The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling

Biochemistry and Cell Biology

Volumn 83, Issue 1, 2005, Pages 1-14

  Dunn, Katherine L ^a   Espino, Paula S ^a   Drobic, Bojan ^a   He, Shihua ^a   Davie, James R ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Breast cancer; Histone H3 phosphorylation; Mitogen activated protein kinase signal transduction pathway; MSK1; Ras

Indexed keywords

CYTOLOGY; ENZYMES; GENES; IMMUNOLOGY; TUMORS;

FIBROBLASTS; GENE EXPRESSION; PHOSPHORYLATION; RAS-MITOGEN-ACTIVATED PROTEIN KINASES (MAPK);

BIOCHEMISTRY;

ESTROGEN RECEPTOR; HISTONE H1; HISTONE H3; MITOGEN ACTIVATED PROTEIN KINASE; SERINE; STRESS ACTIVATED PROTEIN KINASE 1;

ANIMAL CELL; BREAST CANCER; CANCER; CELL TRANSFORMATION; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA METHYLATION; GENE EXPRESSION REGULATION; IMMEDIATE EARLY GENE; NONHUMAN; ONCOGENE C FOS; ONCOGENE C MYC; ONCOGENE RAS; PROTEIN PHOSPHORYLATION; SHORT SURVEY; SIGNAL TRANSDUCTION; TARGET CELL;

ANIMALS; CHROMATIN ASSEMBLY AND DISASSEMBLY; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASMS; PROTO-ONCOGENE PROTEINS P21(RAS); SIGNAL TRANSDUCTION;

EID: 18344390450     PISSN: 08298211     EISSN: None     Source Type: Journal    
DOI: 10.1139/o04-121     Document Type: Short Survey

References (117)

1. Abecassis, L., Rogier, E., Vazquez, A., Atfi, A., and Bourgeade, M.F. 2004. Evidence for a role of MSK1 in transforming growth factor-beta-mediated responses through p38alpha and Smad signaling pathways. J. Biol. Chem. 279: 30474-30479.
2. Adeyinka, A., Nui, Y., Cherlet, T., Snell, L., Watson, P.H., and Murphy, L.C. 2002. Activated mitogen-activated protein kinase expression during human breast tumorigenesis and breast cancer progression. Clin. Cancer Res. 8: 1747-1753.
3. Andreyev, H.J., Norman, A.R., Cunningham, D., Oates, J.R., and Clarke, P.A. 1998. Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study. J. Natl. Cancer Inst. 90: 675-684.
4. Arthur, J.S., and Cohen, P. 2000. MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells. FEBS Lett. 482: 44-48.
5. Arthur, J.S.C., Fong, A.L., Dwyer, J.M., Davare, M., Reese, E., Obrietan, K., and Impey, S. 2004. Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins. J. Neurosci. 24: 4324-41332.
6. Atanaskova, N., Keshamouni, V.G., Rrueger, J.S., Schwartz, J.A., Miller, F., and Reddy, K.B. 2002. MAP kinase/estrogen receptor cross-talk enhances estrogen-mediated signaling and tumor growth but does not confer tamoxifen resistance. Oncogene, 21: 4000-4008.
7. Baisch, H., Collard, J., Zywietz, R, and Jung, H. 1990. No acquisition of metastatic capacity of R1H rhabdomyosarcoma upon transfection with c-Ha-ras oncogene. Invasion Metastasis 10: 193-207.
8. Barbacid, M. 1987. ras genes. Annu. Rev. Biochem. 56: 779-827.
9. Barratt, M.J., Hazzalin, C.A., Cano, E., and Mahadevan, L.C. 1994a. Mitogen-stimulated phosphorylation of histone H3 is targeted to a small hyperacetylation-sensitive fraction. Proc. Natl. Acad. Sci. USA, 91: 4781-4785.
10. Barratt, M.J., Hazzalin, C.A., Zhelev, N., and Mahadevan, L.C. 1994b. A mitogen- and anisomycin-stimulated kinase phosphorylates HMG-14 in its basic amino-terminal domain in vivo and on isolated mononucleosomes. EMBO J. 13: 4524-4535.
11. Biscardi, J.S., Ishizawar, R.C., Silva, C.M., and Parsons, S.J. 2000. Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer. Breast Cancer Res. 2: 203-210.
12. Bos, J.L. 1989. ras oncogenes in human cancer: a review. Cancer Res. 49: 4682-4689.
13. Boulton, T.G., Nye, S.H., Robbins, D.J., Ip, N.Y., Radziejewska, E., Morgenbesser, S.D. et al. 1991. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell, 65: 663-675.
14. Brose, N., and Rosenmund, C. 2002. Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters. J. Cell Sci. 115: 4399-4411.
15. Bunone, G., Briand, P.A., Miksicek, R.J., and Picard, D. 1996. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J. 15: 2174-2183.
16. Caivano, M., and Cohen, P. 2000. Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1 beta in RAW264 macrophages. J. Immunol. 164: 3018-3025.
17. Calipel, A., Lefevre, G., Pouponnot, C., Mouriaux, F., Eychene, A., and Mascarelli, F. 2003. Mutation of B-Raf in human choroidal melanoma cells mediates cell proliferation and transformation through the MEK/ERK pathway. J. Biol. Chem. 278: 42409-42418.
18. Campbell, P.M., and Der, C.J. 2004. Oncogenic Ras and its role in tumor cell invasion and metastasis. Semin. Cancer Biol. 14: 105-114.
19. Chadee, D.N., Taylor, W.R., Hurta, R.A.R., Allis, C.D., Wright, J.A., and Davie, J.R. 1995. Increased phosphorylation of histone H1 in mouse fibroblasts transformed with oncogenes or constitutively active mitogen-activated protein kinase kinase. J. Biol. Chem. 270: 20098-20105.
20. Chadee, D.N., Allis, C.D., Wright, J.A., and Davie, J.R. 1997. Histone H1b phosphorylation is dependent upon ongoing transcription and replication in normal and ras-transformed mouse fibroblasts. J. Biol. Chem. 272: 8113-8116.
21. Chadee, D.N., Hendzel, M.J., Tylipski, C.P., Allis, C.D., Bazett-Jones, D.P., Wright, J.A., and Davie, J.R. 1999. Increased Ser-10 phosphorylation of histone H3 in mitogen-stimulated and oncogene - transformed mouse fibroblasts. J. Biol. Chem. 274: 24914-24920.
22. Chadee, D.N., Peltier, C.P., and Davie, J.R. 2002. Histone H1(S)-3 phosphorylation in Ha-ras oncogene-transformed mouse fibroblasts. Oncogene, 21: 8397-8403.
23. Chang, F., Steelman, L.S., Lee, J.T., Shelton, J.G., Navolanic, P.M., Blalock, W.L. et al. 2003. Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia, 17: 1263-1293.
24. Chen, H., Lin, R.J., Xie, W., Wilpitz, D., and Evans, R.M. 1999. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell, 98: 675-686.
25. Cheung, P., Tanner, K.G., Cheung, W.L., Sassone-Corsi, P., Denu, J.M., and Allis, C.D. 2000. Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation. Mol. Cell, 5: 905-915.
26. Clayton, A.L., and Mahadevan, L.C. 2003. MAP kinase-mediated phosphoacetylation of histone H3 and inducible gene regulation. FEBS Lett. 546: 51-58.
27. Clayton, A.L., Rose, S., Barratt, M.J., and Mahadevan, L.C. 2000. Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation. EMBO J. 19: 3714-3726.
28. Cooke, T. 2000. What is HER2? Eur. J. Oncol. Nurs. 4: 2-9.
29. Coutts, A.S., and Murphy, L.C. 1998. Elevated mitogen-activated protein kinase activity in estrogen- nonresponsive human breast cancer cells. Cancer Res. 58: 4071-4074.
30. Crosio, C., Cermakian, N., Allis, C.D., and Sassone-Corsi, P. 2000. Light induces chromatin modification in cells of the mammalian circadian clock. Nat. Neurosci. 3: 1241-1247.
31. Dalby, K.N., Morrice, N., Caudwell, F.B., Avruch, J., and Cohen, P. 1998. Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK. J. Biol. Chem. 273: 1496-1505.
32. Daujat, S., Bauer, U.M., Shah, V., Turner, B., Berger, S., and Kouzarides, T. 2002. Crosstalk between CARM1 methylation and CBP acetylation on histone H3. Curr. Biol. 12: 2090-2097.
33. Davie, J.R. 2003. MSK1 and MSK2 mediate mitogen- and stress-induced phosphorylation of histone H3: a controversy resolved. Sci. STKE, 2003: E33.
34. Davie, J.R., and Chadee, D.N. 1998. Regulation and regulatory parameters of histone modifications. J. Cell. Biochem. 30/31: 203-213.
35. Davie, J.R., Samuel, S.K., Spencer, V.A., Holth, L.T., Chadee, D.N., Peltier, C.P. et al. 1999. Organization of chromatin in cancer cells:role of signalling pathways. Biochem. Cell Biol. 77: 265-275.
36. Deak, M., Clifton, A.D., Lucocq, L.M., and Alessi, D.R. 1998. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. EMBO J. 17: 4426-4441.
37. Deblois, G., and Giguere, V. 2003. Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation. J. Steroid Biochem. Mol. Biol. 85: 123-131.
38. Dou, Y., Bowen, J., Liu, Y., and Gorovsky, M.A. 2002. Phosphorylation and an ATP-dependent process increase the dynamic exchange of H1 in chromatin. J. Cell Biol. 158: 1161-1170.
39. El Ashry, D., Miller, D.L., Kharbanda, S., Lippman, M.E., and Kern, F.G. 1997. Constitutive Raf-1 kinase activity in breast cancer cells induces both estrogen-independent growth and apoptosis. Oncogene, 15: 423-435.
40. Fearon, E.R., and Vogelstein, B. 1990. A genetic model for colorectal tumorigenesis. Cell, 61: 759-767.
41. Feldman, M., and Eisenbach, L. 1988. Genes controlling the metastatic phenotype. Cancer Surv. 7: 555-572.
42. Fischer, A.H., Chadee, D.N., Wright, J.A., Gansler, T.S., and Davie, J.R. 1998. Ras-associated nuclear structural change appears functionally significant and independent of the mitotic signaling pathway. J. Cell. Biochem. 70: 130-140.
43. Frodin, M., Antal, T.L., Dummler, B.A., Jensen, C.J., Deak, M., Gammeltoft, S., and Biondi, R.M. 2002. A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation. EMBO J. 21: 5396-5407.
44. Goto, H., Yasui, Y., Nigg, E.A., and Inagaki, M. 2002. Aurora-B phosphorylates histone H3 at serine28 with regard to the mitotic chromosome condensation. Genes Cells, 7: 11-17.
45. Hamelers, I.H., and Steenbergh, P.H. 2003. Interactions between estrogen and insulin-like growth factor signaling pathways in human breast tumor cells. Endocr. Relat. Cancer, 10: 331-345.
46. Harari, D., and Yarden, Y. 2000. Molecular mechanisms underlying ErbB2/HER2 action in breast cancer. Oncogene, 19: 6102-6114.
47. Hazzalin, C.A., and Mahadevan, L.C. 2002. MAPK-regulated transcription: a continuously variable gene switch? Nat. Rev. Mol. Cell Biol. 3: 30-40.
48. Hendzel, M.J., and Davie, J.R. 1990. Nucleosomal histones of transcriptionally active/competent chromatin preferentially exchange with newly synthesized histones in quiescent chicken erythrocytes. Biochem. J. 271: 67-73.
49. Herrera, R.E., Chen, F., and Weinberg, R.A. 1996. Increased histone H1 phosphorylation and relaxed chromatin structure in Rb-deficient fibroblasts. Proc. Natl. Acad. Sci. USA, 93: 11510-11515.
50. Hill, C.S., Rimmer, J.M., Green, B.N., Finch, J.T., and Thomas, J.O. 1991. Histone-DNA interactions and their modulation by phosphorylation of -Ser-Pro-X-Lys/Arg- motifs. EMBO J. 10: 1939-1948.
51. Horn, P.J., Carruthers, L.M., Logie, C., Hill, D.A., Solomon, M.J., Wade, P.A. et al. 2002. Phosphorylation of linker histones regulates ATP-dependent chromatin remodeling enzymes. Nat. Struct. Biol. 9: 263-267.
52. Hoshino, R., Chatani, Y., Yamori, T., Tsuruo, T., Oka, H., Yoshida, O. et al. 1999. Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors. Oncogene, 18: 813-822.
53. Iyer, V.R., Eisen, M.B., Ross, D.T., Schuler, G., Moore, T., Lee, J.C.F. et al. 1999. The transcriptional program in the response of human fibroblasts to serum. Science, 283: 83-87.
54. Janes, P.W., Daly, R.J., deFazio, A., and Sutherland, R.L. 1994. Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2. Oncogene, 9: 3601-3608.
55. Janknecht, R. 2003. Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1). Oncogene, 22: 746-755.
56. Joel, P.B., Traish, A.M., and Lannigan, D.A. 1995. Estradiol and phorbol ester cause phosphorylation of serine 118 in the human estrogen receptor. Mol. Endocrinol. 9: 1041-1052.
57. Joel, P.B., Traish, A.M., and Lannigan, D.A. 1998. Estradiol-induced phosphorylation of serine 118 in the estrogen receptor is independent of p42/p44 mitogen-activated protein kinase. J. Biol. Chem. 273: 13317-13323.
58. Kaplan, L.J., Bauer, R., Morrison, E., Langan, T.A., and Fasman, G.D. 1984. The structure of chromatin reconstituted with phosphorylated H1. Circular dichroism and thermal denaturation studies. J. Biol. Chem. 259: 8777-8785.
59. Kasid, A., Lippman, M.E., Papageorge, A.G., Lowy, D.R., and Gelmann, E.P. 1985. Transfection of v-rasH DNA into MCF-7 human breast cancer cells bypasses dependence on estrogen for tumorigenicity. Science, 228: 725-728.
60. Kato, S., Endoh, H., Masuhiro, Y., Kitamoto, T., Uchiyama, S., Sasaki, H. et al. 1995. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein-kinase. Science, 270: 1491-1494.
61. Kazanietz, M.G. 2000. Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters. Mol. Carcinog. 28: 5-11.
62. Kireeva, M.L., Walter, W., Tchernajenko, V., Bondarenko, V., Kashlev, M., and Studitsky, V.M. 2002. Nucleosome remodeling induced by RNA polymerase II. Loss of the H2A/H2B dimer during transcription. Mol. Cell, 9: 541-552.
63. Laitinen, J., Sistonen, L., Alitalo, K., and Holtta, E. 1990. c-Ha-ras (val 12) oncogene-transformed NIH-3T3 fibroblasts display more decondensed nucleosomal organization than normal fibroblasts. J. Cell Biol. 111: 9-17.
64. Laitinen, J., Saris, P., and Holtta, E. 1995. DNA methylation is not involved in the structural alterations of ornithine decarboxylase or total chromatin of c-Ha-rasVal 12 oncogene-transformed NIH-3T3 fibroblasts. J. Cell. Biochem. 57: 670-679.
65. Le Goff, P., Montano, M.M., Schodin, D.J., and Katzenellenbogen, B.S. 1994. Phosphorylation of the human estrogen receptor. Identification of hormone-regulated sites and examination of their influence on transcriptional activity. J. Biol. Chem. 269: 4458-4466.
66. Lechner, S., Muller-Ladner, U., Renke, B., Scholmerich, J., Ruschoff, J., and Kullmann, F. 2003. Gene expression pattern of laser microdissected colonic crypts of adenomas with low grade dysplasia. Gut, 52: 1148-1153.
67. Lefebvre, B., Ozato, K., and Lefebvre, P. 2002. Phosphorylation of histone H3 is functionally linked to retinoic acid receptor beta promoter activation. EMBO Rep. 3: 335-340.
68. Lever, M.A., Th'ng, J.P., Sun, X., and Hendzel, M.J. 2000. Rapid exchange of histone H1.1 on chromatin in living human cells. Nature, 408: 873-876.
69. Li, Y., Sassano, A., Majchrzak, B., Deb, D.K., Levy, D.E., Gaestel, M. et al. 2004. Role of p38alpha Map kinase in Type I interferon signaling. J. Biol. Chem. 279: 970-979.
70. Lim, J.H., Catez, F., Birger, Y., West, K.L., Prymakowska-Bosak, M., Postnikov, Y.V., and Bustin, M. 2004. Chromosomal protein HMGN1 modulates histone H3 phosphorylation. Mol. Cell, 15: 573-584.
71. Liu, G., Zhang, Y., Bode, A.M., Ma, W.Y., and Dong, Z. 2002. Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation. J. Biol. Chem. 277: 8810-8816.
72. Lu, Q., Ebling, H., Mittler, J., Baur, W.E., and Karas, R.H. 2002. MAP kinase mediates growth factor-induced nuclear translocation of estrogen receptor alpha. FEBS Lett. 516: 1-8.
73. Mahadevan, L.C., Willis, A.C., and Barratt, M.J. 1991. Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors. Cell, 65: 775-783.
74. Malaney, S., and Daly, R.J. 2001. The ras signaling pathway in mammary tumorigenesis and metastasis. J. Mammary Gland Biol. Neoplasia, 6: 101-113.
75. Metivier, R., Penot, G., Hubner, M.R., Reid, G., Brand, H., Kos, M., and Gannon, F. 2003. Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell, 115: 751-763.
76. Migliaccio, A., DiDomenico, M., Castoria, G., deFalco, A., Bontempo, P., Nola, E., and Auricchio, F. 1996. Tyrosine kinase/p21(ras)/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells. EMBO J. 15: 1292-1300.
77. Migliaccio, A., Piccolo, D., Castoria, G., Di Domenico, M., Bilancio, A., Lombardi, M. et al. 1998. Activation of the Src/p21(ras)/Erk pathway by progesterone receptor via cross-talk with estrogen receptor. EMBO J. 17: 2008-2018.
78. Mishra, S.K., Mandal, M., Mazumdar, A., and Kumar, R. 2001. Dynamic chromatin remodeling on the HER2 promoter in human breast cancer cells. FEBS Lett. 507: 88-94.
79. Muschel, R.J., Williams, J.E., Lowy, D.R., and Liotta, L.A. 1985. Harvey ras induction of metastatic potential depends upon oncogene activation and the type of recipient cell. Am. J. Pathol. 121: 1-8.
80. Nomura, M., Kaji, A., Ma, W.Y., Zhong, S., Liu, G., Bowden, G.T., Miyamoto, K.I., and Dong, Z. 2001. Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation. J. Biol. Chem. 276: 25558-25567.
81. Oh, A.S., Lorant, L.A., Holloway, J.N., Miller, D.L., Kern, F.G., and El Ashry, D. 2001. Hyperactivation of MAPK induces loss of ERalpha expression in breast cancer cells. Mol. Endocrinol. 15: 1344-1359.
82. Price, J.E., Aukerman, S.L., Ananthaswamy, H.N., McIntyre, B.W., Schackert, G., Schackert, H.K., and Fidler, I.J. 1989. Metastatic potential of cloned murine melanoma cells transfected with activated c-Ha-ras. Cancer Res. 49: 4274-4281.
83. Richmond, T.J., Finch, J.T., Rushton, B., Rhodes, D., and Klug, A. 1984. Structure of the nucleosome core particle at 7 A resolution. Nature, 311: 532-537.
84. Roth, S.Y., and Allis, C.D. 1992. Chromatin condensation: does histone H1 dephosphorylation play a role? Trends Biochem. Sci. 17: 93-98.
85. Samuel, S.K., Minish, T.M., and Davie, J.R. 1997. Altered nuclear matrix protein profiles in oncogene transformed fibroblasts exhibiting high metastatic potential. Cancer Res. 57: 147-151.
86. Santen, R.J., Song, R.X., McPherson, R., Kumar, R., Adam, L., Jeng, M.H., and Yue, W. 2002. The role of mitogen-activated protein (MAP) kinase in breast cancer. J. Steroid Biochem. Mol. Biol. 80: 239-256.
87. Sassone-Corsi, P., Mizzen, C.A., Cheung, P., Crosio, C., Monaco, L., Jacquot, S. et al. 1999. Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3. Science, 285: 886-891.
88. Schuck, S., Soloaga, A., Schratt, G., Arthur, J.S., and Nordheim, A. 2003. The kinase MSK1 is required for induction of c-fos by lysophosphatidic acid in mouse embryonic stem cells. BMC. Mol. Biol. 4: 6.
89. Shang, Y., Hu, X., DiRenzo, J., Lazar, M.A., and Brown, M. 2000. Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell, 103: 843-852.
90. She, Q.B., Ma, W.Y., Zhong, S., and Dong, Z. 2002. Activation of JNK1, RSK2, and MSK1 is involved in serine 112 phosphorylation of Bad by ultraviolet B radiation. J. Biol. Chem. 277: 24039-24048.
91. Sheeler, C.Q., Singleton, D.W., and Khan, S.A. 2003. Mutation of serines 104, 106, and 118 inhibits dimerization of the human estrogen receptor in yeast. Endocr. Res. 29: 237-255.
92. Sivaraman, V.S., Wang, H., Nuovo, G.J., and Malbon, C.C. 1997. Hyperexpression of mitogen-activated protein kinase in human breast cancer. J. Clin. Investig. 99: 1478-1483.
93. Soloaga, A., Thomson, S., Wiggin, G.R., Rampersaud, N., Dyson, M.H., Hazzalin, C. A. et al. 2003. MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. EMBO J. 22: 2788-2797.
94. Song, R.X.D., McPherson, R.A., Adam, L., Bao, Y.D., Shupnik, M., Kumar, R., and Santen, R.J. 2002. Linkage of rapid estrogen action to MAPK activation by ER alpha-Shc association and She pathway activation. Mol. Endocrinol. 16: 116-127.
95. Spencer, V.A., and Davie, J.R. 2002. Isolation of proteins cross-linked to DNA by formaldehyde. In The Proteins Protocol Handbook. Edited by J.M. Walker. Humana Press, Totowa, NJ. pp. 753-757.
96. Strelkov, I.S., and Davie, J.R. 2002. Ser-10 phosphorylation of histone H3 and immediate early gene expression in oncogene-transformed mouse fibroblasts. Cancer Res. 62: 75-78.
97. Surmacz, E. 2000. Function of the IGF-I receptor in breast cancer. J. Mammary Gland Biol. Neoplasia 5: 95-105.
98. Taylor, W.R., Chadee, D.M., Allis, C.D., Wright, J.A., and Davie, J.R. 1995. Fibroblasts transformed by combinations of ras, myc and mutant p53 exhibit increased phosphorylation of histone H1 that is independent of metastatic potential. FEBS Lett. 377: 51-53.
99. Thomson, S., Clayton, A.L., Hazzalin, C.A., Rose, S., Barratt, M.J., and Mahadevan, L.C. 1999. The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase. EMBO J. 18: 4779-4793.
100. Thomson, S., Clayton, A.L., and Mahadevan, L.C. 2001. Independent dynamic regulation of histone phosphorylation and acetylation during immediate-early gene induction. Mol. Cell, 8: 1231-1241.
101. Thomson, S., Hollis, A., Hazzalin, C.A., and Mahadevan, L.C. 2004. Distinct stimulus-specific histone modifications at hsp70 chromatin targeted by the transcription factor heat shock factor-1. Mol. Cell, 15: 585-594.
102. Tsunokawa, Y., Esumi, H., Sasaki, M.S., Mori, M., Sakamoto, H., Terada, M., and Sugimura, T. 1984. Integration of v-rasH does not necessarily transform an immortalized murine cell line. Gann, 75: 732-736.
103. Tuck, A.B., Wilson, S.M., and Chambers, A.F. 1990. ras transfection and expression does not induce progression from tumorigenicity to metastatic ability in mouse LTA cells. Clin. Exp. Metastasis, 8: 417-431.
104. Tuck, A.B., Wilson, S.M., Khokha, R., and Chambers, A.F. 1991. Different patterns of gene expression in ras-resistant and ras- sensitive cells. J. Natl. Cancer Inst. 83: 485-491.
105. Vermeulen, L., De Wilde, G., Van Damme, P., Vanden Berghe, W., and Haegeman, G. 2003. Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). EMBO J. 22: 1313-1324.
106. Vik, T.A., and Ryder, J.W. 1997. Identification of serine 380 as the major site of autophosphorylation of Xenopus pp90rsk. Biochem. Biophys. Res. Commun. 235: 398-402.
107. Wierenga, A.T., Vogelzang, I., Eggen, B.J., and Vellenga, E. 2003. Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway. Exp. Hematol. 31: 398-405.
108. Wiggin, G.R., Soloaga, A., Foster, J.M., Murray-Tail, V., Cohen, P., and Arthur, J.S. 2002. MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Mol. Cell Biol. 22: 2871-2881.
109. Workman, J.L., and Abmayr, S.M. 2004. Histone H3 variants and modifications on transcribed genes. Proc. Natl. Acad. Sci. USA, 101: 1429-1430.
110. Xing, C., and Imagawa, W. 1999. Altered MAP kinase (ERK1,2) regulation in primary cultures of mammary tumor cells: elevated basal activity and sustained response to EGF. Carcinogenesis, 20: 1201-1208.
111. Xu, X., Murdoch, F.E., Curran, E.M., Welshons, W.V., and Fritsch, M.K. 2004. Transcription factor accessibility and histone acetylation of the progesterone receptor gene differs between parental MCF-7 cells and a subline that has lost progesterone receptor expression. Gene, 328: 143-151.
112. Yue, W., Wang, J.P., Conaway, M., Masamura, S., Li, Y.B., and Santen, R.J. 2002. Activation of the MAPK pathway enhances sensitivity of MCF-7 breast cancer cells to the mitogenic effect of estradiol. Endocrinology, 143: 3221-3229.
113. Zhang, Y., Liu, G., and Dong, Z. 2001. MSK1 and JNKs mediate phosphorylation of STATS in UVA-irradiated mouse epidermal JB6 cells. J. Biol. Chem. 276: 42534-42542.
114. Zhong, S., Jansen, C., She, Q.B., Goto, H., Inagaki, M., Bode, A.M., et al. 2001a. Ultraviolet B-induced phosphorylation of histone H3 at serine 28 is mediated by MSK1. J. Biol. Chem. 276: 33213-33219.
115. Zhong, S., Zhang, Y., Jansen, C., Goto, H., Inagaki, M., and Dong, Z. 2001b. MAP kinases mediate UVB-induced phosphorylation of histone H3 at serine 28. J. Biol. Chem. 276: 12932-12937.
116. Zink, D., Fische, A.H., and Nickerson, J.A. 2004. Nuclear structure in cancer cells. Nat. Rev. Cancer, 4: 677-687.
117. Zlatanova, J., Leuba, S.H., and Van Holde, K. 1998. Chromatin fiber structure: morphology, molecular determinants, structural transitions. Biophys. J. 74: 2554-2566.