Inactivation of gating currents of L-type calcium channels: Specific role of the α2δ subunit

Journal of General Physiology

Volumn 111, Issue 6, 1998, Pages 807-823

  Shirokov, Roman ^a,c   Ferreira, Gonzalo ^a,b   Yi, Jianxun ^a   Ríos, Eduardo ^a  

^a RUSH MEDICAL COLLEGE   (United States)

^b DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

^c BOGOMOLETZ INSTITUTE OF PHYSIOLOGY   (Ukraine)

Author keywords

Cardiac muscle; Charge immobilization; Charge interconversion; Continuum model of gating; Heterologous expression

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; POTASSIUM CHANNEL; POTASSIUM ION; SODIUM CHANNEL; SODIUM ION;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; CALCIUM CONDUCTANCE; CALCIUM CURRENT; CHANNEL GATING; DEPOLARIZATION; ELECTRIC ACTIVITY; HEART MUSCLE; NONHUMAN; RABBIT; SIMULATION; STEADY STATE; STRUCTURE ACTIVITY RELATION;

ALGORITHMS; ANIMALS; BARIUM; CALCIUM CHANNELS; CELL LINE; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; HUMANS; ION CHANNEL GATING; KIDNEY; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; PATCH-CLAMP TECHNIQUES; RABBITS;

EID: 0031750471     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.111.6.807     Document Type: Article

References (31)

1. Armstrong, C.M., and F. Bezanilla. 1977. Inactivation of the sodium channel. II. Gating current experiments. J. Gen. Physiol. 70:567-590.
2. 2δ subunit on ionic and gating current in transiently transfected HEK 293 cells. Am. J. Physiol. 270:H1521-H1528.
3. Balser, J.R., H.B. Nuss, D. Romashko, E. Marban, and G.T. Tomaselli. 1996. Functional consequences of lidocaine binding to slow-inactivated sodium channels. J. Gen. Physiol. 107:643-658.
4. Bezanilla, F., R.E. Taylor, and J. Fernandez. 1982. Distribution and kinetics of membrane dielectric polarization. I. Long-term inactivation of gating currents. J. Gen. Physiol. 79:21-40.
5. Brum, G., and E. Ríos. 1987. Intramembrane charge movement in frog skeletal fibers. Properties of charge 2. J. Physiol. (Camb.). 387: 489-517.
6. Brum, G., R. Fitts, G. Pizarro, and E. Ríos. 1988. Voltage sensors of the frog skeletal muscle membrane require calcium to function in excitation-contraction coupling. J. Physiol. (Camb.). 398:475-505.
7. 2+ channels. J. Biol. Chem. 270:30036-30044.
8. Conti, F., and W. Stühmer. 1989. Quantal charge redistributions accompanying the structural transitions of sodium channels. Eur. Biophys. J. 17:53-59.
9. 2δ subunit. J. Neurosci. 17:6884-6891.
10. Ferreira, G., J. Yi, E. Ríos, and R. Shirokov. 1997. Ion-dependent inactivation of barium current through L-type Ca channels. J. Gen. Physiol. 109:449-461.
11. Gurnett, C., and K. Campbell. 1996. Transmembrane auxiliary subunits of voltage-dependent ion channels. J. Biol. Chem. 271: 27975-27978.
12. 2+ channels in guinea-pig ventricular myocytes through independent mechanisms. J. Physiol. (Camb.). 444:257-268.
13. Hoshi, T., W.N. Zagotta, and R.W. Aldrich. 1990. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science. 250:533-538.
14. + channels must deactivate to recover from inactivation. Neuron. 12:819-829.
15. Lauger, P. 1988. Internal motions in proteins and gating kinetics of ionic channels. Biophys. J. 53:877-884.
16. Levitt, D. 1989. Continuum model of voltage-dependent gating. Macroscopic conductance, gating current, and single-channel behavior. Biophys. J. 55:489-498.
17. López-Barneo, J., T. Hoshi, S.H. Heinemann, and R.W. Aldrich. 1993. Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors Channels. 1:1-71.
18. Marks, T., and S.W. Jones. 1992. Calcium currents in the A7r5 smooth muscle-derived cell line. An allosteric model for Ca channel activation and dihydropyridine agonist action. J. Gen. Physiol. 99:367-390.
19. Millhauser, G.L., E.E. Salpeter, and R.E. Oswald. 1988. Diffusion models of ion-channel gating and the origin of power low distributions from single-channel recording. Proc. Natl. Acad. Sci. USA. 85:1503-1507.
20. + channels. J. Gen. Physiol. 110:579-589.
21. Press, W.H., B.P. Flannery, S.A. Teukolsky, and W.T. Vetterling. 1988-1992. Numerical recipes in C: the art of seientific computing. Cambridge University Press. 50-54.
22. 1 protein level. J. Physiol. (Camb.). 489:55-62.
23. Sigg, D., E. Stefani, and F. Bezanilla. 1994. Gating current noise produced by elementary transitions in Shaker potassium channels. Science. 264:578-582.
24. Singer, D., M. Biel, I. Lotan, V. Flockerzi, F. Hofmann, and N. Dascal. 1991. The roles of the subunits in the function of the Ca channel. Science. 253:1553-1557.
25. Shirokov, R., R. Levis, N. Shirokova, and E. Ríos. 1992. Two classes of gating current from L-type Ca channels in guinea pig ventricular myocytes. J. Gen. Physiol. 99:863-895.
26. 2+-dependent inactivation of cardiac L-type Ca channels does not affect their voltage sensor. J. Gen. Physiol. 102:1005-1030.
27. + channels. J. Gen. Physiol. 110:23-33.
28. Vassilev, P.M., T. Scheuer, and W.A. Catterall. 1988. Identification of an intracellular peptide segment involved in sodium channel inactivation. Science. 241:1658-1661.
29. 2/δ subunits in a somatic cell line. J. Physiol. (Camb.). 471:749-765.
30. Yellen, G., D. Sodickson, T.-Y. Chen, and M.E. Yurman. 1994. An engineered cysteine in the external mouth of a K channel allows inactivation to be modulated by metal binding. Biophys. J. 66: 1068-1075.
31. Zagotta, W.N., T. Hoshi, and R.W. Aldrich. 1990. Restoration of inactivation in mutants of Shaker potassium channels by peptide derived from ShB. Science. 250:568-571.