Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression

Journal of the National Cancer Institute

Volumn 93, Issue 9, 2001, Pages 691-699

  Burbee, David G ^a   Forgacs, Eva ^a   Zöchbauer Müller, Sabine ^a   Shivakumar, Latha ^a   Fong, Kwun ^c   Gao, Boning ^a   Randle, Dwight ^a   Kondo, Masashi ^a   Virmani, Arvind ^a   Bader, Scott ^a   Sekido, Yoshitaka ^a   Latif, Farida ^d   Milchgrub, Sara ^b   Toyooka, Shinichi ^a   Gazdar, Adi F ^a   Lerman, Michael I ^e   Zabarovsky, Eugene ^f   White, Michael ^a   Minna, John D ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c THE PRINCE CHARLES HOSPITAL   (Australia)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^e NATIONAL CANCER INSTITUTE   (United States)

^f KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GENE PRODUCT; MESSENGER RNA; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; RASSF1 PROTEIN; RASSF1C PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CANCER SURGERY; CANCER SURVIVAL; CARCINOGENICITY; CELL CULTURE; CHROMOSOME 3P; COLONY FORMATION; CONTROLLED STUDY; EPITHELIUM; FEMALE; GENE INACTIVATION; GENE LOCUS; GENETIC CODE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOTHESIS; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; METHYLATION; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SAMPLE; STATISTICAL ANALYSIS; TUMOR SUPPRESSOR GENE;

EID: 0035795676     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/93.9.691     Document Type: Article

References (36)

1. High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints
2. Progress in understanding the molecular pathogenesis of human lung cancer
3. Molecular damage in the bronchial epithelium of current and former smokers
4. Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma
5. Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes
6. Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: Progress toward the isolation of a lung cancer TSG
7. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: Identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium
8. Cloning of a breast cancer homozygous deletion junction narrows the region of search for a 3p21.3 tumor suppressor gene
9. SMART, a simple modular architecture research tool: Identification of signaling domains
10. Identification of Nore1 as a potential Ras effector
11. Taxonomy and function of C1 protein kinase C homology domains
12. Amino acid sequences common to rapidly degraded proteins: The PEST hypothesis
13. Substrate specificities and identification of putative substrates of ATM kinase family members
14. Alterations in DNA methylation: A fundamental aspect of neoplasia
15. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3
16. FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations
17. Correlation of abnormal RB, p16ink4a, and p53 expression with 3p loss of heterozygosity, other genetic abnormalities, and clinical features in 103 primary non-small cell lung cancers
18. Revisions in the International System for Staging Lung Cancer
19. NCI-Navy Medical Oncology Branch cell line data base
20. Comparison of features of human lung cancer cell lines and their corresponding tumors
21. Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer
22. Molelcular cloning: A laboratory manual
23. Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms
24. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
25. Aberrant promoter methylation of multiple genes in non-small cell lung cancers
26. High sensitivity mapping of methylated cytosines
27. Methylation of the 5′ CpG island of the FHIT gene is closely associated with transcriptional inactivation in esophageal squamous cell carcinomas
28. Heterogeneity of transcriptional activity of mutant p53 proteins and p53 DNA target sequences
29. Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer
30. Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2)
31. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
32. Nonparametric estimation from incomplete observations
33. Molecular changes in the bronchial epithelium of patients with small cell lung cancer
34. p53: A transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer
35. Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis
36. Multiple clonal abnormalities in the bronchial epithelium of patients with lung cancer