Overexpression of 2',3'-cyclic nucleotide 3'-phosphodiesterase in transgenic mice alters oligodendrocyte development and produces aberrant myelination

Molecular and Cellular Neurosciences

Volumn 7, Issue 6, 1996, Pages 453-466

  Gravel, Michel ^a   Peterson, John ^b   Yong, Voon Wee ^c   Kottis, Vicky ^a   Trapp, Bruce ^b   Braun, Peter E ^a  

^a MCGILL UNIVERSITY   (Canada)

^b LERNER RESEARCH INSTITUTE   (United States)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2',3' CYCLIC NUCLEOTIDE 3' PHOSPHODIESTERASE; NUCLEOTIDE BINDING PROTEIN; PROTEOLIPID;

ANIMAL TISSUE; ARTICLE; CELL VACUOLE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; ISOPRENYLATION; MOUSE; MYELIN SHEATH; MYELINATION; NERVE CELL DIFFERENTIATION; NERVE FUNCTION; NONHUMAN; OLIGODENDROGLIA; PHENOTYPE; PRIORITY JOURNAL; STEM CELL; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

EID: 0030174240     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1006/mcne.1996.0033     Document Type: Article

References (40)

1. Ballestero, R. P., Wilmot, G. R., Leski, M. L., Uhler, M. D., and Agranoff, B. W. (1995). Isolation of cDNA clones encoding RICH: A protein induced during goldfish optic nerve regeneration with homology to mammalian CNPases. Proc. Natl. Acad. Sci. USA 92: 8621-8625.
2. Bernier, L., Alvarez, F., Norgard, E. M., Raible, D. W., Mentaberry, A., Schembri, J. G., Sabatini, D. D., and Colman, D. R. (1987). Molecular cloning of a 2′,3′-cyclic nucleotide 3′-phosphodiesterase: mRNAs with different 5′-ends encode the same set of proteins in nervous and lymphoid tissues. J. Neurosci. 7: 2703-2710.
3. Boison, D., and Stoffel, W. (1994). Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice. Proc. Natl. Acad. Sci. USA 91: 11707-11713.
4. Braun, P. E., De Angelis, D. A., Shtybel, W. W., and Bernier, L. (1990). Isoprenoid modification permits 2′,3′-cyclic nucleotide 3′-phosphodiesterase to bind to membranes. J. Neurosci. Res. 30: 540-544.
5. Braun, P. E., Sandillon, F., Edwards, A. M., Mathieu, J. M., and Privat, A. (1988). Immunocytochemical localization by electron microscopy of 2′,3′-cyclic nucleotide 3′-phosphodiesterase in developing oligodendrocytes of normal and mutant brain. J. Neurosci. 8: 3057-3066.
6. Côté, F., Collard, J. F., and Julien, J. P. (1993). Progressive neuropathy in transgenic mice expressing the human neurofilament heavy gene: A mouse model of amyotrophic lateral sclerosis. Cell 73: 35-46.
7. Cox, M. E., Gao, E. N., and Braun, P. E. (1994). C-terminal CTII motif of 2′,3′-cyclic nucleotide 3′-phosphodiesterase undergoes carboxyl-methylation. J. Neurosci. Res. 39: 513-518.
8. De Angelis, D. A., and Braun, P. E. (1994). Isoprenylation of brain 2′,3′-cyclic nucleotide 3′-phosphodiesterase modulates cell morphology. J. Neurosci. Res. 39: 386-397.
9. De Angelis, D., and Braun, P. E. (1996). 2′,3′-cyclic nucleotide 3′-phosphodiesterase binds to actin-based cytoskeletal elements in an isoprenylation independent manner. J. Neurochem., in press.
10. De Angelis, D., Cox, M., Gao, E., and Braun, P. E. (1994). Cellular and molecular characteristics of CNP suggest regulatory mechanisms in myelinogenesis. In A Multidisciplinary Approach to Myelin Diseases II (S. Salvati, Ed.), pp. 49-58. Plenum, New York.
11. Dyer, C. A., and Benjamins, J. A. (1989). Organization of oligodendroglial membrane sheets. I. Association of myelin basis protein and CNP with cytoskeleton. J. Neurosci. Res. 24: 201-211.
12. Gravel, M., De Angelis, D. A., and Braun, P. E. (1994). Molecular cloning and characterization of 2′,3′-cyclic nucleotide 3′-phosphodiesterase isoform 2. J. Neurosci. Res. 38: 243-247.
13. Johnson, R. S., Roder, J. C., and Riordan, J. R. (1995). Over-expression of the DM-20 myelin proteolipid causes central nervous system demyelination in transgenic mice. J. Neurochem. 64: 967-976.
14. Kagawa, T., Ikenaka, K., Inoue, Y., Kuriyama, S., Tsujii, T., Nakao, J., Nakajima, K., Aruga, J., Okano, H., and Mikoshiba, K. (1994). Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein gene. Neuron 13: 427-442.
15. Kirschner, D. A., and Blaurock, A. E. (1992). Organization, phylogenetic variations, and dynamic transitions of myelin. In Myelin: Biology and Chemistry (R. E. Martenson, Ed.), pp. 3-78. CRC Press, Boca Raton, FL.
16. Kurihara, T., Monoh, K., Sakimura, K., and Takahashi, Y. (1990). Alternative splicing of mouse brain 2′,3′-cyclic nucleotide 3′-phosphodiesterase mRNA. Biochem. Biophys. Res. Commun. 170: 1074-1081.
17. Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
18. Martenson, R. E. (1992). In Myelin: Biology and Chemistry (R. E. Martenson, Ed.), pp. 653-780. CRC Press, Boca Raton, FL.
19. Mastronardi, F. G., Ackerley, C. A., Arsenault, L., Roots, B. I., and Moscarello, M. A. (1993). Demyelination in a transgenic mouse: A model for multiple sclerosis. J. Neurosci. Res. 36: 315-324.
20. Monoh, K., Kurihara, T., Takahashi, T., Ichikawa, Y., Kumanishi, T., Hayashi, S., Minoshima, S., and Shimizu, N. (1993). Structure, expression and chromosomal localization of the gene encoding human 2′,3′-cyclic nucleotide 3′-phosphodiesterase. Gene 129: 297-301.
21. Nave, K. A. (1994). Neurological mouse mutants and the genes of myelin. J. Neurosci. Res. 38: 607-612.
22. Norton, W. T., and Poduslo, S. E. (1973). Myelination in the rat brain: Method of myelin isolation. J. Neurochem. 21: 749-757.
23. Pereyra, P. M., Horvath, E., and Braun, P. E. (1988). Triton-X100 extractions of CNS myelin indicate a possible role for the minor myelin proteins in the stability of lamellae. Neurochem. Res. 13: 583-595.
24. Pfeiffer, S. E., Warrington, A. F., and Bansal, R. (1993). The oligodendrocyte and its many cellular processes. Trends Cell Biol. 3: 191-197.
25. Ranscht, B., Clapshaw, P. A., Price, J., Noble, M., and Siefert, W. (1982). Development of oligodendrocytes and Schwann cells studied with a monoclonal antibody against galactocerebroside. Proc. Natl. Acad. Sci. USA 79: 2709-2713.
26. Readhead, C., Schneider, A., Griffiths, I., and Nave, K. A. (1994). Premature arrest of myelin formation in transgenic mice with increased proteolipid protein gene dosage. Neuron 12: 583-595.
27. Scherer, S. S., Braun, P. E., Grinspan, J., Collarini, E., Wang, D. Y., and Kamholz, J. (1994). Differential regulation of the 2′,3′-cyclic nucleotide 3′-phosphodiesterase gene during oligodendrocyte development. Neuron 12: 1363-1375.
28. Sogin, D. D. (1976). 2′,3′-Cyclic NADP as a substrate for 2′,3′-cyclic nucleotide 3′-phosphodiesterase. J. Neurochem. 27: 1333-1337.
29. Sprinkle, T. J. (1989). 2′,3′-Cyclic nucleotide 3′-phosphodiesterase, an oligodendrocyte-Schwann cell and myelin associated enzyme of the nervous system. CRC Crit. Rev. Neurobiol. 4: 235-300.
30. Staugaitis, S. M., Bernier, L., Smith, P. R., and Colman, D. R. (1990). Expression of the oligodendrocyte marker 2′,3′-cyclic nucleotide 3′-phosphodiesterase in non-glial cells. J. Neurosci. Res. 25: 556-560.
31. Trapp, B. D., Bernier, L., Andrews, S. B., and Colman, D. R. (1988). Cellular and subcellular distribution of 2′,3′-cyclic nucleotide 3′-phosphodiesterase and its mRNA in the rat central nervous system. J. Neurochem. 51: 859-868.
32. Tsukada, Y., and Kurihara, T. (1992). 2′,3′-cyclic nucleotide 3′-phosphodiesterase: Molecular characterization and possible functional significance, In Myelin: Biology and Chemistry (R. E. Martenson Ed.), pp. 449-480. CRC Press, Boca Raton, FL.
33. Vogel, U. S., and Thompson, R. J. (1988). Molecular structure, localization and possible functions of the myelin associated enzyme 2′,3′-cyclic nucleotide phosphodiesterase. J. Neurochem. 50: 1667-1677.
34. Waehneldt, T. V., and Malotka, J. (1980). Comparative electrophoretic study of the wolfgram proteins in myelin from several mammalia. Brain Res. 189: 582-587.
35. Wilson, R., and Brophy, P. J. (1989). Role for the oligodendrocyte cytoskeleton in myelination. J. Neurosci. Res. 22: 439-448.
36. Yong, V. W., and Antel, J. P. (1992). Culture of glial cells from human brain biopsies. In Protocols for Neural Cell Culture (S. Fedoroff and A. Richarson, Eds.), pp. 81-96. Humana Press, Clifton, NJ.
37. Yong, V. W., Cheung, J. C. B., Uhm, J. H., and Kim, S. U. (1991). Age dependent decrease of process formation by cultured oligodendrocytes is augmented by protein kinase C stimulation. J. Neurosci. Res. 29: 87-99.
38. Yong, V. W., Dooley, N. P., and Noble, P. G. (1994). Protein kinase C in cultured adult human oligodendrocytes: A potential role for isoform as a mediator of process outgrowth. J. Neurosci. Res. 39: 83-96.
39. Yong, V. W., Sekiguchi, S., Kim, M. W., and Kim, S. U. (1988). Phorbol ester enhances morphological differentiation in oligodendrocytes in culture. J. Neurosci. Res. 19:187-194.
40. Yu, W. P., Collarini, E. J., Pringle, N. P., and Richardson, W. D. (1994). Embryonic expression of myelin genes: Evidence for a focal source of oligodendrocyte precursors in the ventricular zone of the neural tube. Neuron 12: 1353-1362.