Increased number of unmyelinated axons in optic nerves of adult mice deficient in the myelin-associated glycoprotein (MAG)

Brain Research

Volumn 762, Issue 1-2, 1997, Pages 231-234

  Bartsch, Susanne ^a   Montag, Dirk ^a   Schachner, Melitta ^a   Bartsch, Udo ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Knock out mutant; Mouse; Myelin; Myelin associated glycoprotein; Oligodendrocyte; Optic nerve

Indexed keywords

MYELIN ASSOCIATED GLYCOPROTEIN;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; GLIA CELL; MOUSE; MYELIN SHEATH; MYELINATION; NEWBORN; NONHUMAN; NONMYELINATED NERVE; OLIGODENDROGLIA; OPTIC NERVE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; RETINA GANGLION CELL;

ANIMALS; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON; MYELIN SHEATH; MYELIN-ASSOCIATED GLYCOPROTEIN; NERVE FIBERS, MYELINATED; OLIGODENDROGLIA; OPTIC NERVE;

EID: 0030742643     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00484-8     Document Type: Article

References (17)

1. Bartsch U., Kirchhoff F., Schachner M. Immunohistological localization of the adhesion molecules L1, N-CAM, and MAG in the developing and adult optic nerve of mice. J. Comp. Neurol. 284:1989;451-462.
2. Bartsch U., Montag D., Bartsch S., Schachner M. Multiply myelinated axons in the optic nerve of mice deficient for the myelin-associated glycoprotein. Glia. 14:1995;115-122.
3. Bartsch U. Myelination and axonal regeneration in the central nervous system of mice deficient in the myelin-associated glycoprotein. J. Neurocytol. 25:1996;303-313.
4. Fruttiger M., Montag D., Schachner M., Martini R. Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity. Eur. J. Neurosci. 7:1995;511-515.
5. Lassmann H., Bartsch U., Montag D., Schachner M. Dying-back oligodendrogliopathy: a late sequel of myelin associated glycoprotein deficiency. Glia. 19:1997;104-110.
6. Li C., Tropak M.B., Gerial R., Clapoff S., Abramow-Newerly W., Trapp B., Peterson A., Roder J. Myelination in the absence of myelin-associated glycoprotein. Nature. 369:1994;747-750.
7. Martini R., Schachner M. Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM and MAG) and their shared carbohydrate epitope and myelin basic protein in developing sciatic nerve. J. Cell Biol. 103:1986;2439-2448.
8. Meyer-Franke A., Barres B. Myelination without myelin-associated glycoprotein. Curr. Biol. 4:1994;847-850.
9. Montag D., Giese K.P., Bartsch U., Martini R., Lang Y., Blüthmann H., Karthigasan J., Kirschner D.A., Wintergerst E.S., Nave K.-A., Zielasek J., Toyka K.V., Lipp H.-P., Schachner M. Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin. Neuron. 13:1994;229-246.
10. Owens G.C., Bunge R.P. Evidence for an early role for myelin-associated glycoprotein in the process of myelination. Glia. 2:1989;119-128.
11. Owens G.C., Boyd C.J., Bunge R.P., Salzer J.L. Expression of recombinant myelin-associated glycoprotein in primary Schwann cells promotes the initial investment of axons by myelinating Schwann cells. J. Cell Biol. 111:1990;1171-1182.
12. Owens G.C., Bunge R.P. Schwann cells infected with a recombinant retrovirus expressing myelin-associated glycoprotein antisense RNA do not form myelin. Neuron. 7:1991;565-575.
13. Poltorak M., Sadoul R., Keilhauer G., Landa C., Fahrig T., Schachner M. Myelin-associated glycoprotein, a member of the L2/HNK-1 family of neural cell adhesion molecules, is involved in neuron-oligodendrocyte and oligodendrocyte-oligodendrocyte interaction. J. Cell Biol. 105:1987;1893-1899.
14. Sternberger N.H., Quarles R.H., Itoyama Y., Webster H.deF. Myelin-associated glycoprotein demonstrated immunocytochemically in myelin and myelin-forming cells of developing rat. Proc. Natl. Acad. Sci. USA. 76:1979;1510-1514.
15. Trapp B.D. Myelin-associated glycoprotein. Location and potential functions. An. NY Acad. Sci. 605:1990;29-43.
16. Trapp B.D., Andrews S.B., Cootauco C., Quarles R.H. The myelin-associated glycoprotein is enriched in multivesicular bodies and periaxonal membranes of actively myelinating oligodendrocytes. J. Cell Biol. 109:1989;2417-2426.
17. Umemori H., Sato S., Yagi T., Aizawa S., Yamamoto T. Initial events of myelination involve fyn tyrosine kinase signalling. Nature. 367:1994;572-576.