative assessment of brain morphology in acute and chronic schizophrenia. Am J Psychiatry 1992; 149:784-794
10. Degreef G, Ashtari M, Bogerts B, Bilder RM, Jody DN, Alvir JMJ, Lieberman JA: Volumes of ventricular system subdivisions measured from magnetic resonance images in first-episode schizophrenic patients. Arch Gen Psychiatry 1992; 49:531-537
11. Nopoulos P, Torres I, Flaum M, Andreasen NC, Ehrhardt JC, Yuh WTC: Brain morphology in first-episode schizophrenia. Am J Psychiatry 1995; 152:1721-1723
12. Rubin P, Karle A, Mφller-Madsen S, Hertel C, Povlsen UJ, Noring U, Hemmingsen R: Computerised tomography in newly diagnosed schizophrenia and schizophreniform disorder: a controlled blind study. Br J Psychiatry 1993; 163:604-612
13. MacDonald HL, Best JJ: The Scottish First Episode Schizophrenia Study, VI: computerised tomography brain scans in patients and controls. Br J Psychiatry 1989; 154:492-498
14. Keshavan MS, Pettegrew JW, Bagwell WW, Haas GL, Sweeney J, Schooler NR: Gray matter volume deficits in first-episode schizophrenia (abstract). Biol Psychiatry 1994; 35:713
15. Fennig S, Kovasznay B, Rich C, Ram R, Pato C, Miller A, Rubinstein J, Carlson G, Schwartz JE, Phelan J, Lavelle J, Craig T, Bromet E: Six-month stability of psychiatric diagnoses in first-admission patients with psychosis. Am J Psychiatry 1994; 151: 1200-1208
16. Feinberg I, Thode HC, Chugani HT, March JD: Gamma distribution model describes maturational curves for delta wave amplitude, cortical metabolic rate and synaptic density. J Theor Biol 1990; 142:149-161
17. Feinberg I: Schizophrenia caused by a fault in programmed synaptic elimination during adolescence? J Psychiatr Res 1983; 17: 319-334
18. Huttenlocher PR: Synaptic density in human frontal cortex: developmental changes and effects of aging. Brain Res 1979; 163: 195-205
19. DeLisi LE, Stritzke P, Riordan H, Holan V, Boccio A, Kushner M, McClelland J, Vaneyl O, Anand A: The timing of brain morphological changes in schizophrenia and their relationship to clinical outcome. Biol Psychiatry 1992; 31:241-254
20. DeLisi LE, Tew W, Xie S, Hoff AL, Sakuma M, Kushner M, Lee G, Shedlack K, Smith AM, Grimson R: A prospective follow-up study of brain morphology and cognition in first-episode schizophrenic patients: preliminary findings. Biol Psychiatry 1995; 38: 349-360
21. Hoff AL, Neal C, Kushner M, DeLisi LE: Gender differences in corpus callosum size in first-episode schizophrenics. Biol Psychiatry 1994; 35:913-919
22. Hoff AL, Riordan H, O'Donnell D, Stritzke P, Neale C, Boccio A, Anand AK, DeLisi LE: Anomalous lateral sulcus asymmetry and cognitive function in first-episode schizophrenia. Schizophr Bull 1992; 18:257-272; correction, 1994; 20:248
23. Hoff AL, Riordan H, O'Donnell DW, Morris L, DeLisi LE: Neuropsychological functioning in first-episode schizophreniform patients. Am J Psychiatry 1992; 149:898-903
24. Hollingshead AB, Redlich FC: Social Class and Mental Illness: A Community Study. New York, John Wiley & Sons, 1958
25. Overall JF, Gorham DR: The Brief Psychiatric Rating Scale. Psychol Rep 1962; 10:799-812
26. Lim KO, Zipursky RB, Sullivan EV, Pfefferbaum A: Cortical gray matter deficits in schizophrenia: a replication. Schizophr Res 1996; 20:157-164
27. Lane B, Lim KO, Beal M, Harvey RL, Myers T, Sullivan EV, Faustman WO, Pfefferbaum A: Congenital rubella: quantitative MRI study of gray matter volume deficits and white matter lesions in adult patients with schizophrenia-like symptoms, in Abstracts of the Annual Meeting of the American Society of Neuroradiology. Oak Brook, III, ASN, 1994
28. Kittler J, Illingworth J: Minimum error thresholding. Pattern Recognition 1986; 19:41-47
29. Otsu N: A threshold selection method from gray-level histograms. IEEE Trans (SMC) 1979; 9:63-66
30. Lim KO, Zipursky RB, Watts MC, Pfefferbaum A: Decreased gray matter in normal aging: an in vivo magnetic resonance study. J Gerontol 1992; 47:B26-B30
31. Lim KO, Pfefferbaum A: Segmentation of MR brain images into cerebrospinal fluid spaces, white and gray matter. J Comput Assist Tomogr 1989; 13:588-593
32. Pfefferbaum A, Zatz L, Jernigan TL: Computer-interactive method for quantifying cerebrospinal fluid and tissue in brain CT scans: effects of aging. J Comput Assist Tomogr 1986; 10: 571-578
33. Pfefferbaum A, Mathalon DH, Sullivan EV, Rawles JM, Zipursky RB, Lim KO: A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Arch Neurol 1994; 51:874-887
34. Zipursky RB, Lim KO, Sullivan EV, Brown BW, Pfefferbaum A: Widespread cerebral gray matter volume deficits in schizophrenia. Arch Gen Psychiatry 1992; 49:195-205
35. Mathalon DH, Sullivan EV, Rawles JM, Pfefferbaum A: Correction for head size in brain imaging measurements. Psychiatry Res Neuroimaging 1993; 50:121-139
36. Pfefferbaum A, Lim KO, Zipursky RB, Mathalon DH, Lane B, Ha CN, Rosenbloom MJ, Sullivan EV: Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: a quantitative MRI study. Alcohol Clin Exp Res 1992; 16:1078-1089
37. Glejser H: A new test for heteroscedacity. J Am Statistical Assoc 1969; 64:316-323
38. Mathalon DH, Sullivan EV, Rawles JM, Pfefferbaum A: Correction for head size in brain imaging measurements (letter). Psychiatry Res Neuroimaging 1993; 50:284
39. Lauriello J, Hoff A, Weineke M, DeMent S, Faustman WO, Sullivan EV, Lim KO, Pfefferbaum A: Cortical gray matter volume deficits in women with schizophrenia (abstract). Schizophr Res 1995; 15:95-96
40. DeLisi LE, Hoff AL, Kushner M, Calev A, Stritzke P: Left ventricular enlargement associated with diagnostic outcome of schizophreniform. Biol Psychiatry 1992; 32:199-201
41. Smith GN, Iacono WG: Lateral ventricular size in schizophrenia and choice of control group (letter). Lancet 1986; 1:1450