Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia

American Journal of Psychiatry

Volumn 160, Issue 4, 2003, Pages 709-719

  Callicott, Joseph H ^a   Egan, Michael F ^a   Mattay, Venkata S ^a   Bertolino, Alessandro ^a   Bone, Ashley D ^a   Verchinksi, Beth ^a   Weinberger, Daniel R ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BRAIN CORTEX; COGNITION; COHORT ANALYSIS; CONTROLLED STUDY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; SCHIZOPHRENIA; SIBLING; TASK PERFORMANCE; WORKING MEMORY; ADULT; COGNITIVE DEFECT; COMPARATIVE STUDY; FEMALE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HEMISPHERIC DOMINANCE; MALE; MEMORY; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PHENOTYPE; PHYSIOLOGY; PSYCHOLOGY; RISK FACTOR; STATISTICS;

CATECHOL METHYLTRANSFERASE;

ADULT; CATECHOL O-METHYLTRANSFERASE; COGNITION; COGNITION DISORDERS; COHORT STUDIES; FEMALE; FUNCTIONAL LATERALITY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MEMORY; NEUROPSYCHOLOGICAL TESTS; PHENOTYPE; POLYMORPHISM, GENETIC; PREFRONTAL CORTEX; RISK FACTORS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SIBLINGS;

EID: 0038474159     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.160.4.709     Document Type: Article

References (67)

1. Gottesman II: Schizophrenia Genesis: Origins of Madness. San Francisco, WH Freeman, 1991
2. Risch N: Genetic linkage and complex diseases, with special reference to psychiatric disorders. Genet Epidemiol 1990; 7:3-16
3. Faraone SV, Seidman LJ, Kremen WS, Pepple JR, Lyons MJ, Tsuang MT: Neuropsychological functioning among the non-psychotic relatives of schizophrenic patients: a diagnostic efficiency analysis. J Abnorm Psychol 1995; 104:286-304
4. Freedman R, Adler LE, Waldo MC, Pachtman E, Franks RD: Neurophysiological evidence for a defect in inhibitory pathways in schizophrenia: comparison of medicated and drug-free patients. Biol Psychiatry 1983; 18:537-551
5. Tsuang MT: Genotypes, phenotypes, and the brain: a search for connections in schizophrenia. Br J Psychiatry 1993; 163:299-307
6. Weinberger DR, Egan MF, Bertolino A, Callicott JH, Mattay VS, Lipska BK, Berman KF, Goldberg TE: Prefrontal neurons and the genetics of schizophrenia: prefrontal neurons and the genetics of schizophrenia. Biol Psychiatry 2001; 50:825-844
7. James JW: Frequency in relatives for an all-or-none trait. Ann Hum Genet 1971; 35:47-49
8. Risch N: Linkage strategies for genetically complex traits, I: multilocus models. Am J Hum Genet 1990; 46:222-228
9. Egan MF, Weinberger DR: Neurobiology of schizophrenia. Curr Opin Neurobiol 1997; 7:701-707
10. Braff DL, Callaway E, Naylor H: Very short-term memory dysfunction in schizophrenia: defective short-time constant information processing in schizophrenia. Arch Gen Psychiatry 1977; 34:25-30
11. Cannon TD, Zorrilla LE, Shtasel D, Gur RE, Gur RC, Marco EJ, Moberg P, Price RA: Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers. Arch Gen Psychiatry 1994; 51:651-661
12. Goldberg TE, Torrey EF, Gold JM, Bigelow LB, Ragland RD, Taylor E, Weinberger DR: Genetic risk of neuropsychological impairment in schizophrenia: a study of monozygotic twins discordant and concordant for the disorder. Schizophr Res 1995; 17:77-84
13. Park S, Holzman PS, Goldman-Rakic PS: Spatial working memory deficits in the relatives of schizophrenic patients. Arch Gen Psychiatry 1995; 52:821-828
14. Arolt V, Lencer R, Nolte A, Muller-Myhsok B, Purman S, Schurmann M, Leutelt J, Pinnow M, Schwinger E: Eye-tracking dysfunction is a putative phenotypic susceptibility marker of schizophrenia and maps to a locus on chromosome 6p in families with multiple occurrence of the disease. Am J Med Genet 1996; 67:564-579
15. Freedman R, Coon H, Myles-Worsley M, Orr-Urteger A, Olincy A, Davis A, Polymeropoulus M, Holik J, Hopkins J, Hoff M, Rosenthal J, Waldo MC, Reimherr F, Wender P, Yaw J, Young DA, Breese CR, Adams C, Patterson D, Adler LE, Kruglyak L, Leonard S, Byerley W: Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci USA 1997; 94:587-592
16. Egan MF, Goldberg TE, Gscheidle T, Weirich M, Bigelow LB, Weinberger DR: Relative risk of attention deficits in siblings of patients with schizophrenia. Am J Psychiatry 2000; 157:1309-1316
17. Keefe RS, Roitman SE, Harvey PD, Blum CS, DuPre RL, Prieto DM, Davidson M, Davis KL: A pen-and-paper human analogue of a monkey prefrontal cortex activation task: spatial working memory in patients with schizophrenia. Schizophr Res 1995; 17:25-33
18. Carter C, Robertson L, Nordahl T, Chaderjian M, Kraft L, O'Shora-Celaya L: Spatial working memory deficits and their relationship to negative symptoms in unmedicated schizophrenia patients. Biol Psychiatry 1996; 40:930-932
19. Wexler BE, Stevens AA, Bowers AA, Sernyak MJ, Goldman-Rakic PS: Word and tone working memory deficits in schizophrenia. Arch Gen Psychiatry 1998; 55:1093-1096
20. Weickert TW, Goldberg TE, Gold JM, Bigelow LB, Egan MF, Weinberger DR: Cognitive impairments in patients with schizophrenia displaying preserved and compromised intellect. Arch Gen Psychiatry 2000; 57:907-913
21. Weinberger DR, Berman KF, Zec RF: Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia, I: regional cerebral blood flow evidence. Arch Gen Psychiatry 1986; 43:114-124
22. Catafau AM, Parellada E, Lomena FJ, Bernardo M, Pavia J, Ros D, Setoain J, Gonzalez-Monclus E: Prefrontal and temporal blood flow in schizophrenia: resting and activation technetium-99m-HMPAO SPECT patterns in young neuroleptic-naive patients with acute disease. J Nucl Med 1994; 35:935-941
23. Goldman-Rakic PS: Prefrontal cortical dysfunction in schizophrenia: the relevance of working memory, in Psychopathology and the Brain. Edited by Carroll BJ, Barnett JE. New York, Raven Press, 1991
24. Goldberg TE, Kelsoe JR, Weinberger DR, Pliskin NH, Kirwin PD, Berman KF: Performance of schizophrenic patients on putative neuropsychological tests of frontal lobe function. Int J Neurosci 1988; 42:51-58
25. Cannon TD, Huttunen MO, Lonnqvist J, Tuulio-Henriksson A, Pirkola T, Glahn D, Finkelstein J, Hietanen M, Kaprio J, Koskenvuo M: The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia. Am J Hum Genet 2000; 67:369-382
26. Conklin HM, Curtis CE, Katsanis J, Iacono WG: Verbal working memory impairment in schizophrenia patients and their first-degree relatives: evidence from the Digit Span Task. Am J Psychiatry 2000; 157:275-277
27. Manoach DS, Press DZ, Thangaraj V, Searl MM, Goff DC, Halpern E, Saper CB, Warach S: Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biol Psychiatry 1999; 45:1128-1137
28. Manoach DS, Gollub RL, Benson ES, Searl MM, Goff DC, Halpern E, Saper CB, Rauch SL: Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. Biol Psychiatry 2000; 48:99-109
29. Callicott JH, Bertolino A, Mattay VS, Langheim FJ, Duyn J, Coppola R, Goldberg TE, Weinberger DR: Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cereb Cortex 2000; 10:1078-1092
30. Ingvar DH, Franzen G: Distribution of cerebral activity in chronic schizophrenia. Lancet 1974; 2:1484-1486
31. Frith CD, Friston KJ, Herold S, Silbersweig D, Fletcher P, Cahill C, Dolan RJ, Frackowiak RS, Liddle PF: Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task. Br J Psychiatry 1995; 167:343-349
32. Taylor SF: Cerebral blood flow activation and functional lesions in schizophrenia. Schizophr Res 1996; 19:129-140
33. Carter CS, Perlstein W, Ganguli R, Brar J, Mintun M, Cohen JD: Functional hypofrontality and working memory dysfunction in schizophrenia. Am J Psychiatry 1998; 155:1285-1287
34. Spence SA, Hirsch SR, Brooks DJ, Grasby PM: Prefrontal cortex activity in people with schizophrenia and control subjects: evidence from positron emission tomography for remission of "hypofrontality" with recovery from acute schizophrenia. Br J Psychiatry 1998; 172:316-323; correction, 172:543
35. Callicott JH, Ramsey NF, Tallent K, Bertolino A, Knable MB, Coppola R, Goldberg T, van Gelderen P, Mattay VS, Frank JA, Moonen CT, Weinberger DR: Functional magnetic resonance imaging brain mapping in psychiatry: methodological issues illustrated in a study of working memory in schizophrenia. Neuropsychopharmacology 1998; 18:186-196
36. Stevens AA, Goldman-Rakic PS, Gore JC, Fulbright RK, Wexler BE: Cortical dysfunction in schizophrenia during auditory word and tone working memory demonstrated by functional magnetic resonance imaging. Arch Gen Psychiatry 1998; 55:1097-1103
37. Curtis VA, Bullmore ET, Morris RG, Brammer MJ, Williams SC, Simmons A, Sharma T, Murray RM, McGuire PK: Attenuated frontal activation in schizophrenia may be task dependent. Schizophr Res 1999; 37:35-44
38. Honey GD, Bullmore ET, Soni W, Varatheesan M, Williams SC, Sharma T: Differences in frontal cortical activation by a working memory task after substitution of risperidone for typical antipsychotic drugs in patients with schizophrenia. Proc Natl Acad Sci USA 1999; 96:13432-13437
39. Toone BK, Okocha CI, Sivakumar K, Syed GM: Changes in regional cerebral blood flow due to cognitive activation among patients with schizophrenia. Br J Psychiatry 2000; 177:222-228
40. Spence SA, Liddle PF, Stefan MD, Hellewell JS, Sharma T, Friston KJ, Hirsch SR, Frith CD, Murray RM, Deakin JF, Grasby PM: Functional anatomy of verbal fluency in people with schizophrenia and those at genetic risk: focal dysfunction and distributed disconnectivity reappraised. Br J Psychiatry 2000; 176:52-60
41. Barch D, Carter C, Braver T, Sabb F, MacDonald A, Noll D, Cohen J: Selective deficits in prefrontal cortex function in medication-naive patients with schizophrenia. Arch Gen Psychiatry 2001; 58:280-288
42. Li T, Sham PC, Vallada H, Xie T, Tang X, Murray RM, Liu X, Collier DA: Preferential transmission of the high activity allele of COMT in schizophrenia. Psychiatr Genet 1996; 6:131-133
43. Kunugi H, Vallada HP, Sham PC, Hoda F, Arranz MJ, Li T, Nanko S, Murray RM, McGuffin P, Owen M, Gill M, Collier DA: Catechol-O-methyltransferase polymorphisms and schizophrenia: a transmission disequilibrium study in multiply affected families. Psychiatr Genet 1997; 7:97-101
44. Li T, Ball D, Zhao J, Murray RM, Liu X, Sham PC, Collier DA: Family-based linkage disequilibrium mapping using SNP marker haplotypes: application to a potential locus for schizophrenia at chromosome 22q11. Mol Psychiatry 2000; 5:77-84
45. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR: Effect of COMT Val 108/ 158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 2001; 98:6917-6922
46. Callicott JH, Mattay VS, Bertolino A, Finn K, Jones K, Frank JA, Goldberg TE, Weinberger DR: Physiological characteristics of capacity constraints in working memory as revealed by functional MRI. Cereb Cortex 1999; 9:20-26
47. First MB, Spitzer RL, Gibbon M, Williams JBW: Structured Clinical Interview for DSM-IV Axis I Disorders (SCID). Washington, DC, American Psychiatric Press, 1997
48. Weinberger DR, Mattay V, Callicott J, Kotrla K, Santha A, van Gelderen P, Duyn J, Moonen C, Frank J: fMRI applications in schizophrenia research. Neuroimage 1996; 4(3, part 3):S118-S126
49. Oldfield RC: The assessment and analysis of handedness: the Edinburgh Inventory. Neuropsychologia 1971; 9:97-113
50. Hollingshead AB, Redlich FC: Social Class and Mental Illness: A Community Study. New York, John Wiley & Sons, 1958
51. Jastak S, Wilkinson GS: The Wide Range Achievement Test, Revised. Wilmington, Del, Jastak Associates, 1985
52. Bandettini PA, Wong EC, Hinks RS, Tikofsky RS, Hyde JS: Time course EPI of human brain function during task activation. Magn Reson Med 1992; 25:390-397
53. Mattay VS, Frank JA, Santha AK, Pekar JJ, Duyn JH, McLaughlin AC, Weinberger DR: Whole-brain functional mapping with isotropic MR imaging. Radiology 1996; 201:399-404
54. Yang Y, Glover GH, van Gelderen P, Mattay VS, Santha AK, Sexton RH, Ramsey NF, Moonen CT, Weinberger DR, Frank JA, Duyn JH: Fast 3D functional magnetic resonance imaging at 1.5 T with spiral acquisition. Magn Reson Med 1996; 36:620-626
55. Ostuni JL, Santha AK, Mattay VS, Weinberger DR, Levin RL, Frank JA: Analysis of interpolation effects in the reslicing of functional MR images. J Comput Assist Tomogr 1997; 21:803-810
56. Woods RP, Grafton ST, Watson JDG, Sicotte NL, Mazziotta JC: Automated image registration, I: general methods and intrasubject, intramodality validation. J Comput Assist Tomogr 1998; 22:139-152
57. Evans AC, Marrett S, Neelin P, Collins L, Worsley K, Dai W, Milot S, Meyer E, Bub D: Anatomical mapping of functional activation in stereotactic coordinate space. Neuroimage 1992; 1:43-53
58. Mazziotta JC, Toga AW, Evans A, Fox P, Lancaster J: A probabilistic atlas of the human brain: theory and rationale for its development. Neuroimage 1995; 2:89-101
59. Friston KJ, Holmes AP, Worsley KJ, Poline JB, Frith CD, Frackowiak RSJ: Statistical parametric mapping in functional imaging: a general approach. Hum Brain Mapp 1995; 2:189-210
60. Talairach J, Tournoux P: Co-Planar Stereotaxic Atlas of the Human Brain: Three-Dimensional Proportional System. New York, Thieme Medical, 1988
61. Smith EE, Jonides J: Neuroimaging analyses of human working memory. Proc Natl Acad Sci USA 1998; 95:12061-12068
62. Perlstein WM, Carter CS, Noll DC, Cohen JD: Relation of prefrontal cortex dysfunction to working memory and symptoms in schizophrenia. Am J Psychiatry 2001; 158:1105-1113
63. Bertolino A, Esposito G, Callicott JH, Mattay VS, Van Horn JD, Frank JA, Berman KF, Weinberger DR: Specific relationship between prefrontal neuronal N-acetylaspartate and activation of the working memory cortical network in schizophrenia. Am J Psychiatry 2000; 157:26-33
64. Grady CL, Craik FI: Changes in memory processing with age. Curr Opin Neurobiol 2000; 10:224-231
65. Rypma B, D'Esposito M: Isolating the neural mechanisms of age-related changes in human working memory. Nat Neurosci 2000; 3:509-515
66. Freedman R, Leonard S, Gault JM, Hopkins J, Cloninger CR, Kaufmann CA, Tsuang MT, Faraone SV, Malaspina D, Svrakic DM, Sanders A, Gejman P: Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha7-nicotinic acetylcholine receptor subunit gene (CHRNA7). Am J Med Genet 2001; 105:20-22
67. Mannisto PT, Kaakkola S: Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacol Rev 1999; 51:593-628