Inhibition of recombinant Ca2+ channels by benzothiazepines and phenylalkylamines: Class-specific pharmacology and underlying molecular determinants

Molecular Pharmacology

Volumn 51, Issue 5, 1997, Pages 872-881

  Cai, Dongming ^a   Mulle, Jennifer G ^a   Yue, David T ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOTHIAZEPINE DERIVATIVE; CALCIUM CHANNEL; DILTIAZEM; PHENYLALKYLAMINE; VERAPAMIL; CALCIUM CHANNEL BLOCKING AGENT; RECOMBINANT PROTEIN;

ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; KIDNEY CELL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; CELL LINE; CHANNEL GATING; DOSE RESPONSE; DRUG ANTAGONISM;

CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CELL LINE; DILTIAZEM; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ION CHANNEL GATING; RECOMBINANT PROTEINS; VERAPAMIL;

EID: 0030609887     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.51.5.872     Document Type: Article

References (40)

1. Olivera, B. M., G. P. Miljanich, J. Ramachandran, and M. E. Adams. Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins. Annu. Rev. Biochem 63:823-867 (1994).
2. Fleckenstein, A. History of calcium antagonist. Circ Res. 52:13-116 (1983).
3. Janis, R. A., and D. J. Triggle. Drugs action on calcium channels, in Calcium Channels: Their Properties, Functions, Regulation, and Clinic Relevance (L. D. Partridge and J. K. Leach, eds.). CRC Press, Boca Raton, FL, 195-249 (1991).
4. McDonald, T. F., S. Pelzer, W. Trautwein, and D. J. Pelzer. Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells. Physiol. Rev. 74:365-507 (1994).
5. Xiao, W. H., and G. J. Bennett. Synthetic ω-conopeptides applied to the site of nerve injury suppress neuropathic pains in rats. J. Pharmacol. Exp. Ther. 274:666-672 (1995).
6. 2+ channel gene CACNL1A4. Cell 87:543-552 (1996).
7. Grabner, M., Z. Wang, S. Hering, J. Striessnig, and H. Glossmann. Transfer of 1,4-dihydropyridine sensitivity from L-type to class A (BI) calcium channels. Neuron 16:207-218 (1996).
8. Peterson, B. Z., T. N. Tanada, and W. A. Catterall. Molecular determinants of high affinity dihydropyridine binding in L-type calcium channels. J. Biol. Chem. 271:5293-5296 (1996).
9. Schuster, A., L. Lacinova, N. Klugbauer, H. Ito, L. Birnbaumer, and F. Hofmann. The IVS6 segment of the L-type calcium channel is critical for the action of dihydropyridines and phenylalkylamines. EMBO J. 15:2365-2370 (1996).
10. Hockerman, G. H., B. D. Johnson, T. Scheuer, and W. A. Catterall. Molecular determinants of high affinity phenylalkylamine block of L-type calcium channels. J. Biol. Chem. 270:22119-22122 (1995).
11. 1A. J. Biol. Chem. 271:11745-11749 (1996).
12. Hering, S., S. Aczel, M. Grabner, F. Doring, S. Berjukow, J. Mitterdorfer, M. J. Sinnegger, J. Striessnig, V. E. Degtiar, Z. Wang, and H. Glossmann. Transfer of high sensitivity for benzothiazepine from L-type to class A calcium channels. J. Biol. Chem. 271:24471-24475 (1996).
13. 1 subunits. J. Biol. Chem. 271: 20113-20118 (1996).
14. Diochot, S., S. Richard, M. Baldy-Moulinier, J. Nargeot, and J. Valmier. Dihydropyridines, phenylalkylamines and benzothiazepines block N-, P/Q-and R-type calcium currents. Pflueg. Arch. Eur. J. Physiol. 431:10-19 (1995).
15. 2+ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil. Brain Res. 695:88-91 (1995).
16. Hille, B. Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J. Gen. Physiol. 69:497-515 (1977).
17. Hondeghem, L. M., and B. G. Katzung. Time-and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim. Biophys. Acta 472:373-398 (1977).
18. Starmer, C. F., A. O. Grant, and H. C. Strauss. Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics. Biophys. J. 46:15-27 (1984).
19. 2+ channel currents in rat cerebellar granule neurons. J. Neurosci. 15:2995-3012 (1995).
20. Perez-Reyes, E., A. Castellano, H. S. Kim, P. Bertrand, E. Baggstrom, A. E. Lacerda, X. Y. Wei, and L. Birnbaumer. Cloning and expression of a cardiac/brain β subunit of the L-type calcium channel. J. Biol. Chem. 267:1792-1797 (1992).
21. Tomlinson, W. J., A. Stea, E. Bourinet, P. Charnet, J. Nargeot, and T. P. Snutch. Functional properties of a neuronal class C L-type calcium channel. Neuropharmacology 32:1117-1126 (1993).
22. 2+ channels. J. Biol. Chem. 266:21943-7 (1991).
23. Soong, T. W., A. Stea, C. D. Hodson, S. J. Dubel, S. R. Vincent, and T. P. Snutch. Structure and functional expression of a member of the low voltage-activated calcium channel family. Science (Washington D. C.) 260: 1133-1136 (1993).
24. Starr, T. V., W. Prystay, and T. P. Snutch. Primary structure of a calcium channel that is highly expressed in the rat cerebellum. Proc. Natl. Acad. Sci. USA 88:5621-5625 (1991).
25. 1A calcium channel reflect similarities to neuronal Q-and P-type channels. Proc. Natl. Acad. Sci. USA 91:10576-10580 (1994).
26. Gorman, C. M., D. R. Gies, and G. McCray. Transient production of proteins using an adenovirus transformed cell line. DNA Prot. Eng. Techniques 2:3-10 (1990).
27. Dhallan, R. S., K. W. Yau, K. A. Schrader, and R. R. Reed. Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature (Lond.) 347:184-187 (1990).
28. Kaufman, R. J. Identification of the components necessary for adenovirus translational control and their utilization in cDNA expression vectors. Proc. Natl. Acad. Sci. USA 82:689-693 (1985).
29. 1 subunit. J. Biol. Chem. 269:1635-1640 (1994).
30. Higuchi, R. Using PCR to engineer DNA, in PCR Technology (H. A. Erlich, ed.). Stockton Press, Basingstoke, Hants, UK, 61-70 (1989).
31. Lee, K. S., and R. W. Tsien. Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells. Nature (Lond.) 302:790-794 (1983).
32. Bean, B. P. Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state. Proc. Natl Acad. Sci. USA 81:6388-6392 (1984).
33. Kass, R. S., and D. S. Krafte. Negative surface charge density near heart calcium channels: relevance to block calcium channels. J. Gen. Physiol. 89:629-644 (1987).
34. McDonald, T. F., D. Pelzer, and W. Trautwein. Cat ventricular muscle treated with D600: effects on calcium and potassium currents. J. Physiol. (Lond) 352:203-216 (1984).
35. 2+ channel antagonist mibefradil (Ro 40-5967). Mol. Pharmacol. 48: 540-549 (1995).
36. Mon, Y., T. Friedrich, M.-S. Kim, A. Mikami, K. Nakai, P. Ruth, E. Rosse, F. Hoffmann, V. Flockerzi, T. Furuichi, K. Mikoshiba, K. Imoto, T. Tanabe, and S. Numa. Primary structure and functional expression from complementary DNA of brain calcium channel. Nature (Lond.) 350:398-402 (1991)
37. Ruth, P., A. Rohrkasten, M. Miel, E. Bosse, S. Regulla, H. E. Meyer, V. Flockerzi, and F. Hoffmann. Primary structure of the β subunit of the DHP-sensitive calcium channel from skeletal muscle. Science (Washington D.C.) 245:1115-1118 (1989).
38. 1A subunits of brain calcium channels. J. Cell Biol. 134:511-528 (1996).
39. 2+ channels in rat cultured cerebellar granule cells. Soc. Neurosci. Abstr. 22:689.5 (1996).
40. + channels by local anesthetics. Science (Washington D. C.) 265:1724-1728 (1994).