Antisense depletion of β-subunits fails to affect T-type calcium channels properties in a neuroblastoma cell line

Neuropharmacology

Volumn 37, Issue 6, 1998, Pages 701-708

  Leuranguer, Valérie ^a   Bourinet, Emmanuel ^a   Lory, Philippe ^a   Nargeot, Joël ^a  

^a INSTITUTE OF HUMAN GENETICS   (France)

Author keywords

Subunit; Antisense; HVA calcium channels; LVA calcium channels; Neuronal differentiation; NG 108 15 cell line

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; MIBEFRADIL; NITRENDIPINE; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; OMEGA CONOTOXIN;

ANIMAL CELL; ARTICLE; BETA CHAIN; CALCIUM CURRENT; CELL DIFFERENTIATION; CONTROLLED STUDY; DEPLETION; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CALCIUM CHANNELS; GLIOMA; MICE; NEUROBLASTOMA; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PATCH-CLAMP TECHNIQUES; RATS; TUMOR CELLS, CULTURED;

EID: 0031811571     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00060-4     Document Type: Article

References (25)

1. Berrow N.S., Campbell V., Fitzgerald E.M., Brickley K., Dolphin A.C. Antisense depletion of β-subunits modulates the biophysical and pharmacological properties of neuronal calcium channels. J. Physiol. Lond. 482(3):1995;481-491.
2. 1E calcium channel exhibits permeation properties similar to low-voltage-activated calcium channels. J. Neurosci. 16:1996;4983-4993.
3. Brink, D., Guthrie, H., Nelson, D., Kovesdi, I., Snutch, T.P., 1997. Analysis of T-type Ca currents in CNS neurons using an adenovirus based antisense strategy. Soc. Neurosci. Abstr. 784.11.
4. Chen C., Hess P. Mechanism of gating of T-type calcium channels. J. Gen. Physiol. 96:1990;603-630.
5. 2+ channel regulation by a conserved β subunit domain. Neuron. 13:1994;495-503.
6. Huguenard J.R. Low-threshold calcium currents in central nervous system neurons. Annu. Rev. Physiol. 58:1996;329-348.
7. 1D subunit gene. Cell Mol. Neurobiol. 15:1995;307-326.
8. Kasai, H., Neher, E., 1992. Dihydropyridine-sensitive and ω-conotoxin-sensitive calcuim channels in a mammalian neuroblastoma-glioma cell line. J. Physiol. Lond. 448, 161-188.
9. 2+ channel. Nature. 352:1991;527-530.
10. 2+ channel structure and function with antisense oligonucleotides. Mol. Cell. Neurosci. 7:1996;239-246.
11. 2+ channel β subunit depletion in nodosus ganglion neurons. J. Neurosci. 17:1997;6621-6628.
12. 2+ channels by Ro 40-5967. Circ. Res. 75:1994;144-148.
13. Neely A., Wei X., Olcese R., Birnbaumer L., Stefani E. Potentiation by the β subunit of the ratio of the ionic current to the charge movement in the cardiac calcium channel. Science. 262:1993;575-578.
14. Phillips M.I., Gyurko R. Antisense oligonucleotides: new tools for physiology. News Physiol. Sci. 12:1997;99-105.
15. 1 subunit. Nature. 368:1994;67-70.
16. 1E DNA ant its atrial homologue decrease T-type calcium current in atrial myocytes. Proc. Natl. Acad. Sci. USA. 94:1998;14936-14941.
17. Randall A.D., Tsien R.W. Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels. Neuropharmacology. 36:1997;879-893.
18. 2+ channels: diversity of form and function. Curr. Opin. Neurobiol. 2:1992;247-253.
19. Soong T.W., Stea A., Hodson C.D., Dubel S.J., Vincent S.R., Snutch T.P. Structure and functional expression of a member of the low voltage-activated calcium channel family. Science. 260:1993;1133-1136.
20. Stea, A., Soong, T.W., Snutch, T.P., 1995. Voltage-gated calcium channels. In: North, A. (Ed.), Handbook of Receptor and Channels, Ligand- and Voltage-gated Ion Channels. CRC Press, Boca Raton, FL, pp. 113-151.
21. Strong M., Chandy K.G., Gutman G. Molecular evolution of voltage-sensitive ion channel genes: on the origins of electrical excitability. Mol. Biol. Evol. 10:1993;221-242.
22. 1 subunit. Biophys. J. 71:1996;2531-2543.
23. Varadi G., Lory P., Schultz D., Varadi M., Schwartz A. Acceleration of activation and inactivation by the β subunit of skeletal muscle calcium channel. Nature. 352:1991;159-162.
24. 2, and β subunits of a novel human neuronal calcium channel subtype. Neuron. 8:1992;71-84.
25. Williams M.E., Brust P.F., Feldman D.H., Patthi S., Simerson S., Maroufi A., McCue A.F., Velicelebi G., Ellis S.B., Harpold M.M. Structure and functional expression of an ω-conotoxin-sensitive human N-type calcium channel. Science. 257:1992;389-395.