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Volumn 72, Issue 3, 2005, Pages 313-330

Molecular pathology of non-small-cell lung cancer

Author keywords

Carcinogenesis; Lung cancer; Molecular pathology; Non small cell lung cancer; Oncogenes; Tumor suppressor genes

Indexed keywords

BETA CATENIN; CELL NUCLEUS RECEPTOR; CYCLIN D; CYCLIN DEPENDENT KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FRAGILE HISTIDINE TRIAD PROTEIN; K RAS PROTEIN; PROSTAGLANDIN SYNTHASE; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P16; PROTEIN P53; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; SEMAPHORIN; SEMAPHORIN 3F; SURVIVIN; TELOMERASE; UNCLASSIFIED DRUG; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN;

EID: 22144447535     PISSN: 00257931     EISSN: None     Source Type: Journal    
DOI: 10.1159/000085376     Document Type: Review
Times cited : (54)

References (198)
  • 3
    • 0042590987 scopus 로고    scopus 로고
    • The changing epidemiology of lung cancer in Europe
    • Janssen-Heijnen ML, Coebergh JW: The changing epidemiology of lung cancer in Europe. Lung Cancer 2003;41:245-258.
    • (2003) Lung Cancer , vol.41 , pp. 245-258
    • Janssen-Heijnen, M.L.1    Coebergh, J.W.2
  • 4
    • 0018343201 scopus 로고
    • Changes in bronchial epithelium in relation to cigarette smoking, 1955-1960 vs. 1970-1977
    • Auerbach O, Hammond EC, Garfinkel L: Changes in bronchial epithelium in relation to cigarette smoking, 1955-1960 vs. 1970-1977. N Engl J Med 1979;300:381-385.
    • (1979) N Engl J Med , vol.300 , pp. 381-385
    • Auerbach, O.1    Hammond, E.C.2    Garfinkel, L.3
  • 5
    • 0035870243 scopus 로고    scopus 로고
    • A mutator phenotype in cancer
    • Loeb LA: A mutator phenotype in cancer. Cancer Res 2001;61:3230-3239.
    • (2001) Cancer Res , vol.61 , pp. 3230-3239
    • Loeb, L.A.1
  • 6
    • 0035866383 scopus 로고    scopus 로고
    • Sensitivity to DNA damage induced by benzo(a)pyrene diol epoxide and risk of lung cancer: A case-control analysis
    • Li D, Firozi PF, Wang LE, Bosken CH, Spitz MR, Hong WK, Wei Q: Sensitivity to DNA damage induced by benzo(a)pyrene diol epoxide and risk of lung cancer: A case-control analysis. Cancer Res 2001;61:1445-1450.
    • (2001) Cancer Res , vol.61 , pp. 1445-1450
    • Li, D.1    Firozi, P.F.2    Wang, L.E.3    Bosken, C.H.4    Spitz, M.R.5    Hong, W.K.6    Wei, Q.7
  • 8
    • 0029832418 scopus 로고    scopus 로고
    • Reduced DNA repair capacity in lung cancer patients
    • Wei Q, Cheng L, Hong WK, Spitz MR: Reduced DNA repair capacity in lung cancer patients. Cancer Res 1996;56:4103-4107.
    • (1996) Cancer Res , vol.56 , pp. 4103-4107
    • Wei, Q.1    Cheng, L.2    Hong, W.K.3    Spitz, M.R.4
  • 9
    • 0034332586 scopus 로고    scopus 로고
    • Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: A molecular epidemiologic study
    • Wei Q, Cheng L, Amos CI, Wang LE, Guo Z, Hong WK, et al: Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: A molecular epidemiologic study. J Natl Cancer Inst 2000;92:1764-1772.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1764-1772
    • Wei, Q.1    Cheng, L.2    Amos, C.I.3    Wang, L.E.4    Guo, Z.5    Hong, W.K.6
  • 10
    • 0032530875 scopus 로고    scopus 로고
    • A parallel study of in vitro sensitivity to benzo[a]pyrene diol epoxide and bleomycin in lung carcinoma cases and controls
    • Wu X, Gu J, Amos CI, Jiang H, Hong WK, Spitz MR: A parallel study of in vitro sensitivity to benzo[a]pyrene diol epoxide and bleomycin in lung carcinoma cases and controls. Cancer 1998;83:1118-1127.
    • (1998) Cancer , vol.83 , pp. 1118-1127
    • Wu, X.1    Gu, J.2    Amos, C.I.3    Jiang, H.4    Hong, W.K.5    Spitz, M.R.6
  • 11
    • 0036333198 scopus 로고    scopus 로고
    • Cigarette smoking and lung cancer: Chemical mechanisms and approaches to prevention
    • Hecht SS: Cigarette smoking and lung cancer: Chemical mechanisms and approaches to prevention. Lancet Oncol 2002;3:461-469.
    • (2002) Lancet Oncol , vol.3 , pp. 461-469
    • Hecht, S.S.1
  • 12
    • 0034070148 scopus 로고    scopus 로고
    • CYP1A1 polymorphisms and lung cancer risk: A meta-analysis
    • Houlston RS: CYP1A1 polymorphisms and lung cancer risk: A meta-analysis. Pharmacogenetics 2000;10:105-114.
    • (2000) Pharmacogenetics , vol.10 , pp. 105-114
    • Houlston, R.S.1
  • 13
    • 0033394788 scopus 로고    scopus 로고
    • Glutathione S-transferase M1 status and lung cancer risk: A meta-analysis
    • Houlston RS: Glutathione S-transferase M1 status and lung cancer risk: A meta-analysis. Cancer Epidemiol Biomarkers Prev 1999;8:675-682.
    • (1999) Cancer Epidemiol Biomarkers Prev , vol.8 , pp. 675-682
    • Houlston, R.S.1
  • 14
    • 0034111458 scopus 로고    scopus 로고
    • Correlation of genetic instability with mismatch repair protein expression and p53 mutations in non-small cell lung cancer
    • Chang JW, Chen YC, Chen CY, Chen JT, Chen SK, Wang YC: Correlation of genetic instability with mismatch repair protein expression and p53 mutations in non-small cell lung cancer. Clin Cancer Res 2000;6:1639-1646.
    • (2000) Clin Cancer Res , vol.6 , pp. 1639-1646
    • Chang, J.W.1    Chen, Y.C.2    Chen, C.Y.3    Chen, J.T.4    Chen, S.K.5    Wang, Y.C.6
  • 15
    • 0027140481 scopus 로고
    • Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome
    • Peltomaki P, Lothe RA, Aaltonen LA, Pylkkanen L, Nystrom-Lahti M, Seruca R, et al: Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome. Cancer Res 1993;53:5853-5855.
    • (1993) Cancer Res , vol.53 , pp. 5853-5855
    • Peltomaki, P.1    Lothe, R.A.2    Aaltonen, L.A.3    Pylkkanen, L.4    Nystrom-Lahti, M.5    Seruca, R.6
  • 17
    • 8544278896 scopus 로고    scopus 로고
    • Reduced survival in patients with stage-I non-small-cell lung cancer associated with DNA-replication errors
    • Rosell R, Pifarre A, Monzo M, Astudillo J, Lopez-Cabrerizo MP, Calvo R, et al: Reduced survival in patients with stage-I non-small-cell lung cancer associated with DNA-replication errors. Int J Cancer 1997;74:330-334.
    • (1997) Int J Cancer , vol.74 , pp. 330-334
    • Rosell, R.1    Pifarre, A.2    Monzo, M.3    Astudillo, J.4    Lopez-Cabrerizo, M.P.5    Calvo, R.6
  • 18
    • 0029920052 scopus 로고    scopus 로고
    • Microsatellite alterations in bronchial and sputum specimens of lung cancer patients
    • Miozzo M, Sozzi G, Musso K, Pilotti S, Incarbone M, Pastorino U, et al: Microsatellite alterations in bronchial and sputum specimens of lung cancer patients. Cancer Res 1996;56:2285-2288.
    • (1996) Cancer Res , vol.56 , pp. 2285-2288
    • Miozzo, M.1    Sozzi, G.2    Musso, K.3    Pilotti, S.4    Incarbone, M.5    Pastorino, U.6
  • 19
    • 0023637278 scopus 로고
    • Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer
    • Kok K, Osinga J, Carritt B, Davis MB, van der Hout AH, van der Veen AY, et al: Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer. Nature 1987;330:578-581.
    • (1987) Nature , vol.330 , pp. 578-581
    • Kok, K.1    Osinga, J.2    Carritt, B.3    Davis, M.B.4    Van Der Hout, A.H.5    Van Der Veen, A.Y.6
  • 21
    • 0033590626 scopus 로고    scopus 로고
    • Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma
    • Wistuba II, Behrens C, Milchgrub S, Bryant D, Hung J, Minna JD, et al: Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma. Oncogene 1999;18:643-650.
    • (1999) Oncogene , vol.18 , pp. 643-650
    • Wistuba II1    Behrens, C.2    Milchgrub, S.3    Bryant, D.4    Hung, J.5    Minna, J.D.6
  • 22
    • 19244370711 scopus 로고    scopus 로고
    • High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints
    • Wistuba II, Behrens C, Virmani AK, Mele G, Milchgrub S, Girard L, et al: High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints. Cancer Res 2000;60:1949-1960.
    • (2000) Cancer Res , vol.60 , pp. 1949-1960
    • Wistuba II1    Behrens, C.2    Virmani, A.K.3    Mele, G.4    Milchgrub, S.5    Girard, L.6
  • 23
    • 0028234984 scopus 로고
    • Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines
    • Sekido Y, Bader S, Latif F, Gnarra JR, Gazdar AF, Linehan WM, et al: Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines. Oncogene 1994;9:1599-1604.
    • (1994) Oncogene , vol.9 , pp. 1599-1604
    • Sekido, Y.1    Bader, S.2    Latif, F.3    Gnarra, J.R.4    Gazdar, A.F.5    Linehan, W.M.6
  • 25
    • 0024383637 scopus 로고
    • The ninth Gordon Hamilton-Fairley memorial lecture. Hereditary cancers: Clues to mechanisms of carcinogenesis
    • Knudson AG Jr: The ninth Gordon Hamilton-Fairley memorial lecture. Hereditary cancers: Clues to mechanisms of carcinogenesis. Br J Cancer 1989;59:661-666.
    • (1989) Br J Cancer , vol.59 , pp. 661-666
    • Knudson Jr., A.G.1
  • 26
    • 0032549704 scopus 로고    scopus 로고
    • The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
    • Pomerantz J, Schreiber-Agus N, Liegeois NJ, Silverman A, Alland L, Chin L, et al: The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 1998;92:713-723.
    • (1998) Cell , vol.92 , pp. 713-723
    • Pomerantz, J.1    Schreiber-Agus, N.2    Liegeois, N.J.3    Silverman, A.4    Alland, L.5    Chin, L.6
  • 27
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang Y, Xiong Y, Yarbrough WG: ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 1998;92:725-734.
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3
  • 30
    • 0037220167 scopus 로고    scopus 로고
    • The TP53 gene, tobacco exposure, and lung cancer
    • Toyooka S, Tsuda T, Gazdar AF: The TP53 gene, tobacco exposure, and lung cancer. Hum Mutat 2003;21:229-239.
    • (2003) Hum Mutat , vol.21 , pp. 229-239
    • Toyooka, S.1    Tsuda, T.2    Gazdar, A.F.3
  • 32
    • 0030029722 scopus 로고    scopus 로고
    • P53 in squamous metaplasia: A marker for risk of respiratory tract carcinoma
    • Boers JE, ten Velde GP, Thunnissen FB: P53 in squamous metaplasia: A marker for risk of respiratory tract carcinoma. Am J Respir Crit Care Med 1996;153:411-416.
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 411-416
    • Boers, J.E.1    Ten Velde, G.P.2    Thunnissen, F.B.3
  • 33
    • 0031800307 scopus 로고    scopus 로고
    • p53 mutant immunophenotype and deregulation of p53 transcription pathway (Bcl2, Bax, and Waf1) in precursor bronchial lesions of lung cancer
    • Brambilla E, Gazzeri S, Lantuejoul S, Coll JL, Moro D, Negoescu A, et al: p53 mutant immunophenotype and deregulation of p53 transcription pathway (Bcl2, Bax, and Waf1) in precursor bronchial lesions of lung cancer. Clin Cancer Res 1998;4:1609-1618.
    • (1998) Clin Cancer Res , vol.4 , pp. 1609-1618
    • Brambilla, E.1    Gazzeri, S.2    Lantuejoul, S.3    Coll, J.L.4    Moro, D.5    Negoescu, A.6
  • 34
    • 12444343724 scopus 로고    scopus 로고
    • Suprabasal p53 immunostaining in premalignant endobronchial lesions in combination with histology is associated with bronchial cancer
    • Breuer RH, Snijders PJ, Sutedja TG, Linden H, Risse EK, Meijer CJ, et al: Suprabasal p53 immunostaining in premalignant endobronchial lesions in combination with histology is associated with bronchial cancer. Lung Cancer 2003;40:165-172.
    • (2003) Lung Cancer , vol.40 , pp. 165-172
    • Breuer, R.H.1    Snijders, P.J.2    Sutedja, T.G.3    Linden, H.4    Risse, E.K.5    Meijer, C.J.6
  • 35
    • 0028149709 scopus 로고
    • Human non-small cell lung cancer: p53 protein accumulation is an early event and persists during metastatic progression
    • Fontanini G, Vignati S, Bigini D, Merlo GR, Ribecchini A, Angeletti CA, et al: Human non-small cell lung cancer: p53 protein accumulation is an early event and persists during metastatic progression. J Pathol 1994;174:23-31.
    • (1994) J Pathol , vol.174 , pp. 23-31
    • Fontanini, G.1    Vignati, S.2    Bigini, D.3    Merlo, G.R.4    Ribecchini, A.5    Angeletti, C.A.6
  • 36
    • 0037838562 scopus 로고    scopus 로고
    • Value of immunohistochemical markers in preinvasive bronchial lesions in risk assessment of lung cancer
    • Jeanmart M, Lantuejoul S, Fievet F, Moro D, Sturm N, Brambilla C, et al: Value of immunohistochemical markers in preinvasive bronchial lesions in risk assessment of lung cancer. Clin Cancer Res 2003;9:2195-2203.
    • (2003) Clin Cancer Res , vol.9 , pp. 2195-2203
    • Jeanmart, M.1    Lantuejoul, S.2    Fievet, F.3    Moro, D.4    Sturm, N.5    Brambilla, C.6
  • 37
    • 0032950037 scopus 로고    scopus 로고
    • p53 mutation and allelic loss of chromosome 3p, 9p of preneoplastic lesions in patients with nonsmall cell lung carcinoma
    • Kohno H, Hiroshima K, Toyozaki T, Fujisawa T, Ohwada H: p53 mutation and allelic loss of chromosome 3p, 9p of preneoplastic lesions in patients with nonsmall cell lung carcinoma. Cancer 1999;85:341-347.
    • (1999) Cancer , vol.85 , pp. 341-347
    • Kohno, H.1    Hiroshima, K.2    Toyozaki, T.3    Fujisawa, T.4    Ohwada, H.5
  • 38
    • 0028361705 scopus 로고
    • c-k-ras and p53 mutations occur very early in adenocarcinoma of the lung
    • Li ZH, Zheng J, Weiss LM, Shibata D: c-k-ras and p53 mutations occur very early in adenocarcinoma of the lung. Am J Pathol 1994;144: 303-309.
    • (1994) Am J Pathol , vol.144 , pp. 303-309
    • Li, Z.H.1    Zheng, J.2    Weiss, L.M.3    Shibata, D.4
  • 39
    • 0343775767 scopus 로고    scopus 로고
    • p53 immunohistochemistry can identify bronchial dysplastic lesions proceeding to lung cancer: A prospective study
    • Ponticiello A, Barra E, Giani U, Bocchino M, Sanduzzi A: p53 immunohistochemistry can identify bronchial dysplastic lesions proceeding to lung cancer: A prospective study. Eur Respir J 2000;15:547-552.
    • (2000) Eur Respir J , vol.15 , pp. 547-552
    • Ponticiello, A.1    Barra, E.2    Giani, U.3    Bocchino, M.4    Sanduzzi, A.5
  • 40
    • 0028913802 scopus 로고
    • Aberrant expression of p53 or the epidermal growth factor receptor is frequent in early bronchial neoplasia and coexpression precedes squamous cell carcinoma development
    • Rusch V, Klimstra D, Linkov I, Dmitrovsky E: Aberrant expression of p53 or the epidermal growth factor receptor is frequent in early bronchial neoplasia and coexpression precedes squamous cell carcinoma development. Cancer Res 1995;55:1365-1372.
    • (1995) Cancer Res , vol.55 , pp. 1365-1372
    • Rusch, V.1    Klimstra, D.2    Linkov, I.3    Dmitrovsky, E.4
  • 42
    • 11944271246 scopus 로고
    • p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus
    • Sundaresan V, Ganly P, Hasleton P, Rudd R, Sinha G, Bleehen NM, et al: p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus. Oncogene 1992;7:1989-1997.
    • (1992) Oncogene , vol.7 , pp. 1989-1997
    • Sundaresan, V.1    Ganly, P.2    Hasleton, P.3    Rudd, R.4    Sinha, G.5    Bleehen, N.M.6
  • 43
    • 0029340730 scopus 로고
    • Human non-small cell lung cancer: p53 protein accumulation is an early event and persists during metastatic progression
    • Walker C, Dixon GR, Myskow M: Human non-small cell lung cancer: p53 protein accumulation is an early event and persists during metastatic progression. J Pathol 1995;176:319-320.
    • (1995) J Pathol , vol.176 , pp. 319-320
    • Walker, C.1    Dixon, G.R.2    Myskow, M.3
  • 44
    • 0028063159 scopus 로고
    • Patterns of p53 mutations in squamous cell carcinoma of the lung. Acquisition at a relatively early age
    • Zheng J, Shu Q, Li ZH, Tsao JI, Weiss LM, Shibata D: Patterns of p53 mutations in squamous cell carcinoma of the lung. Acquisition at a relatively early age. Am J Pathol 1994;145:1444-1449.
    • (1994) Am J Pathol , vol.145 , pp. 1444-1449
    • Zheng, J.1    Shu, Q.2    Li, Z.H.3    Tsao, J.I.4    Weiss, L.M.5    Shibata, D.6
  • 45
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano M, Hannon GJ, Beach D: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993;366:704-707.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 46
  • 47
    • 0027214544 scopus 로고
    • Inactivation of the retinoblastoma susceptibility gene in non-small-cell lung cancer
    • The Lung Cancer Study Group
    • Reissmann PT, Koga H, Takahashi R, Figlin RA, Holmes EC, Piantadosi S, et al: Inactivation of the retinoblastoma susceptibility gene in non-small-cell lung cancer. The Lung Cancer Study Group. Oncogene 1993;8:1913-1919.
    • (1993) Oncogene , vol.8 , pp. 1913-1919
    • Reissmann, P.T.1    Koga, H.2    Takahashi, R.3    Figlin, R.A.4    Holmes, E.C.5    Piantadosi, S.6
  • 49
  • 51
    • 0032786446 scopus 로고    scopus 로고
    • Alterations of expression of Rb, p16(INK4A) and cyclin D1 in non-small cell lung carcinoma and their clinical significance
    • Brambilla E, Moro D, Gazzeri S, Brambilla C: Alterations of expression of Rb, p16(INK4A) and cyclin D1 in non-small cell lung carcinoma and their clinical significance. J Pathol 1999;188:351-360.
    • (1999) J Pathol , vol.188 , pp. 351-360
    • Brambilla, E.1    Moro, D.2    Gazzeri, S.3    Brambilla, C.4
  • 52
    • 0034666334 scopus 로고    scopus 로고
    • Differential frequen-cies of p16(INK4a) promoter hypermethylation, p53 mutation, and K-ras mutation in exfoliative material mark the development of lung cancer in symptomatic chronic smokers
    • Kersting M, Friedl C, Kraus A, Behn M, Pankow W, Schuermann M: Differential frequen-cies of p16(INK4a) promoter hypermethylation, p53 mutation, and K-ras mutation in exfoliative material mark the development of lung cancer in symptomatic chronic smokers. J Clin Oncol 2000;18:3221-3229.
    • (2000) J Clin Oncol , vol.18 , pp. 3221-3229
    • Kersting, M.1    Friedl, C.2    Kraus, A.3    Behn, M.4    Pankow, W.5    Schuermann, M.6
  • 53
    • 0037054936 scopus 로고    scopus 로고
    • Aberrant methylation of the CDKN2a/p16INK4a gene promoter region in preinvasive bronchial lesions: A prospective study in high-risk patients without invasive cancer
    • Lamy A, Sesboue R, Bourguignon J, Dautreaux B, Metayer J, Frebourg T, et al: Aberrant methylation of the CDKN2a/p16INK4a gene promoter region in preinvasive bronchial lesions: A prospective study in high-risk patients without invasive cancer. Int J Cancer 2002;100:189-193.
    • (2002) Int J Cancer , vol.100 , pp. 189-193
    • Lamy, A.1    Sesboue, R.2    Bourguignon, J.3    Dautreaux, B.4    Metayer, J.5    Frebourg, T.6
  • 54
    • 0033607147 scopus 로고    scopus 로고
    • In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis
    • Nuovo GJ, Plaia TW, Belinsky SA, Baylin SB, Herman JG: In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis. Proc Natl Acad Sci USA 1999;96:12754-12759.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12754-12759
    • Nuovo, G.J.1    Plaia, T.W.2    Belinsky, S.A.3    Baylin, S.B.4    Herman, J.G.5
  • 55
  • 56
    • 0036145156 scopus 로고    scopus 로고
    • Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours
    • Esteller M, Herman JG: Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. J Pathol 2002;196:1-7.
    • (2002) J Pathol , vol.196 , pp. 1-7
    • Esteller, M.1    Herman, J.G.2
  • 57
    • 0033552813 scopus 로고    scopus 로고
    • The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
    • Jacobs JJ, Kieboom K, Marino S, DePinho RA, van Lohuizen M: The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 1999;397:164-168.
    • (1999) Nature , vol.397 , pp. 164-168
    • Jacobs, J.J.1    Kieboom, K.2    Marino, S.3    DePinho, R.A.4    Van Lohuizen, M.5
  • 58
    • 0035906853 scopus 로고    scopus 로고
    • The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression
    • Vonlanthen S, Heighway J, Altermatt HJ, Gugger M, Kappeler A, Borner MM, et al: The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression. Br J Cancer 2001;84:1372-1376.
    • (2001) Br J Cancer , vol.84 , pp. 1372-1376
    • Vonlanthen, S.1    Heighway, J.2    Altermatt, H.J.3    Gugger, M.4    Kappeler, A.5    Borner, M.M.6
  • 59
    • 0030043970 scopus 로고    scopus 로고
    • Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer
    • Betticher DC, Heighway J, Hasleton PS, Altermatt HJ, Ryder WD, Cerny T, et al: Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancer. Br J Cancer 1996;73:294-300.
    • (1996) Br J Cancer , vol.73 , pp. 294-300
    • Betticher, D.C.1    Heighway, J.2    Hasleton, P.S.3    Altermatt, H.J.4    Ryder, W.D.5    Cerny, T.6
  • 60
    • 0033563132 scopus 로고    scopus 로고
    • Overexpression of cyclins D1 and e is frequent in bronchial preneoplasia and precedes squamous cell carcinoma development
    • Lonardo F, Rusch V, Langenfeld J, Dmitrovsky E, Klimstra DS: Overexpression of cyclins D1 and E is frequent in bronchial preneoplasia and precedes squamous cell carcinoma development. Cancer Res 1999;59:2470-2476.
    • (1999) Cancer Res , vol.59 , pp. 2470-2476
    • Lonardo, F.1    Rusch, V.2    Langenfeld, J.3    Dmitrovsky, E.4    Klimstra, D.S.5
  • 61
    • 0037868819 scopus 로고    scopus 로고
    • Cyclin D1 overexpression in bronchial epithelia of patients with lung cancer is associated with smoking and predicts survival
    • Ratschiller D, Heighway J, Gugger M, Kappeler A, Pirnia F, Schmid RA, et al: Cyclin D1 overexpression in bronchial epithelia of patients with lung cancer is associated with smoking and predicts survival. J Clin Oncol 2003;21:2085-2093.
    • (2003) J Clin Oncol , vol.21 , pp. 2085-2093
    • Ratschiller, D.1    Heighway, J.2    Gugger, M.3    Kappeler, A.4    Pirnia, F.5    Schmid, R.A.6
  • 62
    • 0032928459 scopus 로고    scopus 로고
    • Amplification and overexpression of the cyclin D1 and epidermal growth factor receptor genes in non-small-cell lung cancer
    • Lung Cancer Study Group
    • Reissmann PT, Koga H, Figlin RA, Holmes EC, Slamon DJ: Amplification and overexpression of the cyclin D1 and epidermal growth factor receptor genes in non-small-cell lung cancer. Lung Cancer Study Group. J Cancer Res Clin Oncol 1999;125:61-70.
    • (1999) J Cancer Res Clin Oncol , vol.125 , pp. 61-70
    • Reissmann, P.T.1    Koga, H.2    Figlin, R.A.3    Holmes, E.C.4    Slamon, D.J.5
  • 63
    • 0028124330 scopus 로고
    • Cyclin D1 overexpression vs. retinoblastoma inactivation: Implications for growth control evasion in non-small cell and small cell lung cancer
    • Schauer IE, Siriwardana S, Langan TA, Sclafani RA: Cyclin D1 overexpression vs. retinoblastoma inactivation: Implications for growth control evasion in non-small cell and small cell lung cancer. Proc Natl Acad Sci USA 1994;91:7827-7831.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 7827-7831
    • Schauer, I.E.1    Siriwardana, S.2    Langan, T.A.3    Sclafani, R.A.4
  • 65
    • 0029731629 scopus 로고    scopus 로고
    • Molecular analysis of the FHIT gene at 3p14.2 in lung cancer cell lines
    • Yanagisawa K, Kondo M, Osada H, Uchida K, Takagi K, Masuda A, et al: Molecular analysis of the FHIT gene at 3p14.2 in lung cancer cell lines. Cancer Res 1996;56:5579-5582.
    • (1996) Cancer Res , vol.56 , pp. 5579-5582
    • Yanagisawa, K.1    Kondo, M.2    Osada, H.3    Uchida, K.4    Takagi, K.5    Masuda, A.6
  • 68
    • 85047696339 scopus 로고    scopus 로고
    • The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1
    • Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, et al: The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. Oncogene 2002;21:1381-1390.
    • (2002) Oncogene , vol.21 , pp. 1381-1390
    • Ortiz-Vega, S.1    Khokhlatchev, A.2    Nedwidek, M.3    Zhang, X.F.4    Dammann, R.5    Pfeifer, G.P.6
  • 69
    • 0035932393 scopus 로고    scopus 로고
    • Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours
    • Agathanggelou A, Honorio S, Macartney DP, Martinez A, Dallol A, Rader J, et al: Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours. Oncogene 2001;20:1509-1518.
    • (2001) Oncogene , vol.20 , pp. 1509-1518
    • Agathanggelou, A.1    Honorio, S.2    Macartney, D.P.3    Martinez, A.4    Dallol, A.5    Rader, J.6
  • 70
  • 71
    • 0033918563 scopus 로고    scopus 로고
    • Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3
    • Dammann R, Li C, Yoon JH, Chin PL, Bates S, Pfeifer GP: Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat Genet 2000;25:315-319.
    • (2000) Nat Genet , vol.25 , pp. 315-319
    • Dammann, R.1    Li, C.2    Yoon, J.H.3    Chin, P.L.4    Bates, S.5    Pfeifer, G.P.6
  • 72
    • 0035992419 scopus 로고    scopus 로고
    • Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma
    • Tomizawa Y, Kohno T, Kondo H, Otsuka A, Nishioka M, Niki T, et al: Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma. Clin Cancer Res 2002;8:2362-2368.
    • (2002) Clin Cancer Res , vol.8 , pp. 2362-2368
    • Tomizawa, Y.1    Kohno, T.2    Kondo, H.3    Otsuka, A.4    Nishioka, M.5    Niki, T.6
  • 73
    • 0026742534 scopus 로고
    • Multiplicity generates diversity in the retinoic acid signalling pathways
    • Leid M, Kastner P, Chambon P: Multiplicity generates diversity in the retinoic acid signalling pathways. Trends Biochem Sci 1992;17: 427-433.
    • (1992) Trends Biochem Sci , vol.17 , pp. 427-433
    • Leid, M.1    Kastner, P.2    Chambon, P.3
  • 74
    • 0034178010 scopus 로고    scopus 로고
    • RARbeta2 specificity in mediating RA inhibition of growth of lung cancer-derived cells
    • Toulouse A, Morin J, Dion PA, Houle B, Bradley WE: RARbeta2 specificity in mediating RA inhibition of growth of lung cancer-derived cells. Lung Cancer 2000;28:127-137.
    • (2000) Lung Cancer , vol.28 , pp. 127-137
    • Toulouse, A.1    Morin, J.2    Dion, P.A.3    Houle, B.4    Bradley, W.E.5
  • 76
    • 0030997822 scopus 로고    scopus 로고
    • Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: Implications for lung cancer development
    • Xu XC, Sozzi G, Lee JS, Lee JJ, Pastorino U, Pilotti S, et al: Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: Implications for lung cancer development. J Natl Cancer Inst 1997;89:624-629.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 624-629
    • Xu, X.C.1    Sozzi, G.2    Lee, J.S.3    Lee, J.J.4    Pastorino, U.5    Pilotti, S.6
  • 78
    • 0037420022 scopus 로고    scopus 로고
    • Treatment of former smokers with 9-cis-retinoic acid reverses loss of retinoic acid receptor-beta expression in the bronchial epithelium: Results from a randomized placebo-controlled trial
    • Kurie JM, Lotan R, Lee JJ, Lee JS, Morice RC, Liu DD, et al: Treatment of former smokers with 9-cis-retinoic acid reverses loss of retinoic acid receptor-beta expression in the bronchial epithelium: Results from a randomized placebo-controlled trial. J Natl Cancer Inst 2003;95:206-214.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 206-214
    • Kurie, J.M.1    Lotan, R.2    Lee, J.J.3    Lee, J.S.4    Morice, R.C.5    Liu, D.D.6
  • 79
    • 0034214209 scopus 로고    scopus 로고
    • Retinoic acid receptor and retinoid X receptor alterations in lung cancer precursor lesions
    • Martinet N, Alla F, Farre G, Labib T, Drouot H, Vidili R, et al: Retinoic acid receptor and retinoid X receptor alterations in lung cancer precursor lesions. Cancer Res 2000;60:2869-2875.
    • (2000) Cancer Res , vol.60 , pp. 2869-2875
    • Martinet, N.1    Alla, F.2    Farre, G.3    Labib, T.4    Drouot, H.5    Vidili, R.6
  • 81
    • 0037440329 scopus 로고    scopus 로고
    • Retinoic acid receptor beta and telomerase catalytic subunit expression in bronchial epithelium of heavy smokers
    • Soria JC, Xu X, Liu DD, Lee JJ, Kurie J, Morice RC, et al: Retinoic acid receptor beta and telomerase catalytic subunit expression in bronchial epithelium of heavy smokers. J Natl Cancer Inst 2003;95:165-168.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 165-168
    • Soria, J.C.1    Xu, X.2    Liu, D.D.3    Lee, J.J.4    Kurie, J.5    Morice, R.C.6
  • 82
    • 0033875561 scopus 로고    scopus 로고
    • N-(4-hydroxyphenyl)retinamide in the chemoprevention of squamous metaplasia and dysplasia of the bronchial epithelium
    • Kurie JM, Lee JS, Khuri FR, Mao L, Morice RC, Lee JJ, et al: N-(4-hydroxyphenyl)retinamide in the chemoprevention of squamous metaplasia and dysplasia of the bronchial epithelium. Clin Cancer Res 2000;6:2973-2979.
    • (2000) Clin Cancer Res , vol.6 , pp. 2973-2979
    • Kurie, J.M.1    Lee, J.S.2    Khuri, F.R.3    Mao, L.4    Morice, R.C.5    Lee, J.J.6
  • 84
    • 9244262406 scopus 로고    scopus 로고
    • Effects of a combination of beta carotene and vitamin a on lung cancer and cardiovascular disease
    • Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, et al: Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 1996;334:1150-1155.
    • (1996) N Engl J Med , vol.334 , pp. 1150-1155
    • Omenn, G.S.1    Goodman, G.E.2    Thornquist, M.D.3    Balmes, J.4    Cullen, M.R.5    Glass, A.6
  • 86
    • 0038010147 scopus 로고    scopus 로고
    • Expression of VEGF, semaphorin SEMA3F, and their common receptors neuropilins NP1 and NP2 in preinvasive bronchial lesions, lung tumours, and cell lines
    • Lantuejoul S, Constantin B, Drabkin H, Brambilla C, Roche J, Brambilla E: Expression of VEGF, semaphorin SEMA3F, and their common receptors neuropilins NP1 and NP2 in preinvasive bronchial lesions, lung tumours, and cell lines. J Pathol 2003;200:336-347.
    • (2003) J Pathol , vol.200 , pp. 336-347
    • Lantuejoul, S.1    Constantin, B.2    Drabkin, H.3    Brambilla, C.4    Roche, J.5    Brambilla, E.6
  • 87
    • 0033874073 scopus 로고    scopus 로고
    • Semaphorin SEMA3F localization in malignant human lung and cell lines: A suggested role in cell adhesion and cell migration
    • Brambilla E, Constantin B, Drabkin H, Roche J: Semaphorin SEMA3F localization in malignant human lung and cell lines: A suggested role in cell adhesion and cell migration. Am J Pathol 2000;156:939-950.
    • (2000) Am J Pathol , vol.156 , pp. 939-950
    • Brambilla, E.1    Constantin, B.2    Drabkin, H.3    Roche, J.4
  • 89
    • 0034996556 scopus 로고    scopus 로고
    • Reduced expression of alpha-catenin, beta-catenin, and gamma-catenin is associated with high cell proliferative activity and poor differentiation in non-small cell lung cancer
    • Pirinen RT, Hirvikoski P, Johansson RT, Hollmen S, Kosma VM: Reduced expression of alpha-catenin, beta-catenin, and gamma-catenin is associated with high cell proliferative activity and poor differentiation in non-small cell lung cancer. J Clin Pathol 2001;54:391-395.
    • (2001) J Clin Pathol , vol.54 , pp. 391-395
    • Pirinen, R.T.1    Hirvikoski, P.2    Johansson, R.T.3    Hollmen, S.4    Kosma, V.M.5
  • 90
    • 0032431279 scopus 로고    scopus 로고
    • The expression of beta-catenin in non-small-cell lung cancer: A clinicopathological study
    • Retera JM, Leers MP, Sulzer MA, Theunissen PH: The expression of beta-catenin in non-small-cell lung cancer: A clinicopathological study. J Clin Pathol 1998;51:891-894.
    • (1998) J Clin Pathol , vol.51 , pp. 891-894
    • Retera, J.M.1    Leers, M.P.2    Sulzer, M.A.3    Theunissen, P.H.4
  • 93
    • 0041970897 scopus 로고    scopus 로고
    • Expression of the TSLC1 adhesion molecule in pulmonary epithelium and its down-regulation in pulmonary adenocarcinoma other than bronchioloalveolar carcinoma
    • Ito A, Okada M, Uchino K, Wakayama T, Koma Y, Iseki S, et al: Expression of the TSLC1 adhesion molecule in pulmonary epithelium and its down-regulation in pulmonary adenocarcinoma other than bronchioloalveolar carcinoma. Lab Invest 2003;83:1175-1183.
    • (2003) Lab Invest , vol.83 , pp. 1175-1183
    • Ito, A.1    Okada, M.2    Uchino, K.3    Wakayama, T.4    Koma, Y.5    Iseki, S.6
  • 94
    • 0042916159 scopus 로고    scopus 로고
    • Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines
    • Fukami T, Fukuhara H, Kuramochi M, Maruyama T, Isogai K, Sakamoto M, et al: Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines. Int J Cancer 2003;107:53-59.
    • (2003) Int J Cancer , vol.107 , pp. 53-59
    • Fukami, T.1    Fukuhara, H.2    Kuramochi, M.3    Maruyama, T.4    Isogai, K.5    Sakamoto, M.6
  • 95
    • 0042388405 scopus 로고    scopus 로고
    • Clinical implication and prognostic significance of the tumor suppressor TSLC1 gene detected in adenocarcinoma of the lung
    • Uchino K, Ito A, Wakayama T, Koma Y, Okada T, Ohbayashi C, et al: Clinical implication and prognostic significance of the tumor suppressor TSLC1 gene detected in adenocarcinoma of the lung. Cancer 2003;98:1002-1007.
    • (2003) Cancer , vol.98 , pp. 1002-1007
    • Uchino, K.1    Ito, A.2    Wakayama, T.3    Koma, Y.4    Okada, T.5    Ohbayashi, C.6
  • 96
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, et al: PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997;275:1943-1947.
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3    Podsypanina, K.4    Bose, S.5    Wang, S.I.6
  • 97
  • 98
  • 99
    • 0034282535 scopus 로고    scopus 로고
    • Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering
    • Girard L, Zochbauer-Muller S, Virmani AK, Gazdar AF, Minna JD: Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering. Cancer Res 2000;60:4894-4906.
    • (2000) Cancer Res , vol.60 , pp. 4894-4906
    • Girard, L.1    Zochbauer-Muller, S.2    Virmani, A.K.3    Gazdar, A.F.4    Minna, J.D.5
  • 100
    • 0032006029 scopus 로고    scopus 로고
    • Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors
    • Okami K, Wu L, Riggins G, Cairns P, Goggins M, Evron E, et al: Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors. Cancer Res 1998;58:509-511.
    • (1998) Cancer Res , vol.58 , pp. 509-511
    • Okami, K.1    Wu, L.2    Riggins, G.3    Cairns, P.4    Goggins, M.5    Evron, E.6
  • 102
    • 0032806874 scopus 로고    scopus 로고
    • Alteration of the PTEN/MMAC1 gene locus in primary lung cancer with distant metastasis
    • Hosoya Y, Gemma A, Seike M, Kurimoto F, Uematsu K, Hibino S, et al: Alteration of the PTEN/MMAC1 gene locus in primary lung cancer with distant metastasis. Lung Cancer 1999;25:87-93.
    • (1999) Lung Cancer , vol.25 , pp. 87-93
    • Hosoya, Y.1    Gemma, A.2    Seike, M.3    Kurimoto, F.4    Uematsu, K.5    Hibino, S.6
  • 103
  • 104
    • 0032581519 scopus 로고    scopus 로고
    • PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers
    • Yokomizo A, Tindall DJ, Drabkin H, Gemmill R, Franklin W, Yang P, et al: PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers. Oncogene 1998;17:475-479.
    • (1998) Oncogene , vol.17 , pp. 475-479
    • Yokomizo, A.1    Tindall, D.J.2    Drabkin, H.3    Gemmill, R.4    Franklin, W.5    Yang, P.6
  • 105
    • 0036094196 scopus 로고    scopus 로고
    • Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation
    • Soria JC, Lee HY, Lee JI, Wang L, Issa JP, Kemp BL, et al: Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation. Clin Cancer Res 2002;8:1178-1184.
    • (2002) Clin Cancer Res , vol.8 , pp. 1178-1184
    • Soria, J.C.1    Lee, H.Y.2    Lee, J.I.3    Wang, L.4    Issa, J.P.5    Kemp, B.L.6
  • 106
    • 0035146778 scopus 로고    scopus 로고
    • Heterogeneous lack of expression of the tumour suppressor PTEN protein in human neoplastic tissues
    • Torres J, Navarro S, Rogla I, Ripoll F, Lluch A, Garcia-Conde J, et al: Heterogeneous lack of expression of the tumour suppressor PTEN protein in human neoplastic tissues. Eur J Cancer 2001;37:114-121.
    • (2001) Eur J Cancer , vol.37 , pp. 114-121
    • Torres, J.1    Navarro, S.2    Rogla, I.3    Ripoll, F.4    Lluch, A.5    Garcia-Conde, J.6
  • 107
    • 0037453909 scopus 로고    scopus 로고
    • Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells
    • Chun KH, Kosmeder JW, Sun S, Pezzuto JM, Lotan R, Hong WK, Lee HY: Effects of deguelin on the phosphatidylinositol 3-kinase/ Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J Natl Cancer Inst 2003;95:291-302.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 291-302
    • Chun, K.H.1    Kosmeder, J.W.2    Sun, S.3    Pezzuto, J.M.4    Lotan, R.5    Hong, W.K.6    Lee, H.Y.7
  • 108
    • 0027722067 scopus 로고
    • Precise mapping of the EGF receptor gene on the human chromosome 7p12 using an improved fish technique
    • Wang Y, Minoshima S, Shimizu N: Precise mapping of the EGF receptor gene on the human chromosome 7p12 using an improved fish technique. Jpn J Hum Genet 1993;38: 399-406.
    • (1993) Jpn J Hum Genet , vol.38 , pp. 399-406
    • Wang, Y.1    Minoshima, S.2    Shimizu, N.3
  • 109
    • 0030944455 scopus 로고    scopus 로고
    • ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
    • Graus-Porta D, Beerli RR, Daly JM, Hynes NE: ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J 1997;16:1647-1655.
    • (1997) EMBO J , vol.16 , pp. 1647-1655
    • Graus-Porta, D.1    Beerli, R.R.2    Daly, J.M.3    Hynes, N.E.4
  • 110
    • 0035419867 scopus 로고    scopus 로고
    • ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways
    • Lenferink AE, Busse D, Flanagan WM, Yakes FM, Arteaga CL: ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways. Cancer Res 2001;61:6583-6591.
    • (2001) Cancer Res , vol.61 , pp. 6583-6591
    • Lenferink, A.E.1    Busse, D.2    Flanagan, W.M.3    Yakes, F.M.4    Arteaga, C.L.5
  • 111
    • 0036118262 scopus 로고    scopus 로고
    • Epidermal growth factor receptor family in lung cancer and premalignancy
    • Franklin WA, Veve R, Hirsch FR, Helfrich BA, Bunn PA Jr: Epidermal growth factor receptor family in lung cancer and premalignancy. Semin Oncol 2002;29(1 suppl 4):3-14.
    • (2002) Semin Oncol , vol.29 , Issue.1 SUPPL. 4 , pp. 3-14
    • Franklin, W.A.1    Veve, R.2    Hirsch, F.R.3    Helfrich, B.A.4    Bunn Jr., P.A.5
  • 112
    • 10244243723 scopus 로고    scopus 로고
    • Increased epidermal growth factor receptor expression in metaplastic bronchial epithelium
    • Kurie JM, Shin HJ, Lee JS, Morice RC, Ro JY, Lippman SM, et al: Increased epidermal growth factor receptor expression in metaplastic bronchial epithelium. Clin Cancer Res 1996;2:1787-1793.
    • (1996) Clin Cancer Res , vol.2 , pp. 1787-1793
    • Kurie, J.M.1    Shin, H.J.2    Lee, J.S.3    Morice, R.C.4    Ro, J.Y.5    Lippman, S.M.6
  • 113
    • 0036307913 scopus 로고    scopus 로고
    • Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung
    • Piyathilake CJ, Frost AR, Manne U, Weiss H, Bell WC, Heimburger DC, et al: Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung. Clin Cancer Res 2002;8:734-744.
    • (2002) Clin Cancer Res , vol.8 , pp. 734-744
    • Piyathilake, C.J.1    Frost, A.R.2    Manne, U.3    Weiss, H.4    Bell, W.C.5    Heimburger, D.C.6
  • 114
    • 0027159063 scopus 로고
    • Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung
    • Rusch V, Baselga J, Cordon-Cardo C, Orazem J, Zaman M, Hoda S, et al: Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung. Cancer Res 1993;53(10 suppl):2379-2385.
    • (1993) Cancer Res , vol.53 , Issue.10 SUPPL. , pp. 2379-2385
    • Rusch, V.1    Baselga, J.2    Cordon-Cardo, C.3    Orazem, J.4    Zaman, M.5    Hoda, S.6
  • 115
    • 0025013846 scopus 로고
    • Immunohistochemical evidence of autocrine growth factors in adenocarcinoma of the human lung
    • Tateishi M, Ishida T, Mitsudomi T, Kaneko S, Sugimachi K: Immunohistochemical evidence of autocrine growth factors in adenocarcinoma of the human lung. Cancer Res 1990;50:7077-7080.
    • (1990) Cancer Res , vol.50 , pp. 7077-7080
    • Tateishi, M.1    Ishida, T.2    Mitsudomi, T.3    Kaneko, S.4    Sugimachi, K.5
  • 117
    • 0033869769 scopus 로고    scopus 로고
    • HER-2/neu expression in archival non-small cell lung carcinomas using PDA-approved Hercep test
    • Scheurle D, Jahanzeb M, Aronsohn RS, Watzek L, Narayanan R: HER-2/neu expression in archival non-small cell lung carcinomas using PDA-approved Hercep test. Anticancer Res 2000;20:2091-2096.
    • (2000) Anticancer Res , vol.20 , pp. 2091-2096
    • Scheurle, D.1    Jahanzeb, M.2    Aronsohn, R.S.3    Watzek, L.4    Narayanan, R.5
  • 118
    • 0024421662 scopus 로고
    • Differential expression of the c-erbB-2 gene in human small cell and non-small cell lung cancer
    • Schneider PM, Hung MC, Chiocca SM, Manning J, Zhao XY, Fang K, et al: Differential expression of the c-erbB-2 gene in human small cell and non-small cell lung cancer. Cancer Res 1989;49:4968-4971.
    • (1989) Cancer Res , vol.49 , pp. 4968-4971
    • Schneider, P.M.1    Hung, M.C.2    Chiocca, S.M.3    Manning, J.4    Zhao, X.Y.5    Fang, K.6
  • 119
    • 0141921933 scopus 로고    scopus 로고
    • The role of HER-2/neu expression on the survival of patients with lung cancer: A systematic review of the literature
    • Meert AP, Martin B, Paesmans M, Berghmans T, Mascaux C, Verdebout JM, et al: The role of HER-2/neu expression on the survival of patients with lung cancer: A systematic review of the literature. Br J Cancer 2003;89:959-965.
    • (2003) Br J Cancer , vol.89 , pp. 959-965
    • Meert, A.P.1    Martin, B.2    Paesmans, M.3    Berghmans, T.4    Mascaux, C.5    Verdebout, J.M.6
  • 120
    • 3042609876 scopus 로고    scopus 로고
    • Automated real-time PCR to determine K-ras codon 12 mutations in non-small cell lung cancer: Comparison with immunohistochemistry and clinico-pathological features
    • Hilbe W, Dlaska M, Duba HC, Dirnhofer S, Eisterer W, Oberwasserlechner F, et al: Automated real-time PCR to determine K-ras codon 12 mutations in non-small cell lung cancer: Comparison with immunohistochemistry and clinico-pathological features. Int J Oncol 2003;23:1121-1126.
    • (2003) Int J Oncol , vol.23 , pp. 1121-1126
    • Hilbe, W.1    Dlaska, M.2    Duba, H.C.3    Dirnhofer, S.4    Eisterer, W.5    Oberwasserlechner, F.6
  • 121
  • 122
    • 0023707058 scopus 로고
    • Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung
    • Rodenhuis S, Slebos RJ, Boot AJ, Evers SG, Mooi WJ, Wagenaar SS, et al: Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung. Cancer Res 1988;48:5738-5741.
    • (1988) Cancer Res , vol.48 , pp. 5738-5741
    • Rodenhuis, S.1    Slebos, R.J.2    Boot, A.J.3    Evers, S.G.4    Mooi, W.J.5    Wagenaar, S.S.6
  • 125
    • 0026533937 scopus 로고
    • Prognostic significance of the expression of ras oncogene product in non-small cell lung cancer
    • Harada M, Dosaka-Akita H, Miyamoto H, Kuzumaki N, Kawakami Y: Prognostic significance of the expression of ras oncogene product in non-small cell lung cancer. Cancer 1992;69:72-77.
    • (1992) Cancer , vol.69 , pp. 72-77
    • Harada, M.1    Dosaka-Akita, H.2    Miyamoto, H.3    Kuzumaki, N.4    Kawakami, Y.5
  • 126
    • 0026325903 scopus 로고
    • Prognostic value of nuclear DNA content and expression of the ras oncogene product in lung cancer
    • Miyamoto H, Harada M, Isobe H, Akita HD, Haneda H, Yamaguchi E, et al: Prognostic value of nuclear DNA content and expression of the ras oncogene product in lung cancer. Cancer Res 1991;51:6346-6350.
    • (1991) Cancer Res , vol.51 , pp. 6346-6350
    • Miyamoto, H.1    Harada, M.2    Isobe, H.3    Akita, H.D.4    Haneda, H.5    Yamaguchi, E.6
  • 127
    • 0035863302 scopus 로고    scopus 로고
    • Lack of prognostic significance of p53 and K-ras mutations in primary resected non-small-cell lung cancer on E4592: A Laboratory Ancillary Study on an Eastern Cooperative Oncology Group Prospective Randomized Trial of Postoperative Adjuvant Therapy
    • Schiller JH, Adak S, Feins RH, Keller SM, Fry WA, Livingston RB, Hammond ME, Wolf B, Sabatini L, Jett J, Kohman L, Johnson DH: Lack of prognostic significance of p53 and K-ras mutations in primary resected non-small-cell lung cancer on E4592: A Laboratory Ancillary Study on an Eastern Cooperative Oncology Group Prospective Randomized Trial of Postoperative Adjuvant Therapy. J Clin Oncol 2001;19:448-457.
    • (2001) J Clin Oncol , vol.19 , pp. 448-457
    • Schiller, J.H.1    Adak, S.2    Feins, R.H.3    Keller, S.M.4    Fry, W.A.5    Livingston, R.B.6    Hammond, M.E.7    Wolf, B.8    Sabatini, L.9    Jett, J.10    Kohman, L.11    Johnson, D.H.12
  • 128
    • 0027637343 scopus 로고
    • Expression of c-myc in progenitor cells of the bronchopulmonary epithelium and in a large number of non-small cell lung cancers
    • Broers JL, Viallet J, Jensen SM, Pass H, Travis WD, Minna JD, et al: Expression of c-myc in progenitor cells of the bronchopulmonary epithelium and in a large number of non-small cell lung cancers. Am J Respir Cell Mol Biol 1993;9:33-43.
    • (1993) Am J Respir Cell Mol Biol , vol.9 , pp. 33-43
    • Broers, J.L.1    Viallet, J.2    Jensen, S.M.3    Pass, H.4    Travis, W.D.5    Minna, J.D.6
  • 129
    • 0030724731 scopus 로고    scopus 로고
    • High telomerase activity in primary lung cancers: Association with increased cell proliferation rates and advanced pathologic stage
    • Albanell J, Lonardo F, Rusch V, Engelhardt M, Langenfeld J, Han W, et al: High telomerase activity in primary lung cancers: Association with increased cell proliferation rates and advanced pathologic stage. J Natl Cancer Inst 1997;89:1609-1615.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1609-1615
    • Albanell, J.1    Lonardo, F.2    Rusch, V.3    Engelhardt, M.4    Langenfeld, J.5    Han, W.6
  • 130
    • 0034780884 scopus 로고    scopus 로고
    • Clinicopathologic significance of telomerase activity and hTERT mRNA expression in non-small cell lung cancer
    • Hara H, Yamashita K, Shinada J, Yoshimura H, Kameya T: Clinicopathologic significance of telomerase activity and hTERT mRNA expression in non-small cell lung cancer. Lung Cancer 2001;34:219-226.
    • (2001) Lung Cancer , vol.34 , pp. 219-226
    • Hara, H.1    Yamashita, K.2    Shinada, J.3    Yoshimura, H.4    Kameya, T.5
  • 132
    • 0035127217 scopus 로고    scopus 로고
    • Telomerase activity and expression of human telomerase RNA component and human telomerase reverse transcriptase in lung carcinomas
    • Kumaki F, Kawai T, Hiroi S, Shinomiya N, Ozeki Y, Ferrans VJ, et al: Telomerase activity and expression of human telomerase RNA component and human telomerase reverse transcriptase in lung carcinomas. Hum Pathol 2001;32:188-195.
    • (2001) Hum Pathol , vol.32 , pp. 188-195
    • Kumaki, F.1    Kawai, T.2    Hiroi, S.3    Shinomiya, N.4    Ozeki, Y.5    Ferrans, V.J.6
  • 134
    • 0035880754 scopus 로고    scopus 로고
    • Increased telomerase activity and elevated hTERT mRNA expression during multistage carcinogenesis of squamous cell carcinoma of the lung
    • Shibuya K, Fujisawa T, Hoshino H, Baba M, Saitoh Y, Iizasa T, et al: Increased telomerase activity and elevated hTERT mRNA expression during multistage carcinogenesis of squamous cell carcinoma of the lung. Cancer 2001;92:849-855.
    • (2001) Cancer , vol.92 , pp. 849-855
    • Shibuya, K.1    Fujisawa, T.2    Hoshino, H.3    Baba, M.4    Saitoh, Y.5    Iizasa, T.6
  • 135
    • 15444341922 scopus 로고    scopus 로고
    • Telomerase expression in respiratory epithelium during the multistage pathogenesis of lung carcinomas
    • Yashima K, Litzky LA, Kaiser L, Rogers T, Lam S, Wistuba II, et al: Telomerase expression in respiratory epithelium during the multistage pathogenesis of lung carcinomas. Cancer Res 1997;57:2373-2377.
    • (1997) Cancer Res , vol.57 , pp. 2373-2377
    • Yashima, K.1    Litzky, L.A.2    Kaiser, L.3    Rogers, T.4    Lam, S.5    Wistuba, I.I.6
  • 137
    • 0030745448 scopus 로고    scopus 로고
    • hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
    • Meyerson M, Counter CM, Eaton EN, Ellisen LW, Steiner P, Caddle SD, et al: hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 1997;90:785-795.
    • (1997) Cell , vol.90 , pp. 785-795
    • Meyerson, M.1    Counter, C.M.2    Eaton, E.N.3    Ellisen, L.W.4    Steiner, P.5    Caddle, S.D.6
  • 138
    • 17344363008 scopus 로고    scopus 로고
    • Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas
    • Nakayama J, Tahara H, Tahara E, Saito M, Ito K, Nakamura H, et al: Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat Genet 1998;18:65-68.
    • (1998) Nat Genet , vol.18 , pp. 65-68
    • Nakayama, J.1    Tahara, H.2    Tahara, E.3    Saito, M.4    Ito, K.5    Nakamura, H.6
  • 139
    • 0035815901 scopus 로고    scopus 로고
    • Telomerase suppression by chromosome 6 in a human papillomavirus type 16-immortalized keratinocyte cell line and in a cervical cancer cell line
    • Steenbergen RD, Kramer D, Meijer CJ, Walboomers JM, Trott DA, Cuthbert AP, et al: Telomerase suppression by chromosome 6 in a human papillomavirus type 16-immortalized keratinocyte cell line and in a cervical cancer cell line. J Natl Cancer Inst 2001;93: 865-872.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 865-872
    • Steenbergen, R.D.1    Kramer, D.2    Meijer, C.J.3    Walboomers, J.M.4    Trott, D.A.5    Cuthbert, A.P.6
  • 142
    • 0036716816 scopus 로고    scopus 로고
    • hTERT expression is a prognostic factor of survival in patients with stage I non-small cell lung cancer
    • Wang L, Soria JC, Kemp BL, Liu DD, Mao L, Khuri FR: hTERT expression is a prognostic factor of survival in patients with stage I non-small cell lung cancer. Clin Cancer Res 2002;8:2883-2889.
    • (2002) Clin Cancer Res , vol.8 , pp. 2883-2889
    • Wang, L.1    Soria, J.C.2    Kemp, B.L.3    Liu, D.D.4    Mao, L.5    Khuri, F.R.6
  • 144
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, et al: Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 1996;379:88-91.
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3    De Housman4    Koch, C.J.5    Lowe, S.W.6
  • 145
    • 0025204548 scopus 로고
    • Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
    • Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990;348:334-336.
    • (1990) Nature , vol.348 , pp. 334-336
    • Hockenbery, D.1    Nunez, G.2    Milliman, C.3    Schreiber, R.D.4    Korsmeyer, S.J.5
  • 146
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • Oltvai ZN, Milliman CL, Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993;74:609-619.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.J.3
  • 147
    • 0029024368 scopus 로고
    • Mapping of the human BAX gene to chromosome 19q13.3-q13.4 and isolation of a novel alternatively spliced transcript, BAX delta
    • Apte SS, Mattei MG, Olsen BR: Mapping of the human BAX gene to chromosome 19q13.3-q13.4 and isolation of a novel alternatively spliced transcript, BAX delta. Genomics 1995;26:592-594.
    • (1995) Genomics , vol.26 , pp. 592-594
    • Apte, S.S.1    Mattei, M.G.2    Olsen, B.R.3
  • 150
    • 0033039989 scopus 로고    scopus 로고
    • Expression of Bcl-2, Bax, and p53 proteins in carcinogenesis of squamous cell lung cancer
    • Chen Y, Sato M, Fujimura S, Endo C, Sakurada A, Aikawa H, et al: Expression of Bcl-2, Bax, and p53 proteins in carcinogenesis of squamous cell lung cancer. Anticancer Res 1999;19:1351-1356.
    • (1999) Anticancer Res , vol.19 , pp. 1351-1356
    • Chen, Y.1    Sato, M.2    Fujimura, S.3    Endo, C.4    Sakurada, A.5    Aikawa, H.6
  • 151
    • 0029053428 scopus 로고
    • Expression of the BCL-2 protein in normal and dysplastic bronchial epithelium and in lung carcinomas
    • Walker C, Robertson L, Myskow M, Dixon G: Expression of the BCL-2 protein in normal and dysplastic bronchial epithelium and in lung carcinomas. Br J Cancer 1995;72:164-169.
    • (1995) Br J Cancer , vol.72 , pp. 164-169
    • Walker, C.1    Robertson, L.2    Myskow, M.3    Dixon, G.4
  • 152
    • 0041343301 scopus 로고    scopus 로고
    • Role of Bcl-2 as a prognostic factor for survival in lung cancer: A systematic review of the literature with meta-analysis
    • Martin B, Paesmans M, Berghmans T, Branle F, Ghisdal L, Mascaux C, et al: Role of Bcl-2 as a prognostic factor for survival in lung cancer: A systematic review of the literature with meta-analysis. Br J Cancer 2003;89:55-64.
    • (2003) Br J Cancer , vol.89 , pp. 55-64
    • Martin, B.1    Paesmans, M.2    Berghmans, T.3    Branle, F.4    Ghisdal, L.5    Mascaux, C.6
  • 154
    • 1542682242 scopus 로고    scopus 로고
    • Clinical trials referral resource. Current clinical trials of G3139
    • Huntingt
    • Tock B, Zwiebel JA, Schoenfeldt M: Clinical trials referral resource. Current clinical trials of G3139. Oncology (Huntingt) 2003;17: 1244-1258.
    • (2003) Oncology , vol.17 , pp. 1244-1258
    • Tock, B.1    Zwiebel, J.A.2    Schoenfeldt, M.3
  • 155
    • 0030746636 scopus 로고    scopus 로고
    • A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
    • Ambrosini G, Adida C, Altieri DC: A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 1997;3:917-921.
    • (1997) Nat Med , vol.3 , pp. 917-921
    • Ambrosini, G.1    Adida, C.2    Altieri, D.C.3
  • 156
    • 0032522738 scopus 로고    scopus 로고
    • IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
    • Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, et al: IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO J 1998;17:2215-2223.
    • (1998) EMBO J , vol.17 , pp. 2215-2223
    • Deveraux, Q.L.1    Roy, N.2    Stennicke, H.R.3    Van Arsdale, T.4    Zhou, Q.5    Srinivasula, S.M.6
  • 158
    • 0036032266 scopus 로고    scopus 로고
    • Expression of inhibitors of apoptosis (IAP) proteins in non-small cell human lung cancer
    • Hofmann HS, Simm A, Hammer A, Silber RE, Bartling B: Expression of inhibitors of apoptosis (IAP) proteins in non-small cell human lung cancer. J Cancer Res Clin Oncol 2002;128:554-560.
    • (2002) J Cancer Res Clin Oncol , vol.128 , pp. 554-560
    • Hofmann, H.S.1    Simm, A.2    Hammer, A.3    Silber, R.E.4    Bartling, B.5
  • 160
    • 0032986544 scopus 로고    scopus 로고
    • A novel anti-apoptosis gene: Re-expression of survivin messenger RNA as a prognosis marker in non-small-cell lung cancers
    • Monzo M, Rosell R, Felip E, Astudillo J, Sanchez JJ, Maestre J, et al: A novel anti-apoptosis gene: Re-expression of survivin messenger RNA as a prognosis marker in non-small-cell lung cancers. J Clin Oncol 1999;17:2100-2104.
    • (1999) J Clin Oncol , vol.17 , pp. 2100-2104
    • Monzo, M.1    Rosell, R.2    Felip, E.3    Astudillo, J.4    Sanchez, J.J.5    Maestre, J.6
  • 161
    • 0032948381 scopus 로고    scopus 로고
    • Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas
    • Achiwa H, Yatabe Y, Hida T, Kuroishi T, Kozaki K, Nakamura S, et al: Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas. Clin Cancer Res 1999;5:1001-1005.
    • (1999) Clin Cancer Res , vol.5 , pp. 1001-1005
    • Achiwa, H.1    Yatabe, Y.2    Hida, T.3    Kuroishi, T.4    Kozaki, K.5    Nakamura, S.6
  • 162
    • 0037083634 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-1 and cyclooxygenase-2 in bronchial epithelium and nonsmall cell lung carcinoma
    • Hasturk S, Kemp B, Kalapurakal SK, Kurie JM, Hong WK, Lee JS: Expression of cyclooxygenase-1 and cyclooxygenase-2 in bronchial epithelium and nonsmall cell lung carcinoma. Cancer 2002;94:1023-1031.
    • (2002) Cancer , vol.94 , pp. 1023-1031
    • Hasturk, S.1    Kemp, B.2    Kalapurakal, S.K.3    Kurie, J.M.4    Hong, W.K.5
  • 163
    • 0032170955 scopus 로고    scopus 로고
    • Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas
    • Hida T, Yatabe Y, Achiwa H, Muramatsu H, Kozaki K, Nakamura S, et al: Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas. Cancer Res 1998;58:3761-3764.
    • (1998) Cancer Res , vol.58 , pp. 3761-3764
    • Hida, T.1    Yatabe, Y.2    Achiwa, H.3    Muramatsu, H.4    Kozaki, K.5    Nakamura, S.6
  • 164
    • 0034901568 scopus 로고    scopus 로고
    • Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage I
    • Khuri FR, Wu H, Lee JJ, Kemp BL, Lotan R, Lippman SM, et al: Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage I non-small cell lung cancer. Clin Cancer Res 2001;7:861-867.
    • (2001) Clin Cancer Res , vol.7 , pp. 861-867
    • Khuri, F.R.1    Wu, H.2    Lee, J.J.3    Kemp, B.L.4    Lotan, R.5    Lippman, S.M.6
  • 167
    • 0033118480 scopus 로고    scopus 로고
    • Increased expression of cyclooxygenase-2 in rat lung tumors induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone: The impact of a high-fat diet
    • El Bayoumy K, Iatropoulos M, Amin S, Hoffmann D, Wynder EL: Increased expression of cyclooxygenase-2 in rat lung tumors induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone: The impact of a high-fat diet. Cancer Res 1999;59: 1400-1403.
    • (1999) Cancer Res , vol.59 , pp. 1400-1403
    • El Bayoumy, K.1    Iatropoulos, M.2    Amin, S.3    Hoffmann, D.4    Wynder, E.L.5
  • 169
    • 0028803728 scopus 로고
    • Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
    • Tsujii M, DuBois RN: Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 1995;83:493-501.
    • (1995) Cell , vol.83 , pp. 493-501
    • Tsujii, M.1    DuBois, R.N.2
  • 170
    • 0003504049 scopus 로고    scopus 로고
    • Cyclooxygenase regulates angiogenesis induced by colon cancer cells
    • Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, DuBois RN: Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 1998;93:705-716.
    • (1998) Cell , vol.93 , pp. 705-716
    • Tsujii, M.1    Kawano, S.2    Tsuji, S.3    Sawaoka, H.4    Hori, M.5    DuBois, R.N.6
  • 171
    • 0030952695 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential
    • Tsujii M, Kawano S, DuBois RN: Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad Sci USA 1997;94:3336-3340.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3336-3340
    • Tsujii, M.1    Kawano, S.2    DuBois, R.N.3
  • 172
    • 0037378456 scopus 로고    scopus 로고
    • Cyclooxygenase (COX) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxygenase independent pathways
    • Sanchez-Alcazar JA, Bradbury DA, Pang L, Knox AJ: Cyclooxygenase (COX) inhibitors induce apoptosis in non-small cell lung cancer through cyclooxygenase independent pathways. Lung Cancer 2003;40:33-44.
    • (2003) Lung Cancer , vol.40 , pp. 33-44
    • Sanchez-Alcazar, J.A.1    Bradbury, D.A.2    Pang, L.3    Knox, A.J.4
  • 173
    • 0042631411 scopus 로고    scopus 로고
    • Celecoxib, a selective cyclo-oxygenase-2 inhibitor, enhances the response to preoperative paclitaxel and carboplatin in early-stage non-small-cell lung cancer
    • Altorki NK, Keresztes RS, Port JL, Libby DM, Korst RJ, Flieder DB, et al: Celecoxib, a selective cyclo-oxygenase-2 inhibitor, enhances the response to preoperative paclitaxel and carboplatin in early-stage non-small-cell lung cancer. J Clin Oncol 2003;21:2645-2650.
    • (2003) J Clin Oncol , vol.21 , pp. 2645-2650
    • Altorki, N.K.1    Keresztes, R.S.2    Port, J.L.3    Libby, D.M.4    Korst, R.J.5    Flieder, D.B.6
  • 174
    • 0028325496 scopus 로고
    • Aspirin use and lung, colon, and breast cancer incidence in a prospective study
    • Schreinemachers DM, Everson RB: Aspirin use and lung, colon, and breast cancer incidence in a prospective study. Epidemiology 1994;5:138-146.
    • (1994) Epidemiology , vol.5 , pp. 138-146
    • Schreinemachers, D.M.1    Everson, R.B.2
  • 176
    • 0030996171 scopus 로고    scopus 로고
    • Angiogenesis as a prognostic indicator of survival in non-small-cell lung carcinoma: A prospective study
    • Fontanini G, Lucchi M, Vignati S, Mussi A, Ciardiello F, De Laurentiis M, et al: Angiogenesis as a prognostic indicator of survival in non-small-cell lung carcinoma: A prospective study. J Natl Cancer Inst 1997;89:881-886.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 881-886
    • Fontanini, G.1    Lucchi, M.2    Vignati, S.3    Mussi, A.4    Ciardiello, F.5    De Laurentiis, M.6
  • 177
    • 18244364180 scopus 로고    scopus 로고
    • A high vascular count and overexpression of vascular endothelial growth factor are associated with unfavourable prognosis in operated small cell lung carcinoma
    • Fontanini G, Faviana P, Lucchi M, Boldrini L, Mussi A, Camacci T, et al: A high vascular count and overexpression of vascular endothelial growth factor are associated with unfavourable prognosis in operated small cell lung carcinoma. Br J Cancer 2002;86:558-563.
    • (2002) Br J Cancer , vol.86 , pp. 558-563
    • Fontanini, G.1    Faviana, P.2    Lucchi, M.3    Boldrini, L.4    Mussi, A.5    Camacci, T.6
  • 178
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • Shweiki D, Itin A, Soffer D, Keshet E: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992;359:843-845.
    • (1992) Nature , vol.359 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3    Keshet, E.4
  • 179
    • 0032907687 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptors
    • Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z: Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 1999;13: 9-22.
    • (1999) FASEB J , vol.13 , pp. 9-22
    • Neufeld, G.1    Cohen, T.2    Gengrinovitch, S.3    Poltorak, Z.4
  • 180
    • 0028822834 scopus 로고
    • Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis
    • Rak J, Mitsuhashi Y, Bayko L, Filmus J, Shirasawa S, Sasazuki T, et al: Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis. Cancer Res 1995;55:4575-4580.
    • (1995) Cancer Res , vol.55 , pp. 4575-4580
    • Rak, J.1    Mitsuhashi, Y.2    Bayko, L.3    Filmus, J.4    Shirasawa, S.5    Sasazuki, T.6
  • 181
    • 0031779403 scopus 로고    scopus 로고
    • Tumor angiogenesis and vascular endothelial growth factor expression in stage I lung adenocarcinoma
    • Shibusa T, Shijubo N, Abe S: Tumor angiogenesis and vascular endothelial growth factor expression in stage I lung adenocarcinoma. Clin Cancer Res 1998;4:1483-1487.
    • (1998) Clin Cancer Res , vol.4 , pp. 1483-1487
    • Shibusa, T.1    Shijubo, N.2    Abe, S.3
  • 182
    • 0032826888 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and osteopontin in stage I lung adenocarcinoma
    • Shijubo N, Uede T, Kon S, Maeda M, Segawa T, Imada A, et al: Vascular endothelial growth factor and osteopontin in stage I lung adenocarcinoma. Am J Respir Crit Care Med 1999;160:1269-1273.
    • (1999) Am J Respir Crit Care Med , vol.160 , pp. 1269-1273
    • Shijubo, N.1    Uede, T.2    Kon, S.3    Maeda, M.4    Segawa, T.5    Imada, A.6
  • 183
    • 1842328560 scopus 로고    scopus 로고
    • Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer
    • Volm M, Koomagi R, Mattern J: Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer. Int J Cancer 1997;74:64-68.
    • (1997) Int J Cancer , vol.74 , pp. 64-68
    • Volm, M.1    Koomagi, R.2    Mattern, J.3
  • 184
    • 0030769701 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and lymph node metastasis in primary lung cancer
    • Ohta Y, Watanabe Y, Murakami S, Oda M, Hayashi Y, Nonomura A, et al: Vascular endothelial growth factor and lymph node metastasis in primary lung cancer. Br J Cancer 1997;76:1041-1045.
    • (1997) Br J Cancer , vol.76 , pp. 1041-1045
    • Ohta, Y.1    Watanabe, Y.2    Murakami, S.3    Oda, M.4    Hayashi, Y.5    Nonomura, A.6
  • 187
    • 0029870954 scopus 로고    scopus 로고
    • The war on cancer
    • Sporn MB: The war on cancer. Lancet 1996;347:1377-1381.
    • (1996) Lancet , vol.347 , pp. 1377-1381
    • Sporn, M.B.1
  • 188
    • 0034956272 scopus 로고    scopus 로고
    • The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis
    • John A, Tuszynski G: The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis. Pathol Oncol Res 2001;7:14-23.
    • (2001) Pathol Oncol Res , vol.7 , pp. 14-23
    • John, A.1    Tuszynski, G.2
  • 189
    • 0031974799 scopus 로고    scopus 로고
    • Effects of epidermal growth factor on the invasion activity of the bladder cancer cell line
    • Kanno N, Nonomura N, Miki T, Kojima Y, Takahara S, Nozaki M, et al: Effects of epidermal growth factor on the invasion activity of the bladder cancer cell line. J Urol 1998;159:586-590.
    • (1998) J Urol , vol.159 , pp. 586-590
    • Kanno, N.1    Nonomura, N.2    Miki, T.3    Kojima, Y.4    Takahara, S.5    Nozaki, M.6
  • 190
    • 0031870786 scopus 로고    scopus 로고
    • Vascular endothelial growth factor increases release of gelatinase a and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitro
    • Lamoreaux WJ, Fitzgerald ME, Reiner A, Hasty KA, Charles ST: Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitro. Microvasc Res 1998;55:29-42.
    • (1998) Microvasc Res , vol.55 , pp. 29-42
    • Lamoreaux, W.J.1    Fitzgerald, M.E.2    Reiner, A.3    Hasty, K.A.4    Charles, S.T.5
  • 191
    • 0034790275 scopus 로고    scopus 로고
    • Organ-specific molecular classification of primary lung, colon, and ovarian adenocarcinomas using gene expression profiles
    • Giordano TJ, Shedden KA, Schwartz DR, Kuick R, Taylor JM, Lee N, et al: Organ-specific molecular classification of primary lung, colon, and ovarian adenocarcinomas using gene expression profiles. Am J Pathol 2001;159:1231-1238.
    • (2001) Am J Pathol , vol.159 , pp. 1231-1238
    • Giordano, T.J.1    Shedden, K.A.2    Schwartz, D.R.3    Kuick, R.4    Taylor, J.M.5    Lee, N.6
  • 192
    • 0035923521 scopus 로고    scopus 로고
    • Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses
    • Bhattacharjee A, Richards WG, Staunton J, Li C, Monti S, Vasa P, et al: Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci USA 2001;98:13790-13795.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 13790-13795
    • Bhattacharjee, A.1    Richards, W.G.2    Staunton, J.3    Li, C.4    Monti, S.5    Vasa, P.6
  • 194
    • 0038297500 scopus 로고    scopus 로고
    • Expression profiles of non-small cell lung cancers on cDNA microarrays: Identification of genes for prediction of lymph-node metastasis and sensitivity to anti-cancer drugs
    • Kikuchi T, Daigo Y, Katagiri T, Tsunoda T, Okada K, Kakiuchi S, et al: Expression profiles of non-small cell lung cancers on cDNA microarrays: Identification of genes for prediction of lymph-node metastasis and sensitivity to anti-cancer drugs. Oncogene 2003;22:2192-2205.
    • (2003) Oncogene , vol.22 , pp. 2192-2205
    • Kikuchi, T.1    Daigo, Y.2    Katagiri, T.3    Tsunoda, T.4    Okada, K.5    Kakiuchi, S.6
  • 198
    • 0037683738 scopus 로고    scopus 로고
    • Discovery of distinct protein profiles specific for lung tumors and premalignant lung lesions by SELDI mass spectrometry
    • Zhukov TA, Johanson RA, Cantor AB, Clark RA, Tockman MS: Discovery of distinct protein profiles specific for lung tumors and premalignant lung lesions by SELDI mass spectrometry. Lung Cancer 2003;40:267-279.
    • (2003) Lung Cancer , vol.40 , pp. 267-279
    • Zhukov, T.A.1    Johanson, R.A.2    Cantor, A.B.3    Clark, R.A.4    Tockman, M.S.5


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