Voltage-dependent calcium channels

General Physiology and Biophysics

Volumn 24, Issue SUPPL. 1, 2005, Pages 1-78

  Lacinová, Lubica ^a  

^a INSTITUTE OF MOLECULAR PHYSIOLOGY AND GENETICS   (Slovakia)

Author keywords

1 subunit; Auxiliary subunits; Calcium channel; Dihydropyridines; High voltage activated; Low voltage activated

Indexed keywords

AMILORIDE; AMLODIPINE; BARIUM; CADMIUM; CALCIUM ION; DIHYDROPYRIDINE DERIVATIVE; ETHOSUXIMIDE; ETOMIDATE; FLUNARIZINE; FLUSPIRILENE; GALLOPAMIL; HALOPERIDOL; ISOFLURANE; ISRADIPINE; KETAMINE; LAMOTRIGINE; LANTHANUM; MEMBRANE PROTEIN; MIBEFRADIL; NICKEL; NIFEDIPINE; NIMODIPINE; PHENYTOIN; PIMOZIDE; PROPOFOL; SIPATRIGINE; THIOPENTAL; UNINDEXED DRUG; VALPROIC ACID; VERAPAMIL; VOLTAGE GATED CALCIUM CHANNEL;

AMINO ACID SEQUENCE; BINDING AFFINITY; CALCIUM CURRENT; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE DEPOLARIZATION; CONCENTRATION RESPONSE; DRUG BLOOD LEVEL; HUMAN; MEMBRANE ELECTROPHYSIOLOGY; MOLECULAR MECHANICS; MOLECULAR WEIGHT; NONHUMAN; PHYLOGENY; REGULATORY MECHANISM; REVIEW; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TISSUE DISTRIBUTION;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; CALCIUM CHANNELS, T-TYPE; HUMANS; ION CHANNEL GATING; NEURONS; PROTEIN SUBUNITS;

MURINAE;

EID: 22644444450     PISSN: 02315882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (281)

1. Adams B., Tanabe T. (1997): Structural regions of the cardiac Ca channel α subunit involved in Ca-dependent inactivation. J. Gen. Physiol. 110, 379-389
2. Aggarwal R., Shorofsky S. R., Goldman L., Balke C. W. (1997): Tetrodotoxin-blockable calcium currents in rat ventricular myocytes; a third type of cardiac cell sodium current. J. Physiol. 505, 353-369
3. 1 subunit interactions within the skeletal muscle L-type voltage-gated calcium channels. J. Biol. Chem. 278, 1212-1219
4. Baindur N., Rutledge A., Triggle D. J. (1993): A homologous series of permanently charged 1,4-dihydropyridines: novel probes designed to localize drug binding sites on ion channels. J. Med. Chem. 36, 3743-3745
5. Balke C. W., Goldman L., Aggarwal R., Shorofsky S. (1999): Whether "slip-mode conductance" occurs? Science 284, 711a
6. Bangalore R., Baindur N., Rutledge A., Triggle D. J., Kass R. S. (1994): L-type calcium channels: asymmetrical intramembrane binding domain revealed by variable length, permanently charged 1,4-dihydropyridines. Mol. Pharmacol. 46, 660-666
7. 2/δ-subunit on ionic and gating current in transiently transfected HEK 293 cells. Am. J. Physiol. 270, H1521-1528
8. Beedle A. M., Hamid J., Zamponi G. W. (2002): Inhibition of transiently expressed low-and high-voltage-activated calcium channels by trivalent metal cations. J. Membr. Biol. 187, 225-238
9. Bech-Hansen N. T., Naylor M. J., Maybaum T. A., Pearce W. G., Koop B., Fishman G. A., Mets M., Musarella M. A., Boycott K. M. (1998): Loss-of-function mutations in a calcium-channel α1-subunit gene in Xp11.23 cause incomplete X-linked congenital stationary night blindness. Nat. Genet. 19, 264-267
10. 1c channel. Biophys. J. 75, 1727-1739
11. Berrow N. S., Campbell V., Fitzgerald E. M., Brickley K., Dolphin A. C. (1995): Antisense depletion of β-subunits modulates the biophysical and pharmacological properties of neuronal calcium channels. J. Physiol. 482, 481-491
12. Beydoun A., Uthman B. M., Sackellares J. C. (1995): Gabapentin: pharmacokinetics, efficacy, and safety. Clin. Neuropharmacol. 18, 469-481
13. Biel M., Ruth P., Bosse E., Hullin R., Stuhmer W., Flockerzi V., Hofmann F. (1990): Primary structure and functional expression of a high voltage activated calcium channel from rabbit lung. FEBS Lett. 269, 409-412
14. Biel M., Hullin R., Freundner S., Singer D., Dascal N., Flockerzi V., Hofmann F. (1991): Tissue-specific expression of high-voltage-activated dihydropyridine-sensitive L-type calcium channels. Eur. J. Biochem. 200, 81-88
15. Birnbaumer L., Campbell K. P., Catterall W. A., Haxpold M. M., Hofmann F., Horne W. A., Mori Y., Schwartz A., Snutch T. P., Tanabe T., et al. (1994): The naming of voltage-gated calcium channels. Neuron 13, 505-506
16. Birnbaumer L., Qin N., Olcese R., Tareilus E., Platano D., Costantin J., Stefani E. (1998): Structures and functions of calcium channel β subunits. J. Bioenerg. Biomembr. 30, 357-375
17. 2+ channels. Critical involvement of tyrosine residues in motif IIIS6 and IVS6. J. Biol. Chem. 272, 24952-24960
18. 2+ channel. Purification and subunit composition. J. Biol. Chem. 260, 14255-14263
19. Bosse E., Regulla S., Biel M., Ruth P., Meyer H. E., Flockerzi V., Hofmann F. (1990): The cDNA and deduced amino acid sequence of the γ subunit of the L-type calcium channel from rabbit skeletal muscle. FEBS Lett. 267, 153-156
20. Boyett M. R., Honjo H., Harrison S. M., Zang W. J., Kirby M. S. (1994): Ultra-slow voltage-dependent inactivation of the calcium current in guinea-pig and ferret ventricular myocytes. Pflügers. Arch. 428, 39-50
21. Brehm P., Eckert R. (1978): Calcium entry leads to inactivation of calcium channel in Paramecium. Science 202, 1203-1206
22. 2+ channels. FEBS Lett. 364, 129-133
23. 2δ calcium channel subunit from porcine cerebral cortex. Expression of a soluble form of the protein that retains [3H]gabapentin binding activity. J. Biol. Chem. 273, 25458-25465
24. 2δ subunits using [3H]leucine. Anal. Biochem. 255, 236-243
25. 2+ channel γ subunit genes on chromosome 19q13.4: evolution and expression profile of the γ subunit gene family. Genomics 71, 339-350
26. 2+ channels by benzothiazepines and phenylalkylamines: class-specific pharmacology and underlying molecular determinants. Mol. Pharmacol. 51, 872-881
27. Calabresi P., Centonze D., Marfia G. A., Pisani A., Bernardi G. (1999): An in vitro electrophysiological study on the effects of phenytoin, lamotrigine and gabapentin on striatal neurons. Br. J. Pharmacol. 126, 689-696
28. 1B calcium channels in Xenopus oocytes. J. Physiol. 527, 419-432
29. Castellano A., Wei X., Birnbaumer L., Perez-Reyes E. (1993a): Cloning and expression of a third calcium channel β subunit. J. Biol. Chem. 268, 3450-3455
30. Castellano A., Wei X., Birnbaumer L., Perez-Reyes E. (1993b): Cloning and expression of a neuronal calcium channel β subunit. J. Biol. Chem. 268, 12359-12366
31. Cataldi M., Gaudino A., Lariccia V., Russo M., Amoroso S., di Renzo G., Annunziato L. (2004): Imatinib-mesylate blocks recombinant T-type calcium channels expressed in human embryonic kidney-293 cells by a protein tyrosine kinase-independent mechanism. J. Pharmacol. Exp. Ther. 309, 208-215
32. 2+ channel antagonists. Trends Pharmacol. Sci. 13, 256-262
33. Cens T., Restituito S., Galas S., Charnet P. (1999): Voltage and calcium use the same molecular determinants to inactivate calcium channels. J. Biol. Chem. 274, 5483-5490
34. Chemin J., Monteil A., Perez-Reyes E., Nargeot J., Lory P. (2001a): Direct inhibition of T-type calcium channels by the endogenous cannabinoid anandamide. EMBO J. 20, 7033-7040
35. 1I T-type calcium channel exhibits faster gating properties when overexpressed in neuroblastoma/glioma NG 108-15 cells. Eur. J. Neurosci. 14, 1678-1686
36. Chen L., Chetkovich D. M., Petralia R. S., Sweeney N. T., Kawasaki Y., Wenthold R. J., Bredt D. S., Nicoll R. A. (2000): Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature 408, 936-943
37. 2+ channels. Nature 429, 675-680
38. Chu P. J., Robertson H. M., Best P. M. (2001): Calcium channel γ subunits provide insights into the evolution of this gene family. Gene 280, 37-48
39. Chuang R. S., Jaffe H., Cribbs L., Perez-Reyes E., Swartz K. J. (1998): Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin. Nat. Neurosci. 1, 668-674
40. Clozel J. P., Ertel E. A., Ertel S. I. (1997): Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker. J. Hypertens. (Suppl.) 15, S17-25
41. + and angiotensin II increase T-type Ca channel current. Proc. Natl. Acad. Sci. U.S.A. 85, 2412-2416
42. Cox D. H., Dunlap K. (1994): Inactivation of N-type calcium current in chick sensory neurons: calcium and voltage dependence. J. Gen. Physiol. 104, 311-336
43. 2+ channel gene family. Circ. Res. 83, 103-109
44. v3.1c, a T-type calcium channel from human brain. FEBS Lett. 466, 54-58
45. Curtis B. M., Catterall W. A. (1984): Purification of the calcium antagonist receptor of the voltage-sensitive calcium channel from skeletal muscle transverse tubules. Biochemistry 23, 2113-2118
46. Dai S., Klugbauer N., Zong X., Seisenberger C., Hofmann F. (1999): The role of subunit composition on prepulse facilitation of the cardiac L-type calcium channel. FEBS Lett. 442, 70-74
47. 2 and δ are encoded by the same gene. J. Biol. Chem. 265, 14738-14741
48. 2+ channels. Science 270, 1502-1506
49. 2+ channel expressed in Xenopus oocytes. J. Physiol. 485, 619-634
50. 2+ channel regulation by a conserved β subunit domain. Neuron 13, 495-503
51. 2+ channels. FEBS Lett. 380, 272-276
52. Delisle B. P., Satin J. (2000): pH modification of human T-type calcium channel gating. Biophys. J. 78, 1895-1905
53. v1.2. Mol. Pharmacol. 64, 491-501
54. v1.2. Mol. Pharmacol. 66, 1236-1247
55. 1G. J. Physiol. 519, 35-45
56. Dubel S. J., Starr T. V., Hell J., Ahlijanian M. K., Enyeart J. J., Catterall W. A., Snutch T. P. (1992): Molecular cloning of the α-1 subunit of an ω-conotoxin-sensitive calcium channel. Proc. Natl. Acad. Sci. U.S.A. 89, 5058-5062
57. 1 subunits is modulated by high voltage-activated auxiliary subunits. J. Biol. Chem. 279, 29263-29269
58. Dunham I., Shimizu N., Roe B. A., Chissoe S., Hunt A. R., Collins J. E., Bruskiewich R., Beare D. M., Clamp M., Smink L. J., Ainscough R., Almeida J. P., Babbage A., Bagguley C., Bailey J., Barlow K., Bates K. N., Beasley O., Bird C. P., Blakey S., Bridgeman A. M., Buck D., Burgess J., Burrill W. D., O'Brien K. P., et al. (1999): The DNA sequence of human chromosome 22. Nature 402, 489-495
59. Ellinor P. T., Zhang J. F., Randall A. D., Zhou M., Schwarz T. L., Tsien R. W., Horne W. A. (1993): Functional expression of a rapidly inactivating neuronal calcium channel. Nature 363, 455-458
60. Ellinor P. T., Zhang J. F., Horne W. A., Tsien R. W. (1994): Structural determinants of the blockade of N-type calcium channels by a peptide neurotoxin. Nature 372, 272-275
61. 2 subunits of a DHP-sensitive calcium channel. Science 241, 1661-1664
62. Ertel E. A., Campbell K. P., Haxpold M. M., Hofmann F., Mori Y., Perez-Reyes E., Schwartz A., Snutch T. P., Tanabe T., Birnbaumer L., Tsien R. W., Catterall W. A. (2000): Nomenclature of voltage-gated calcium channels. Neuron 25, 533-535
63. Fatt P., Katz B. (1953): The electrical properties of crustacean muscle fibres. J. Physiol. 120, 171-204
64. 2δ subunit. J. Neurosci. 17, 6884-6891
65. Ferreira G., Yi J., Rios E., Shirokov R. (1997): Ion-dependent inactivation of barium current through L-type calcium channels. J. Gen. Physiol. 109, 449-461
66. 2+ influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices. Br. J. Pharmacol. 130, 900-906
67. Flanagan R. J. (1998): Guidelines for the interpretation of analytical toxicology results and unit of measurement conversion factors. Ann. Clin. Biochem. 35, 261-267
68. Flockerzi V., Oeken H. J., Hofmann F. (1986): Purification of a functional receptor for calcium-channel blockers from rabbit skeletal-muscle microsomes. Eur. J. Biochem. 161, 217-224
69. Fox A. P., Nowycky M. C., Tsien R. W. (1987): Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones. J. Physiol. 394, 149-172
70. 2+ channels. Biophys. J. 86, B307
71. 2+ currents and alters channel inactivation properties. J. Biol. Chem. 275, 14476-14481
72. Fujita Y., Mynlieff M., Dirksen R. T., Kim M. S., Niidome T., Nakai J., Friedrich T., Iwabe N., Miyata T., Furuichi T., et al. (1993): Primary structure and functional expression of the ω-conotoxin-sensitive N-type calcium channel from rabbit brain. Neuron 10, 585-598
73. Ganitkevich V., Shuba M. F., Smirnov S. V. (1986): Potential-dependent calcium inward current in a single isolated smooth muscle cell of the guinea-pig taenia caeci. J. Physiol. 380, 1-16
74. 2δ auxiliary subunit gene (CACNA2D2). J. Biol. Chem. 275, 12237-12242
75. 2+ channels of skeletal muscle. J. Physiol. 545, 407-419
76. 2δ subunit of a calcium channel. J. Biol. Chem. 271, 5768-5776
77. Glauner K. S., Mannuzzu L. M., Gandhi C. S., Isacoff E. Y. (1999): Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel. Nature 402, 813-817
78. Glossmann H., Striessnig J. (1990): Molecular properties of calcium channels. Rev. Physiol. Biochem. Pharmacol. 114, 1-105
79. Gomora J. C., Daud A. N., Weiergraber M., Perez-Reyes E. (2001): Block of cloned human T-type calcium channels by succinimide antiepileptic drugs. Mol. Pharmacol. 60, 1121-1132
80. Grabner M., Wang Z., Hering S., Striessnig J., Glossmann H. (1996): Transfer of 1,4-dihydropyridine sensitivity from L-type to class A (BI) calcium channels. Neuron 16, 207-218
81. 2+ channel γ subunit. J. Physiol. 533, 467-478
82. 2δ subunit in current stimulation and subunit interaction. Neuron 16, 431-440
83. Hadley R. W., Lederer W. J. (1991): Properties of L-type calcium channel gating current in isolated guinea pig ventricular myocytes. J. Gen. Physiol. 98, 265-285
84. Hagiwara S., Ozawa S., Sand O. (1975): Voltage clamp analysis of two inward current mechanisms in the egg cell membrane of a starfish. J. Gen. Physiol. 65, 617-644
85. 2+ channel currents. Eur. J. Pharmacol. 467, 77-80
86. 2δ-3 subunit gene from a putative tumor suppressor gene region at chromosome 3p21.1 in conventional renal cell carcinoma. Gene 264, 69-75
87. He M., Bodi I., Mikala, G., Schwartz A. (1997): Motif III S5 of L-type calcium channels is involved in the dihydropyridine binding site. A combined radioligand binding and electrophysiological study. J. Biol. Chem. 272, 2629-2633
88. 2+ channel block. Trends Pharmacol. Sci. 23, 509-513
89. Hering S., Aczel S., Grabner M., Doring F., Berjukow S., Mitterdorfer J., Sinnegger M. J., Striessnig J., Degtiar V. E., Wang Z., Glossmann H. (1996): Transfer of high sensitivity for benzothiazepines from L-type to class A (BI) calcium channels. J. Biol. Chem. 271, 24471-24475
90. Hescheler J., Pelzer D., Trube G., Trautwein W. (1982): Does the organic calcium channel blocker D600 act from inside or outside on the cardiac cell membrane? Pflügers Arch. 393, 287-291
91. 4 subunit. Proc. Natl. Acad. Sci. U.S.A. 100, 307-312
92. 2δ-2 subunit. Eur. J. Neurosci. 12, 1217-1226
93. Hockerman G. H., Johnson B. D., Scheuer T., Catterall W. A. (1995): Molecular determinants of high affinity phenylalkylamine block of L-type calcium channels. J. Biol. Chem. 270, 22119-22122
94. 1 subunit. J. Biol. Chem. 272, 18759-18765
95. 2+ channel. Proc. Natl. Acad. Sci. U.S.A. 94, 14906-14911
96. Hodgkin A. L., Huxley A. F. (1952a): Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo. J. Physiol. 116, 473-496
97. Hodgkin A. L., Huxley A. F. (1952b): The components of membrane conductance in the giant axon of Loligo. J. Physiol. 116, 473-496
98. Hodgkin A. L., Huxley A. F. (1952c): The dual effect of membrane potential on sodium conductance in the giant axon of Loligo. J. Physiol. 116, 497-506
99. Hodgkin A. L., Huxley A. F. (1952d): A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. 117, 500-544
100. Hofmann F., Lacinová L., Klugbauer N. (1999): Voltage-dependent calcium channels: from structure to function. Rev. Physiol. Biochem. Pharmacol. 139, 33-87
101. 1 subunits from the marine ray Discopyge ommata. Proc. Natl. Acad. Sci. U.S.A. 90, 3787-3791
102. Huang L., Keyser B. M., Tagmose T. M., Hansen J. B., Taylor J. T., Zhuang H., Zhang M., Ragsdale D. S., Li M. (2004): NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl] -N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels. J. Pharmacol. Exp. Ther. 309, 193-199
103. Huguenard J. R. (1996): Low-threshold calcium currents in central nervous system neurons. Annu. Rev. Physiol. 58, 329-348
104. Hullin R., Singer-Lahat D., Freichel M., Biel M., Dascal N., Hofmann F., Flockerzi V. (1992): Calcium channel β subunit heterogeneity: functional expression of cloned cDNA from heart, aorta and brain. EMBO J. 11, 885-890
105. v2.1 channels, revealed by mammalian two-hybrid and fluorescence resonance energy transfer measurements. J. Biol. Chem. 278, 49386-49400
106. Ihara Y., Yamada Y., Fujii Y., Gonoi T., Yano H., Yasuda K., Inagaki N., Seino Y., Seino S. (1995): Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic β-cells. Mol. Endocrinol. 9, 121-130
107. Ito H., Klugbauer N., Hofmann F. (1997): Transfer of the high affinity dihydropyridine sensitivity from L-type to non-L-type calcium channel. Mol. Pharmacol. 52, 735-740
108. Jay S. D., Ellis S. B., McCue A. F., Williams M. E., Vedvick T. S., Harpold M. M., Campbell K. P. (1990): Primary structure of the γ subunit of the DHP-sensitive calcium channel from skeletal muscle. Science 248, 490-492
109. 2-subunit and the associated δ peptides. J. Biol. Chem. 266, 3287-3293
110. 1 subunit from jellyfish. J. Biol. Chem. 273, 22792-22799
111. + channel. Nature 423, 33-41
112. + channel. Nature 423, 42-48
113. Jimenez C., Bourinet E., Leuranguer V., Richard S., Snutch T. P., Nargeot J. (2000): Determinants of voltage-dependent inactivation affect Mibefradil block of calcium channels. Neuropharmacology 39, 1-10
114. 2+-dependent inactivation in a mammalian central neuron involves the cytoskeleton. Pflügers Arch. 429, 14-21
115. Johnson B. D., Hockerman G. H., Scheuer T., Catterall W. A. (1996): Distinct effects of mutations in transmembrane segment IVS6 on block of L-type calcium channels by structurally similar phenylalkylamines. Mol. Pharmacol. 50, 1388-1400
116. Jones L. P., Patil P. G., Snutch T. P., Yue D. T. (1997): G-protein modulation of N-type calcium channel gating current in human embryonic kidney cells (HEK 293). J. Physiol. 498, 601-610
117. 1E calcium channels. J. Gen. Physiol. 112, 125-143
118. Jones L. P., DeMaria C. D., Yue D. T. (1999): N-type calcium channel inactivation probed by gating-current analysis. Biophys. J. 76, 2530-2552
119. 2+ channels. Pflügers Arch. 433, 321-329
120. 2+ channels. Biophys. J. 70, 1285-1293
121. Jouvenceau A., Giovannini F., Bath C. P., Trotman E., Sher E. (2000): Inactivation properties of human recombinant class E calcium channels. J. Neurophysiol. 83, 671-684
122. 1 subunit of the skeletal muscle L-type calcium channel. FEBS Lett. 331, 177-181
123. 1c subunit in a human embryonic kidney cell line. J. Physiol. 492, 89-96
124. 2+ channels. J. Biol. Chem. 276, 32917-32924
125. Katz A. M. (1999): T-type calcium channels may provide a unique target for cardiovascular therapy. Eur. Heart J. 1, H18-23
126. 2+ release in developing myocardium. J. Mol. Cell. Cardiol. 35, 515-523
127. 2+ channels. Eur. J. Neurosci. 11, 4171-4178
128. Klugbauer N., Marais E., Lacinová L., Hofmann F. (1999a): A T-type calcium channel from mouse brain. Pflügers Arch. 437, 710-715
129. 2δ subunit. J. Neurosci. 19, 684-691
130. Klugbauer N., Dai S., Specht V., Lacinová L., Marais E., Bohn G., Hofmann F. (2000): A family of γ-like calcium channel subunits. FEBS Lett. 470, 189-197
131. Koch W. J., Ellinor P. T., Schwartz A. (1990): cDNA cloning of a dihydropyridine-sensitive calcium channel from rat aorta. Evidence for the existence of alternatively spliced forms. J. Biol. Chem. 265, 17786-17791
132. 2+ channels activating at negative voltages. J. Biol. Chem. 276, 22100-22106
133. 2+ entry and frequency-dependence during mock action potentials. Eur. J. Neurosci. 11, 4149-4158
134. Kumar P. P., Stotz S. C., Paramashivappa R., Beedle A. M., Zamponi G. W., Rao A. S. (2002): Synthesis and evaluation of a new class of nifedipine analogs with T-type calcium channel blocking activity. Mol. Pharmacol. 61, 649-658
135. 2+ channel. J. Biol. Chem. 273, 4635-4641
136. 2+ channel. Mol. Pharmacol. 51, 262-268
137. 2+ channel. Nature 352, 527-530
138. Lacinová L. (2004): Pharmacology of recombinant low-voltage activated calcium channels. Curr. Drug Targets CNS Neurol. Disord. 3, 105-111
139. Lacinová L., Hofmann F. (1998): Isradipine interacts with the open state of the L-type calcium channel at high concentrations. Recept. Channels 6, 153-164
140. 5 subunits. Arch. Biochem. Biophys. 425, 207-213
141. v1.2 calcium channel. Arch. Biochem. Biophys. 437, 42-50
142. 3 subunit. FEBS Lett. 373, 103-107
143. Lacinová L., Klugbauer N., Hu M., Hofmann F. (1999a): Reconstruction of the dihydropyridine site in a non-L-type calcium channel: the role of the IS6 segment. FEBS Lett. 451, 152-156
144. Lacinová L., An R. H., Xia J., Ito H., Klugbauer N., Triggle D., Hofmann F., Kass R. S. (1999b): Distinctions in the molecular determinants of charged and neutral dihydropyridine block of L-type calcium channels. J. Pharmacol. Exp. Ther. 289, 1472-1479
145. 2δ subunits. J. Physiol. 516, 639-645
146. Lacinová L'., Klugbauer N., Hofmann F. (2000a): Low voltage activated calcium channels: from genes to function. Gen. Physiol. Biophys. 19, 121-136
147. 1C L-type calcium channel. Pflügers Arch. 440, 50-60
148. 1G subunit by divalent cations and organic blockers. Neuropharmacology 39, 1254-1266
149. 2+ ions on the inactivation of L-type and T-type calcium channels. Proceedings of 4th Czech-French-Slovak Symposium New Frontiers in Basic Cardiovascular Research, pp. 22-23
150. v3.1 calcium channel. FEBS Lett. 531, 235-240
151. 2+ channel β subunit depletion in nodosus ganglion neurons. J. Neurosci. 17, 6621-6628
152. 2+ /calmodulin binds to and modulates P/Q-type calcium channels. Nature 399, 155-159
153. 2+ channels. J. Neurosci. 20, 6830-6838
154. Lee J. H., Daud A. N., Cribbs L. L., Lacerda A. E., Pereverzev A., Klöckner U., Schneider T., Perez-Reyes E. (1999a): Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family. J. Neurosci. 19, 1912-1921
155. 1H. Biophys. J. 77, 3034-3042
156. 2+-channel γ subunit. Nat. Genet. 19, 340-347
157. Leung A. T., Imagawa, T., Block B., Franzini-Armstrong C., Campbell K. P. (1988): Biochemical and ultrastructural characterization of the 1,4-dihydropyridine receptor from rabbit skeletal muscle. Evidence for a 52,000 Da subunit. J. Biol. Chem. 263, 994-1001
158. Leuranguer V., Bourinet E., Lory P., Nargeot J. (1998): Antisense depletion of β-subunits fails to affect T-type calcium channels properties in a neuroblastoma cell line. Neuropharmacology 37, 701-708
159. Llinas R., Yarom Y. (1981): Electrophysiology of mammalian inferior olivary neurones in vitro. Different types of voltage-dependent ionic conductances. J. Physiol. 315, 549-567
160. Llinas R., Sugimori M., Lin J. W., Cherksey B. (1989): Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel-web spider poison. Proc. Natl. Acad. Sci. U.S.A. 86, 1689-1693
161. + channel result in corresponding decreases in gating charge. Neuron 8, 531-540
162. 1 and β subunit of high voltage-activated calcium channels in rat brain. J. Neurosci. 17, 1339-1349
163. Macdonald R. L., Kelly K. M. (1995): Antiepileptic drug mechanisms of action. Epilepsia 36 (Suppl. 2) S2-12
164. 2δ subunits-structure and Gabapentin binding. Mol. Pharmacol. 59, 1243-1248
165. v3.1. J. Physiol. 537, 27-34
166. 2+ channels in mouse ventricular myocytes. Am. J. Physiol. 272, H606-612
167. 2+ channels by the neuroprotective agent BW619C89 (Sipatrigine). Neuropharmacology 39, 1247-1253
168. 2+ channel by SB-209712. Eur. J. Pharmacol. 407, 53-60
169. +-induced synaptosomal calcium influx by gabapentin. Brain Res. 875, 157-159
170. Mikami A., Imoto K., Tanabe T., Niidome T., Mori Y., Takeshima H., Narumiya S., Numa S. (1989): Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel. Nature 340, 230-233
171. 2+ channel currents. Am. J. Physiol. 279, C603-610
172. 1-subunit. FEBS Lett. 352, 141-145
173. 1 subunit. Biochemistry 34, 9350-9355
174. 1 subunit. Neurosci. Lett. 274, 143-146
175. 1G subunit that forms T-type calcium channels. J. Biol. Chem. 275, 6090-6100
176. 1I subunit. J. Biol. Chem. 275, 16530-16535
177. 1-subunits. Br. J. Pharmacol. 125, 1005-1012
178. Mori Y., Friedrich T., Kim M. S., Mikami A., Nakai J., Ruth P., Bosse E., Hofmann F., Flockerzi V., Furuichi T., et al. (1991): Primary structure and functional expression from complementary DNA of a brain calcium channel. Nature 350, 398-402
179. v2.2) calcium channels. J. Biol. Chem. 279, 34705-34714
180. 2+ currents. Neuropharmacology 37, 957-972
181. Neely A., Wei X., Olcese R., Birnbaumer L., Stefani E. (1993): Potentiation by the β subunit of the ratio of the ionic current to the charge movement in the cardiac calcium channel. Science 262, 575-578
182. Ng G. Y., Bertrand S., Sullivan R., Ethier N., Wang J., Yergey J., Belley M., Trimble L., Bateman K., Alder L., Smith A., McKernan R., Metters K., O'Neill G. P., Lacaille J. C., Hebert T. E. (2001): γ-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action. Mol. Pharmacol. 59, 144-152
183. Niidome T., Kim M. S., Friedrich T., Mori Y. (1992): Molecular cloning and characterization of a novel calcium channel from rabbit brain. FEBS Lett. 308, 7-13
184. Nowycky M. C., Fox A. P., Tsien R. W. (1985): Three types of neuronal calcium channel with different calcium agonist sensitivity. Nature 316, 440-443
185. + channels. Biochem. Biophys. Res. Commun. 299, 562-568
186. Olcese R., Qin N., Schneider T., Neely A., Wei X., Stefani E., Birnbaumer L. (1994): The amino terminus of a calcium channel β subunit sets rates of channel inactivation independently of the subunit's effect on activation. Neuron 13, 1433-1438
187. 1E calcium channels. J. Physiol. 497, 675-686
188. 2+ channels by neuroleptic drugs. Neurophysiology 35, 7-16
189. 1E calcium channel. J. Membr. Biol. 160, 127-140
190. 2+ channels by protein kinase C. FEBS Lett. 547, 37-42
191. Perez-Reyes E., Castellano A., Kim H. S., Bertrand P., Baggstrom E., Lacerda A. E., Wei X. Y., Birnbaumer L. (1992): Cloning and expression of a cardiac/brain β subunit of the L-type calcium channel. J. Biol. Chem. 267, 1792-1797
192. Perez-Reyes E., Cribbs L. L., Daud A., Lacerda A. E., Barclay J., Williamson M. P., Fox M., Rees M., Lee J. H. (1998): Molecular characterization of a neuronal low-voltage-activated T-type calcium channel. Nature 391, 896-900
193. 2+ channel cloned from human heart. Naunyn Schmiedebergs Arch. Pharmacol. 361, 590-599
194. Peterson B. Z., Catterall W. A. (1995): Calcium binding in the pore of L-type calcium channels modulates high affinity dihydropyridine binding. J. Biol. Chem. 270, 18201-18204
195. Peterson B. Z., Johnson B. D., Hockerman G. H., Acheson M., Scheuer T., Catterall. W. A. (1997): Analysis of the dihydropyridine receptor site of L-type calcium channels by alanine-scanning mutagenesis. J. Biol. Chem. 272, 18752-18758
196. 2+-dependent inactivation of L-type calcium channels. Neuron 22, 549-558
197. 2+ channels. Biophys. J. 78, 1906-1920
198. 2δ subunit interferes with prepulse facilitation in cardiac L-type calcium channels. Biophys. J. 78, 2959-2972
199. 1-subunit. Nature 368, 67-70
200. Qin N., Olcese R., Zhou J., Cabello O. A., Birnbaumer L., Stefani E. (1996): Identification of a second region of the β-subunit involved in regulation of calcium channel inactivation. Am. J. Physiol. 271, C1539-1545
201. 2δ-subunit. Am. J. Physiol. 274, C1324-1331
202. 2+ channel depends on calmodulin. Proc. Natl. Acad. Sci. U.S.A. 96, 2435-2438
203. 2δ-4 subunit. Mol. Pharmacol. 62, 485-496
204. Randall A. D., Tsien R. W. (1997): Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels. Neuropharmacology 36, 879-893
205. Regulla S., Schneider T., Nastainczyk W., Meyer H. E., Hofmann F. (1991): Identification of the site of interaction of the dihydropyridine channel blockers nitrendipine and azidopine with the calcium-channel α 1 subunit. EMBO J. 10, 45-49
206. Richard S., Charnet P., Nerbonne J. M. (1993): Interconversion between distinct gating pathways of the high threshold calcium channel in rat ventricular myocytes. J. Physiol. 462, 197-228
207. 2+ channel expressed in Xenopus oocytes. J. Physiol. 532, 583-593
208. Ruth P., Rohrkasten A., Biel M., Bosse E., Regulla S., Meyer H. E., Flockerzi V., Hofmann F. (1989): Primary structure of the β subunit of the DHP-sensitive calcium channel from skeletal muscle. Science 245, 1115-1118
209. Santi C. M., Cayabyab F. S., Sutton K. G., McRory J. E., Mezeyova J., Hamming K. S., Parker D., Stea A., Snutch T. P. (2002): Differential inhibition of T-type calcium channels by neuroleptics. J. Neurosci. 22, 396-403
210. 2+ channel isoform in murine atrial myocytes (AT-1 cells). Circ. Res. 86, 636-642
211. 2+. Eur. J. Biochem. 200, 245-253
212. 1 subunit. Recept. Channels 2, 255-270
213. 1D) calcium channel subunit from an insulin-secreting cell line. Mol. Endocrinol. 15, 1211-1221
214. Schumacher T. B., Beck H., Steinhauser C., Schramm J., Elger C. E. (1998): Effects of phenytoin, carbamazepine, and gabapentin on calcium channels in hippocampal. granule cells from patients with temporal lobe epilepsy. Epilepsia 39, 355-363
215. Schuster A., Lacinova L., Klugbauer N., Ito H., Birnbaumer L., Hofmann F. (1996): The IVS6 segment of the L-type calcium channel is critical for the action of dihydropyridines and phenylalkylamines. EMBO J. 15, 2365-2370
216. 1 subunit of a voltage-dependent calcium channel expressed in pancreatic β cells. Proc. Natl. Acad. Sci. U.S.A. 89, 584-588
217. 2+ channels are abnormal in genetically determined cardiomyopathic hamster hearts. Circ. Res. 75, 149-155
218. 1G T-type calcium channel. J. Gen. Physiol. 114, 185-201
219. 2+ signalling. J. Physiol. 500, 285-295
220. 2+ channels and ryanodine receptors in cardiac myocytes. Proc. Natl. Acad. Sci. U.S.A. 92, 121-125
221. 2+ channels. J. Physiol. 518, 697-703
222. Shirokov R., Levis R., Shirokova N., Rios E. (1992): Two classes of gating current from L-type Ca channels in guinea pig ventricular myocytes. J. Gen. Physiol. 99, 863-895
223. 2δ subunit. J. Gen. Physiol. 111, 807-823
224. 1 protein level. J. Physiol. 489, 55-62
225. Sieber M., Nastainczyk W., Zubor V., Wernet W., Hofmann F. (1987): The 165-kDa, peptide of the purified skeletal muscle dihydropyridine receptor contains the known regulatory sites of the calcium channel. Eur. J. Biochem. 167, 117-122
226. Singer D., Biel M., Lotan I., Flockerzi V., Hofmann F., Dascal N. (1991): The roles of the subunits in the function of the calcium channel. Science 253, 1553-1557
227. 1A subunit. Role of L-type Met1188. J. Biol. Chem. 272, 27686-27693
228. Snutch T. P., Leonard J. P., Gilbert M. M., Lester H. A., Davidson N. (1990): Rat brain expresses a heterogeneous family of calcium channels. Proc. Natl. Acad. Sci. U.S.A. 87, 3391-3395
229. v1.2 sensitivity for the phenylalkylamine (-)gallopamil. Circ. Res. 89, 700-708
230. Soong T. W., Stea A., Hodson C. D., Dubel S. J., Vincent S. R., Snutch T. P. (1993): Structure and functional expression of a member of the low voltage-activated calcium channel family. Science 260, 1133-1136
231. 1G. J. Physiol. 530, 35-45
232. Starr T. V., Prystay W., Snutch T. P. (1991): Primary structure of a calcium channel that is highly expressed in the rat cerebellum. Proc. Natl. Acad. Sci. U.S.A. 88, 5621-5625
233. 1-subunit. Neuropharmacology 32, 1103-1116
234. 1A calcium channel reflect similarities to neuronal Q- and P-type channels. Proc. Natl. Acad. Sci. U.S.A. 91, 10576-10580
235. Stefani A., Spadoni F., Bernardi G. (1998): Gabapentin inhibits calcium currents in isolated rat brain neurons. Neuropharmacology 37, 83-91
236. 2+ channel amino terminus contributes determinants for β subunit-mediated voltage-dependent inactivation properties. J. Physiol. 525, 377-390
237. Stotz S. C., Barr W., McRory J. E., Chen L., Jarvis S. E., Zamponi G. W. (2004): Several structural domains contribute to the regulation of N-type calcium channel inactivation by the β3 subunit. J. Biol. Chem. 279, 3793-3800
238. Strom T. M., Nyakatura G., Apfelstedt-Sylla E., Hellebrand H., Lorenz B., Weber B. H., Wutz K., Gutwillinger N., Ruther K., Drescher B., Sauer C., Zrenner E., Meitinger T., Rosenthal A., Meindl A. (1998): An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness. Nat. Genet. 19, 260-263
239. 2+ channel blocker. Mol. Pharmacol. 50, 1330-1337
240. 2δ subunits. Recept. Channels 4, 217-225
241. Takahashi M., Seagar M. J., Jones J. F., Reber B. F., Catterall W. A. (1987): Subunit structure of dihydropyridine-sensitive calcium channels from skeletal muscle. Proc. Natl. Acad. Sci. U.S.A. 84, 5478-5482
242. v3.1). J. Gen. Physiol. 121, 511-528
243. 1G. J. Gen. Physiol. 124, 225-238
244. Talley E. M., Cribbs L. L., Lee J. H., Daud A., Perez-Reyes E., Bayliss D. A. (1999): Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels. J. Neurosci. 19, 1895-1911
245. Talley E. M., Solorzano G., Depaulis A., Perez-Reyes E., Bayliss D. A. (2000): Low-voltage-activated calcium channel subunit expression in a genetic model of absence epilepsy in the rat. Brain Res., Mol. Brain Res. 75, 159-165
246. Tanabe T., Takeshima H., Mikami A., Flockerzi V., Takahashi H., Kangawa, K., Kojima M., Matsuo H., Hirose T., Numa S. (1987): Primary structure of the receptor for calcium channel blockers from skeletal muscle. Nature 328, 313-318
247. Tareilus E., Roux M., Qin N., Olcese R., Zhou J., Stefani E., Birnbaumer L. (1997): A Xenopus oocyte β subunit: evidence for a role in the assembly/expression of voltage-gated calcium channels that is separate from its role as a regulatory subunit. Proc. Natl. Acad. Sci. U.S.A. 94, 1703-1708
248. Todorovic S. M., Perez-Reyes E., Lingle C. J. (2000): Anticonvulsants but not general anesthetics have differential blocking effects on different T-type current variants. Mol Pharmacol. 58, 98-108
249. v3.2 channel is a molecular substrate for inhibition of T-type calcium currents in rat sensory neurons by nitrous oxide. Mol. Pharmacol. 60, 603-610
250. Tsakiridou E., Bertollini L., de Curtis M., Avanzini G., Pape H. C. (1995): Selective increase in T-type calcium conductance of reticular thalamic neurons in a rat model of absence epilepsy. J. Neurosci. 15, 3110-3117
251. Tsien R. W., Lipscombe D., Madison D. V., Bley K. R., Fox A. P. (1988): Multiple types of neuronal calcium channels and their selective modulation. Trends Neurosci. 11, 431-438
252. Vaghy P. L., Striessnig J., Miwa K., Knaus H. G., Itagaki K., McKenna E., Glossmann H., Schwartz A. (1987): Identification of a novel 1,4-dihydropyridine- and phenylalkylamine-binding polypeptide in calcium channel preparations. J. Biol. Chem. 262, 14337-14342
253. Van Petegem F., Clark K. A., Chatelain F. C., Minor D. L. Jr. (2004): Structure of a complex between a voltage-gated calcium channel β-subunit and an α-subunit domain. Nature 429, 671-675
254. Varadi G., Lory P., Schultz D., Varadi M., Schwartz A. (1991): Acceleration of activation and inactivation by the β subunit of the skeletal muscle calcium channel. Nature 352, 159-162
255. Volsen S. G., Day N. C., McCormack A. L., Smith W., Craig P. J., Beattie R. E., Smith D., Ince P. G., Shaw P. J., Ellis S. B., Mayne N., Burnett J. P., Gillespie A., Harpold M. M. (1997): The expression of voltage-dependent calcium channel β subunits in human cerebellum. Neuroscience 80, 161-174
256. 1A subunit. J. Biol. Chem. 273, 2361-2367
257. 2+ channel activation. J. Biol. Chem. 274, 12383-12390
258. 1 subunit of the skeletal muscle calcium channel. FEBS Lett. 334, 261-264
259. 2+ channels. J. Biol. Chem. 266, 21943-21947
260. 2+ channel pharmacology. Subunit requirement for the high affinity and allosteric regulation of dihydropyridine binding. J. Biol. Chem. 270, 27106-27111
261. 2 /δ subunits in a somatic cell line. J. Physiol. 471, 749-765
262. Welling A., Kwan Y. W., Bosse E., Flockerzi V., Hofmann F., Kass R. S. (1993b): Subunit-dependent modulation of recombinant L-type calcium channels. Molecular basis for dihydropyridine tissue selectivity. Circ. Res. 73, 974-980
263. Welling A., Lacinova L., Donatin K., Ludwig A., Bosse E., Flockerzi V., Hofmann F. (1995): Expression of the L-type calcium channel with two different β subunits and its modulation by Ro 40-5967. Pflügers Arch. 429, 400-411
264. 2+ channels. Circ. Res. 81, 526-532
265. 2+ /calmodulin-dependent kinase II. J. Neurosci. 23, 10116-10121
266. Welty D. F., Schielke G. P., Vartanian M. G., Taylor C. P. (1993): Gabapentin anticonvulsant action in rats: disequilibrium with peak drug concentrations in plasma and brain microdialysate. Epilepsy Res. 16, 175-181
267. 2, and β subunits of a novel human neuronal calcium channel subtype. Neuron 8, 71-84
268. Williams M. E., Brust P. F., Feldman D. H., Patthi S., Simerson S., Maroufi A., McCue A. F., Velicelebi G., Ellis S. B., Harpold M. M. (1992b): Structure and functional expression of an ω-conotoxin-sensitive human N-type calcium channel. Science 257, 389-395
269. 1E calcium channel subtypes. J. Biol. Chem. 269, 22347-22357
270. Williams M. E., Washburn M. S., Hans M., Urrutia A., Brust P. F., Prodanovich P., Harpold M. M., Stauderman K. A. (1999): Structure and functional characterization of a novel human low-voltage activated calcium channel. J. Neurochem. 72, 791-799
271. 2+ channels is a single transmembrane extracellular protein which is involved in regulated secretion. FEBS Lett. 379, 15-20
272. 2+ channel currents by CaMKIIγ(C). J. Physiol. 538, 343-355
273. 2+ channel currents in undifferentiated mammalian NG108-15 cells. J. Physiol. 510, 347-360
274. 2+ channel agonists. Mol. Pharmacol. 64, 235-248
275. 1 subunit domain I-II linker affect piperidine block of neuronal calcium channels. J. Neurosci. 16, 2430-2443
276. 1H, a cloned human T-type calcium channel. Am. J. Physiol. 278, H184-193
277. 2+-binding domains. Proc. Natl. Acad. Sci. U.S.A. 94, 2301-2305
278. 1 subunit. FEBS Lett. 378, 121-125
279. 1C subunit. Proc. Natl. Acad. Sci. U.S.A. 95, 3287-3294
280. 1C subunit gene. FEBS Lett. 427, 220-224
281. Zühlke R. D., Pitt G. S., Deisseroth K., Tsien R. W., Reuter H. (1999): Calmodulin supports both inactivation and facilitation of L-type calcium channels. Nature 399, 159-162