Repression by the Mad(Mxi1)-Sin3 complex

BioEssays

Volumn 20, Issue 10, 1998, Pages 808-818

  Schreiber Agus, Nicole ^a   DePinho, Ronald A ^a,b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; DNA BINDING PROTEIN; MAD PROTEIN, MOUSE; MAX PROTEIN, MOUSE; MXD1 PROTEIN, HUMAN; MXI1 PROTEIN, HUMAN; MXI1 PROTEIN, MOUSE; MYC ASSOCIATED FACTOR X; MYC PROTEIN; NUCLEAR PROTEIN; NUCLEAR RECEPTOR CO REPRESSOR 1; NUCLEAR RECEPTOR CO-REPRESSOR 1; REPRESSOR PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; SIN3 PROTEIN, S CEREVISIAE; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN;

ANIMAL; BINDING COMPETITION; BINDING SITE; BIOLOGICAL MODEL; CELL TRANSFORMATION; CHROMATIN; CONSENSUS SEQUENCE; DIMERIZATION; DRUG ANTAGONISM; EUKARYOTIC CELL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; MOUSE MUTANT; MULTIGENE FAMILY; NEOPLASM; PHYSIOLOGY; REVIEW; TRANSACTIVATION; TUMOR SUPPRESSOR GENE;

ANIMALS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; BINDING SITES; BINDING, COMPETITIVE; CELL TRANSFORMATION, NEOPLASTIC; CHROMATIN; CONSENSUS SEQUENCE; DIMERIZATION; DNA-BINDING PROTEINS; EUKARYOTIC CELLS; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; MICE; MICE, KNOCKOUT; MODELS, GENETIC; MULTIGENE FAMILY; NEOPLASMS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA; EUKARYOTA;

EID: 0032192408     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-1878(199810)20:10<808::AID-BIES6>3.0.CO;2-U     Document Type: Review

References (86)

1. Sheiness DK, Hughes SH, Varmus HE, Stubblefield E, Bishop JM (1980) The vertebrate homolog of the putative transforming gene of avian myelocytomatosis virus: characteristics of the DNA locus and its RNA transcript. Virology 105:415-424.
2. Morgenbesser SD, DePinho RA (1994) Use of transgenic mice to study myc family gene function in normal mammalian development and in cancer. Semin Cancer Biol 5: 21-36.
3. DePinho RA, Schreiber-Agus N, Alt FW (1991) myc family oncogenes in the development of normal and neoplastic cells. Adv Cancer Res 57: 1-46.
4. Evan G, Harrington E, Fanidi A, Land H, Amati B, Bennett M (1994) Integrated control of cell proliferation and cell death by the c-myc oncogene. Philos Trans R Soc Lond B Biol Sci 345: 269-275.
5. Kato GJ, Barrett J, Villa-Garcia M, Dang CV (1990) An amino-terminal c-Myc domain required for neoplastic transformation activates transcription. Mol Cell Biol 10: 5914-5920.
6. Blackwell TK, Kretzner L, Blackwood EM, Eisenman RN, Weintraub H (1990) Sequence-specific DNA binding by the c-myc protein. Science 250: 1149-1151.
7. Landschulz WH, Johnson PF, McKnight SL (1988) The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science 240: 1759-1764.
8. Murre C, Schonleber-McCaw P, Baltimore D (1989) A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughter-less, MyoD, and myc proteins. Cell 56: 777-83.
9. Galaktionov K, Chen X, Beach D (1996) Cdc25 cell cycle phosphatase as a target of c-myc. Nature 382: 511-517.
10. Perez-Roger I, Solomon DLC, Sewing A, Land H (1997) Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27KIP1 binding to newly formed complexes. Oncogene 14: 2373-2381.
11. Eilers M, Schrim S, Bishop JM (1991) The Myc protein activates transcription of the α-prothymosin gene. EMBO J 10: 133-141.
12. Bello-Fernandez C, Packham G, Cleveland JL (1993) The ornithine decarboxylase gene is a transcriptional target of c-Myc. Proc Natl Acad Sci USA 90: 7804-7808.
13. Gu W, Bhatia K, Magrath IT, Dang CV, Dalla-Favera R (1994) Binding and suppression of the Myc transcriptional activation domain by p107. Science 264: 251-254.
14. Beijersbergen RL, Hijmans EM, Zhu L, Bernards R (1994) Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation. EMBO J 13: 4080-4086.
15. Hateboer G, Timmers HT, Rustgi AK, Billaud M, van't Veer LJ, Bernards R (1993) TATA-binding protein and the retinoblastoma gene product bind to overlapping epitopes on c-Myc and adenovirus E1A protein. Proc Natl Acad Sci USA 90: 8489-8493.
16. Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K (1993) Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc. Science 262: 1889-1892 .
17. Gaubatz S, Imhof A, Dosch R, Werner O, Mitchell P, Buettner R, Eilers M (1995) Transcriptional activation by Myc is under negative control by the transcription factor AP-2. EMBO J 14: 1508-1519.
18. Blackwood EM, Eisenman RN (1991) Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA binding complex with Myc. Science 251: 1211-1217.
19. Prendergast GC, Lawe D, Ziff EB (1991) Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and Ras cotransformation. Cell 65: 395-407.
20. Amati B, Dalton S, Brooks MW, Littlewood TD, Evan GI, Land H (1992) Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max.. Nature 359: 423-426.
21. Amati B, Littlewood TD, Evan GI, Land H (1993a) The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max. EMBO J 12: 5083-5087.
22. Amati B, Brooks MW, Levy M, Littlewood TD, Evan GI, Land H (1993b) Oncogenic activity of the c-Myc protein requires dimerization with Max. Cell 72: 233-245.
23. Kretzner L, Blackwood EM, Eisenman RN (1992) Myc and Max proteins possess distinct transcriptional activities. Nature 359: 426-429.
24. Kato GJ, Lee WMF, Chen L, Dang CV (1992) Max: functional domains and interaction with c-Myc. Genes Dev 6: 81-92.
25. Ayer DE, Kretzner L, Eisenman RN (1993) Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell 72: 211-222.
26. Zervos AS, Gyuris J, Brent R (1993) Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. Cell 72: 223-232.
27. Hurlin PJ, Queva C, Koskinen PJ, Steingrimsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN (1996) Mad3 and Mad-4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J 14: 5646-5659.
28. Henriksson M, Luscher B (1996) Proteins of the Myc network: essential regulators of cell growth and differentiation. Adv Cancer Res 68: 109-182.
29. Lahoz EG, Xu L, Schreiber-Agus N, DePinho RA (1994) Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1. Proc Natl Acad Sci USA 91: 5503-5507.
30. Cerni C, Bousset K, Seelos C, Burkhardt H, Henriksson M, Luscher B (1995) Differential effects by Mad and Max on transformation by cellular and viral oncoproteins. Oncogene 11: 587-596.
31. Ayer DE, Eisenman RN (1993) A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation. Genes Dev 7:2110-2119.
32. Chin L, Schreiber-Agus N, Pellicer I, Chen K, Lee HW, Dudast M, Cordon-Cardo C, DePinho RA (1995) Contrasting roles for Myc and Mad proteins in cellular growth and differentiation. Proc Natl Acad Sci USA 92: 8488-8492.
33. Vastrik I, Kaipainen A, Penttila TL, Lymboussakis A, Alitalo R, Parvinen M, Alitalo K (1995) Expression of the mad gene during cell differentiation in vivo and its inhibition of cell growth in vitro. J Cell Biol 128: 1197-1208.
34. Schreiber-Agus N, Chin L, Chen K, Torres R, Rao G, Guida P, Skoultchi AI, DePinho RA (1995) An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional represser SIN3. Cell 80: 777-786.
35. Schreiber-Agus N, Chin L, Chen K, Torres R, Thomson C, Sacchettini JC, DePinho RA (1994) Evolutionary relationships and functional conservation among vertebrate Max-associated proteins: the zebra fish homolog of Mxi1. Oncogene 9: 3167-3177.
36. Hurlin PJ, Queva C, Eisenman RN (1997) Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites. Genes Dev 11: 44-58.
37. Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter D, Brent R, Ballabio A, Carrozzo R (1997) Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor. EMBO J 16: 2892-2906.
38. Ayer DE, Lawrence QA, Eisenman RN (1995) Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell 80: 767-776.
39. Koskinen PJ, Ayer DE, Eisenman RN (1995) Repression of Myc-Ras cotransformation by Mad is mediated by multiple protein-protein interactions. Cell Growth Differ 6: 623-629.
40. Ayer DE, Laherty CD, Lawrence QA, Armstrong AP, Eisenman RN (1996) Mad proteins contain a dominant transcription repression domain. Mol Cell Biol 16: 5772-5781.
41. Harper SE, Qiu Y, Sharp PA (1996) Sin3 corepressor function in Myc-induced transcription and transformation. Proc Natl Acad Sci USA 93: 8536-8540.
42. Vidal M, Strich R, Esposito RE, Gaber RF (1991) RPD1 (SIN3/UME4) is required for maximal activation and repression of diverse yeast genes. Mol Cell Biol 11: 6306-6316.
43. Wang HI, Clark PR, Nicholson I, Herskowitz I, Stillman DJ (1990) The Saccharomyces cerevisiae SIN3 gene, a negative regulator of HO, contains four paired amphipathic helix motifs. Mol Cell Biol 10: 5927-5936.
44. Rao G, Alland L, Guida P, Schreiber-Agus N, Chen K, Chin L, Rochelle JM, Seldin MF, Skoultchi AS, DePinho RA (1996) Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression domain of the Myc antagonist Mxi1. Oncogene 12: 1165-1172.
45. Alland L, Muhle R, Hou H Jr, Potes J, Chin L, Schreiber-Agus N, DePinho RA (1997) Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature 387: 49-55.
46. Laherty CD, Yang W-M, Sun J-M, Davie JR, Seto E, Eisenman RN (1997) Histone deacetylases associated with the mSin3 corepressor mediate Mad transcriptional repression. Cell 89: 349-356.
47. Hassig CA, Fleischer TC, Billin AN, Schreiber SL, Ayer DE (1997) Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell 89: 341-347.
48. Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (1997) Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell 89: 357-364.
49. Heinzel T, Lavinsky RM, Mullen T-M, Soderstrom M, Laherty CD, Torchia J, Yang W-M, Brad G, Ngo SD, Davie JR, Seto E, Eisenman RN, Rose DW, Glass CK, Rosenfeld MG (1997) A complex containing N-CoR, mSin3, and histone deacetylase mediates transcriptional repression. Nature 387: 43-48.
50. Nagy L, Kao H-Y, Chakravarti D, Lin RJ, Hassig CA, Ayer DE, Schreiber SL, Evans RM (1997) Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell 89: 373-380.
51. Kadosh D, Struhl K (1997) Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell 89: 365-371.
52. Horlein AJ, Naar AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Soderstrom M, Glass CK, Rosenfeld MG (1995) Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear co-repressor. Nature 377: 397-404.
53. Zamir I, Harding HP, Atkins GB, Horlein A, Glass CK, Rosenfeld MG, Lazar MA (1996) A nuclear hormone receptor corepressor mediates transcriptional silencing by receptors with distinct repression domains. Mol Cell Biol 16: 5458-5465.
54. Chen JD, Evans RM (1995) A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377: 454-457.
55. Vidal M, Gaber RF (1991) RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae. Mol Cell Biol 11: 6317-27.
56. Kingston RE, Bunker CA, Imbalzano AN (1996) Repression and activation by multiprotein complexes that alter chromatin structure. Genes Dev 10: 905-920.
57. Taunton J, Hassig CA, Schreiber SL (1996) A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272: 408-411.
58. Yang W-M, Inouye C, Zeng Y, Bearss D, Seto E (1996) Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc Natl Acad Sci USA 93: 12845-12850.
59. Wade PA, Pruss D, Wolffe AP (1997) Histone acetylation: chromatin in action. Trends Biochem Sci 22: 128-132.
60. Stillman DJ, Dorland S, Yu Y (1994) Epistasis analysis of suppressor mutations that allow HO expression in the absence of the yeast SW15 transcriptional activator. Genetics 136: 781-788.
61. Sommer A, Hilfenhaus S, Menkel A, Kremmer E, Seiser C, Loidl P, Luscher B (1997) Cell growth inhibition by the Mad/Max complex through recruitment of histone deacetylase activity. Curr Biol 7: 357-365.
62. Wu S, Pena A, Korcz A, Soprano DR, Soprano KJ (1996) Overexpression of Mxi1 inhibits the induction of the human ornithine decarboxylase gene by the Myc/Max protein complex. Oncogens 12: 621-629.
63. Li LH, Nerlov C, Prendergast G, MacGregor D, Ziff EB (1994) c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II. EMBO J 13: 4070-4079.
64. Philipp A, Schneider A, Vasrik I, Finke K, Xiong Y, Beach D, Alitalo K, Eilers M (1994) Repression of cyclin D1: a novel function of MYC. Mol Cell Biol 14: 4032-4043.
65. De Rubertis F, Kadosh D, Henchoz S, Pauli D, Reuter G, Struhl K, Spierer P (1996) The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast. Nature 384: 589-591.
66. Hurlin PJ, Foley KP, Ayer DE, Eisenman RN, Hanahan D, Arbeit JM (1995) Regulation of Myc and Mad during epidermal differentiation and HPV-associated tumorigenesis. Oncogene 11: 2487-2501.
67. Larsson LG, Pettersson M, Oberg F, Nilsson K, Luscher B (1994) Expression of mad, mxi1, max and c-myc during induced differentiation of hematopoietic cells: opposite regulation of mad and myc. Oncogene 9: 1247-1252.
68. Delgado MD, Lerga A, Canelles M, Gomez-Casares MT, Leon J (1995) Differential regulation of Max and role of Myc during erythroid and myelomonocytic differentiation of K562 cells. Oncogene 10: 1659-1665.
69. Cultraro CM, Bino T, Segal S (1997) Function of the c-Myc antagonist Mad1 during a molecular switch from proliferation to differentiation. Mol Cell Biol 17: 2353-2359.
70. Lymboussaki A, Kaipainen A, Hatva E, Vastrik I, Jeskanen L, Jalkanen M, Werner S, Stenback F, Alitalo R (1996) Expression of Mad, an antagonist of Myc oncoprotein function, in differentiating keratinocytes during tumorigenesis of the skin. Br J Cancer 73: 1347-1355.
71. Chin L, Liegeois N, DePinho RA, Schreiber-Agus N (1996) Functional interactions among members of the Myc superfamily and potential relevance to cutaneous growth and development. J Invest Dermatol 2: 128-135.
72. Chen J, Willingham T, Margraf LF, Schreiber-Agus N, DePinho RA, Nisen PD (1995) Effects of the Myc oncogene antagonist, MAD, on proliferation, cell cycling and the malignant phenotype of human brain tumor cells. Nat Med 1: 638-643.
73. Roussel MF, Ashmun RA, Sherr CJ, Eisenman RN, Ayer DE (1996) Inhibition of cell proliferation by the Mad1 transcriptional repressor. Mol Cell Biol 16:2796-2801.
74. Roy B, Reisman D (1995) Inducible expression of Mad accelerates growth arrest of serum deprived human glioblastoma cells. Cell Biol Int 19: 307-313.
75. Wechsler DS, Shelly CA, Petroff CA, Dang CV (1997) MXI1, a putative tumor suppressor gene suppresses the growth of human glioblastoma cells. Cancer Res 57: 4905-4912.
76. Edelhoff S, Ayer DE, Zervos AS, Steingrimsson E, Jenkins NA, Copeland NG, Eisenman RN, Brent R, Disteche CM (1994) Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19. Oncogens 9: 665-668.
77. Eagle LR, Yin X, Brothman AR, Williams BJ, Atkin NB, Prochownik EV (1995) Mutation of the MXI1 gene in prostate cancer. Nat Genet 9: 249-255.
78. Albarosa R, DiDonato S, Finocchiaro G (1995) Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3′ non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas. Hum Genet 95:709-711.
79. Prochownik EV, Grove LE, Deubler D, Zhu XL, Stephenson RA, Rohr LR, Yin X, Brothman AR (1998) Commonly occurring loss and mutation of the MXI1 gene in prostate cancer. Genes Chromosomes Cancer 22: 295-304.
80. Schreiber-Agus N, Meng Y, Hoang T, Hou H Jr, Chen K, Greenberg R, Cordon-Cardo C, Lee H-W, DePinho RA (1998) Role of Mxi1 in aging organ systems and the regulation of normal and neoplastic growth. Nature 393: 483-487.
81. Foley KP, McArthur GM, Queva C, Hurlin PJ, Spriano P, Eisenman RN (1998) Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation. EMBO J 17: 774-785.
82. Barone MV, Courtneidge SA (1995) Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src. Nature 378: 509-512.
83. Schreiber-Agus N, Stein D, Chen K, Goltz JS, Stevens L, DePinho RA (1997) Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype. Proc Natl Acad Sci USA 94: 1235-1240.
84. Gallant P, Shiio Y, Cheng PF, Parkhurst SM, Eisenman RN (1996) Myc and Max homologs in Drosophila. Science 274: 1523-1527.
85. Alexandrova N, Niklinski J, Bliskovsky V, Otterson GA, Blake M, Kaye FJ, Zajac-Kaye M (1995) The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro. Mol Cell Biol 15: 5188-5195.
86. Roy AL, Carruthers C, Gutjahr T, Roeder RG (1993) Direct role for Myc in transcription initiation mediated by interactions with TFII-I. Nature 365: 359-361.