Potent inhibition of a recombinant low voltage-activated Ca2+ channel by SB-209712

European Journal of Pharmacology

Volumn 407, Issue 1-2, 2000, Pages 53-60

  McNaughton, Nicolle C L ^a   Warre, Ruth ^a   Cooper, David G ^a   Nasir, Shabina ^a   Ranson, Jennie L ^a   Randall, Andrew ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Ca2+ channel; HEK293 cell; Pharmacology; Recombinant

Indexed keywords

CALCIUM ANTAGONIST; MIBEFRADIL; SB 209712; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM ANTAGONISM; CALCIUM CHANNEL; CONTROLLED STUDY; IC 50; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, T-TYPE; CELL LINE; MIBEFRADIL; PIPERIDINES; RATS; RECOMBINANT PROTEINS;

EID: 0034721995     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00740-8     Document Type: Article

References (43)

1. Dihydropyridine-sensitive low-threshold calcium channels in isolated rat hypothalamic neurones
2. 2+ currents and oxidative metabolism in dissociated mammalian CNS neurons
3. Mechanisms of oscillatory activity in guinea-pig nucleus reticularis thalami in vitro: a mammalian pacemaker
4. Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state
5. 2+ channels by alphatic monoamines
6. 2+ channel antagonist mibefradil (Ro 40-5967)
7. Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels
8. Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin
9. Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker
10. Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons
11. 2+ channel gene family
12. High affinity interaction of mibefradil with voltage-gated calcium and sodium channels
13. Mibefradil potently blocks ATP-activated K((+)) channels in adrenal cells
14. Blockade of receptor-operated calcium channels by mibefradil (Ro 40-5967): effects on intracellular calcium and platelet aggregation
15. + channels in the NG108-15 cell-line
16. Low-threshold calcium currents in central nervous system neurons
17. Intrathalamic rhythmicity studied in vitro: nominal T-current modulation causes robust antioscillatory effects
18. Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family
19. + currents in human fusion-competent myoblasts
20. Electrophysiology of mammalian inferior olivary neurones in vitro. Different types of voltage-dependent ionic conductances
21. Antiepileptic drug mechanisms of action
22. Mibefradil inhibition of T-type calcium channels in cerebellar Purkinje neurons
23. 2+ containing solutions
24. 2+ channel III: pH-dependent inhibition by a synthetic macrocyclic polyamine
25. 2+ channels by the neuroprotective agent BW619C89 (Sipatrigine)
26. The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels
27. Block of Ca channels in rat central neurons by the spider toxin w-Aga-IIIA
28. 2+ channels by Ro 40-5967
29. Structure and alternative splicing of the gene encoding alpha(1I), a human brain T calcium channel alpha(1) subunit
30. Specific properties of T-type calcium channels generated by the human α(1I) subunit
31. 2+ current through human alpha 1E channels by two steroid analogs, (+)-ACN and (+)-ECN
32. - channels in macrovascular endothelial cells
33. Molecular characterization of a neuronal low voltage-activated T-type calcium channel
34. 2+ channel antagonist Ro 405967
35. 2+ channels
36. Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels
37. Inhibition of T-type calcium currents by dihydropyridines in mouse embryonic dorsal root ganglion neurons
38. Low voltage-activated calcium channel subunit expression in a genetic model of absence epilepsy in the rat
39. 2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents
40. 2+ current in adult rat sensory neurons by a steroid that lacks gamma-aminobutyric acid-modulatory activity
41. Selective increase in T-type calcium conductance of reticular thalamic neurons in a rat model of absence epilepsy
42. Mibefradil (Ro 40-5967) blocks multiple types of voltage-gated calcium channels in cultured rat spinal motoneurones