Hypofrontality in schizophrenia: Distributed dysfunctional circuits in neuroleptic-naive patients

Lancet

Volumn 349, Issue 9067, 1997, Pages 1730-1734

  Andreasen, Nancy C ^a   O'Leary, Daniel S ^a   Flaum, Michael ^a   Nopoulos, Peg ^a   Watkins, G Leonard ^a   Boles Ponto, Laura L ^a   Hichwa, Richard D ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BRAIN BLOOD FLOW; BRAIN METABOLISM; BRAIN PERFUSION; CEREBELLUM; CLINICAL ARTICLE; DELUSION; FEMALE; HALLUCINATION; HUMAN; MALE; PARIETAL LOBE; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA; TEMPORAL CORTEX; THALAMUS;

EID: 0030941817     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(96)08258-X     Document Type: Article

References (30)

1. Ingvar DH, Franzen G. Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatr Scand 1974; 50: 425-62.
2. Gur RE, Gur RC, Skolnick BE, et al. Brain function in psychiatric disorders: regional cerebral blood flow in unmedicated schizophrenics. Arch Gen Psychiatry 1985; 42: 329-34.
3. Berman KF, Illowsky BP, Weinberger DR. Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia: further evidence for regional and behavioral specificity. Arch Gen Psychiatry 1988; 45: 616-22.
4. Buchsbaum MS, Ingvar DH, Kessler R, et al. Cerebral glucography with positron tomography. Arch Gen Psychiatry 1982; 39: 251-59.
5. Volkow ND, Wolf AP, Van Gelder P, et al. Phenomenological correlates of metabolic activity in 18 patients with chronic schizophrenia. Am J Psychiatry 1987; 144: 151-58.
6. Early TS, Reiman EM, Raichle ME, Spitznagel EL. Left globus pallidus abnormality in never-medicated patients with schizophrenia. Proc Natl Acad Sci USA 1987; 84: 561-63.
7. Liddle PF, Friston KJ, Frith CD, Hirsch SR, Jones T, Frackowiak RSJ. Patterns of cerebral blood flow in schizophrenia. Br J Psychiatry 1992; 60: 179-86.
8. Benes FM. Is there a neuroanatomic basis for schizophrenia? An old question revisited. Neuroscientist 1995; 1: 104-15.
9. Andreasen NC, Nasrallah HA, Dunn VD, Olson SC, Grove WM, Ehrhardt JC, et al. Structural abnormalities in the frontal system in schizophrenia: a magnetic resonance imaging study. Arch Gen Psychiatry 1986; 43: 136-44.
10. Andreasen NC, Flashman L, Flaum M, et al. Regional brain abnormalities in schizophrenia measured with magnetic resonance imaging. JAMA 1994; 272: 1763-69.
11. Goldman-Rakic PS, Selemon LD, Schwartz ML. Dual pathways connecting the dorsolateral prefrontal cortex with the hippocampal formation and parahippocampal cortex in the rhesus monkey. Neuroscience 1984; 12: 719-43.
12. Bilder RM, Turkel E, Lipschutz-Borch L, Lieberman JA. Antipsychotic medication effects on neuropsychological functions. Psychopharmacol Bull 1992; 28: 353-66.
13. Frith CD. The cognitive neuropsychology of schizophrenia. East Sussex: Lawrence Erlbaum, 1992.
14. Gur RC, Gur RE. Hypofrontality in schizophrenia: RIP. Lancet 1995; 345:1383-85.
15. Andreasen NC, Rezai K, Alliger R, et al. Hypofrontality in neuroleptic-naive and chronic schizophrenic patients: assessment with xenon-133 single-photon emission computed tomography and the Tower of London. Arch Gen Psychiatry 1992; 49: 943-58.
16. Mega MS, Cummings JL. Frontal-subcortical circuits and neuropsychiatric disorders. J Neuropsychiatry Clin Neurosci 1994; 6: 358-70.
17. Weingerger DR, Berman KF, Zec RF. Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia I: regional cerebral blood flow (rCBF) evidence. Arch Gen Psychiatry 1986; 43: 114-24.
18. Wiesel FA, Wik G, Sjogren I, Blomqvist G, Greitz T. Altered relationships between metabolic rates of glucose in brain regions of schizophrenic patients. Acta Psychiatr Scand 1987; 76: 642-47.
19. Gur RE, Mozley PD, Resnick SM, et al. Resting cerebral glucose metabolism in first-episode and previously treated patients with first episode schizophrenia relates to clinical features. Arch Gen Psychiatry 1995; 52: 657-67.
20. Cleghorn JM, Garnett ES, Nahmias C, et al. Increased frontal and reduced parietal glucose metabolism in acute untreated schizophrenia. Psychiatry Res 1989; 28: 119-33.
21. Szechtman H, Nahmias C, Garnett S, et al. Effect of neuroleptics on altered cerebral glucose metabolism in schizophrenia. Arch Gen Psychiatry 1988; 45: 523-32.
22. Berman KF, Zec RF, Weinberger DR. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia: role of neuroleptic treatment, attention, and mental effort. Arch Gen Psychiatry 1986; 43: 126-35.
23. Andreasen NC, O'Leary DS, Cizadlo T, et al. Remembering the past: two facets of episodic memory explored with positron emission tomography. Am J Psychiatry 1995; 152: 1576-85.
24. Buchsbaum MS, Neuchterlein KH, Haier RJ, et al. Glucose metabolic rate in normals and schizophrenics during the continuous performance test assessed by positron emission tomography. Br J Psychiatry 1990; 156: 216-27.
25. Andreasen NC, O'Leary DS, Cizadlo T, et al. Schizophrenia and cognitive dysmetria: a PET study of dysfunctional prefrontalthalamic-cerebellar circuitry. Proc Natl Acad Sci USA 1996; 93: 9985-90.
26. Silbersweig DA, Stern E, Frith C, et al. A functional neuroanatomy of hallucinations in schizophrenia. Nature 1995; 378: 176-79.
27. Andreasen NC, Rajarethinam R, Cizadlo T, et al. Automatic atlasbased volume estimation of human brain regions from the MR images. J Comput Assist Tomogr 1996; 20: 98-106.
28. Arndt S, Cizadlo T, Andreasen NC, Heckel D, Gold S, O'Leary DS. Tests for comparing images based on randomization and permutation methods. J Cereb Blood Flow Metab 1996; 16: 1271-79.
29. Goldman-Rakic PS. Circuitry of the prefrontal cortex and the regulation of behavior by representational knowledge. In: Plum F, Mountcastle V, eds. Handbook of physiology, vol 5. Bethesda: American Physiological Society, 1987: 373-417.
30. Andreasen NC, O'Leary DS, Arndt S, et al. Short-term and long-term verbal memory: a positron emission tomography study. Proc Natl Acad Sci USA 1995; 92: 5111-15.