Insulin-like growth factor-1 inhibits mature oligodendrocyte apoptosis during primary demyelination

Journal of Neuroscience

Volumn 20, Issue 15, 2000, Pages 5703-5708

  Mason, J L ^a,b   Ye, P ^a   Suzuki, K ^a   D'Ercole, A J ^a   Matsushima, G K ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b Department of Pathology ^*  (United States)

Author keywords

Apopto sis; Demyelination; Insulin like growth factor 1; Mice; Myelin; Oligodendrocytes; Progenitors; Transgenic

Indexed keywords

CUPRIZONE; SOMATOMEDIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CORPUS CALLOSUM; DEMYELINATION; IN VIVO STUDY; MACROPHAGE; MICROGLIA; MOUSE; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; REMYELINIZATION;

EID: 0034255494     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-15-05703.2000     Document Type: Article

References (25)

1. Multiple extracellular signals are required for long-term oligodendrocyte survival
2. Tissue culture model of Krabbe's disease: Psychosine cytotoxicity in rat oligodendrocyte cultures
3. Remyelination of the central nervous system
4. Myelination in the absence of galactocerebroside and sulfatide: Normal structure with abnormal function and regional stability
5. The role of the insulin-like growth factors in the central nervous system
6. Endogenous progenitors remyelinate demyelinated axons in the adult CNS
7. Microglial/macrophage accumulation during Cuprizone-induced demyelination in C57BL/6 mice
8. The demyelination of recurrent demyelination and remyelination of axons in the central nervous system
9. Response of the oligodendrocyte progenitor cell population (defined by NG2 labeling) to demyelination of the adult spinal cord
10. Blood-brain barrier permeability to horseradish peroxidase in twitcher and cuprizone-intoxicated mice
11. Insulin-like growth factor I treatment reduces clinical deficits and lesion severity in acute demyelinating experimental autoimmune encephalomyelitis
12. Insulin-like growth factor-1 treatment reduces immune cell responses in acute non-demyelinative experimental autoimmune encephalomyelitis
13. Mature oligodendrocyte apoptosis precedes IGF-1 production and oligodendrocyte progenitor accumulation and differentiation during demyelination/remyelination
14. Gene expression in brain during Cuprizone-induced demyelination and remyelination
15. Insulin-like growth factor I stimulates oligodendrocyte development and myelination in rat aggregate cultures
16. Apoptosis in the nervous system in experimental allergic encephalomyelitis
17. The Norton Lecture: A review of the oligodendrocyte in the multiple sclerosis lesion
18. An apoptotic depletion of oligodendrocytes in the twitcher, a murine model of globoid cell leukodystrophy
19. The role of the insulin-like growth factor system in the developing brain
20. Cryogenic spinal cord injury induces astrocytic gene expression of insulin-like growth factor 1 and insulin-like growth factor binding protein 2 during myelin regeneration
21. Insulin-like growth factor-1 given subcutaneously reduces clinical deficits, decreases lesion severity and upregulates synthesis of lyelin proteins in experimental autoimmune encephalomyelitis
22. In vivo actions of insulin-like growth factor-1 (IGF-1) on brain myelination: Studies of IGF-1 and IGF binding protein-1 (IGFBP-1) transgenic mice
23. In vivo actions of insulin-like growth factor-1 (IGF-1) on cerebellum development in transgenic mice: Evidence that IGF-1 increases proliferation of granule cell progenitors
24. Insulin-like growth factor I protects oligodendrocytes from tumor necrosis factor-α-induced injury