Synthesis and evaluation of a new class of nifedipine analogs with T-type calcium channel blocking activity

Molecular Pharmacology

Volumn 61, Issue 3, 2002, Pages 649-658

  Phani Kumar, P ^a   Stotz, Stephanie C ^a   Paramashivappa, R ^a   Beedle, Aaron M ^a   Zamponi, Gerald W ^a   Srinivasa Rao, A ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

(6' PENTADECYLPHENYL) 2,6 DIMETHYL 3,5 PYRIDINE DICARBOXYLATE DERIVATIVE; ANACARDIC ACID; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL T TYPE; CARBOXYLIC ACID DERIVATIVE; NIFEDIPINE DERIVATIVE; PPK 12; PPK 5; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CASHEW NUT; CELL LINE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MEMBRANE STEADY POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, T-TYPE; CELLS, CULTURED; ELECTROPHYSIOLOGY; HUMANS; NIFEDIPINE; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0036176214     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.3.649     Document Type: Article

References (55)

1. Low-voltage-activated calcium current in rat aorta smooth muscle cells in primary culture
2. L-type calcium channels: Asymmetrical intramembrane binding domain revealed by variable length, permanently charged 1,4-dihydropyridines
3. Nitrendipine block of cardiac calcium channels: High-affinity binding to the inactivated state
4. Loss-of-function mutations in a calcium-channel alpha1-subunit gene in Xp11.23 cause incomplete X-linked congenital stationary night blindness
5. The molecular mode of action of the Ca agonist (-) BAY K 8644 on the cardiac Ca channel
6. Molecular mechanism of calcium channel block by isradipine role of a drug-induced inactivated channel conformation
7. Splicing of alpha 1a subunit gene generates phenotypic variants of P- and Q-type calcium channels
8. 2+ channels
9. 1,4-Dihydropyridine antagonist activities at the calcium channel: A quantitative structure-activity relationship approach
10. Molecular cloning of the alpha-1 subunit of an omega-conotoxinsensitive calcium channel
11. 2+ channels in mammalian central neurons
12. Low-voltage activated calcium channels are differently affected by nimodipine
13. 1,4-Dihydropyridines: Effects of chirality and conformation on the calcium antagonist and agonist activities
14. Transfer of 1,4-dihydropyridine sensitivity from L-type to class A (BI) calcium channels
15. Inhibition of lipoxygenase and prostaglandin endoperoxide synthase by anacardic acids
16. Transfer of the high affinity dihydropyridine sensitivity from L-type to non-L-type calcium channel
17. Block of L-type calcium channels by charged dihydropyridines
18. A family of gamma-like calcium channel subunits
19. Molecular diversity of the calcium channel alpha2delta subunit
20. 2+ channels activating at negative voltages
21. Structure-antibacterial activity relationships of anacardic acids
22. Anti tumor agents from the cashew (Anacardium occidentale) apple juice
23. Naturally occurring anti-acne agents
24. Tyrosinase inhibitors from Anacardium occidentale fruits
25. Low voltage activated calcium channels from genes to function
26. Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells
27. "Hantzsch-type" dihydropyridine hypotensive agents
28. Molecular and functional characterization of a family of rat brain T-type calcium channels
29. Molecular and functional properties of the human α(1G) subunit that forms T-type calcium channels
30. Three types of neuronal calcium channel with different calcium agonist sensitivity
31. Novel method for isolation of major phenolic constituents from cashew (Anacardium occidentale L.) nut shell liquid
32. On the olefinic nature of anacardic acid from Indian cashew nut shell liquid
33. Calcium binding in the pore of L-type calcium channels modulates high affinity dihydropyridine binding
34. Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit
35. 2+ currents in atrial myocytes
36. Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents
37. 2+ current carrier in mouse primary spermatocytes
38. Comparison of L-type calcium channel blockade by nifedipine and/or cadmium in guinea pig ventricular myocytes
39. Inhibition of soyabeen lipoxygenase-1 by anacardic acids, cardols and cardanols
40. Structure and functional expression of a member of the low voltage- activated calcium channel family
41. Voltage-gated calcium channels
42. Evidence for an external location of the dihydropyridine agonist receptor site on smooth muscle and skeletal muscle calcium channels
43. Calcium channel antagonists: Cardiovascular selectivity of action
44. 2+ currents in isolated rat hippocampal ca1 pyramidal neurons
45. Primary structure of the receptor for calcium channel blockers from skeletal muscle
46. Functional properties of a neuronal class C L-type calcium channel
47. Functional diversity of P-type and R-type calcium channels in rat cerebellar neurons
48. 2+ channels
49. 2+ channel alpha 1 subunits
50. 2+ channels in supporting hippocampal synaptic transmission
51. Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype
52. 2-MeOH
53. 2+ channel agonists
54. Antagonist sites of voltage-dependent calcium channels